GlycosylTransferase Family 2

Activities in Familycellulose synthase (EC 2.4.1.12); chitin synthase (EC 2.4.1.16); dolichyl-phosphate β-D-mannosyltransferase (EC 2.4.1.83); dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117); N-acetylglucosaminyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); hyaluronan synthase (EC 2.4.1.212); chitin oligosaccharide synthase (EC 2.4.1.-); β-1,3-glucan synthase (EC 2.4.1.34); β-1,4-mannan synthase (EC 2.4.1.-); β-mannosylphosphodecaprenol-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: galactofuranosyl-galactofuranosyl-rhamnosyl-N-acetylglucosaminyl-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); dTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289); alternating β-1,3/4-N-acetylmannan synthase (2.4.1.-); UDP-GlcA: N-acetylglucosaminyl-proteoglycan β-1,4-glucuronosyltransferase (EC 2.4.1.225); [inverting] UDP-Glc: glycocin S-β-glucosyltransferase (EC 2.4.1.-); [inverting] UDP-Glc: protein O-β-glucosyltransferase (EC 2.4.1.-)
Mechanism Inverting
3D Structure StatusGT-A
NoteDistant similarity to families GT12, GT21, GT27, GT55, GT81 etc.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (303948); Uniprot accession (382); PDB accession (54); 3D entries (21); cryst (0)
| 1 | 2 | 3 |
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 UDP-GlcNAc: [chitooligosaccharide] β-1,4-N-acetylglucosaminyltransferase (NodC) 2.4.1.-   Rhizobium leguminosarum bv. phaseoli AAA98211.1 P24151  
 UDP-GlcNAc: [chitooligosaccharide] β-1,4-N-acetylglucosaminyltransferase (NodC) 2.4.1.-   Rhizobium leguminosarum bv. viciae CAA25814.1
BAA06086.1
CAA68619.1
P04340  
 N-acetylglucosaminyltransferase (NodC) 2.4.1.-   Rhizobium sp. N33 AAB16897.1 P72334  
 UDP-ManNAc: GlcNAc-PP-Und β-N-acetylmannosaminyltransferase (WbbE;RfbA) (priming) 2.4.1.-   Salmonella enterica subsp. enterica serovar Borreze AAC98401.1 Q52256  
 alternating β-1,3/4-N-acetylmannan synthase WbbF 2.4.1.-   Salmonella enterica subsp. enterica serovar Borreze AAC98402.1 Q52257  
 cellulose synthase (BcsA) 2.4.1.12   Salmonella typhimurium ATCC14028 CAC44015.1 Q93IN2  
 UDP-Glc: (LOS) D-glycero-L-manno-heptitose I β-1,4-glucosyltransferase (WaaE;KdtX) 2.4.1.-   Serratia marcescens N28b AAC44433.1 Q54435  
 dTDP-rhamnose: L-Rha α-1,2-rhamnosyltransferase (RfbF) 2.4.1.-   Shigella flexneri 02A CAA50772.1 P37782  
 dTDP-Rha: α-1,3-rhamnosyltransferase (RfbG) (probable fragment) 2.4.1.-   Shigella flexneri O2A CAA50773.1 P37783  
 N-acetylglucosaminyltransferase (NodC;Y4hG;NGR234_136) 2.4.1.-   Sinorhizobium fredii NGR234 AAB91695.1
CAA51774.1
P50357  
 N-acetylglucosaminyltransferase (NodC) 2.4.1.-   Sinorhizobium meliloti AAA98362.1
AAB24745.1
ACX32962.1
CAA25810.1
D0EJK4
P04341
 
 β-1,3-glucosyltransferase (ExoA;SMb20957) 2.4.1.-   Sinorhizobium meliloti 1021 AAA16046.1
CAC49482.1
NP_437622.1
P33691  
 β-1,4-glucosyltransferase (ExoM;SMb20958) 2.4.1.-   Sinorhizobium meliloti 1021 AAA16045.1
CAC49483.1
NP_437623.1
P33695  
 β-1,6-glucosyltransferase (ExoO;SMb20959) 2.4.1.-   Sinorhizobium meliloti 1021 CAC49484.1
AAA16044.1
NP_437624.1
P33697  
 β-1,6-glucosyltransferase (ExoU;SMb20948) 2.4.1.-   Sinorhizobium meliloti 1021 CAA80359.1
AAA16053.1
CAC49471.1
NP_437611.1
P33700
P33700
 
 β-1,3-glucosyltransferase (ExoW;SMb21690) 2.4.1.-   Sinorhizobium meliloti 1021 CAA80361.1
AAA16051.1
CAC49473.1
NP_437613.1
P33702  
 [EPS] bDGlcAp-1,4-bDGlcp-PPI β-1,4'-glucosyltransferase (SpsL) 2.4.1.- pubmed
Sphingomonas sp. S88 AAC44061.1 P74820  
 L-rhamnosyltransferase (SpsQ) 2.4.1.-   Sphingomonas sp. S88 AAC44058.1 P74817  
 poly-β-1,6-N-acetylglucosamine synthase (IcaA) 2.4.1.-   Staphylococcus aureus ATCC 35556 AAD52055.1 Q9RQP9  
 UDP-GlcNAc: teichoic acid β-N-acetylglucosaminyltransferase (TarS;SAV0258) 2.4.1.-   Staphylococcus aureus subsp. aureus Mu50 BAB56420.1
NP_370782.1
A0A0H3JPC6
Q99WW5
5TZ8[A,B,C]
5TZE[C,E]
5TZI[C]
5TZJ[A,C]
5TZK[C]
5U02[A]
 staphyloxanthin β-glucosyltransferase (CrtQ; NWMN_2463) 2.4.1.-   Staphylococcus aureus subsp. aureus str. Newman BAF68735.1
CAA66627.1
Q53590
Q53590
 
 β-1,6-N-acetylglucosaminyltransferase (IcaA;SE2293) 2.4.1.-   Staphylococcus epidermidis RP62A AAW53175.1
AAC06117.1
Q5HKQ0  
 UDP-forming cellulose synthase catalytic subunit (BcsA) 2.4.1.12 pubmed
Starkeya sp. N1B QCS37654.1    
 N-acetylglucosaminyltransferase (CpsIaI;CpsH) 2.4.1.-   Streptococcus agalactiae TYPE IA BAA33749.1
BAA82283.1
O87182  
 β-1,4-galactosyltransferase (CpsIaJ;CpsI) 2.4.1.-   Streptococcus agalactiae TYPE IA BAA82284.1
BAA33750.1
O87183  
 β-1,3-galactosyltransferase (CpsIbJ) 2.4.1.-   Streptococcus agalactiae TYPE IB BAB21602.1
AAW18824.1
Q9AQI9  
 β-1,3-N-acetylglucosaminyltransferase (CpsIbI) 2.4.1.-   Streptococcus agalactiae TYPE IB BAB21601.1 Q9AQJ0  
 hyaluronan synthase (HasA;Se-HAS) 2.4.1.212   Streptococcus dysgalactiae subsp. equisimilis D181 AAB87874.1
ABA69780.1
ABE19381.1
ABH66176.1
ABH92224.1
ABJ25635.1
ABJ29050.1
ABJ29057.1
ABJ29058.1
ABJ29059.1
ABJ29060.1
ABJ29061.1
ABJ29062.1
ABJ29063.1
ABJ29064.1
ABJ29065.1
ABJ29066.1
ABJ29067.1
ABJ29068.1
ABJ29069.1
ABJ29070.1
ABJ29071.1
ABJ43062.1
ACP88139.1
CAJ87401.1
CAL40945.1
CAL44809.1
CAL47726.1
O50201  
 hyaluronan synthase (HasA) 2.4.1.212   Streptococcus equi subsp. zooepidemicus ATCC 35246 AAO20097.1
AAQ03572.1
Q84GC8  
 β-glucosyltransferase (RgpI) 2.4.1.-   Streptococcus mutans XC BAC11844.1 Q8KZ90  
 bimodular dual β-glycosyltransferase, N-term GT101 transfers β-Glc; C-term GT2 transfers β-GlcNAc (?dGT1;Spaf_1933) 2.4.1.-   Streptococcus parasanguinis FW213 ACF35268.1
AFJ26875.1
B5A7M0
I1ZPA1
5HEA[A,B,C]
5HEC[A,B]
 β-1,3-N-acetylglucosaminyltransferase Cps14I 2.4.1.-   Streptococcus pneumoniae 14 CAA59781.1 O07339  
 β-1,4-galactosyltransferase (Cps14J) 2.4.1.- pubmed
Streptococcus pneumoniae 14 CAA59782.1 O07340  
 α-1,3-rhamnosyltransferase (SPC28A_0012; WcxN) 2.4.1.-   Streptococcus pneumoniae 1982/45 CAI34031.1    
 α-1,3-rhamnosyltransferase (SPC28F_0012; WcxN) 2.4.1.-   Streptococcus pneumoniae 34372 CAI34056.2    
 UDP-Glc: CPS β-1,2/3-glucosyltransferase / processive polysaccharide synthase (Tts) 2.4.1.-   Streptococcus pneumoniae 37 CAB51329.1 Q9X9S1  
 UDP-Glc: β-glucosyltransferase (GlyG;SP1764) 2.4.1.-   Streptococcus pneumoniae TIGR4 AAK75839.1
AAY71774.1
NP_346199.1
A0A0H2UR96
Q97P78
 
 processive [UDP-GluA/UDP-Glc β-1,4-GlcUA/β-1,3-Glc] polysaccharide synthase Cps3S 2.4.1.-   Streptococcus pneumoniae TYPE 3 WU2 AAC43312.1 Q54611  
 hyaluronan synthase 1 (HasA) 2.4.1.212   Streptococcus pyogenes S43 AAA17981.1
AAA17984.1
AAN23420.1
Q5X9A9  
 UDP-Glc: validoxylamine A 4'-O-β-glucosyltransferase (ValG;SHJG_0282) 2.4.1.-   Streptomyces hygroscopicus subsp. jinggangensis 5008 ABA41511.1
AEY85560.1
H2K893
Q1L2K4
 
 dTDP-spectinose: actinamine β-1,5-spectinosyltransferase (SpcG) 2.4.1.-   Streptomyces spectabilis ATCC 27741 ABW87806.1
AAD28487.1
A8WEZ8
Q9X6T3
 
 UDP-Glc: undecaprenyl-P β-glucosyltransferase (GtrB;GtrBSyn;sll0501) 2.4.1.-   Synechocystis sp. PCC 6803 BAA10834.1
AGF53125.1
ALJ69004.1
BAK51619.1
NP_442763.1
QWO80272.1
Q55487 5EKE[A,B,C,D]
5EKP[A,B,C,D]
 monoglucosyldiacylglycerol synthase (sll1377;MGlcDG) 2.4.1.157   Synechocystis sp. PCC 6803 BAA18254.1
AGF51942.1
ALJ67909.1
BAK50427.1
NP_441574.1
QWO79128.1
P74165  
 cellulose synthase (Tvtll0007) 2.4.1.12   Thermostichus vulcanus RKN BAJ61012.1 E5RST0  
 UDP-Glc:Und-P-P-OC5-β-1,6-glucosyltransferase WbcK 2.4.1.-   Yersinia enterocolitica CAA87699.1 Q56914  
 UDP-Glc:Und-P-P-OC4-β-1,3-glucosyltransferase (WbcL) 2.4.1.-   Yersinia enterocolitica CAA87700.1 Q56915  
 UDP-Glc: (LOS) D-glycero-L-manno-heptitose I β-1,4-glucosyltransferase (WaaE) 2.4.1.-   Yersinia enterocolitica R102 AAL78078.1 Q8RSW8  
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 chitin synthase 2.4.1.16   Aedes aegypti AAF34699.2 Q9NHE6  
 At5g05170 (cellulose synthase A3;CesA3;Cev1;Rsw5) (AtCesA3) 2.4.1.12   Arabidopsis thaliana AAC39336.1
AAN86168.1
AAO95208.1
AAY06383.1
AED90836.1
AHL38644.1
BAB09693.1
BAF01916.1
CAC09627.1
CAC09633.1
CAW91425.1
CAW94243.1
CBC96120.1
NP_196136.1
A0A384K963
O48948
Q941L0
W8Q6G0
7CK1[A,B]
7CK2[A,B]
7CK3[A,B]
 cellulose synthase A7 (Irx3;At5g17420) (AtCesA7) 2.4.1.12   Arabidopsis thaliana AAD32031.1
AAD40885.1
AAM98075.1
AAO42789.1
AED92424.1
AHL38621.1
CAC01737.1
CAW91434.1
CAW94252.1
CBC96128.1
NP_197244.1
A0A384LP57
Q9SWW6
Q9XHP6
W8PV01
 
 At4g39350 (cellulose synthase A2;CesA2) (AtCesA2) 2.4.1.12   Arabidopsis thaliana AAC39335.1
AAL24340.1
AAM13307.1
AAO95207.1
AEE87059.1
AHL38978.1
CAB43650.1
CAB80598.1
CAC09626.1
CAC09632.1
CAW91423.1
CAW94241.1
CBC96118.1
NP_195645.1
A0A384LAI4
O48947
W8QPD2
 
 β-1,4-mannan synthase / glucomannan synthase (CslA1;At4g16590/dl4320w) (AtCslA1) 2.4.1.-   Arabidopsis thaliana AAO42230.1
AEE83774.1
AEE83774.2
AHL38690.1
BAD94168.1
CAB10434.1
CAB78701.1
NP_193392.2
Q84W54
W8Q2Z5
 
 At4g32410 (cellulose-synthase A1;CesA1;Rsw1) (AtCesA1) 2.4.1.12   Arabidopsis thaliana AAC39334.1
AAO95206.1
AAO95209.1
AAP40467.1
AEE86053.1
AHL38667.1
BAD95078.1
BAE98406.1
CAA22568.1
CAB79958.1
CAC09624.1
CAC09625.1
CAC09628.1
CAC09630.1
CAC09631.1
CAC09634.1
CAW90576.1
CAW91421.1
CAW93142.1
CAW94239.1
CAW96361.1
CAW96969.1
CAW97701.1
CBC98739.1
NP_194967.1
A0A384LG35
O48946
W8PUJ0
 
 β-1,4-mannan synthase / glucomannan synthase (CslA7;At2g35650/T20F21.16) (AtCslA7) 2.4.1.-   Arabidopsis thaliana AAL24081.1
AAD15455.2
AAM61171.1
AAM91741.1
AEC09136.1
AHL38812.1
ANM63110.1
ANM63111.1
ANM63112.1
CAD32548.1
NP_565813.1
A0A1P8B2I0
A0A1P8B2I3
Q8LFW7
Q9ZQN8
W8PUY9
 
 GDP-Man: [glucomannan] β-mannosyltransferase (CslD5;At1g02730) (AtCslD5) 2.4.1.-   Arabidopsis thaliana AAF02892.1
AEE27464.1
AHL38973.1
NP_171773.1
A0A384L2H6
Q9SRW9
W8QPC8
 
 (gluco)mannan synthase (KOJAK;CslD3;At3g03050) (AtCslD3) 2.4.1.-   Arabidopsis thaliana AAF26119.1
AAG60543.1
AAK25890.1
AAK64073.1
AEE73896.1
AHL38784.1
CAC82909.1
NP_186955.1
A0A384LKM5
Q9M9M4
W8Q6V3
 
 β-1,4-mannan synthase / glucomannan synthase (CslA9;At5g03760/F17C15_180) (AtCslA9) 2.4.1.-   Arabidopsis thaliana CAB82941.1
AAL31192.1
AAN31089.1
AED90651.1
AHL38649.1
BAB08601.1
BAE98718.1
NP_195996.1
A0A384KRA8
Q9LZR3
W8Q6G5
 
 xyloglucan β-1,4-glucan synthase (At3g28180;MIG10.8) (AtCslC4) 2.4.1.-   Arabidopsis thaliana BAB01433.1
AAL07135.1
AAM14372.1
AEE77412.1
AHL38749.1
NP_566835.1
A0A654FCT3
Q9LJP4
W8Q6R3
 
 (gluco)mannan synthase (CslD2;At5g16910) (AtCslD2) 2.4.1.-   Arabidopsis thaliana CAC01704.1
AED92357.1
NP_197193.1
Q9LFL0  
 β-1,4-mannan synthase / glucomannan synthase (CslA2;At5g22740/MDJ22.16) (AtCslA2) 2.4.1.-   Arabidopsis thaliana BAB11680.1
AAL24334.1
AAL25573.1
AAM13292.1
AED93069.1
AHL38612.1
NP_197666.1
A0A654G3G8
Q9FNI7
W8PUD8
 
 chitin synthase (class VI) 2.4.1.16   Aspergillus fumigatus AAB60781.1
CAF31978.1
CAL85388.1
P78746  
 Chitin synthase C 2.4.1.16   Aspergillus fumigatus CAA63929.1
CAL85387.1
Q92197  
 Chitin synthase G 2.4.1.16   Aspergillus fumigatus AAB07678.1
AAB07679.1
AAO30660.1
CAA63928.1
CAL85389.1
P54267  
 β-1,3;1,4 glucan synthase (AFUA_3G03620) 2.4.1.-   Aspergillus fumigatus Af293 EAL86644.1
XP_748682.1
Q4WF33  
 AN1555.2 (chitin synthase E) 2.4.1.16   Aspergillus nidulans FGSC A4 AAA97482.1
BAA11866.2
EAA64262.1
P78611  
 chitin synthase (CsmA;ChsD) 2.4.1.16   Aspergillus nidulans FGSC A89 BAA21714.1
AAB05797.1
O13281
Q4U208
 
 chitin synthase C (ChsC) 2.4.1.16   Aspergillus nidulans FGSC A89 BAA75501.1 O94165
P30583
 
 Chitin synthase A 2.4.1.16   Aspergillus nidulans FGSC89 BAA04806.1
AAA33303.1
P30584  
 Chitin synthase B 2.4.1.16   Aspergillus nidulans FGSC89 AAO30659.1
BAA04807.1
BAA11845.1
Q00757  
 chitin synthase (ChsZ;CsmA) 2.4.1.16   Aspergillus oryzae A1560 / RIB40 BAB88208.1
AAL27566.1
BAB88127.1
Q8TF96
Q96UR2
 
 chitin synthase (ChsB) 2.4.1.16   Aspergillus oryzae IFO 4177 AAK31732.1
CAL85390.1
Q9C164  
 chitin synthase 2.4.1.16   Atrina rigida AAY86556.1 Q288C6  
 hyaluronan synthase 2 (Has2) 2.4.1.212   Bos taurus CAA06239.1
ABA69794.1
BAA76547.1
CAJ87391.1
CAL40932.1
CAL44796.1
CAL47713.1
NP_776504.1
O97711  
 dolichol-phosphate mannosyltransferase 2.4.1.83   Caenorhabditis briggsae AAC98796.1 O17511  
 chitin synthase 2 (Chs-2;F48A11.1) 2.4.1.16   Caenorhabditis elegans Bristol N2 AAX62733.1
AAB71283.1
AAB71283.2
CCD71483.1
NP_493682.1
G5EBQ8
O17368
 
 chitin synthase 2 (CHS2) 2.4.1.16   Candida albicans AAB59308.2 P30572  
 chitin synthase 3 (CHS3) 2.4.1.16   Candida albicans BAA02707.1 P30573  
 chitin synthase 1 (CHS1) 2.4.1.16   Candida albicans CAA21947.1
BAE44784.1
CAA36671.1
G1UA94
P23316
Q9URM1
 
 chitin synthase 8 (Chs8) 2.4.1.16   Candida albicans SC5314 AAO37822.1 G1UAP4
Q5A7T2
 
 cellulose synthase 2.4.1.12   Ciona savignyi AAR89623.1 Q6RCS2  
 chitin synthase III (CHSIII) 2.4.1.16   Coccidioides posadasii AAG16851.1 Q9HFT1  
 chitin synthase I (CHSI) 2.4.1.16   Coccidioides posadasii SILVEIRA AAF82801.1 Q9P442  
 Dolichol-phosphate mannosyltransferase 2.4.1.83   Cricetulus griseus AAD30975.1 Q9WU83  
 hyaluronan synthase (Cps1) 2.4.1.212   Cryptococcus neoformans AAQ92917.1 Q6YNJ4  
 hyaluronan synthase (Cps1;CNI02290) 2.4.1.212   Cryptococcus neoformans var. neoformans JEC21 AAW45548.1 F5H8V6  
 chitin synthase (Chs3;CNH02270) 2.4.1.16   Cryptococcus neoformans var. neoformans JEC21 AAW45092.1 Q5KCU4  
 β-1,4-mannan synthase (ManS) 2.4.1.-   Cyamopsis tetragonoloba AAR23313.1
ADF47159.1
D5LXN1
Q6UDF0
 
 cellulose synthase DcsA 2.4.1.12   Dictyostelium discoideum AAF00200.1 Q9U720  
 cellulose synthase DcsA 2.4.1.12   Dictyostelium discoideum AAF00200.1 Q9U720  
 chitin synthase (Chs-1) 2.4.1.16   Dirofilaria immitis AAG39382.1
AAL92023.1
Q8T655
Q9GQ90
 
 GDP-Man: glucosylceramide β-1,4-mannosyltransferase (egh;egghead;CG9659) 2.4.1.-   Drosophila melanogaster AAB49734.1
AAB49735.1
AAF43419.1
AAF45792.1
AAN09081.1
ACN43733.1
ACO95729.1
ACX37660.1
AEX93160.1
AHN59300.1
CAB72293.1
NP_525052.1
NP_726818.1
A4V3W0
C0PTV2
C3KGI6
O01346
 
 chitin synthase A (ChsA;CG7464) 2.4.1.16   Drosophila melanogaster AAF51798.2
AAF51798.1
AAF51798.3
ACL83352.1
ACL83352.2
ADN43899.1
CAC83726.1
NP_524209.2
B7Z099
E1NZB3
Q8WQ83
Q9VNW7
 
 UDP-Glc: dolichyl-phosphate β-glucosyltransferase (Alg5;Wol;Wollknäuel;Dmel_CG7870) 2.4.1.117   Drosophila melanogaster AAF52633.1
AAM11045.1
NP_609202.1
Q9VLQ1  
 chitin synthase 1 or B (DmCS-1;ChsB;CG2666) 2.4.1.16   Drosophila melanogaster AAS65101.1
AAG09735.1
AAG22215.2
AAG22215.3
AAK92858.1
AAM75067.1
AAN13280.1
ADT78485.1
CAC83725.1
NP_524233.1
NP_730928.1
Q8IPN4
Q8MQN8
Q8WQ84
Q961Q5
Q9GTZ7
Q9I7P4
 
 chitin synthase 1 (fragment) 2.4.1.16   Entamoeba invadens AAW19636.1 Q5IFQ8  
 chitin synthase (Chs2) 2.4.1.16   Exophiala dermatitidis AAC34496.1
AAA30335.1
P30601  
 chitin synthase (Chs3) 2.4.1.16   Exophiala dermatitidis AAC35278.1
AAA30336.1
P30602  
 chitin synthase class I (Chs1) 2.4.1.16   Fusarium graminearum CAC41025.1 Q96VK2  
 Chitin synthase 2.4.1.16   Glomus versiforme CAA08762.1 O93962  
 cellulose synthase (CesA1;CelA1) 2.4.1.12   Gossypium hirsutum AAB37766.1
AAQ41472.1
AAT64028.1
ABG06122.1
ABR14737.1
ADY68800.1
CAW90440.1
CAW91306.1
CAW93014.1
CAW94123.1
CAW96303.1
CAW96911.1
CAW97572.1
CBC98625.1
A6MUT5
F1BWZ9
P93155
Q1EG93
 
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