Glycoside Hydrolase Family 99

Activities in Familyglycoprotein endo-α-1,2-mannosidase (EC 3.2.1.130); mannan endo-1,2-α-mannanase (3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseUnclear, possible neighboring group participation from O2 (after Thompson et al. Proc. Natl. Acad. Sci. USA., 2012, 109, 781-786)
Catalytic Proton DonorGlu (experimental)
NoteCreated after Spiro, Bhoyroo and Spiro (1997) J. Biol. Chem. 272, 29356-29363
External resourcesCAZypedia;
Statistics GenBank accession (152); Uniprot accession (30); PDB accession (18); 3D entries (2); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ENSANGG00000018734 (fragment)   Anopheles gambiae str. PEST XP_320623.1
EAA00122.2
   
 ORF (fragment)   Ascaris suum ADY46293.1    
 endo-α-mannosidase (protein for IMAGE:7984259) (fragment)   Bos taurus AAI03139.1
AEM43818.1
AFK84025.1
AFK84026.1
AFK84027.1
AFK84028.1
Q3ZBS4  
 Unknown (protein for MGC:152422)   Bos taurus AAI51267.1 A7MB02  
 ORF (fragment)   Coptotermes formosanus AGM32803.1    
 endomannosidase   Cricetulus griseus ABH07382.1 A7RDN7  
 Manea (fragment)   Danio rerio AAH81681.1 Q66HT9  
 CH211-30B16.2-001   Danio rerio CAK04938.1 Q1L8D2  
 Dbus_chr2Lg2204   Drosophila busckii ALC40119.1    
 CG14015   Drosophila melanogaster AAF52260.2
AAL49145.1
NP_608937.1
Q9VMQ2  
 GA12699   Drosophila pseudoobscura MV2-25 EAL34552.1    
 ORF (fragment)   Equus caballus AEQ00826.1    
 LOC421807   Gallus gallus XP_419831.1    
 LOC419611   Gallus gallus XP_417758.1    
 glycoprotein endo-α-1,2-mannosidase (ManeA) 3.2.1.130 Homo sapiens CAE12165.1
AAI46672.1
AAI50200.1
AAL07306.1
AAL07307.1
AAQ75077.1
ACH33940.1
BAB14298.1
BAF84629.1
CAD97640.1
CAE45927.1
CAH33902.1
CAI17346.1
CAI17347.1
NP_078917.2
A6H8M6
Q5SRI9
 
 Rp11-109p14.3   Homo sapiens CAH70081.1
AAH09952.2
AAH31903.1
AAH63587.1
AAH77730.1
ABE14780.1
BAB71068.1
BAG62934.1
CAH70082.1
NP_689709.1
Q5VSG8  
 ORF (ManeA)   Ictalurus punctatus AHH39207.1    
 glycoprotein endo-α-1,2-mannosidase (ManeA)   Macaca mulatta AFE66476.1
AFH27753.1
   
 ORF (fragment)   Macaca mulatta AFE70497.1    
 Manea   Mus musculus AAH67076.1
BAC26805.1
CAM23963.1
NP_766453.2
Q6NXH2  
 Gm50 (ManeaL)   Mus musculus AAH65047.1
BAE23227.1
CAM16102.1
Q6P1J0  
 ORF   Mustela putorius furo AES01516.1    
 ORF (fragment)   Mustela putorius furo AES01517.1    
 ORF (fragment)   Mustela putorius furo AES01518.1    
 LOC472074   Pan troglodytes XP_527453.1 H2QTF2  
 DKFZp469G135   Pongo abelii CAH90264.1 Q5RD93  
 endo-α-1,2-mannosidase (Enman) 3.2.1.130 Rattus norvegicus AAT44962.1
AAB86925.1
NP_542963.1
XP_346734.1
Q5GF25  
 LOC366466 (fragment)   Rattus norvegicus XP_345581.1    
 Smp_016880   Schistosoma mansoni Puerto Rico CAZ29389.1
CCD80792.1
C4Q1N7  
 SRAE_2000015400   Strongyloides ratti ED321 Heterogonic CEF65474.1    
 GSTEN:00031982:G:001   Tetraodon nigroviridis CAG10373.1 Q4RMK9  
 Maneα-prov   Xenopus laevis AAH77304.1 Q6DE40  
 Unknown (protein for MGC:121847)   Xenopus tropicalis AAI35933.1
AAI52045.1
A4IIA4  
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