GlycosylTransferase Family 109

Activities in FamilyUDP-GalNAc: β-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.-)
Mechanism inverting (inferred)
3D Structure StatusGT-A
NoteFamily created after Hirata et al., 2018 (PMID=29374258) who have shown that the human enzyme probably is a b-1,4-N-acetylgalactosaminyltransferase that adds GalNAc to the first mannose residue of GPI anchors; the GTs of this family are characterized by the presence of two transmembrane domains inserted in the GT-A fold; very distant relatedness to GT54
Statistics GenBank accession (153); Uniprot accession (1);
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ACHE_11895S   Aspergillus chevalieri M1 BCR84493.1    
 G4B11_006024   Aspergillus flavus AF13 QMW42654.1    
 G4B11_001318   Aspergillus flavus AF13 QMW38082.1    
 G4B11_000132 (fragment)   Aspergillus flavus AF13 QMW36896.1    
 F9C07_934   Aspergillus flavus NRRL 3357 QRD87952.1    
 F9C07_2250994 (fragment)   Aspergillus flavus NRRL 3357 QRD89198.1    
 F9C07_2282945   Aspergillus flavus NRRL 3357 QRD89485.1    
 G4B84_000142   Aspergillus flavus NRRL3357 QMW24897.1    
 G4B84_001244   Aspergillus flavus NRRL3357 QMW25999.1    
 G4B84_005982   Aspergillus flavus NRRL3357 QMW30601.1    
 AKAW2_20731A   Aspergillus luchuensis IFO 4308 BCR95791.1    
 AKAW2_40994A   Aspergillus luchuensis IFO 4308 BCR99311.1    
 AKAW2_61014A   Aspergillus luchuensis IFO 4308 BCS02750.1    
 AKAW2_71036A   Aspergillus luchuensis IFO 4308 BCS04158.1    
 ALUC_40955A   Aspergillus luchuensis RIB2601 BCS11615.1    
 ALUC_20694A   Aspergillus luchuensis RIB2601 BCS08324.1    
 ALUC_60961A   Aspergillus luchuensis RIB2601 BCS14405.1    
 ALUC_70987A   Aspergillus luchuensis RIB2601 BCS15754.1    
 An01g06350   Aspergillus niger CBS 513.88 CAK43755.1    
 An14g03100   Aspergillus niger CBS 513.88 CAK46547.1    
 An10g00410   Aspergillus niger CBS 513.88 CAK49131.1    
 An12g06180   Aspergillus niger CBS 513.88 CAK41155.1
XP_001395682.1
A2QZU3  
 AO090012000113 (fragment)   Aspergillus oryzae RIB40 BAE60339.1    
 AO090012000114 (fragment)   Aspergillus oryzae RIB40 BAE60340.1    
 APUU_71127A   Aspergillus puulaauensis MK2 BCS29557.1    
 APUU_11729S   Aspergillus puulaauensis MK2 BCS18901.1    
 APUU_22179A   Aspergillus puulaauensis MK2 BCS21747.1    
 APUU_60124A   Aspergillus puulaauensis MK2 BCS27076.1    
 BCIN_14g04430   Botrytis cinerea B05.10 ATZ57289.1    
 BofuT4_P092570.1   Botrytis cinerea T4 CCD49985.1    
 CELE_F35C11.4   Caenorhabditis elegans Bristol N2 CAA90244.1    
 transmembrane protein, partial (fragment)   Callorhinchus milii AFP08214.1    
 A9K55_006541   Cordyceps militaris ATCC 34164 ATY61131.1    
 A9K55_007848   Cordyceps militaris ATCC 34164 ATY63381.1    
 C2857_006030   Epichloe festucae Fl1 QPG94429.1    
 HYE67_001147   Fusarium culmorum Class2-1B QPC58916.1    
 HYE67_005385   Fusarium culmorum Class2-1B QPC63154.1    
 HYE67_009995   Fusarium culmorum Class2-1B QPC67764.1    
 CEK26_012345   Fusarium fujikuroi Augusto2 QGI99276.1    
 CEK26_009351   Fusarium fujikuroi Augusto2 QGI96282.1    
 CEK26_006935   Fusarium fujikuroi Augusto2 QGI93866.1    
 CEK27_012355   Fusarium fujikuroi CSV1 QGI68384.1    
 CEK27_009372   Fusarium fujikuroi CSV1 QGI65401.1    
 CEK27_006951   Fusarium fujikuroi CSV1 QGI62980.1    
 CEK25_006879   Fusarium fujikuroi I1.3 QGI80150.1    
 CEK25_009380   Fusarium fujikuroi I1.3 QGI82651.1    
 CEK25_012325   Fusarium fujikuroi I1.3 QGI85596.1    
 FFUJ_12639   Fusarium fujikuroi IMI 58289 CCT72747.1    
 FFUJ_13120   Fusarium fujikuroi IMI 58289 CCT66945.1    
 FFUJ_05470   Fusarium fujikuroi IMI 58289 CCT69574.1    
 FGRAMCML3066_01t22309.1   Fusarium graminearum CZS86211.1    
 FGRAMCML3066_01t11569.1   Fusarium graminearum CZS80842.1    
 FGRAMCML3066_01t05219.1   Fusarium graminearum CZS77667.1    
 FGRAMPH1_01T22223   Fusarium graminearum PH-1 CEF88725.1    
 FGRAMPH1_01T05195   Fusarium graminearum PH-1 CEF74403.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF77547.1    
 FOBC_09578   Fusarium oxysporum Fo47 QKD55464.1    
 FOBC_04175   Fusarium oxysporum Fo47 QKD50139.1    
 FOBC_16193   Fusarium oxysporum Fo47 QKD61942.1    
 HYE68_011206   Fusarium pseudograminearum Class2-1C QPC80454.1    
 HYE68_001077   Fusarium pseudograminearum Class2-1C QPC70325.1    
 FVRRES_10974 (fragment)   Fusarium venenatum A3/5 CEI70897.1    
 FVRRES_05755   Fusarium venenatum A3/5 CEI61319.1    
 FVRRES_02542   Fusarium venenatum A3/5 CEI66030.1    
 β-1,4-GalNAc transferase (TMEM246; C9orf125) 2.4.1.- Homo sapiens AAH06115.1
AAH33550.1
   
 ORF   Hypocrella siamensis MTCC 10142 ANH56524.1    
 LEMA_P012550.1   Leptosphaeria maculans JN3 CBY02468.1    
 transmembrane protein C9orf125   Macaca mulatta AFE64597.1    
 G6M90_00g050480   Metarhizium brunneum 4556 QLI68477.1    
 unnamed protein product   Mus musculus C57BL/6J BAE38239.1
BAC30023.1
BAC30454.1
BAC31328.1
BAC32406.1
BAC36105.1
   
 unnamed protein product   Mus musculus C57BL/6J BAB28725.1    
 JI435_029220   Parastagonospora nodorum SN15 QRC95219.1    
 PCH_Pc21g21470   Penicillium rubens Wisconsin 54-1255 CAP97044.1    
 PCH_Pc22g20740   Penicillium rubens Wisconsin 54-1255 CAP99362.1    
 PCH_Pc16g12710   Penicillium rubens Wisconsin 54-1255 CAP93941.1    
 PCH_Pc22g20720   Penicillium rubens Wisconsin 54-1255 CAP99360.1    
 Putative Glycosyltransferase   Podospora anserina S mat+ CDP31972.1    
 PODANS_7_1950   Podospora anserina S mat+ CAP68499.1    
 PODCO_701950   Podospora comata VBB86456.1    
 ORF   Pristionchus pacificus PS312 ACZ54500.1
ADA57112.1
ADA57113.1
ADA57114.1
ADA57115.1
ADA57116.1
   
 PTTW11_00735   Pyrenophora teres f. teres CAE6998545.1    
 PoMZ_12467   Pyricularia oryzae QBZ65506.1    
 SMAX5B_005525   Scophthalmus maximus AWP05192.1    
 EYB26_009743   Talaromyces marneffei QGA22029.1    
 EYB26_007348   Talaromyces marneffei QGA19659.1    
 TRUGW13939_07539   Talaromyces rugulosus W13939 QKX60394.1    
 TRUGW13939_11931   Talaromyces rugulosus W13939 QKX64755.1    
 MYCTH_2294852   Thermothelomyces thermophilus ATCC 42464 AEO53481.1    
 THITE_2116328   Thermothielavioides terrestris NRRL 8126 AEO67452.1    
 chromosome 9 open reading frame 125 (fragment)   Xenopus clivii AEP24458.1
AEP24455.1
AEP24456.1
AEP24457.1
AEP24459.1
AEP24460.1
AEP24461.1
AEP24462.1
AEP24463.1
AEP24464.1
AEP24465.1
AEP24466.1
AEP24467.1
AEP24468.1
AEP24469.1
AEP24470.1
AEP24471.1
AEP24472.1
AEP24473.1
AEP24474.1
AEP24475.1
AEP24476.1
AEP24477.1
AEP24478.1
AEP24479.1
AEP24480.1
   
 LOC100137688 protein (fragment)   Xenopus laevis AAI57723.1    
 chromosome 9 open reading frame 125, partial   Xenopus largeni AEP24496.1
AEP24481.1
AEP24482.1
AEP24483.1
AEP24484.1
AEP24485.1
AEP24486.1
AEP24487.1
AEP24488.1
AEP24489.1
AEP24490.1
AEP24491.1
AEP24492.1
AEP24493.1
AEP24494.1
AEP24495.1
AEP24497.1
AEP24498.1
   
 ZT1A5_G9081   Zymoseptoria tritici ST99CH_1A5 SMY27636.1    
 ZT1A5_G9473   Zymoseptoria tritici ST99CH_1A5 SMY28028.1    
 ZT1E4_G9545   Zymoseptoria tritici ST99CH_1E4 SMR58810.1    
 ZT3D1_G9469   Zymoseptoria tritici ST99CH_3D1 SMR61807.1    
 ZT3D7_G9537   Zymoseptoria tritici ST99CH_3D7 SMQ54382.1    
 ZT3D7_G9153 (fragment)   Zymoseptoria tritici ST99CH_3D7 SMQ53999.1    
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