GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (1036); Uniprot accession (0); PDB accession (1); 3D entries (1); cryst (0)
All (1039) Bacteria (1039) Structure (1) Characterized (4)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 B1R35_10265   Pseudomonas syringae pv. actinidiae CRAFRU 12.29 AQX62237.1    
 B1F85_25685   Pseudomonas syringae pv. actinidiae CRAFRU 14.08 AQX68363.1    
 NZ708_09040   Pseudomonas syringae pv. actinidiae ICMP 18708 AOE59956.1    
 IYO_009055   Pseudomonas syringae pv. actinidiae ICMP 18884 AKT29669.1    
 JN853_09300   Pseudomonas syringae pv. actinidiae ICMP 9853 AQL40478.1    
 CT122_09605   Pseudomonas syringae pv. actinidiae MAFF212063 ATV20864.1    
 PsaNZ45_09595   Pseudomonas syringae pv. actinidiae NZ-45 APQ00918.1    
 PsaNZ47_09035   Pseudomonas syringae pv. actinidiae NZ-47 APQ06664.1    
 ACA40_17920   Pseudomonas syringae pv. lapsa ATCC 10859 ALU61642.1    
 PsyrB_18735   Pseudomonas syringae pv. syringae B301D AKF47208.1    
 Psyr_3629   Pseudomonas syringae pv. syringae B728a AAY38661.1    
 PsyrH_08270   Pseudomonas syringae pv. syringae HS191 AKF50463.1    
 PSYRMG_08645   Pseudomonas syringae UMAF0158 ALD97210.1    
 SAMN04490204_2275   Pseudomonas thivervalensis BS3779 SDF90390.1    
 B5P22_29365   Pseudomonas tolaasii 2192T ARB31247.1    
 SAMN04490205_3018   Pseudomonas trivialis BS3111 SDS60601.1    
 AA957_05555   Pseudomonas trivialis IHBB745 AKS05587.1    
 SAMN04490206_3621   Pseudomonas umsongensis BS3657 SDT54706.1    
 SAMN05216558_3525   Pseudomonas vancouverensis BS3656 SDV11998.1    
 PVE_R1G1783   Pseudomonas veronii 1YdBTEX2 SBW79669.1    
 PverR02_08855   Pseudomonas veronii R02 AQY65170.1    
 AOC04_03550   Pseudomonas versuta L10.10 ALE87348.1    
 CFBP1590__1637   Pseudomonas viridiflava CFBP 1590 SMS09223.1    
 SAMN05216535_2934   Pseudomonas xanthomarina LMG 23572 SEH95378.1    
 SAMN05216237_1409   Pseudomonas yamanorum LMG 27247 SDU01599.1    
 PT7_0406   Pusillimonas sp. T7-7 AEC18946.1    
 H16_A2548   Ralstonia eutropha H16 CAJ93631.1    
 Reut_A2245   Ralstonia eutropha JMP134 AAZ61608.1    
 A9Y76_10945   Ralstonia insidiosa ATCC 49129 ANJ74484.1    
 ACS15_2328   Ralstonia insidiosa FC1138 ANH71978.1    
 TK49_09580   Ralstonia mannitolilytica SN82F48 AJW44935.1    
 VZ52_14025   Ralstonia mannitolilytica SN83A39 ANA34429.1    
 Rpic12D_1000   Ralstonia pickettii 12D ACS62300.1    
 Rpic_0935   Ralstonia pickettii 12J ACD26085.1    
 N234_14495   Ralstonia pickettii DTP0602 AGW91235.1    
 CO705_10635   Ralstonia pickettii FDAARGOS_410 ATG20289.1    
 CDC45_05470   Ralstonia pseudosolanacearum RS 476 AST26696.1    
 CIG66_11300   Ralstonia solanacearum 10319 AST86982.1    
 RCFBP_20407   Ralstonia solanacearum CFBP2957 CBJ43597.1    
 CMR15_20188   Ralstonia solanacearum CMR15 CBJ38233.1    
 AC251_12190   Ralstonia solanacearum EP1 API75244.1    
 BCR16_12800   Ralstonia solanacearum FJAT-1458 APF87616.1    
 BC427_05825   Ralstonia solanacearum FJAT-91 ARS55667.1    
 F504_1039   Ralstonia solanacearum FQY_4 AGH83558.1    
 RSc1070   Ralstonia solanacearum GMI1000 CAD14772.1    
 RALBFv3_14505   Ralstonia solanacearum IBSBF1503 AMP75304.1    
 LBM2029_11395   Ralstonia solanacearum KACC 10722 AMP38092.1    
 LBM341_00839   Ralstonia solanacearum KACC10709 AOE89149.1    
 RSM_02140   Ralstonia solanacearum M7 ASS42327.1    
 RSOE_CAD01655   Ralstonia solanacearum OE1-1 APC68107.1    
 RUN215_v1_1420046   Ralstonia solanacearum Phyl III-seqv23 CUV57617.1    
 PSS4_v1_150047   Ralstonia solanacearum Phyl III-seqv23 CUV16587.1    
 RUN1985_v1_1230009   Ralstonia solanacearum Phyl III-seqv23 CUV31870.1    
 TO10_v1_50046   Ralstonia solanacearum Phyl III-seqv23 CUV43409.1    
 RUN39_v1_670036   Ralstonia solanacearum Phyl III-seqv23 CUV13978.1    
 RD1301_v1_460033   Ralstonia solanacearum Phyl III-seqv23 CUV59577.1    
 RUN1744_v1_70009   Ralstonia solanacearum Phyl III-seqv23 CUV21624.1
CUV35165.1
CUV39491.1
   
 RSPO_c02296   Ralstonia solanacearum Po82 AEG69592.1    
 RPSI07_2322   Ralstonia solanacearum PSI07 CBJ51687.1    
 CCY86_07445   Ralstonia solanacearum RS 488 ATI27346.1    
 CDC59_07390   Ralstonia solanacearum RS 489 ATJ86109.1    
 RSSE_c2327   Ralstonia solanacearum SEPPX05 ARU22739.1    
 UW163_11975   Ralstonia solanacearum UW163 AMP70138.1    
 RSUY_14890   Ralstonia solanacearum UY031 ALF87847.1    
 A3768_2513   Ralstonia solanacearum YC40-M ANH33655.1    
 ACH51_11545   Ralstonia solanacearum YC45 AKZ26908.1    
 RALSY_40210   Ralstonia syzygii R24 CCA86010.1    
 UC35_20085   Ramlibacter tataouinensis 5-10 AMO24715.1    
 Rta_24520   Ramlibacter tataouinensis TTB310 AEG93550.1    
 REIFOR_02785   Reinekea forsetii Hel1_31_D35 ATX77906.1    
 CPZ87_16645   Rhizobacter gummiphilus NBRC 109400 ATU66063.1    
 CPZ87_16645   Rhizobacter gummiphilus NBRC 109400 ATU66063.1    
 A4W93_16560   Rhizobacter gummiphilus NS21 ARN21378.1    
 RA876_11600   Rhodoferax antarcticus DSM 24876 APW46897.1    
 Rfer_2243   Rhodoferax ferrireducens T118 DSM 15236 ABD69965.1    
 RS694_08345   Rhodoferax saidenbachensis DSM 22694 APW42539.1    
 RD110_18910   Rhodoferax sp. DCY110 APW39022.1    
 RD2015_2110   Roseateles depolymerans KCTC 42856 ALV06585.1    
 RGE_16210   Rubrivivax gelatinosus IL144 BAL94962.1    
 Sama_1700   Shewanella amazonensis SB2B ABL99906.1    
 Sbal175_2279   Shewanella baltica BA175 AEG11532.1    
 Sbal117_2354   Shewanella baltica OS117 AEH14075.1    
 Sbal_2231   Shewanella baltica OS155 ABN61727.1
ABN63880.1
   
 Shew185_2140   Shewanella baltica OS185 ABS08282.1    
 Sbal195_2190   Shewanella baltica OS195 ABX49359.1    
 Sbal223_2244   Shewanella baltica OS223 ACK46743.1    
 Sbal678_2193   Shewanella baltica OS678 ADT94350.1    
 CF168_10050   Shewanella bicestrii JAB-1 ASK69185.1    
 Sden_1991   Shewanella denitrificans OS217 ABE55274.1    
 Sfri_1909   Shewanella frigidimarina NCIMB 400 ABI71755.1    
 Shal_2244   Shewanella halifaxensis HAW-EB4 ABZ76803.1    
 SJ2017_1983   Shewanella japonica KCTC 22435 ARD22284.1    
 Shew_1916   Shewanella loihica PV-4 ABO23782.1    
 CFF01_09770   Shewanella marisflavi EP1 ASJ96844.1    
 dTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EarP; SO_2329) 2.4.1.- Shewanella oneidensis MR-1 AAN55363.1    
 Spea_2050   Shewanella pealeana ATCC 700345 ABV87370.1    
 swp_2617   Shewanella piezotolerans WP3 ACJ29353.1    
 Sps_00780   Shewanella psychrophila WP2 AQS35973.1    
 Sputcn32_1876   Shewanella putrefaciens CN-32 ABP75599.1    
 Ssed_2338   Shewanella sediminis HAW-EB3 ABV36947.1    
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