GlycosylTransferase Family 29

Activities in Familysialyltransferase (EC 2.4.99.-); β-galactoside α-2,6-sialyltransferase (EC 2.4.99.1); α-N-acetylgalactosaminide α-2,6-sialyltransferase (EC 2.4.99.3); β-galactoside α-2,3-sialyltransferase (EC 2.4.99.4); N-acetyllactosaminide α-2,3-sialyltransferase (EC 2.4.99.6); (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase (EC 2.4.99.7); α-N-acetyl-neuraminide α-2,8-sialyltransferase (EC 2.4.99.8); lactosylceramide α-2,3-sialyltransferase (EC 2.4.99.9)
Mechanism Inverting
NoteThese enzymes use CMP-beta-N-acetylneuraminate as the sugar donor
External resourcesCFG(Core1); CFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap;
Statistics GenBank accession (1476); Uniprot accession (488); PDB accession (11); 3D entries (4); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CMP-N-acetylneuraminate-β-1,4-galactoside α-2,3-sialyltransferase isoform j (St3gal3)   Macaca mulatta AFE79717.1
AFH33647.1
   
 α-N-acetylgalactosaminide α-2,6-sialyltransferase 6 (St6galnac6)   Macaca mulatta AFE65151.1
AFH28687.1
   
 α-N-acetylgalactosaminide α-2,6-sialyltransferase 3 isoform 1 (St6galnac3)   Macaca mulatta AFE77581.1    
 CMP-N-acetylneuraminate-β-galactosamide-α-2, 3-sialyltransferase 2 (St3gal2)   Macaca mulatta AFE75884.1
AFH27656.1
AFI34321.1
   
 CMP-N-acetylneuraminate-β-galactosamide-α-2, 3-sialyltransferase 4 isoform 1 precursor (St3gal4)   Macaca mulatta AFE66355.1
AFI34007.1
   
 lactosylceramide α-2,3-sialyltransferase isoform 1 (St3gal5)   Macaca mulatta AFE66481.1    
 β-galactoside α-2,6-sialyltransferase 2 isoform a, partial (St6gal2) (fragment)   Macaca mulatta AFE70088.1    
 α-N-acetylgalactosaminide α-2,6-sialyltransferase 5, partial (St6galnac5) (fragment)   Macaca mulatta AFE70183.1    
 CMP-N-acetylneuraminate-β-galactosamide-α-2, 3-sialyltransferase 1, partial (St3gal1) (fragment)   Macaca mulatta AFE70602.1    
 α-N-acetylneuraminide α-2,8-sialyltransferase, partial (St8sia1) (fragment)   Macaca mulatta AFE70895.1    
 α-N-acetyl-neuraminyl-2,3-β-galactosyl-1, 3-N-acetyl-galactosaminide α-2,6-sialyltransferase isoform a, partial (St6galnac4) (fragment)   Macaca mulatta AFE70994.1    
 CMP-N-acetylneuraminate-β-1,4-galactoside α-2,3-sialyltransferase isoform b, partial (St3gal3) (fragment)   Macaca mulatta AFE72118.1    
 CMP-N-acetylneuraminate-β-galactosamide-α-2, 3-sialyltransferase 1, partial (St3gal1) (fragment)   Macaca mulatta AFE74255.1    
 CMP-N-acetylneuraminate-poly-α-2,8-sialyltransferase isoform a precursor, partial (St8sia4) (fragment)   Macaca mulatta AFE74686.1    
 β-galactoside α-2,6-sialyltransferase 1 isoform a, partial (St6gal1) (fragment)   Macaca mulatta AFE75594.1    
 CMP-N-acetylneuraminate-poly-α-2,8-sialyltransferase isoform a precursor, partial (St8sia4) (fragment)   Macaca mulatta AFE75671.1    
 CMP-N-acetylneuraminate-poly-α-2,8-sialyltransferase isoform a precursor, partial (St8sia4) (fragment)   Macaca mulatta AFE69251.1    
 β-galactoside α-2,6-sialyltransferase 1 isoform a, partial (St6gal1) (fragment)   Macaca mulatta AFE72116.1    
 α-N-acetyl-neuraminyl-2,3-β-galactosyl-1, 3-N-acetyl-galactosaminide α-2,6-sialyltransferase isoform a (St6galnac4)   Macaca mulatta AFH31984.1
AFI36836.1
   
 CMP-N-acetylneuraminate-β-galactosamide-α-2, 3-sialyltransferase 1 (St3gal1)   Macaca mulatta AFH29922.1
AFH29923.1
   
 CMP-N-acetylneuraminate-poly-α-2,8-sialyltransferase isoform a (St8sia4)   Macaca mulatta AFH29846.1    
 type 2 lactosamine α-2,3-sialyltransferase (St3gal6)   Macaca mulatta AFH30039.1    
 β-galactoside α-2,6-sialyltransferase 1 isoform a (St6gal1)   Macaca mulatta AFH30338.1    
 α-N-acetylgalactosaminide α-2,6-sialyltransferase 1 (St6galnac1)   Macaca mulatta AFI34178.1    
 α-N-acetylgalactosaminide α-2,6-sialyltransferase 5 (St6galnac5)   Macaca mulatta AFJ70710.1    
 CMP-N-acetylneuraminate-β-1,4-galactoside α-2,3-sialyltransferase isoform b (St3gal3)   Macaca mulatta AFJ70779.1    
 α-2,8-sialyltransferase E (Siat8E)   Macaca mulatta CAM33426.1
AFE70958.1
AFJ70324.1
A2VBC1  
 Stv3   Malus domestica CAJ15151.1 Q4JEY9  
 MtrDRAFT_AC144515g16v1 (Stv1)   Medicago truncatula CAJ15149.1
ABE93190.1
AFK35664.1
Q4JEZ1  
 Stv3   Medicago truncatula CAJ15150.1
ACJ83331.1
Q4JEZ0  
 GD3 synthase (fragment) ST8Sia I   Mesocricetus auratus AAD33879.1 Q9WUL1  
 polysialyltransferase (ST8Sia IV) 2.4.99.- Mesocricetus auratus CAB53396.1 Q9QXF4  
 Gal β-1,3/4-GlcNAc α-2,3-sialyltransferase (ST3Gal IV) 2.4.99.6 Mesocricetus auratus CAB53395.1 Q9QXF5  
 Gal β-1,3/4-GlcNAc α-2,3-sialyltransferase (ST3Gal III) 2.4.99.6 Mesocricetus auratus CAB53394.1
CAM14706.1
CAM14708.1
Q9QXF6  
 ST6Gal I   Monodelphis domestica CBQ74107.1 E4ZFH4  
 ST6Gal II   Monodelphis domestica CBQ74108.1 E4ZFH5  
 α-2,8-sialyltransferase VI (ST8SiaVI;Siat8f) (St8sia6)   Mus musculus BAC01265.1
AAI15913.1
AAI18064.1
BAC39367.1
BAE42986.1
CAM16856.1
CAM23460.1
NP_665837.1
Q148N5
Q8BI43
Q8K4T1
 
 α-2,6-sialyltransferase II (ST6GalII) (St6gal2)   Mus musculus BAC87752.1
AAI25587.1
BAC38534.1
BAC98272.1
CAP19180.1
CAP19181.1
CAP19182.1
NP_766417.1
Q76K27  
 α-2,3-sialyltransferase I (ST3GalI;Siat4A;Sait4;St3gal-1) (St3gal1) 2.4.99.4 Mus musculus AAH84730.1
AAF60973.1
AAH99670.1
AAH99693.1
BAC27356.1
BAC37290.1
BAE23767.1
CAA51919.1
NP_033203.1
P54751
Q544T4
Q9JL30
 
 α-2,3-sialyltransferase IV (ST3GalIV;Siat4c) (St3gal4) 2.4.99.4 Mus musculus AAH50773.1
AAH11121.1
BAA06068.1
BAB25732.1
BAB47508.1
BAE20844.1
CAA65076.1
NP_033204.2
P97354
Q91Y74
Q921R5
Q9CVE8
 
 α-2,3-sialyltransferase II (ST3GalII;Siat4b;Siat5) (St3gal2) 2.4.99.4 Mus musculus AAH15264.1
AAH66064.1
BAC28752.1
BAC28859.1
BAC35543.1
BAE20742.1
BAE22346.1
CAA54294.1
NP_033205.1
NP_835149.1
Q11204
Q8BPL0
Q8BSA0
Q8BSE9
Q91WH6
 
 α-2,6-sialyltransferase III (ST6GalNAcIII;Siat7c) (St6galnac3)   Mus musculus CAB95031.1
AAH58387.1
AAI31988.1
AAI32318.1
BAC28836.1
CAA72181.2
NP_035502.1
Q544M3
Q9WUV2
 
 α-2,8-sialyltransferase II (ST8SiaII;SiaT8b;STX) (St8sia2) 2.4.99.- Mus musculus CAA58548.1
AAH96546.1
CAA67965.1
NP_033207.1
O35696  
 α-2,8-sialyltransferase I / GD3 synthase (ST8SiaI;Siat8a;Siat8;GD3S) (St8sia1) 2.4.99.8 Mus musculus AAH24821.1
AAA91869.1
ABK96807.1
BAC32625.1
BAC34994.1
BAE20627.1
CAA59014.1
NP_035504.1
Q64468
Q64687
Q8BL76
Q8BWI0
Q8K1C1
 
 α-2,8-sialyltransferase IV (ST8SiaIV;SiaT8d;PST-1) (St8sia4) 2.4.99.- Mus musculus CAA11685.1
AAH60112.1
BAB22941.1
BAC31044.1
CAA59992.1
CAA70692.1
NP_033209.1
Q53WR7
Q64692
Q8BY70
 
 α-2,8-sialytransferase III (ST8SiaIII;Siat8c) (St8sia3) 2.4.99.- Mus musculus CAA56665.1
AAH75645.1
BAB30012.1
BAE21835.1
BAE22237.1
NP_033208.1
Q64689
Q9CUJ6
 
 α-2,6-sialyltransferase I (ST6GalI;Siat1) (St6gal1) 2.4.99.1 Mus musculus BAA03680.1
AAE68031.1
AAH27833.1
AAH92222.1
AAH96026.1
BAC28828.1
BAC39120.1
NP_666045.1
Q64685
Q8BM62
Q8K1L1
 
 α-2,8-sialyltransferase V (ST8SiaV;Siat8e) (St8sia5) 2.4.99.8 Mus musculus CAA66642.1
AAH34855.1
BAC37354.1
BAE36964.1
CAA66643.1
CAA66644.1
NP_038694.1
NP_694764.1
NP_803135.1
P70126
Q8BJW0
Q8JZQ3
 
 α-2,6-sialyltransferase V / GD1 synthase (ST6GalNAcV;Siat7e) (St6galnac5)   Mus musculus AAH55737.1
BAA85747.1
BAA89292.1
BAC28693.1
BAC29997.1
BAC31331.1
NP_036158.2
Q6GTI0
Q8CAM7
Q8CBX1
Q9QYJ1
 
 N-acetylgalactosaminide α-2,6-sialyltransferase VI (ST6GalNAcVI;Siat7f) (St6galnac6) 2.4.99.7 Mus musculus CAM16606.1
AAH22924.1
AAH36985.1
BAA87036.1
BAA95940.1
BAC27064.1
CAM16604.1
CAM16605.1
CAM16607.1
CAM16609.1
CAM16610.1
CAM16611.1
NP_058669.1
Q8JZW3
Q9JM95
Q9R0G9
 
 α-2,6-sialyltransferase I (ST6GalNAcI;Siat7a) (St6galnac1) 2.4.99.3 Mus musculus CAA72137.1
AAI41096.1
AAI45374.1
AAI45375.1
CAM25276.1
CAM25277.1
NP_035501.1
Q9QZ39  
 α-2,6-sialyltransferase II (ST6GalNAcII;Siat7b;Siat7) (St6galnac2) 2.4.99.3 Mus musculus NP_033206.1
AAH10208.1
BAB00637.1
BAB23410.1
BAE22955.1
CAA63821.1
CAM20516.1
NP_033206.2
A2A7Y2
P70277
P70277
Q9JJM5
 
 α-2,3-sialyltransferase VI (St3galVI;Siat10) (St3gal6) 2.4.99.4 Mus musculus BAB79494.1
AAD39130.1
AAH52338.1
BAC28360.1
BAC30851.1
BAE36994.1
CAO78161.1
NP_061254.1
A6X951
Q8BLV1
Q8VIB3
Q8VIB3
 
 α-2,3-sialyltransferase III (ST3GalIII;Siat6) (St3gal3) 2.4.99.6 Mus musculus C57BL/6J BAB23779.1
AAH06710.1
BAB28598.1
BAE22980.1
CAA59013.1
CAM14710.1
CAM14711.1
CAM26719.1
CAM26720.1
CAM26721.1
CAM26722.1
CAM27381.1
CAM27383.1
CAM27384.1
NP_033202.2
P97325
Q922X5
Q9CZ48
Q9DBB6
 
 α-2,6-sialyltransferase IV (ST6GalNAcIV;Siat7d) (St6galnac4) 2.4.99.7 Mus musculus ICR CAB43514.1
AAH56451.1
AAH56451.2
AAH86784.1
BAC39523.1
BAE26116.1
BAE31668.1
BAE35308.1
BAE36463.1
CAA07446.1
CAB43507.1
CAB43508.1
CAB93946.1
CAB93948.1
CAM16603.1
NP_035503.1
Q8C3J2
Q9JHP2
Q9R2B6
 
 α-2,3-sialyltransferase V / GM3 synthase (ST3GalV;St3GA;Siat9) (St3gal5) 2.4.99.9 Mus musculus ICR CAA75235.1
AAF66147.1
AAP65063.1
BAA33491.1
BAA76467.1
BAB28571.1
BAE34763.1
BAE38355.1
CAA75236.1
CAJ44922.1
NP_035505.1
B2RRS1
O88829
Q9CZ65
Q9QWF9
 
 ORF   Mustela putorius furo AES07456.1    
 ORF (fragment)   Mustela putorius furo AES07455.1    
 ORF (partial)   Mustela putorius furo AES07457.1    
 ORF (fragment)   Mustela putorius furo AES07463.1    
 ORF (fragment)   Mustela putorius furo AES07464.1    
 ORF (partial)   Mustela putorius furo AES07466.1    
 ORF (fragment)   Mustela putorius furo AES07470.1    
 ORF (fragment)   Mustela putorius furo AES07458.1    
 ORF   Mustela putorius furo AES07459.1    
 ORF   Mustela putorius furo AES07462.1    
 ORF   Mustela putorius furo AES07465.1    
 ORF   Mustela putorius furo AES07469.1    
 ORF   Nicotiana tabacum AII99815.1    
 β-galactoside α-2,3-sialyltransferase 1 (fragment)   Notamacropus eugenii AEP16457.1    
 β-galactoside α-2,6-sialyltransferase 1 (fragment)   Notamacropus eugenii AEP16458.1    
 ST6 (fragment)   Notamacropus eugenii AEP16459.1    
 α-2,8-polysialyltransferase IV (ST8Sia IV;PST) 2.4.99.- Oncorhynchus mykiss BAC77411.1 Q7T2X5  
 GalNAc α-2,6-sialyltransferase (RtST6GalNAc) 2.4.99.- Oncorhynchus mykiss BAC77520.1 Q7T2X4  
 α-2,3-sialyltransferase (St3Gal-I)   Oncorhynchus mykiss CAE51384.1 Q70D59  
 α-2,6-sialyltransferase (Siat1)   Oncorhynchus mykiss CAF05848.1    
 α-2,8-polysialyltransferase IIa (ST8Sia IIa;STX-ov) 2.4.99.- Oncorhynchus mykiss BAF37192.1 A0PAB2  
 α-2,8-polysialyltransferase IIb (ST8Sia IIb;STX-em) 2.4.99.- Oncorhynchus mykiss BAF37193.1 A0PAB3  
 α-2,8-sialyltransferase III (ST8Sia III) (fragment)   Oncorhynchus mykiss BAF44529.1 A1IHM5  
 α-2,8-sialyltransferase VI (ST8Sia VI)   Oncorhynchus mykiss BAF44530.1 A1IHM6  
 sialyltransferase om (StoM)   Oncorhynchus mykiss BAF64432.1 A6BLJ3  
 α-2,3-sialyltransferase (ST3Gal IV)   Oryctolagus cuniculus AAF28871.1 Q9N257  
 Stv1   Oryza sativa CAJ15152.1 Q4JEY8  
 OSIGBa0145C12.8   Oryza sativa Indica Group CAH67271.1
CAH67332.1
A2XVC2  
 OSNPB_020119000 (Os02g0119000) (fragment)   Oryza sativa Japonica Group BAS76685.1    
 CMP-NeuAc: [asialofetuin] sialyltransferase (OsSTLP3;Os04g0506800) 2.4.99.- Oryza sativa Japonica Group CAD41185.1
BAF15173.1
BAG92108.1
BAG96936.1
BAS89985.1
CAE04714.1
Q7FA29  
 Os02g0118400   Oryza sativa Japonica Group BAD07616.1
BAF07608.1
BAG88957.1
BAS76677.1
Q6ZH45  
 Os11g0572400   Oryza sativa Japonica Group BAF28488.1
BAG94988.1
BAT14537.1
Q2R2B1  
 Os12g0151500 (OsSTLP2)   Oryza sativa Japonica Group BAF29189.1
BAG86679.1
BAG97401.1
BAT15915.1
Q2QXM3  
 CMP-NeuAc: LacNac/glycoprotein sialyltransferase (OsSTLP1;Os01g0858900) 2.4.99.- Oryza sativa Japonica Group BAB63715.1
BAB90552.1
BAF06777.1
BAS75321.1
NP_915574.1
Q94DD4  
 α-2,6-sialyltransferase ST6GalNAc V (Siat7E) (fragment)   Oryzias latipes CAG26705.1 Q6ZXY5  
 α-2,3-sialyltransferase ST3Gal I (Siat4)   Oryzias latipes CAI39226.1 Q5ND67  
 α-2,3-sialyltransferase ST3Gal V (Siat9)   Oryzias latipes CAI39230.1 Q5ND63  
 α-2,3-sialyltransferase ST3Gal II (Siat5.2)   Oryzias latipes CAI39228.1 Q5ND65  
 α-2,3-sialyltransferase ST3Gal III (Siat6)   Oryzias latipes CAI39229.1 Q5ND64  
 α-2,3-sialyltransferase ST3Gal II (Siat5.1)   Oryzias latipes CAI39227.1 Q5ND66  
 Siat7d   Oryzias latipes CAI39648.1 Q5K023  
 Siat8c2   Oryzias latipes CAI39651.1 Q5K020  
 Siat2   Oryzias latipes CAI39644.1 Q5K027  
 Siat8c1   Oryzias latipes CAI39650.1 Q5K021  
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