GlycosylTransferase Family 29

Activities in Familysialyltransferase (EC 2.4.99.-); β-galactoside α-2,6-sialyltransferase (EC 2.4.99.1); α-N-acetylgalactosaminide α-2,6-sialyltransferase (EC 2.4.99.3); β-galactoside α-2,3-sialyltransferase (EC 2.4.99.4); N-acetyllactosaminide α-2,3-sialyltransferase (EC 2.4.99.6); (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase (EC 2.4.99.7); α-N-acetyl-neuraminide α-2,8-sialyltransferase (EC 2.4.99.8); lactosylceramide α-2,3-sialyltransferase (EC 2.4.99.9)
Mechanism Inverting
NoteThese enzymes use CMP-beta-N-acetylneuraminate as the sugar donor
External resourcesCFG(Core1); CFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap;
Statistics GenBank accession (1476); Uniprot accession (488); PDB accession (11); 3D entries (4); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-2,8-sialyltransferase III (ST8Sia III;Siat8c) 2.4.99.- Homo sapiens AAB87642.1
AAC15901.2
AAH74909.1
BAD92233.1
BAF82206.1
BAG35879.1
CAS91697.1
NP_056963.1
A8K0F2
O43173
5BO6[A,B] 2.07
5BO7[A,B] 1.85
5BO8[A,B] 2.70
5BO9[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-GlcpNAc6SO3
2.30
5CXY[A,A,B,B] 2.15
 CMP-NeuAc: β-galactoside α-2,6-sialyltransferase I (ST6GAL1;ST6Gal I;Siat1;Siat-1;ST6N) 2.4.99.1 Homo sapiens CAA01327.1
AAH31476.1
AAH40009.1
ACM80808.1
ACM85639.1
ACQ18409.1
BAF85568.1
BAG34960.1
CAA01686.1
CAA35111.1
CAA38246.1
CAA44634.1
CAS91678.1
NP_003023.1
NP_775323.1
A8KA14
D3DNV3
P15907
4JS1[A] 2.09
4JS2[A] 2.30
 β-galactoside α-2,6-sialyltransferase I (ST6GalI;ST6Gal1;Siat1) 2.4.99.1 Rattus norvegicus AAA41196.1
AAB07233.1
NP_671738.1
P13721
4MPS[A,B] 2.40
 CMP-Neu5Ac: α-2,3-sialyltransferase (ST3Gal I) 2.4.99.4 Sus scrofa AAA31125.1 Q02745
2WML[A] 1.90
2WNB[A] β-D-Galp-(1-3)-α-D-GalpNAc-(1-1)-<non_carb>
1.55
2WNF[A] β-D-Galp-(1-3)-α-D-GalpNAc-(1-1)-<non_carb>
1.25
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