Activities in Family	UDP-Gal: β-1,3-galactan β-1,6-galactosyltransferase (EC 2.4.1.-); UDP-Gal: β-1,6-galactan β-1,6-galactosyltransferase (EC 2.4.1.-); CMP-NeuAc: α-2,8-polysialyltransferase (EC 2.4.3.-); Sialyltransferase (EC 2.4.3.-); CMP-NeuAc: β-galactoside α-2,6-sialyltransferase (EC 2.4.3.1); CMP-Neu5Ac: α-N-acetylgalactoside α-2,6-sialyltransferase (EC 2.4.3.3); CMP-Neu5Ac: β-galactoside α-2,3-sialyltransferase (EC 2.4.3.4); CMP-Neu5Ac: N-acetyllactoside α-2,3-sialyltransferase (EC 2.4.3.6); α-N-acetylneuraminyl-2,3-β-galactosyl-1,3-N-acetylgalactoside α-2,6-sialyltransferase (EC 2.4.3.7); CMP-Neu5Ac : α-N-acetylneuraminate α-2,8-sialyltransferase (EC 2.4.3.8); Lactosylceramide α-2,3-sialyltransferase (EC 2.4.3.9); Transferring other glycosyl groups (EC 2.4.99.-);
Mechanism	Inverting
Note	These enzymes use CMP-beta-N-acetylneuraminate as the sugar donor
External resources	CFG(Core1); CFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap;
Statistics	GenBank accession (2061); Uniprot accession (180); PDB accession (16); 3D entries (6); cryst (0)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
α-2,8-polysialyltransferase IV (ST8Sia IV;Siat8d;PST-1)	2.4.3.-	Homo sapiens	AAH53657.1 AAC41775.1 AAH27866.1 ACM85043.1 BAF85561.1 CAN37586.1 CAS91698.1 NP_005659.1	A8KA07 Q8N1F4 Q92187	6AHZ[A] NMR
α-2,8-sialyltransferase III (ST8Sia III;Siat8c)		Homo sapiens	AAB87642.1 AAC15901.2 AAH74909.1 BAD92233.1 BAF82206.1 BAG35879.1 CAS91697.1 NP_056963.1	A8K0F2 O43173 Q59GW3	5BO6[A,B] 2.07 5BO7[A,B] 1.85 5BO8[A,B] 2.70 5BO9[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-GlcpNAc6SO3 2.30 5CXY[A,B] 2.15
CMP-NeuAc: β-galactoside α-2,6-sialyltransferase I (ST6GAL1;ST6Gal I;Siat1;Siat-1;ST6N)	2.4.3.1	Homo sapiens	CAA01327.1 AAH31476.1 AAH40009.1 ACM80808.1 ACM85639.1 ACQ18409.1 BAF85568.1 BAG34960.1 CAA01686.1 CAA35111.1 CAA38246.1 CAA44634.1 CAS91678.1 NP_003023.1 NP_775323.1	A8KA14 D3DNV3 P15907	4JS1[A] 2.09 4JS2[A] 2.30 6QVS[A,B] 1.60 6QVT[A,B] 1.70
CMP-NeuAc:N-acetylgalactosaminide α-2,6-sialyltransferase II (ST6GalNAc II;Sia7b;SThM)	2.4.3.3	Homo sapiens	AAH40455.1 AAA52228.1 AAV38775.1 CAB61434.1 CAS91683.1 NP_006447.1	A0A024R8M1 Q9UJ37	6APJ[A,B,C,D,E,F] 3.10 6APL[A,B,C,D,E,F] 2.35
β-galactoside α-2,6-sialyltransferase I (ST6GalI;ST6Gal1;Siat1)	2.4.3.1	Rattus norvegicus	AAA41196.1 AAB07233.1 NP_671738.1	F2Z3S3 P13721	4MPS[A,B] 2.40
CMP-Neu5Ac: α-2,3-sialyltransferase (ST3Gal I)	2.4.3.4	Sus scrofa	AAA31125.1	Q02745	2WML[A] 1.90 2WNB[A] β-D-Galp-(1-3)-α-D-GalpNAc-(1-1)-<non_carb> 1.55 2WNF[A] β-D-Galp-(1-3)-α-D-GalpNAc-(1-1)-<non_carb> 1.25
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