Glycoside Hydrolase Family 99

Activities in Familyglycoprotein endo-α-1,2-mannosidase (EC 3.2.1.130); mannan endo-1,2-α-mannanase (3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseUnclear, possible neighboring group participation from O2 (after Thompson et al. Proc. Natl. Acad. Sci. USA., 2012, 109, 781-786)
Catalytic Proton DonorGlu (experimental)
NoteCreated after Spiro, Bhoyroo and Spiro (1997) J. Biol. Chem. 272, 29356-29363
External resourcesCAZypedia;
Statistics GenBank accession (152); Uniprot accession (30); PDB accession (18); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endo-α-1,2-mannosidase (BtGH99;BT3862) (BtGH99) 3.2.1.130
3.2.1.-
Bacteroides thetaiotaomicron VPI-5482 AAO78967.1
NP_812773.1
Q8A109 4ACY[A,B]
4ACZ[A,B]
4AD0[A,B,C,D]
 endo-α-1,2-mannosidase (BxGH99;EndoMan;BXY_34140) (BxGH99) 3.2.1.130
3.2.1.-
Bacteroides xylanisolvens XB1A CBK68409.1 D6D1V7 4AD1[A]
4AD2[A,B,C,D]
4AD3[A,B,C,D]
4AD4[A]
4AD5[A]
4UTF[A]
4V27[A]
4V28[A]
5LYR[A]
5M03[A]
5M17[A]
5M3W[A]
5M5D[A]
5MC8[A]
5MEL[A]
 endo-α-1,2-mannosidase (Sama99;Sama_0297) 3.2.1.130 Shewanella amazonensis SB2B ABL98508.1 A1S2A2  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 glycoprotein endo-α-1,2-mannosidase (ManeA) 3.2.1.130 Homo sapiens CAE12165.1
AAI46672.1
AAI50200.1
AAL07306.1
AAL07307.1
AAQ75077.1
ACH33940.1
BAB14298.1
BAF84629.1
CAD97640.1
CAE45927.1
CAH33902.1
CAI17346.1
CAI17347.1
NP_078917.2
A6H8M6
Q5SRI9
 
 endo-α-1,2-mannosidase (Enman) 3.2.1.130 Rattus norvegicus AAT44962.1
AAB86925.1
NP_542963.1
XP_346734.1
Q5GF25  
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