Glycoside Hydrolase Family 99

Activities in Familyglycoprotein endo-α-1,2-mannosidase (EC 3.2.1.130); mannan endo-1,2-α-mannanase (3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseUnclear, possible neighboring group participation from O2 (after Thompson et al. Proc. Natl. Acad. Sci. USA., 2012, 109, 781-786)
Catalytic Proton DonorGlu (experimental)
NoteCreated after Spiro, Bhoyroo and Spiro (1997) J. Biol. Chem. 272, 29356-29363
External resourcesCAZypedia;
Statistics GenBank accession (152); Uniprot accession (30); PDB accession (18); 3D entries (2); cryst (0)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ACAM_0412   Aeropyrum camini SY1 = JCM 12091 BAN89881.1    
 APE_0727 (fragment)   Aeropyrum pernix K1 BAA79703.1    
 HALDL1_09485   Halobacterium sp. DL1 AHG05266.1    
 Pars_1633   Pyrobaculum arsenaticum DSM 13514 ABP51186.1    
 L593_09755   Salinarchaeum sp. Harcht-Bsk1 AGN01896.1    
 A3L01_02480   Thermococcus barossii SHCK-94 ASJ04282.1    
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 LuPra_04144   Acidobacteria bacterium DSM 100886 AMY10901.1    
 Btheta7330_00449   Bacteroides thetaiotaomicron 7330 ALJ40035.1    
 endo-α-1,2-mannosidase (BtGH99;BT3862) (BtGH99) 3.2.1.130
3.2.1.-
Bacteroides thetaiotaomicron VPI-5482 AAO78967.1
NP_812773.1
Q8A109 4ACY[A,B]
4ACZ[A,B]
4AD0[A,B,C,D]
 endo-α-1,2-mannosidase (BxGH99;EndoMan;BXY_34140) (BxGH99) 3.2.1.130
3.2.1.-
Bacteroides xylanisolvens XB1A CBK68409.1 D6D1V7 4AD1[A]
4AD2[A,B,C,D]
4AD3[A,B,C,D]
4AD4[A]
4AD5[A]
4UTF[A]
4V27[A]
4V28[A]
5LYR[A]
5M03[A]
5M17[A]
5M3W[A]
5M5D[A]
5MC8[A]
5MEL[A]
 CLDAP_14670   Caldilinea aerophila DSM 14535 = NBRC 104270 BAL99506.1    
 644968214   Chitinophaga pinensis DSM 2588 ACU63492.1    
 CK934_17660   Chitinophaga sp. MD30 ASZ12652.1    
 OK18_05290   Chryseobacterium gallinarum DSM 27622 AKK72127.1    
 CHSO_4479   Chryseobacterium sp. StRB126 BAP33516.1    
 CYFUS_004517   Cystobacter fuscus DSM 52655 ATB39078.1    
 Deba_3244   Desulfarculus baarsii DSM 2075 ADK86597.1 E1QM12  
 OP10G_1502   Fimbriimonas ginsengisoli Gsoil 348 AIE84870.1    
 D770_00985   Flammeovirgaceae bacterium 311 AHM58471.1    
 BB050_03160   Flavobacterium johnsoniae GSE09 AOC96249.1    
 Fjoh_4327   Flavobacterium johnsoniae UW101 ABQ07335.1    
 ALW18_03240   Flavobacterium psychrophilum Z1 AOE54296.1    
 AMR72_03240   Flavobacterium psychrophilum Z2 ALM50674.1    
 Haur_3007   Herpetosiphon aurantiacus DSM 785 ABX05645.1    
 GJA_1091   Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628 CDG81746.1    
 ORF   Kibdelosporangium sp. MJ126-NF4 CTQ91594.1    
 Kole_0482   Kosmotoga olearia TBF 19.5.1 ACR79205.1 C5CEA1  
 LA76x_2943 (ManeA)   Lysobacter antibioticus 76 ALN81073.1    
 LA76x_0982   Lysobacter antibioticus 76 ALN79143.1    
 GLA29479_246   Lysobacter antibioticus ATCC 29479 ALN61132.1    
 GLA29479_2173   Lysobacter antibioticus ATCC 29479 ALN63043.1    
 MEBOL_003633   Melittangium boletus DSM 14713 ATB30178.1    
 BN4615_P5528   Nonomuraea gerenzanensis ATCC 39727 SBO96012.1    
 AY601_2188   Pedobacter cryoconitis PAMC 27485 AMP99086.1    
 STSP2_03000   Phycisphaerae bacterium ST-NAGAB-D1 AQT69803.1    
 STSP1_00024   Phycisphaerae bacterium ST-PulAB-D4 ARN55664.1    
 BW723_17595   Polaribacter reichenbachii 6Alg 8T APZ47999.1    
 BW723_17590   Polaribacter reichenbachii 6Alg 8T APZ47998.1    
 HMPREF0659_A6411   Prevotella melaninogenica ATCC 25845 ADK95453.1 D9RT77  
 CEP85_00160   Prevotella melaninogenica FDAARGOS_306 ASE16633.1    
 PMEL1_01415   Prevotella melaninogenica GAI 07411 BBA29477.1    
 AXF22_01650   Prevotella scopos JCM 17725 ANR73274.1    
 Plabr_4762   Rubinisphaera brasiliensis DSM 5305 ADY62333.1    
 endo-α-1,2-mannosidase (Sama99;Sama_0297) 3.2.1.130 Shewanella amazonensis SB2B ABL98508.1 A1S2A2  
 Solca_2945   Solitalea canadensis DSM 3403 AFD07964.1    
 STHERM_c15300   Spirochaeta thermophila DSM 6192 ADN02470.1 E0RTU5  
 Spith_1563   Spirochaeta thermophila DSM 6578 AEJ61824.1    
 STAUR_3309   Stigmatella aurantiaca DW4/3-1 ADO71101.1 Q08X64  
 BV401_08475   Streptomyces autolyticus CGMCC0516 AQA10517.1    
 SBI_00635   Streptomyces bingchenggensis BCW-1 ADI03756.1 D7C2A2  
 SBI_09400   Streptomyces bingchenggensis BCW-1 ADI12518.1 D7C5Y9  
 BN159_0556   Streptomyces davawensis JCM 4913 CCK24935.1    
 SFUL_1990   Streptomyces fulvissimus DSM 40593 AGK76953.1    
 WQO_10015   Streptomyces globisporus C-1027 ALU93662.1    
 SGR_5090   Streptomyces griseus subsp. griseus NBRC 13350 BAG21919.1 B1VYD4  
 SHXM_08303   Streptomyces hygroscopicus XM201 AQW54840.1    
 SIRAN8449   Streptomyces iranensis CDR14748.1    
 SMALA_0936   Streptomyces malaysiensis DSM 4137 ATL81171.1    
 BBN63_24330   Streptomyces niveus SCSIO 3406 AQU68854.1    
 SPRI_6730   Streptomyces pristinaespiralis HCCB 10218 ALC25036.1    
 M271_42530   Streptomyces rapamycinicus NRRL 5491 AGP59881.1    
 CGL27_42775   Streptomyces sp. 11-1-2 ASQ98848.1    
 AA958_26800   Streptomyces sp. CNQ-509 AKH85244.1    
 TK78_24890   Streptomyces sp. Tue 6075 Tue6075 APS21788.1    
 Strvi_5963   Streptomyces violaceusniger Tu 4113 AEM85470.1    
 Sros_3784   Streptosporangium roseum DSM 43021 ACZ86705.1 D2ATI5  
 TJEJU_3218   Tenacibaculum jejuense KCTC 22618 SNR16870.1    
 THTE_1595   Thermogutta terrifontis R1 ASV74197.1    
 Trebr_0184   Treponema brennaborense DSM 12168 AEE15635.1    
 ORF   uncultured bacterium AIA15982.1    
 SAMN04489797_1037   Winogradskyella sp. RHA_55 SDS17746.1    
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ENSANGG00000018734 (fragment)   Anopheles gambiae str. PEST XP_320623.1
EAA00122.2
   
 ORF (fragment)   Ascaris suum ADY46293.1    
 endo-α-mannosidase (protein for IMAGE:7984259) (fragment)   Bos taurus AAI03139.1
AEM43818.1
AFK84025.1
AFK84026.1
AFK84027.1
AFK84028.1
Q3ZBS4  
 Unknown (protein for MGC:152422)   Bos taurus AAI51267.1 A7MB02  
 ORF (fragment)   Coptotermes formosanus AGM32803.1    
 endomannosidase   Cricetulus griseus ABH07382.1 A7RDN7  
 Manea (fragment)   Danio rerio AAH81681.1 Q66HT9  
 CH211-30B16.2-001   Danio rerio CAK04938.1 Q1L8D2  
 Dbus_chr2Lg2204   Drosophila busckii ALC40119.1    
 CG14015   Drosophila melanogaster AAF52260.2
AAL49145.1
NP_608937.1
Q9VMQ2  
 GA12699   Drosophila pseudoobscura MV2-25 EAL34552.1    
 ORF (fragment)   Equus caballus AEQ00826.1    
 LOC421807   Gallus gallus XP_419831.1    
 LOC419611   Gallus gallus XP_417758.1    
 glycoprotein endo-α-1,2-mannosidase (ManeA) 3.2.1.130 Homo sapiens CAE12165.1
AAI46672.1
AAI50200.1
AAL07306.1
AAL07307.1
AAQ75077.1
ACH33940.1
BAB14298.1
BAF84629.1
CAD97640.1
CAE45927.1
CAH33902.1
CAI17346.1
CAI17347.1
NP_078917.2
A6H8M6
Q5SRI9
 
 Rp11-109p14.3   Homo sapiens CAH70081.1
AAH09952.2
AAH31903.1
AAH63587.1
AAH77730.1
ABE14780.1
BAB71068.1
BAG62934.1
CAH70082.1
NP_689709.1
Q5VSG8  
 ORF (ManeA)   Ictalurus punctatus AHH39207.1    
 glycoprotein endo-α-1,2-mannosidase (ManeA)   Macaca mulatta AFE66476.1
AFH27753.1
   
 ORF (fragment)   Macaca mulatta AFE70497.1    
 Manea   Mus musculus AAH67076.1
BAC26805.1
CAM23963.1
NP_766453.2
Q6NXH2  
 Gm50 (ManeaL)   Mus musculus AAH65047.1
BAE23227.1
CAM16102.1
Q6P1J0  
 ORF   Mustela putorius furo AES01516.1    
 ORF (fragment)   Mustela putorius furo AES01517.1    
 ORF (fragment)   Mustela putorius furo AES01518.1    
 LOC472074   Pan troglodytes XP_527453.1 H2QTF2  
 DKFZp469G135   Pongo abelii CAH90264.1 Q5RD93  
 endo-α-1,2-mannosidase (Enman) 3.2.1.130 Rattus norvegicus AAT44962.1
AAB86925.1
NP_542963.1
XP_346734.1
Q5GF25  
 LOC366466 (fragment)   Rattus norvegicus XP_345581.1    
 Smp_016880   Schistosoma mansoni Puerto Rico CAZ29389.1
CCD80792.1
C4Q1N7  
 SRAE_2000015400   Strongyloides ratti ED321 Heterogonic CEF65474.1    
 GSTEN:00031982:G:001   Tetraodon nigroviridis CAG10373.1 Q4RMK9  
 Maneα-prov   Xenopus laevis AAH77304.1 Q6DE40  
 Unknown (protein for MGC:121847)   Xenopus tropicalis AAI35933.1
AAI52045.1
A4IIA4  
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 BN138_675   termite gut metagenome CCO21487.1    
 BN138_915   termite gut metagenome CCO21727.1    
 BN138_935   termite gut metagenome CCO21747.1    
 BN138_955   termite gut metagenome CCO21767.1    
 BN138_1026   termite gut metagenome CCO21838.1    
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