GlycosylTransferase Family 2

Activities in Familycellulose synthase (EC 2.4.1.12); chitin synthase (EC 2.4.1.16); dolichyl-phosphate β-D-mannosyltransferase (EC 2.4.1.83); dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117); N-acetylglucosaminyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); hyaluronan synthase (EC 2.4.1.212); chitin oligosaccharide synthase (EC 2.4.1.-); β-1,3-glucan synthase (EC 2.4.1.34); β-1,4-mannan synthase (EC 2.4.1.-); β-mannosylphosphodecaprenol-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: galactofuranosyl-galactofuranosyl-rhamnosyl-N-acetylglucosaminyl-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); dTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289)
Mechanism Inverting
3D Structure StatusGT-A
NoteDistant similarity to families GT12, GT21, GT27, GT55, GT81 etc.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (118847); Uniprot accession (17782); PDB accession (28); 3D entries (11); cryst (0)
All (113414) Archaea (3300) Bacteria (103522) Eukaryota (5990) Viruses (534) unclassified (68) Structure (11) Characterized (277)
| 1 | 2 | 3 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 glycosyltransferase E (AglE) 2.4.1.- Haloferax volcanii DS70 / WR536 (H53) CAP09656.1 A8E1V5  
 Dol-P glycosyltransferase J (AglJ) 2.4.1.- Haloferax volcanii WR536 (H53) CAR66203.1 B5U882  
 C55-P-Dol-tetraoside β-mannosyltransferase D (AglD;Alg5-A) 2.4.1.- Haloferax volcanii WR536 (H53) CAM91696.1 A4VB68  
 GDP-Man: dolichyl-phosphate β-mannosyltransferase (PH0051) 2.4.1.83 Pyrococcus horikoshii OT3 BAA29119.1
NP_142068.1
O57812  
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 poly-β-1,6-N-acetylglucosamine synthase (PgaC) 2.4.1.- Acinetobacter baumannii S1 ACV90435.1 C8YYH7  
 poly-β-1,6-N-acetylglucosamine synthase (PgaC;AagC) 2.4.1.- Actinobacillus pleuropneumoniae IA1 AAT46092.1
ABW37046.1
Q5QFG3  
 poly-β-1,6-N-acetylglucosamine synthase (PgaC;AagC) 2.4.1.- Aggregatibacter actinomycetemcomitans CU1000 AAR97320.1
ABH85974.1
ACP74815.1
Q5VJB2  
 poly-β-1,6-N-acetylglucosamine synthase (PgaC) 2.4.1.- Aggregatibacter actinomycetemcomitans HK1651 ABQ02267.1
AKU28339.1
   
 UDP-Glc: β-1,3-glucan (curdlan) synthase (CrdS) 2.4.1.34 Agrobacterium sp. ATCC 31749 AAD20440.2 Q9X2V0  
 cellulose synthase (CelA) 2.4.1.12 Agrobacterium tumefaciens AAC41436.1
AAC41435.1
Q44418  
 UDP-GlcNAc: [chitooligosaccharide] β-1,4-N-acetylglucosaminyltransferase (NodC;AZC_3816) 2.4.1.- Azorhizobium caulinodans ORS 571 BAF89814.1
AAB51164.1
Q07755  
 β-1,3-glucanosyltransglucosidase (Glt7;Avin_39140) 2.4.1.- Azotobacter vinelandii DJ ATCC BAA-1303 ACO80054.1 C1DSW1  
 UDP-Glc: (sublancin 168) S-β-glucosyltransferase / sublancin S-glycosyltransferase (SunS;YolJ;BSU21450) 2.4.1.- Bacillus subtilis subsp. subtilis str. 168 CAB14063.1
AAC12995.1
AAC38304.1
AIY93467.1
AQR82152.1
AQR86366.1
NP_390028.1
O31986
O64036
 
 UDP-Gal: [CPSA] bactoprenol-PP-AADGal β-1,3-galactosyltransferase (WcfQ;BF1375) 2.4.1.- Bacteroides fragilis NCTC 9343 CAH07088.1
AAK68920.1
Q5LFK5  
 cyclic β-1-3-glucan synthase (NdvB;blr4614) 2.4.1.-
2.4.1.-
Bradyrhizobium diazoefficiens USDA 110 AAC62210.1
BAC49879.1
NP_771254.1
O87342
Q89LD1
 
 β-N-acetylglucosaminyltransferase (NodC) 2.4.1.- Bradyrhizobium sp. WM9 AAK00157.1 Q9AQ23  
 poly-β-1,6-N-acetylglucoamine synthase (PgaC;Bmul_4484;BMULJ_04026) 2.4.1.- Burkholderia multivorans ATCC 17616 ABX18163.1
BAG45885.1
A9ALG6  
 UDP-Gal : GA2 β-1,3-galactosyltransferase (CgtB) 2.4.1.- Campylobacter jejuni ATCC 43438 AAK91724.1 Q93MQ1  
 UDP-GalNAc: Gb3 β-1,3-N-acetylgalactosaminyltransferase (CgtE;ORF7) 2.4.1.- Campylobacter jejuni LIO87 AAM90646.1 Q8KWR0  
 UDP-Gal: GM2 β-1,3-galactosyltransferase (CgtB) 2.4.1.- Campylobacter jejuni OH4384 AAF31770.1
AAO96674.1
ACK29137.1
ADB45264.1
ADB45270.1
CAF04177.1
CAK26620.1
Q9K2V8  
 UDP-Glc: β-1,3-glucosyltransferase (PglI;WlaD;Cj1128c) 2.4.1.- Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CAB73383.1
CAA04330.1
CAL35245.1
NP_282276.1
O52906
Q0P9C6
Q9PNG6
 
 UDP-Gal: GM2 β-1,3-galactosyltransferase (WlaN;CgtB;Cj1139c) 2.4.1.- Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CAB73394.1
AAO96675.1
AAT17978.1
AAU96108.1
AAW18151.1
ACK29138.1
CAF04178.1
CAK26621.1
CAL35256.1
NP_282287.1
Q0P9B5
Q9PNF5
 
 holdfast β-N-acetylglucosaminyltransferase (HfsG;CC2427) 2.4.1.- Caulobacter crescentus CB15 AAK24398.1
NP_421230.1
Q9A5M0  
 chondroitin synthase/polymerase (Cpha266_2341) 2.4.1.175
2.4.1.226
Chlorobium phaeobacteroides DSM 266 ABL66329.1 A1BIV2  
 chondroitin synthase/polymerase (Cpha266_2341) 2.4.1.175
2.4.1.226
Chlorobium phaeobacteroides DSM 266 ABL66329.1 A1BIV2  
 chlorobactene β-glucosyltransferase (CruC;CT1987) 2.4.1.- Chlorobium tepidum TLS AAM73205.1
NP_662863.1
Q8KB11  
 BcsA 2.4.1.12 Citrobacter sp. Fec2 CAD56668.1 Q7X246  
 chondroitin polymerase (KfoC;K4CP) 2.4.1.175
2.4.1.226
Escherichia coli K4 BAC00523.1
CAD87418.1
CAD87419.1
CAV13380.1
CAV13381.1
Q8L0V4 2Z86[A,B,C,D]
2Z87[A,B]
 chondroitin polymerase (KfoC;K4CP) 2.4.1.175
2.4.1.226
Escherichia coli K4 BAC00523.1
CAD87418.1
CAD87419.1
CAV13380.1
CAV13381.1
Q8L0V4 2Z86[A,B,C,D]
2Z87[A,B]
 UDP-GlcA: β-glucuronosyltransferase (KfiC) 2.4.1.17 Escherichia coli K5 CAA54709.1
ABY16658.1
ACW41679.1
Q47330  
 GDP-L-Colitose: LPS/UndPP-GlcNAc-Gal-Glc α-L-1,3/1,6-colitosyltransferase (WbdL) 2.4.1.- Escherichia coli O111 M92 AAD46731.1
CAV33038.1
Q9S520  
 UDP-Gal: O-polysaccharide N-acetylgalactosaminyl β-1,3-galactosyltransferase (WbiP;Orf12) 2.4.1.- Escherichia coli O127:K63(B8) AAR90893.1 Q5J7C7  
 β-1,3-glucosyltransferase (WbdN; ECH74115_2974) 2.4.1.305 Escherichia coli O157:H7 str. EC4115 ACI39394.1 B5YU97  
 β-1,3-galactosyltransferase (WbgO) 2.4.1.- Escherichia coli O55:H7 TB182A BAG11838.1 B1B4J9  
 β-1,3-glucosyltransferase (WfaP) 2.4.1.- Escherichia coli O56 ABB29913.1 Q077R2  
 UDP-Gal: α-GlcNAc-PP-lipid β-1,3-galactosyltransferase (WbbD;ORF275) 2.4.1.- Escherichia coli O7:K1 VW187 AAC27537.1 Q03084  
 glucosyltransferase (MdoH;OpgH) 2.4.1.- Escherichia coli str. K-12 substr. MG1655 AAC74133.1
CAA45522.1
NP_415567.1
P33137  
 UDP-L-Arap-4N-formyl : undecaprenyl-P α-L-4N-formylarabinosyltransferase (ArnC;YfbF;b2254) 2.4.2.- Escherichia coli str. K-12 substr. MG1655 AAC75314.1
AAY34350.1
AIZ90672.1
ALI40000.1
AMC95209.1
NP_416757.1
P77757  
 cellulose synthase (YhjO) 2.4.1.12 Escherichia coli str. K-12 substr. MG1655 AAC76558.2
AAB18510.1
AIZ89467.1
ALI38786.1
AMC96413.1
NP_417990.2
P37653  
 UDP-Glc: undecaprenyl-P β-glucosyltransferase (FlmF1;GtrB;FTN_1403) 2.4.1.- Francisella tularensis subsp. novicida U112 ABK90273.1
AJI60634.1
A0Q7Q8  
 UDP-GalNAc: undecaprenyl-P β-N-acetylgalactosaminyltransferase (FlmF2;FTN_0545) 2.4.1.- Francisella tularensis subsp. novicida U112 ABK89440.1 A0Q5C5  
 UDP-Gal: (human N-glycan) N-acetylglucosaminyl β-1,4-galactosyltransferase (Fnu_GT;FN1243) 2.4.1.- Fusobacterium nucleatum subsp. nucleatum ATCC 25586 AAL95439.1
NP_604140.1
Q8R632  
 UDP-Glc: LOS β-1,4-glucosyltransferase (LgtF) 2.4.1.- Haemophilus ducreyi 35000 AAF72876.1 Q9L875  
  β-1,3-N-acetylgalactosaminyltransferase (LgtA;HD0466) 2.4.1.- Haemophilus ducreyi 35000HP AAN05638.1
AAP95426.1
NP_873037.1
G1UB95  
 UDP-Glc: LOS β-1,4-glucosyltransferase (LgtF;HD1201) 2.4.1.- Haemophilus ducreyi 35000HP AAP96048.1
NP_873659.1
G1UB77  
 UDP-GalNAc: globotriose β-1,3-N-acetylgalactosaminyltransferase / UDP-Gal:globotetraose β-1,3-galactosyltransferase (LgtD;HI1578) 2.4.1.- Haemophilus influenzae Rd KW20 AAC23227.1
NP_439724.1
Q57287  
 UDP-Glc: (LOS) D-glycero-L-manno-heptitose I β-1,4-glucosyltransferase (WaaE) 2.4.1.- Klebsiella aerogenes CECT684 AAL78075.1 Q8RSX1  
 UDP-GlcA: (LOS) L-glycero-D-manno-heptose III β-1,7-glucuronyltransferase (WabO;ORF10) 2.4.1.- Klebsiella pneumoniae 52145 AAX20106.1 Q4QTM5  
 UDP-GlcA: (LOS) L-glycero-D-manno-heptose III β-1,7-glucuronyltransferase (WabO) 2.4.1.- Klebsiella pneumoniae C3 AAD37770.1 Q9XC92  
 UDP-Glc: (LOS) L-glycero-D-mannoheptose I β-1,4-glucosyltransferase (WaaE) 2.4.1.- Klebsiella pneumoniae C3 AAD37772.1
AAL88674.1
Q8RNK1
Q9XC90
 
 cellulose synthase subunit AB (AcsAB) 2.4.1.12 Komagataeibacter hansenii ATCC 23769 BAC82543.1
AIX47786.1
Q76KJ8  
 cellulose synthase (BcsA) 2.4.1.12 Komagataeibacter sucrofermentans BPR2001 AAQ41476.1
AAQ38001.1
BAA31463.1
O82859  
 cellulose synthase (AcsA;BcsA) 2.4.1.12 Komagataeibacter xylinus 1306-3 AAA21884.1 P19449  
 cellulose synthase (CesA;BcsA;AcsAB;AcsA;AcsB;GxCesA) 2.4.1.12 Komagataeibacter xylinus ATCC 53582 AAP61563.1
AAQ41475.1
CAA38487.1
P21877  
 cellulose synthase (AcsAII) 2.4.1.12 Komagataeibacter xylinus AY201 AAA85264.1 Q59167  
 β-1,6-glucosyltransferase (AceP) 2.4.1.- Komagataeibacter xylinus CKE CAB44443.1 Q9XBL5  
 β-1,3-galactosyltransferase (EpsJ;Eps6) 2.4.1.- Lactobacillus helveticus NCC2745 CAC07467.1    
 β-1,6-galactosyltransferase EpsI (Eps5) 2.4.1.- Lactobacillus helveticus NCC2745 CAC07466.1    
 UDP-GlcNAc: (glycocin F) S- and/or O-β-N-acetylglucosaminyltransferase (GccA) 2.4.1.- Lactobacillus plantarum KW30 ADV57361.1    
 bifunctional UDP-GlcNAc: flagellin β-O-N-acetylglucaminyltransferase / flagellin anti-repressor (GmaR;Lmo0688) 2.4.1.- Listeria monocytogenes EGD-e NP_464215.1
CAC98766.1
Q8Y949  
 teichoic acid/polyribitol-phosphate β-N-acetylglucosyltransferase (Lmo2550) 2.4.1.- Listeria monocytogenes EGD-e NP_466073.1
CAD00628.1
CUM44302.1
SIW59356.1
Q7AP48
Q93RN0
 
 UDP-GlcNAc: [chitooligosaccharide] β-1,4-N-acetylglucosaminyltransferase (NodC) 2.4.1.- Mesorhizobium loti CAA37131.1 P17862  
 UDP-Glc: (LOS) α-Glu-KDO2-lipidA β-glucosyltransferase (Lgt3) 2.4.1.- Moraxella catarrhalis 2951 AAZ29046.1 Q1PSV5  
 UDP-Glc: (LOS) α-Glu-KDO2-lipidA β-glucosyltransferase (Lgt3) 2.4.1.- Moraxella catarrhalis 2951 AAZ29046.1 Q1PSV5  
 rhamnose α-1,3-fucosyltransferase (GtfD) 2.4.1.- Mycobacterium avium TMC 724 AAD20376.1 O88109
Q7BR87
 
 dTDP-Rha: α-D-GlcNAc-PP-C50 α-1,3-L-rhamnosyltransferase (WbbL) 2.4.1.289 Mycobacterium smegmatis AAF04376.1 Q9RN49
Q9RN50
 
 dTDP-Rha: α-D-GlcNAc-PP-C50 α-1,3-L-rhamnosyltransferase (LJ00_09105) 2.4.1.289 Mycobacterium smegmatis str. MC2 155 AAF04375.1
AFP38255.1
AIU07048.1
   
 UDP-Galf: galactan anchor β-1,4-/β-1,5-galactofuranosyltransferase (GlfT1;MSMEG_6367) 2.4.1.287 Mycobacterium smegmatis str. MC2 155 ABK69689.1
AFP42625.1
AIU11348.1
A0R5Z2  
 dTDP-Rha: α-GlcNAc-PP-C50 α-1,3-L-rhamnosyltransferase (MT3365) 2.4.1.289 Mycobacterium tuberculosis CDC1551 AAK47706.1
NP_337892.1
P9WMY2  
 phosphatidylinositol mannoside mannosyltransferase (LosA;PimF;Rv1500) 2.4.1.199 Mycobacterium tuberculosis H37Rv CAB02014.1
AFN49415.1
CCP44262.1
NP_216016.1
P71781  
 mono-rhamnosylated phenophthiocerol dimycocerosate glycosyltransferase (Rv2957) 2.4.1.- Mycobacterium tuberculosis H37Rv CAB05419.1
AAA50938.1
AFN50939.1
CCP45761.1
NP_217473.1
Q50459  
 polyprenol monophosphomannose synthase (Ppm1;Rv2051c) 2.4.1.- Mycobacterium tuberculosis H37Rv CAA17265.1
AFN49992.1
CCP44824.1
NP_216567.1
O53493  
 UDP-Galf: galactan anchor β-1,4-/β-1,5-galactofuranosyltransferase (GlfT1;RfbE;Rv3782) 2.4.1.287 Mycobacterium tuberculosis H37Rv CAB02461.1
AFN51808.1
CAE55639.1
CCP46611.1
NP_218299.1
   
 dTDP-Rha: α-GlcNAc-PP-C50 α-1,3-L-rhamnosyltransferase (Rv3265c; WbbL1) 2.4.1.289 Mycobacterium tuberculosis H37Rv CAE55576.1
AFN51271.1
CAB07092.1
CCP46084.1
NP_217782.1
   
 UDP-Galf; galactan b-(1,5)- / b-(1,6)-galactofuranosyltransferase (GlfT2;GlfT;Rv3808c) 2.4.1.288 Mycobacterium tuberculosis H37Rv CAA17872.1
ACS09801.1
AFN51834.1
CCP46637.1
NP_218325.1
O53585 4FIX[A,B]
4FIY[A,B]
 UDP-Glc: diacylglycerol β-1,3-glucosyltransferase / UDP-Glc: β-glucosyl-3-diacylglycerol β-1,6-glucosyltransferase (MG_517;MG507;MG335.2) 2.4.1.157
2.4.1.-
Mycoplasma genitalium G37 AAC71559.1
NP_073005.1
Q9ZB73  
 UDP-Gal/Glc: β-Gal-1,2-diacylglycerol β-1,6-glycosyltransferase / processive glycosyltransferase (YibD;MPN483) (large specificity) 2.4.1.157
2.4.1.-
Mycoplasma pneumoniae M129 AAB96007.1
NP_110171.1
P75302  
 lsi2 (probable β-N-acetyl-glucosaminyltransferase) 2.4.1.- Neisseria gonorrhoeae 1291 AAA92074.1
AAF14359.1
Q50951
Q9RGN2
 
 N-acetyl-galactosaminyltransferase (LgtD) 2.4.1.- Neisseria gonorrhoeae F62 AAA68012.1
AAV26682.1
AAV26686.1
Q50949  
 UDP-Glc: lipooligosaccharide β-1,4-glucosyltransferase (LgtF) 2.4.1.- Neisseria meningitidis CDC8201085 NMB AAC44647.1 P95373  
 β-N-acetylglucosaminyltransferase (LgtA) 2.4.1.- Neisseria meningitidis MC58 AAC44084.1 Q51115  
 UDP-GlcNAc: [chitooligosaccharide] β-1,4-N-acetylglucosaminyltransferase (NodC) 2.4.1.- Neorhizobium galegae CAA60879.1 P50356  
 monoglucosyldiacylglycerol synthase (all4933;MGlcDG) 2.4.1.157 Nostoc sp. PCC 7120 BAB76632.1
NP_488973.1
Q8YMK0  
 β-glucan synthase (Gtf) 2.4.1.- Oenococcus oeni I4 AAY87028.1 A0PJ42  
 hyaluronan synthase (PmHAS;HAS) 2.4.1.-
2.4.1.-
2.4.1.212
Pasteurella multocida P-1059 ATCC 15742 AAC38318.1
AAC38318.2
AAF68412.1
AAN88232.1
AAW91046.1
ABA69782.1
ABE17757.1
ABH66178.1
ABJ25637.1
ABJ29053.1
ACP88140.1
ACW37627.1
ACW41670.1
Q7BLV3  
 hyaluronan synthase (PmHAS;HAS) 2.4.1.-
2.4.1.-
2.4.1.212
Pasteurella multocida P-1059 ATCC 15742 AAC38318.1
AAC38318.2
AAF68412.1
AAN88232.1
AAW91046.1
ABA69782.1
ABE17757.1
ABH66178.1
ABJ25637.1
ABJ29053.1
ACP88140.1
ACW37627.1
ACW41670.1
Q7BLV3  
 heparosan synthase A (HssA;PmHS1) 2.4.1.- Pasteurella multocida P4058 (TYPE D) AAL84705.1
ABY16655.1
ABY16660.1
ACW41684.1
Q8RP78  
 chondroitin synthase CS 2.4.1.175
2.4.1.226
Pasteurella multocida P4679 AAF97500.2
AAN88233.1
ABE17758.1
ABH92244.1
ACS05697.1
ACW32461.1
ACW32462.1
CAX69226.1
CAX87019.1
Q9CMP0  
 chondroitin synthase CS 2.4.1.175
2.4.1.226
Pasteurella multocida P4679 AAF97500.2
AAN88233.1
ABE17758.1
ABH92244.1
ACS05697.1
ACW32461.1
ACW32462.1
CAX69226.1
CAX87019.1
Q9CMP0  
 heparosan synthase A (HssA;PmHS1) 2.4.1.- Pasteurella multocida P5695 (TYPE D) AAL84702.1
ABY16654.1
Q8RP92  
 heparosan synthase (HssB;PglA;PmHS2;PM0414) 2.4.1.- Pasteurella multocida subsp. multocida str. Pm70 AAK02498.1
ABY16656.1
ACW41673.1
NP_245351.1
Q9CNL4  
 polysaccharide synthase (Gtf) 2.4.1.- Propionibacterium freudenreichii subsp. shermanii TL0034 / TL34 CAO99134.1
CBI83408.1
B4ERA8  
 UDP-Glc: (LOS) D-glycero-L-manno-heptose I β-1,4-glucosyltransferase (WaaE) 2.4.1.- Proteus mirabilis CECT170 AAL78071.1
AAR44212.1
Q8RSX5  
 UDP-Glc: (LOS) D-glycero-L-manno-heptose I β-1,4-glucosyltransferase (WaaE) 2.4.1.- Proteus mirabilis R110 ADK56067.1 E0YP68  
 dTDP-L-Rha: LPS α-1,3-L-rhamnosyltransferase (WapR;PA5000) 2.4.1.- Pseudomonas aeruginosa PAO1 AAG08385.1
NP_253687.1
Q9HUG5  
 GDP-ManA: alginate mannuronyltransferase (alginate synthase) (Alg8;PA3541) 2.4.1.- Pseudomonas aeruginosa PAO1 AAG06929.1
AAW77926.1
NP_252231.1
Q52463  
 cyclic β-1-3-glucan synthase (NdvB;Glt1;PA1163) 2.4.1.-
2.4.1.-
Pseudomonas aeruginosa PAO1 AAG04552.1
NP_249854.1
Q9I4H4  
 dTDP-L-Rha: L-Rhα-β-hydroxydecanoyl-β-hydroxydecanoate rhamnosyltransferase 2 (RhlC;PA1130) 2.4.1.- Pseudomonas aeruginosa PAO1 AAG04519.1
NP_249821.1
Q9I4K5  
 dTDP-L-Rha: LPS α-1,6-L-rhamnosyltransferase (MigA;PA0705) 2.4.1.- Pseudomonas aeruginosa PAO1 AAG04094.1
NP_249396.1
Q9I5M1  
 LPS glucosyltransferase (WbjA) 2.4.1.- Pseudomonas aeruginosa SEROTYPE 011 / PA103 AAD45263.1
AAM27573.1
Q8KNB2
Q9XC63
 
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