GlycosylTransferase Family 1

Activities in FamilyUDP-glucuronosyltransferase (EC 2.4.1.17); zeatin O-β-xylosyltransferase (EC 2.4.2.40); 2-hydroxyacylsphingosine 1-β-galactosyltransferase (EC 2.4.1.45); N-acylsphingosine galactosyltransferase (EC 2.4.1.47); flavonol 3-O-glucosyltransferase (EC 2.4.1.91); anthocyanidin 3-O-glucosyltransferase (EC 2.4.1.115); sinapate 1-glucosyltransferase (EC 2.4.1.120); indole-3-acetate β-glucosyltransferase (EC 2.4.1.121); flavonol L-rhamnosyltransferase (EC 2.4.1.159); sterol glucosyltransferase (EC 2.4.1.173); UDP-Glc: 4-hydroxybenzoate 4-O-β-glucosyltransferase (EC 2.4.1.194); zeatin O-β-glucosyltransferase (EC 2.4.1.203); limonoid glucosyltransferase (EC 2.4.1.210); UDP-GlcA: baicalein 7-O-β-glucuronosyltransferase (EC 2.4.1.253); UDP-Glc: chalcone 4′-O-β-glucosyltransferase (EC 2.4.1.286); ecdysteroid UDP-glucosyltransferase (EC 2.4.1.-); salicylic acid β-glucosyltransferase (EC 2.4.1.-); anthocyanin 3-O-galactosyltransferase (EC 2.4.1.-); anthocyanin 5-O-glucosyltransferase (EC 2.4.1.-); dTDP-β-2-deoxy-L-fucose: α-L-2-deoxyfucosyltransferase (EC 2.4.1.-); UDP-β-L-rhamnose: α-L-rhamnosyltransferase (EC 2.4.1.-); zeaxanthin glucosyltransferase (EC 2.4.1.-)
Mechanism Inverting
3D Structure StatusGT-B
NoteDistantly related to family GT28; several members of this family are made of two subunits (for instance Alg13 and Alg14 in Saccharomyces); the complete enzyme has been reconstituted whenever possible, and appears with the two subunit names separated by a + sign and with the N-terminal subunit followed by the C-terminal one
External resourcesArabidopsis GT1s; CFG(Glycosphingolipid); Glymap;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (18406); Uniprot accession (3361); PDB accession (68); 3D entries (31); cryst (2)
All (13599) Archaea (189) Bacteria (8500) Eukaryota (4672) Viruses (213) unclassified (25) Structure (31 - 2 cryst) Characterized (371)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 EspG2   Actinomadura verrucosospora    
5DU2[B] 2.70
5DU2[A] 2.70
 dTDP-β-L-4-epi-epivancosamine: epivancosaminyltransferase (GtfA;PCZA361.19) 2.4.1.- Amycolatopsis orientalis A82846 AAB49292.1
AAE12045.1
CAA11774.1
P96558
1PN3[A,B] β-D-Glcp-(1-1)-<non_carb>
2.80
1PNV[A,B] α-L-2-deoxy-Fucp3N-(1-2)-β-D-Glcp-(1-1)-<non_carb>
2.80
 TDP/UDP-Glc: aglycosyl-vancomycin: glucosyltransferase (GtfB;PCZA361.20) 2.4.1.- Amycolatopsis orientalis A82846 AAB49293.1
AAE12046.1
CAA11775.1
P96559
1IIR[A] 1.80
 UDP-β-L-4-epi-vancosamine: vancomycin-pseudoaglycone vancosaminyltransferase (GtfD) 2.4.1.- Amycolatopsis orientalis ATCC19795 AAK31352.1
CCD33143.1
Q9AFC7
1RRV[A,B] β-D-Glcp-(1-1)-<non_carb>
2.00
 calicheamicin glycostyltransferase (CalG1)   Micromonospora echinospora AAM70336.1
AAU99317.1
CAD60080.1
Q8KNF2
3OTG[A] 2.08
3OTH[A,B] β-D-6-deoxy-Glcp4N-(1-1)-<non_carb>
2.30
 calicheamicin glycosyltransferase (CalG2)   Micromonospora echinospora AAM70348.1
AAU99283.1
CAD60022.1
Q8KNE0
3IAA[A,B] 2.50
3RSC[A,B] β-D-6-deoxy-Glcp4N-(1-1)-<non_carb>
2.19
 calicheamicin glycostyltransferase (CalG3)   Micromonospora echinospora AAM70351.1
AAM94798.1
AAU99290.1
CAD60029.1
Q8KND7
3D0Q[A,B] 2.79
3D0R[A,B] 1.90
3OTI[A,B] β-D-6-deoxy-Glcp4N-(1-1)-<non_carb>
1.60
 calicheamicin glycosyltransferase (CalG4)   Micromonospora echinospora AAM70365.1 Q8KNC3
3IA7[A,B] 1.91
 TDP-desosamine: α-mycarosyl erythronolide B desosaminyltransferase (EryCIII;SACE_0726) 2.4.1.- Saccharopolyspora erythraea NRRL 2338 CAA74710.1
AAB84067.1
AAE39406.1
CAM00067.1
A4F7P3
O54224
2YJN[A,B] 3.09
 TDP-forosamine: spinosyn β-D-forosaminyltransferase (SpnP)   Saccharopolyspora spinosa AAG23277.1
AAP01027.1
ABE23725.1
ABX94169.1
Q9ALN7
4LDP[A,B] 2.50
4LEI[A,B] 3.15
 TDP-β-L-Rha: spinosyn 9-O-α-L-rhamnosyltransferase (SpnG) 2.4.1.- Saccharopolyspora spinosa NRLL18537 AAG23268.1
AAP01018.1
ABE23716.1
ABX94159.1
Q9ALM8
3TSA[A,B] α-D-Glcp
1.70
3UYK[A,B] β-D-Glcp
1.70
3UYL[A,B] α-D-Glcp
1.85
 UDP-Glc: oleandomycin glycosyltransferase (OleD;UGT102A2) 2.4.1.- Streptomyces antibioticus ATCC 11891 DSM 40868 ABA42119.2
CAA80301.1
Q3HTL6
Q53685
2IYF[A,B] <carb_like_ERY>
1.7
4M60[A] 1.77
4M7P[A] 1.77
4M83[A,B] <carb_like_ERY>
1.70
 oleandomycin glycosyltransferase (OleI) 2.4.1.- Streptomyces antibioticus DSM 40868 ATCC 11891 ABA42118.2
ABA42118.1
Q3HTL7
2IYA[A,B] <carb_like_ZIO>
1.7
 8-O-tetrangulol β-D-olivosyltransferase (LanGT2) 2.4.1.- Streptomyces cyanogenus S136 AAD13553.1 Q9ZGC0
4RIE[A,B] 2.16
4RIF[A,B] 1.85
4RIG[A,B] 1.90
4RIH[A,B] 2.22
4RII[A,B] 2.00
 D-olivosyltransferase (UrdGT2) 2.4.1.- Streptomyces fradiae T#2717 AAF00209.1 Q9RPA7
2P6P[A,B] 1.88
 dTDP-vicenisamine: vicenilactam β-vicenisaminyltransferase (VinC) 2.4.1.- Streptomyces halstedii HC34 BAD08357.1 Q76KZ6
3WAD[A,B] 2.00
3WAG[A,B] 2.10
 TDP-nogalamine : 3prime,4prime-demethoxynogalose-1-hydroxynogalamycinone nogalaminyltransferase (SnogD) 2.4.1.- Streptomyces nogalater AAF01811.1 Q9RN61
4AMB[A,B] 2.62
4AMG[A,B] 2.59
4AN4[A,B,C,D] 2.70
 glycosyltransferase (ElaGT)   Streptomyces sp. SCSIO 01934 ADP68587.2
ADP68587.1
E5L4T5
cryst    
 NDP-olivose: tetracycline β-olivosyltransferase (SsfS6)   Streptomyces sp. SF2575 ADE34512.1 D6MSX4
4FZR[A] 2.40
4G2T[A] 2.40
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 UDP-Glc: sinapoyl-alcohol-, 2,5-DHBA-, 3,4-DHBA-glucosyltransferase (UGT72B1;At4g01070) 2.4.1.- Arabidopsis thaliana CAB80916.1
AAB61023.1
AAK25972.1
AAK64133.1
AAM61455.1
ABJ18919.1
AEE81977.1
AEE81978.1
AHL38715.1
NP_192016.1
O04622
Q9M156
2VCE[A] 1.90
2VCH[A] 1.45
2VCU[A] 1.75
2VG8[A] 1.75
 UDP-Glc: salicylic acid /anthranilate / BA-β-glucosyltransferase (UGT74F2;At2g43820) (salicylic acid glucose ester-forming) 2.4.1.- Arabidopsis thaliana AAB64024.1
AAL32561.1
AAM64890.1
AAQ55278.1
ABD66577.1
ACH17570.1
AEC10331.1
AHL38795.1
CAF04403.1
CAF04404.1
CAF04405.1
CAF04406.1
CAF04407.1
NP_181910.1
O22822
5U6M[A,B] β-D-Glcp-(1-0)-TYR
2.57
5U6N[A,B] β-D-Glcp-(1-0)-TYR
β-D-Glcp-(1-3)-β-D-Glcp-(1-0)-TYR
2.00
5U6S[A,B] β-D-Glcp-(1-0)-TYR
β-D-Glcp-(1-3)-β-D-Glcp-(1-0)-TYR
2.00
5V2J[A,B] β-D-Glcp-(1-0)-TYR
β-D-Glcp-(1-3)-β-D-Glcp-(1-0)-TYR
1.80
5V2K[A,B] β-D-Glcp-(1-0)-TYR
β-D-Glcp-(1-3)-β-D-Glcp-(1-0)-TYR
2.00
 UDP-Glc: anthocyanidin 3-O-glucosyltransferase (Ct3GT-A;UGT78K6) 2.4.1.115 Clitoria ternatea BAF49297.1 A4F1R4
3WC4[A] 1.85
4REL[A] 1.75
4REM[A] 2.55
4REN[A] 2.70
4WHM[A] 1.85
 UDP-GlcA: β-glucuronosyltransferase 2B7 (Ugt2b7) 2.4.1.17
2.4.1.-
Homo sapiens AAA36793.1
AAD14400.1
AAG01472.1
AAH30974.1
AAO65542.1
AAQ46846.1
AAY41045.1
ABL16197.1
BAD96862.1
BAG36007.1
NP_001065.1
P16662
Q99912
Q9HCT7
2O6L[A,B] 1.80
 UDP-Glc : flavonoid β-glucosyltransferase (UGT71G1) 2.4.1.- Medicago truncatula AAW56092.1
CAX02405.1
CBD06499.1
Q5IFH7
2ACV[A,B] 2.00
2ACW[A,B] 2.60
 multifunctional UDP-Glc : (iso)flavonoid β-glucosyltransferase (UGT85H2;MtrDRAFT_AC151740g36v2) 2.4.1.- Medicago truncatula ABE87250.1
ABI94024.1
ACJ84676.1
ACJ85365.1
AFK43163.1
CAX02340.1
CBD06371.1
A6XNC5
2PQ6[A] 2.10
 UDP-Glc : (iso)flavonoid β-glucosyltransferase (UGT78G1) 2.4.1.- Medicago truncatula ABI94025.1 A6XNC6
3HBF[A] 2.10
3HBJ[A] 2.10
 UDP-Glc: deoxynivalenol β-glucosyltransferase (Os79;Os04g0206600) 2.4.1.- Oryza sativa Japonica Group CAD40043.1
BAF14158.1
BAG97673.1
BAS88084.1
BAS88104.1
CAE01609.2
CAX02310.1
CBD06310.1
Q7XT97
5TMB[A] 2.34
5TMD[A] 2.19
5TME[A] 1.78
 arbutin synthase (As) 2.4.1.- Rauvolfia serpentina CAC35167.1
CAX02568.1
CBD06752.1
Q9AR73
cryst    
 YBR070c (Sat2;Alg14) + YGL047W (Sat2;Alg13)   Saccharomyces cerevisiae S288c CAA96749.1
NP_011468.1
P53178
2JZC[A] NMR
2KS6[A] NMR
 UDP-Glc: sterol glucosyltransferase (Atg26;YLR189c;UGT51) 2.4.1.173 Saccharomyces cerevisiae S288c AAB67475.1
AAO95499.1
AAO95504.1
AAO95509.1
NP_013290.1
Q06321
5GL5[A,B] 1.90
5XVM[A,B]
 UDP-Glc: anthocyanidin 3-O-glucosyltransferase (Ufgt;VvGT1) 2.4.1.115 Vitis vinifera AAB81683.1
AAB81682.1
ABF59818.1
AHZ46155.1
AHZ46156.1
AHZ46157.1
AHZ46158.1
AST51826.1
AST51827.1
AST51828.1
BAB41017.1
BAB41018.1
BAB41019.1
BAB41020.1
BAB41021.1
BAB41022.1
BAB41023.1
BAB41024.1
BAB41025.1
BAB41026.1
CAX02331.1
CAX02337.1
CAX02524.1
CAX02526.1
CAX02528.1
CAX02531.1
CAX02533.1
CBD06353.1
CBD06365.1
CBD06708.1
CBD06710.1
CBD06712.1
CBD06714.1
CBD06716.1
O22304
P51094
Q9AQV0
Q9AR43
Q9AR45
2C1X[A] 1.9
2C1Z[A] 1.9
2C9Z[A] 2.1
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