GlycosylTransferase Family 109

Activities in FamilyUDP-GalNAc: β-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.-);
Mechanism inverting (inferred)
3D Structure StatusGT-A
NoteFamily created after Hirata et al., 2018 (PMID=29374258) who have shown that the human enzyme probably is a b-1,4-N-acetylgalactosaminyltransferase that adds GalNAc to the first mannose residue of GPI anchors; the GTs of this family are characterized by the presence of two transmembrane domains inserted in the GT-A fold; very distant relatedness to GT54
Statistics GenBank accession (77); Uniprot accession (1);
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 R9X50_00757400   Acrodontium crateriforme isolate 169a WPH04681.1    
 I4U23_026362   Adineta vaga UJR23350.1    
 I4U23_006896   Adineta vaga UJR25551.1    
 L3Y34_017315   Caenorhabditis briggsae isolate QX1410_ONT ULU04458.1    
 CELE_F35C11.4   Caenorhabditis elegans Bristol N2 CAA90244.1    
 transmembrane protein, partial (fragment)   Callorhinchus milii AFP08214.1    
 568363   Fimicolochytrium jonesii JEL569 v1.0 (Fimjon1)      
 306280   Geranomyces variabilis JEL559 v1.0 (Gervar1)      
 148472   Guillardia theta CCMP2712 (Guith1)      
 UDP-Gal: [GPI-anchor] β-1,4-N-acetylgalactosaminyltransferase (TMEM246; C9orf125) 2.4.1.- Homo sapiens AAH06115.1
AAH33550.1
SJX37796.1
Q9BRR3  
 transmembrane protein C9orf125   Macaca mulatta AFE64597.1    
 1938   Metarhizium anisopliae ARSEF 549 (Metani1)      
 unnamed protein product   Mus musculus C57BL/6J BAE38239.1
BAC30023.1
BAC30454.1
BAC31328.1
BAC32406.1
BAC36105.1
   
 unnamed protein product   Mus musculus C57BL/6J BAB28725.1    
 MAR_000283   Mya arenaria isolate MELC-2E11 WAR18445.1    
 KARACHINF001_ LOCUS 3270   Naegleria fowleri CAG4710915.1    
 66228   Naegleria gruberi (Naegr1)      
 OCTVUL_1B009500   Octopus vulgaris CAI9718775.1    
 PECUL_23A052044   Pelobates cultripes CAH2321457.1    
 MPIPNATIZW_LOCUS2069   Pipistrellus nathusii CAK6433763.1    
 PODLI_1B022037   Podarcis lilfordi CAI5796646.1    
 124988   Powellomyces hirtus BR81 v1.0 (Powhir1)      
 ORF   Pristionchus pacificus PS312 ACZ54500.1
ADA57112.1
ADA57113.1
ADA57114.1
ADA57115.1
ADA57116.1
   
 MRATA1EN1_LOCUS20237   Rangifer tarandus platyrhyncus CAI9171275.1    
 2657   Rozella allomycis CSF55 (Rozal1_1)      
 SMAX5B_005525   Scophthalmus maximus AWP05192.1    
 chromosome 9 open reading frame 125 (fragment)   Xenopus clivii AEP24458.1
AEP24455.1
AEP24456.1
AEP24457.1
AEP24459.1
AEP24460.1
AEP24461.1
AEP24462.1
AEP24463.1
AEP24464.1
AEP24465.1
AEP24466.1
AEP24467.1
AEP24468.1
AEP24469.1
AEP24470.1
AEP24471.1
AEP24472.1
AEP24473.1
AEP24474.1
AEP24475.1
AEP24476.1
AEP24477.1
AEP24478.1
AEP24479.1
AEP24480.1
   
 LOC100137688 protein (fragment)   Xenopus laevis AAI57723.1    
 chromosome 9 open reading frame 125, partial   Xenopus largeni AEP24496.1
AEP24481.1
AEP24482.1
AEP24483.1
AEP24484.1
AEP24485.1
AEP24486.1
AEP24487.1
AEP24488.1
AEP24489.1
AEP24490.1
AEP24491.1
AEP24492.1
AEP24493.1
AEP24494.1
AEP24495.1
AEP24497.1
AEP24498.1
   
 XNOV1_A029855   Xyrichtys novacula CAJ1054146.1    
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