GlycosylTransferase Family 29

Activities in Familysialyltransferase (EC 2.4.99.-); β-galactoside α-2,6-sialyltransferase (EC 2.4.99.1); α-N-acetylgalactosaminide α-2,6-sialyltransferase (EC 2.4.99.3); β-galactoside α-2,3-sialyltransferase (EC 2.4.99.4); N-acetyllactosaminide α-2,3-sialyltransferase (EC 2.4.99.6); (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase (EC 2.4.99.7); α-N-acetyl-neuraminide α-2,8-sialyltransferase (EC 2.4.99.8); lactosylceramide α-2,3-sialyltransferase (EC 2.4.99.9)
Mechanism Inverting
NoteThese enzymes use CMP-beta-N-acetylneuraminate as the sugar donor
External resourcesCFG(Core1); CFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap;
Statistics GenBank accession (1476); Uniprot accession (488); PDB accession (11); 3D entries (4); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 DLA_Ib04550 (St6galnac1)   Dicentrarchus labrax CBN81613.1    
 st6Gal   Drosophila ananassae CAL44593.1 Q0E5A8  
 Dbus_chr2Rg1588   Drosophila busckii ALC42009.1    
 st6Gal   Drosophila erecta CAL44594.1 Q0E5A7  
 st6Gal   Drosophila grimshawi CAL44595.1 Q0E5A6  
 α-2,6-sialyltransferase (CG4871) ST6Gal I 2.4.99.1 Drosophila melanogaster AAG13185.1
AAF47256.1
AAK92126.1
AAM70791.1
ABC86303.1
NP_523853.1
NP_726474.1
Q9GU23
Q9W121
 
 st6Gal   Drosophila mojavensis CAL44596.1 Q0E5A5  
 st6Gal   Drosophila persimilis CAL44597.1 Q0E5A4  
 α-2,6-sialyltransferase (ST6Gal)   Drosophila pseudoobscura CAH25389.1    
 st6Gal   Drosophila sechellia CAL44598.1 Q0E5A3  
 st6Gal   Drosophila simulans CAL44599.1 Q0E5A2  
 st6Gal   Drosophila virilis CAL44600.1 Q0E5A1  
 α-2,6-sialyltransferase (ST6Gal)   Drosophila yakuba CAH25388.1 Q683P1  
 ORF (fragment)   Equus caballus AEH58261.1    
 ORF (fragment)   Equus caballus AEH58694.1    
 ORF (fragment)   Equus caballus AEQ00758.1    
 α-2,3-sialyltransferase ST3Gal IV (fragment)   Gallus gallus AAC14163.1 O73724  
 α-2,3-sialyltransferase I (ST3Gal I;St3Gal1;Siat4A) 2.4.99.4 Gallus gallus CAA56666.1
NP_990548.1
Q11200  
 α-2,6-sialyltransferase I (ST6GalNAcI;Siat7a) 2.4.99.3 Gallus gallus CAA52902.1
AAE68028.1
AAE68029.1
NP_990571.1
Q92183  
 α-2,6-sialyltransferase II (ST6GalNAcII;Siat7b) 2.4.99.3 Gallus gallus CAA54813.1
AAE68030.1
NP_990564.1
Q92184  
 α-2,6-sialyltransferase ST6Gal I 2.4.99.1 Gallus gallus CAA53235.1
NP_990572.1
Q92182  
 α-2,8-sialyltransferase / GD3 Synthase (ST8SiaI;Sial-T2) 2.4.99.- Gallus gallus AAC28888.1 P79783  
 α-2,8-polysialyltransferase IV (ST8Sia IV;PST) 2.4.99.- Gallus gallus AAB95120.1
CAN37585.1
O42399  
 α-2,3-sialyltransferase (ST3Gal-VI)   Gallus gallus CAE51391.1
CAF25503.1
Q70D52  
 α-2,3-sialytransferase (ST3GAL-II)   Gallus gallus CAE51385.2
CAG32103.1
Q70D58  
 α-2,6-sialyltransferase (Siat7b)   Gallus gallus CAF05852.1 Q704X2  
 β-galactosamide α-2,6-sialyltransferase II (ST6Gal II)   Gallus gallus CAF29497.1
AFN40453.1
Q701R0  
 α-2,6-sialyltransferase ST6GalNAc III (SIAT7C) (fragment)   Gallus gallus CAG25677.1 Q6ZYP0  
 α-2,6-sialyltransferase ST6GalNAc V (SIAT7E) (fragment)   Gallus gallus CAG26706.1 Q6ZXY4  
 GM3 synthase (SIAT9) 2.4.99.9 Gallus gallus AAS83519.1
AFN40451.1
CAG31234.1
Q6R3Q5  
 α-2,8-sialyltransferase (SIAT8F)   Gallus gallus CAG27886.1 Q6ZXC6  
 α-2,8-sialyltransferase (SIAT8C)   Gallus gallus CAG27882.1 Q6ZXD0  
 α-2,8-sialyltransferase (SIAT8B)   Gallus gallus CAG27881.1 Q6ZXD1  
 α-2,8-syalyltransferase ST8Siα-V (SIAT8C)   Gallus gallus CAG28697.1 Q6ZX98  
 α-2,3-sialyltransferase ST3Gal IV (Siat4c)   Gallus gallus CAI29182.1
AFN40450.1
Q5QQ39  
 α-2,3-sialyltransferase ST3Gal III (Siat6)   Gallus gallus CAI26252.1
AFK24468.1
Q5TIL8  
 ST3 β-galactoside α-2,3-sialyltransferase 1 (St3gal1)   Gallus gallus AFN40455.1    
 ST6 β-galactosamide α-2,6-sialyltransferase 1 (St6gal1)   Gallus gallus AFN40452.1    
 ST3 β-galactoside α-2,3-sialyltransferase 6 (St3gal6)   Gallus gallus AFN40454.1    
 ST3 β-galactoside α-2,3-sialyltransferase 3 (St3gal3)   Gallus gallus AFN40456.1    
 ST6Gal I   Gasterosteus aculeatus CBQ74103.1 E4ZFH0  
 ST6Gal II   Gasterosteus aculeatus CBQ74104.1 E4ZFH1  
 α-2,8-sialyltransferase ST8Sia VI (siat 8F)   Gasterosteus aculeatus CAL91581.1 A1KQY8  
 α-2,8-sialyltransferase ST8Sia V (siat 8E)   Gasterosteus aculeatus CAM12264.1 A2BCP6  
 α-2,8-sialyltransferase II (ST8Sia II;SiaT8b)   Gasterosteus aculeatus CAM12268.1 A2BCQ0  
 α-2,8-sialyltransferase ST8Sia IIIA (siat 8C)   Gasterosteus aculeatus CAM12269.1 A2BCQ1  
 α-2,8-sialyltransferase ST8Sia IIIB (siat 8Cr)   Gasterosteus aculeatus CAM12270.1 A2BCQ2  
 α-2,8-sialyltransferase ST8Sia I (siat 8A)   Gasterosteus aculeatus CAM12271.1 A2BCQ3  
 Stv2A   Glycine max CAJ15143.1 Q4JEZ7  
 Stv2B   Glycine max CAJ15144.1
ACU19810.1
Q4JEZ6  
 Stv1   Gossypium raimondii CAJ15145.1 Q4JEZ5  
 sialyltransferase 4 (St4)   Hemicentrotus pulcherrimus BAI77454.1 D3KYH8  
 sialyltransferase 5 (St5)   Hemicentrotus pulcherrimus BAI77455.1 D3KYH9  
 sialyltransferase 3 (St3)   Hemicentrotus pulcherrimus BAI77453.1 D3KYH7  
 sialyltransferase 7 (St7) (partial)   Hemicentrotus pulcherrimus BAJ10551.1 D7UT13  
 sialyltransferase 8 (St8)   Hemicentrotus pulcherrimus BAM36888.1    
 α-2,3-sialyltransferase I (ST3Gal I;Siat4A) 2.4.99.4 Homo sapiens AAG29876.1
AAA36612.1
AAC17874.1
AAC37574.1
AAD39238.1
AAH18357.1
CAS91688.1
NP_003024.1
NP_775479.1
Q11201  
 α-2,3-sialyltransferase III (ST3Gal III;SiaT6) 2.4.99.6 Homo sapiens CAF25177.1
AAA35778.1
AAH50380.1
AAO13859.1
AAO13861.1
AAO13862.1
AAO13863.1
AAO13864.1
AAO13866.1
AAO13867.1
AAO13869.1
AAO13870.1
AAO13871.1
AAO13872.1
AAO13874.1
AAO38807.1
AAO38808.1
AAO38809.1
AAO38810.1
AAO38811.1
ANZ79617.1
BAG63274.1
CAH71022.1
CAH71023.1
CAH71024.1
CAH71027.1
CAH71028.1
CAH71029.1
CAH71030.1
CAH71031.1
CAH71032.1
CAH71033.1
CAI16785.1
CAI16786.1
CAI16787.1
CAI16790.1
CAI16791.1
CAI16792.1
CAI16793.1
CAI16794.1
CAI16795.1
CAI16796.1
CAI22181.1
CAI22182.1
CAI22183.1
CAI22186.1
CAI22187.1
CAI22188.1
CAI22189.1
CAI22190.1
CAI22191.1
CAI22192.1
CAS91690.1
CAT03463.1
NP_006270.1
NP_777624.1
NP_777626.1
NP_777629.1
NP_777632.1
D3DPX8
P61132
Q11203
Q11203
Q5T4X0
 
 α-2,3-sialyltransferase IV (ST3Gal IV;ST3GAL4;Siat4c;STZ) 2.4.99.4 Homo sapiens AAH10645.1
AAA16460.1
AAC14162.1
AAK93790.1
AAM66431.1
AAM66432.1
AAM66433.1
AAM81378.1
ACM84702.1
BAB13940.1
BAF84266.1
BAG37279.1
CAA52662.1
CAE91353.1
CAG33139.1
CAS91691.1
NP_006269.1
Q11206
Q8N6A6
Q8N6A7
Q8NFD3
Q8NFG7
 
 α-2,3-sialyltransferase II (ST3Gal II;Siat4B;Siat5) 2.4.99.4 Homo sapiens AAH36777.1
AAB40389.1
BAG35855.1
BAG54481.1
CAA65447.1
CAS91689.1
NP_008858.1
Q16842  
 α-2,3-sialyltransferase VI (ST3GalVI;St3Gal6;Siat10) (St3gal6) 2.4.99.4 Homo sapiens AAD39131.1
AAH23312.1
BAA77609.1
BAG50993.1
CAE89895.1
CAF00161.1
CAS91693.1
NP_006091.1
B2RCH2
D3DN39
Q9Y274
 
 α-2,8-polysialyltransferase IV (ST8Sia IV;Siat8d;PST-1) 2.4.99.- Homo sapiens AAH53657.1
AAC41775.1
AAH27866.1
ACM85043.1
BAF85561.1
CAN37586.1
CAS91698.1
NP_005659.1
A8KA07
Q8N1F4
Q92187
 
 α-2,8-sialyltransferase V (ST8SiaV;Siat8e;SAT-V) (St8sia5) 2.4.99.- Homo sapiens AAC51727.1
AAI08911.1
BAG51661.1
BAG52854.1
BAH11545.1
BAH12893.1
CAG33318.1
CAS91699.1
NP_037437.1
O15466  
 α-2,8-sialyltransferase III (ST8Sia III;Siat8c) 2.4.99.- Homo sapiens AAB87642.1
AAC15901.2
AAH74909.1
BAD92233.1
BAF82206.1
BAG35879.1
CAS91697.1
NP_056963.1
A8K0F2
O43173
5BO6[A,B]
5BO7[A,B]
5BO8[A,B]
5BO9[A,B]
5CXY[A,A,B,B]
 α-2,8-sialyltransferase I (ST8Sia I;Siat8a;SAT-II;GD3 synthase) 2.4.99.8 Homo sapiens AAC37586.1
AAA62366.1
AAH31081.1
AAI17286.1
AAI26163.1
AAQ53140.1
ABN29101.1
ACM80809.1
ACM82503.1
BAA05391.1
BAF83630.1
BAG59776.1
CAA54891.1
CAS91695.1
NP_003025.1
A8K4H6
Q92185
 
 α-2,8-sialyltransferase II (ST8Sia II;St8Sia2;SiatbB;STX) 2.4.99.- Homo sapiens AAC24458.1
AAA36613.1
AAB51242.1
AAH69584.1
AAH96202.1
AAH96203.1
AAH96204.1
AAH96205.1
ACM83967.1
ACS13735.1
ACS13736.1
CAS91696.1
NP_006002.1
B2R9U8
Q92186
 
 CMP-NeuAc: β-galactoside α-2,6-sialyltransferase I (ST6GAL1;ST6Gal I;Siat1;Siat-1;ST6N) 2.4.99.1 Homo sapiens CAA01327.1
AAH31476.1
AAH40009.1
ACM80808.1
ACM85639.1
ACQ18409.1
BAF85568.1
BAG34960.1
CAA01686.1
CAA35111.1
CAA38246.1
CAA44634.1
CAS91678.1
NP_003023.1
NP_775323.1
A8KA14
D3DNV3
P15907
4JS1[A]
4JS2[A]
 lactosylceramide α-2,3-sialyltransferase V (ST3Gal V;Siat9) 2.4.99.9 Homo sapiens AAD14634.1
AAF66146.1
AAH65936.2
AAO16866.1
AAO16866.2
AAP65066.1
AAQ89463.1
AAY24147.1
ABI12336.1
ABX94074.1
ABX96367.1
ABX96677.1
ABY05141.1
ABY16080.1
ABY18877.1
ACC23222.1
ACE08868.1
ACG89779.1
ACK00075.1
ACM84564.1
ACM95185.1
ACP58739.1
ACP73940.1
ACP88674.1
ACS06566.1
ACW23933.1
ALQ33905.1
ALQ33906.1
BAA33950.1
BAG50894.1
CAE89320.1
CAJ44921.1
CAS91692.1
NP_003887.2
B3KM82
Q9UNP4
 
 CMP-NeuAc:N-acetylgalactosaminide α-2,6-sialyltransferase II (ST6GalNAc II;Sia7b;SThM) 2.4.99.3 Homo sapiens AAH40455.1
AAA52228.1
AAV38775.1
CAB61434.1
CAS91683.1
NP_006447.1
Q9UJ37  
 N-acetylgalactosaminide α-2,6-sialyltransferase VI (ST6GalNAc VI;St6GalNAc6) 2.4.99.- Homo sapiens AAH06564.1
AAH07802.1
AAH16299.1
AAH36102.1
AAQ89035.1
ABA31389.1
ABA36389.1
ABA37971.1
ABA68648.1
ABA69651.1
ABA70033.1
ABA70156.1
ABC03977.1
ABC16012.1
ABE23467.1
ABE26030.1
ABE26303.1
ABH64540.1
ABH64663.1
ABH64820.1
ABH66049.1
ABH70868.1
ABH70991.1
ABH72505.1
ABH75620.1
ABH99405.1
ABI02510.1
ABI07311.1
ABI10959.1
ABI12183.1
ABJ19344.1
ABJ34339.1
ABL21803.1
ABX93921.1
ABX96214.1
ABX96524.1
ABY04988.1
ABY15927.1
ABY18724.1
ACC22759.1
ACC35829.1
ACE08715.1
ACG89626.1
ACJ99921.1
ACM95032.1
ACN08791.1
ACP73787.1
ACS06413.1
ACS08565.1
ACW23780.1
ALQ34075.1
ALQ34076.1
BAA87035.1
BAB14715.1
BAG51863.1
BAG62242.1
CAD45373.1
CAE91145.1
CAG33599.1
CAI12609.1
CAI12610.1
CAI12611.1
CAI12612.1
CAS91687.1
NP_038471.2
Q969X2
Q9H8A2
 
 N-acetylgalactosaminide α-2,6-sialyltransferase IV (ST6GalNAcIV;Siat7d;Siat3c) (St6galnac4) 2.4.99.7 Homo sapiens BAA87034.1
AAF00102.1
AAH36705.1
AAP63349.1
ACG89841.1
ACH33352.1
BAA91281.1
BAF84738.1
CAB44353.1
CAB44354.1
CAC07404.1
CAC24981.1
CAC27250.1
CAF14360.1
CAI12613.1
CAS91685.1
CAX11911.1
NP_055218.3
NP_778204.1
Q5T9D0
Q9H4F1
 
 N-acetylgalactosaminide α-2,6-sialyltransferase V (St6alNAc5;ST6GalNAcV;Siat7e)   Homo sapiens AAH01201.1
ABE14908.1
AHA82580.1
BAB71127.1
BAG53123.1
BAG58078.1
CAB72344.1
CAD45372.1
CAI21821.1
CAM28274.1
CAS91686.1
EAX06386.1
NP_112227.1
B1AK82
Q9BVH7
 
 N-acetylgalactosaminide α-2,6-sialyltransferase I (Siat7A;Sia7a;ST6GALNAC1;ST6GalNAc I) 2.4.99.3 Homo sapiens CAA72179.2
AAH22462.1
AAM22800.1
AAQ89277.1
ABA13600.1
ABA33477.1
ABC03856.1
ABC04774.1
ABC15951.1
ABE24539.1
ABE25352.1
ABH65894.1
ABH72000.1
ABH72444.1
ABH72821.1
ABH75559.1
ABH83062.1
ABH93236.1
ABH98460.1
ABI01924.1
ABI02448.1
ABI11364.1
ABI12733.1
ABJ18775.1
ABJ30959.1
ABJ35147.1
ABJ39089.1
ABJ41693.1
ABL13582.1
ABN30350.1
ABX91728.1
ABX92004.1
ABX92280.1
ABX92556.1
ABX92832.1
ABX93266.1
ABX93773.1
ABX94507.1
ABX95514.1
ABX95790.1
ABX96066.1
ABY04288.1
ABY04564.1
ABY04840.1
ABY16532.1
ABY18024.1
ABY18300.1
ABY18576.1
ACC00203.1
ACC25401.1
ACC26418.1
ACC36990.1
ACE07635.1
ACE09473.1
ACE10685.1
ACG89184.1
ACJ96248.1
ACN02514.1
ACN06924.1
ACP58316.1
ACP73639.1
ACP89167.1
ACR89117.1
ACR89669.1
ACW28759.1
BAA90953.1
CAS91682.1
NP_060884.1
Q9NSC7  
 α-2,6-sialyltransferase 2 (ST6GAL2;ST6Gal II;KIAA1877) 2.4.99.1 Homo sapiens BAB47506.1
AAH08680.1
AAY15022.1
BAB47506.2
BAC24793.1
CAD54408.1
CAE48260.1
CAE48261.1
CAS91680.1
NP_115917.1
D3DVK3
Q86Y44
Q96HE4
Q96JF0
 
 α-2,8-sialyltransferase VI (ST8SIA VI)   Homo sapiens CAF21722.1
AAI37103.1
AAI37104.1
ACA06074.1
ACA06075.1
ACA06076.1
BAE94653.1
CAH70722.1
CAI40658.1
CAI40659.1
CAS91700.1
NP_001004470.1
XP_291725.3
P61647  
 N-acetylgalactosaminide α-2,6-sialyltransferase III (ST6GalNAc III;Sia7c) 2.4.99.7 Homo sapiens CAD45371.1
AAH59363.1
AAQ88904.1
ABA66708.1
ABI12351.1
ABX96382.1
ABX96692.1
ABY05156.1
ABY16095.1
ABY18892.1
ACC23237.1
ACC35997.1
ACC36307.1
ACE08883.1
ACH32638.1
ACK00090.1
ACM95200.1
ACP73955.1
ACS06581.1
ACW23948.1
BAC03611.1
BAG59810.1
CAK32360.1
CAS91684.1
NP_694541.1
Q8NDV1
Q8NDV1
 
 Stv3   Hordeum vulgare CAJ15146.1 Q4JEZ4  
 predicted protein   Hordeum vulgare subsp. vulgare BAK05762.1    
 ORF (fragment)   Hymenochirus curtipes AEQ17925.1    
 Sia7E   Ictalurus punctatus ADO28996.1 E3TFB0  
 ORF (St6galnac3)   Ictalurus punctatus AHH40167.1    
 ORF (St8sia4)   Ictalurus punctatus AHH37676.1    
 ORF (St6gal2)   Ictalurus punctatus AHH37986.1    
 ORF (St6galnac3)   Ictalurus punctatus AHH38248.1    
 ORF (St3gal5)   Ictalurus punctatus AHH39684.1    
 ORF (St8sia1)   Ictalurus punctatus AHH40000.1    
 ORF (St8sia3)   Ictalurus punctatus AHH40132.1    
 ORF (St8sia5)   Ictalurus punctatus AHH40334.1    
 ORF (St3gal3)   Ictalurus punctatus AHH42788.1    
 ST6Gal (fragment)   Ixodes scapularis ADO17789.1 E5FGC7  
 Stv2   Lotus japonicus CAJ15148.2
CAJ15148.1
Q4JEZ2  
 ORF7   Lupinus angustifolius CCH47222.1    
 SIAT8B (fragment)   Macaca fascicularis AAW55579.1 Q5IFJ6  
 ORF   Macaca fascicularis BAE72949.1 Q2PG21  
 ORF (fragment)   Macaca fascicularis BAE72971.1 Q2PFZ9  
 unnamed protein product (fragment)   Macaca fascicularis BAE87253.1    
 unnamed protein product   Macaca fascicularis BAE88437.1    
 CMP-N-acetylneuraminate-β-galactosamide-α-2, 3-sialyltransferase 4 (St3gal4)   Macaca mulatta AFE79710.1
AFH33640.1
AFI38029.1
   
 type 2 lactosamine α-2,3-sialyltransferase (St3gal6)   Macaca mulatta AFE64276.1    
 siα-a-2,3-Gal-β-1,4-GlcNAc-R:alpha 2,8-sialyltransferase (St8sia3)   Macaca mulatta AFE65983.1    
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