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Glycoside Hydrolase Family 99

Activities in Familyglycoprotein endo-α-1,2-mannosidase (EC 3.2.1.130); mannan endo-1,2-α-mannanase (3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseUnclear, possible neighboring group participation from O2 (after Thompson et al. Proc. Natl. Acad. Sci. USA., 2012, 109, 781-786)
Catalytic Proton DonorGlu (experimental)
NoteCreated after Spiro, Bhoyroo and Spiro (1997) J. Biol. Chem. 272, 29356-29363
External resourcesCAZypedia;
Statistics GenBank accession (280); Uniprot accession (30); PDB accession (40); 3D entries (3); cryst (0)
Summary
All (236) Archaea (7) Bacteria (178) Eukaryota (46) unclassified (5) Structure (3) Characterized (5)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ACAM_0412   Aeropyrum camini SY1 = JCM 12091 BAN89881.1    
 APE_0727 (fragment)   Aeropyrum pernix K1 BAA79703.1    
 HALDL1_09485   Halobacterium sp. DL1 AHG05266.1    
 HPS36_15655   Halorubrum sp. RHB-C QKG94318.1    
 Pars_1633   Pyrobaculum arsenaticum DSM 13514 ABP51186.1    
 L593_09755   Salinarchaeum sp. Harcht-Bsk1 AGN01896.1    
 A3L01_02480   Thermococcus barossii SHCK-94 ASJ04282.1    
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 LuPra_04144   Acidobacteria bacterium DSM 100886 AMY10901.1    
 YIM_39930   Amycolatopsis sp. YIM 10 QFU93125.1    
 STSP2_03000   Anaerohalosphaera lusitana ST-NAGAB-D1 AQT69803.1    
 G4Y79_00285   Anaerolinea sp. rifampicinis QPC82847.1    
 G4Y79_02790   Anaerolinea sp. rifampicinis QPC83322.1    
 D1815_10990   Aquimarina sp. AD1 AXT56255.1    
 D1816_23440   Aquimarina sp. AD10 AXT63173.1    
 D1818_20890   Aquimarina sp. BL5 AXT53162.1    
 OJF2_46290   Aquisphaera giovannonii OJF2 QEH36069.1    
 JQX13_00745   Archangium violaceum SDU34 QRK08748.1    
 JRI60_31015   Archangium violaceum SDU8 QRN93594.1    
 DJ013_01705   Arcticibacterium luteifluviistationis SM1504 AWV96957.1    
 H8796_12000   Bacteroides sp. M10 QNL36596.1    
 Btheta7330_00449   Bacteroides thetaiotaomicron 7330 ALJ40035.1    
 FE838_09215   Bacteroides thetaiotaomicron DSM 2079 QMW86225.1    
 BatF92_03560   Bacteroides thetaiotaomicron F9-2 BCA48414.1    
 I6G92_21785   Bacteroides thetaiotaomicron FDAARGOS_935 QQA08026.1    
 endo-α-1,2-mannosidase (BtGH99;BT3862) (BtGH99) 3.2.1.130
3.2.1.198		 Bacteroides thetaiotaomicron VPI-5482 AAO78967.1
NP_812773.1		 Q8A109 4ACY[A,B]
4ACZ[A,B]
4AD0[A,B,C,D]
 Bun01g_02270 (fragment)   Bacteroides uniformis NBRC 113350 BBK85857.1    
 FKZ68_10440   Bacteroides xylanisolvens H207 QDH54618.1    
 endo-α-1,2-mannosidase (BxGH99;EndoMan;BXY_34140) (BxGH99) 3.2.1.130
3.2.1.198		 Bacteroides xylanisolvens XB1A CBK68409.1 D6D1V7 4AD1[A]
4AD2[A,B,C,D]
4AD3[A,B,C,D]
4AD4[A]
4AD5[A]
4UTF[A]
4V27[A]
4V28[A]
5LYR[A]
5M03[A]
5M17[A]
5M3W[A]
5M5D[A]
5MC8[A]
5MEL[A]
6FAM[A]
6FAR[A]
6FWG[A]
6FWI[A]
6FWJ[A]
6FWL[A]
6FWM[A]
6FWO[A]
6FWP[A]
6FWQ[A]
6HMG[A]
6HMH[A]
6ZJ6[AAA]
 Spa11_27040   Botrimarina mediterranea Spa11 QDV74500.1    
 Spa11_21520   Botrimarina mediterranea Spa11 QDV73953.1    
 Pr1d_36860   Bythopirellula goksoyri Pr1d QEG36372.1    
 Pr1d_40310   Bythopirellula goksoyri Pr1d QEG36695.1    
 CLDAP_14670   Caldilinea aerophila DSM 14535 = NBRC 104270 BAL99506.1    
 GWR21_10375   Chitinophaga agri H33E-04 QHS59984.1    
 644968214   Chitinophaga pinensis DSM 2588 ACU63492.1    
 CK934_17660   Chitinophaga sp. MD30 ASZ12652.1    
 EGY05_19145   Chryseobacterium arthrosphaerae FDAARGOS_519 AYZ13922.1    
 EG339_03120   Chryseobacterium bernardetii G0229 AZB23683.1    
 EG351_12080   Chryseobacterium bernardetii H4638 AZB34285.1    
 EG345_00145   Chryseobacterium carnipullorum F9942 AZA63289.1    
 EG346_09240   Chryseobacterium carnipullorum G0188 AZA48356.1    
 JNG87_02420   Chryseobacterium cucumeris MW-6 QRA43625.1    
 OK18_05290   Chryseobacterium gallinarum DSM 27622 AKK72127.1    
 FOB44_16545   Chryseobacterium gallinarum FDAARGOS_636 QIY92168.1    
 DDI74_11285   Chryseobacterium gleum 110146 QBJ86806.1    
 I6I60_06810   Chryseobacterium gleum FDAARGOS_1103 QQY33478.1    
 NCTC11432_02793   Chryseobacterium gleum NCTC11432 VEE08661.1    
 EU348_02070   Chryseobacterium indologenes StR 01 QBA20017.1    
 EG359_12225   Chryseobacterium joostei DSM 16927 AZB00339.1    
 EG343_11535   Chryseobacterium nakagawai G0041 AZA91221.1    
 NCTC13529_04913   Chryseobacterium nakagawai NCTC13529 VEH22787.1    
 EG344_14000   Chryseobacterium sp. G0162 AZB11819.1    
 EG347_11820   Chryseobacterium sp. G0186 AZA78153.1    
 CHRYMOREF3P_2369   Chryseobacterium sp. JV274 F3_Prior CAD0221633.1    
 CHSO_4479   Chryseobacterium sp. StRB126 BAP33516.1    
 D4L85_32505   Chryseolinea soli KIS68-18 AYB35017.1    
 CYFUS_004517   Cystobacter fuscus DSM 52655 ATB39078.1    
 Deba_3244   Desulfarculus baarsii DSM 2075 ADK86597.1 E1QM12  
 G7050_05950   Dysgonomonas sp. HDW5A QIK59402.1    
 G7051_06215   Dysgonomonas sp. HDW5B QIK53953.1    
 D1013_13780   Euzebyella marina RN62 AYN68372.1    
 OP10G_1502   Fimbriimonas ginsengisoli Gsoil 348 AIE84870.1    
 EI427_22690   Flammeovirga pectinis L12M1 AZQ65031.1    
 D770_00985   Flammeovirgaceae bacterium 311 AHM58471.1    
 FUA48_08145   Flavobacterium alkalisoli XS-5 QEE49551.1    
 HYN56_21320   Flavobacterium crocinum HYN0056 AWK06632.1    
 FFWV33_08520   Flavobacterium faecale WV33 AWG21571.1    
 BB050_03160   Flavobacterium johnsoniae GSE09 AOC96249.1    
 Fjoh_4327   Flavobacterium johnsoniae UW101 ABQ07335.1    
 HYN49_08890   Flavobacterium pallidum HYN0049 AWI26003.1    
 ALW18_03240   Flavobacterium psychrophilum Z1 AOE54296.1    
 AMR72_03240   Flavobacterium psychrophilum Z2 ALM50674.1    
 HAV12_009000   Flavobacterium sp. CLA17 QSB28852.1    
 HYN86_17750   Flavobacterium sp. HYN0086 AXB58340.1    
 B0M43_0020470   Flavobacterium sp. KBS0721 QDW22397.1    
 IHE43_11510   Flavobacterium sp. MDT1-60 QOG04772.1    
 GIY83_04210   Flavobacterium sp. SLB02 SGTM QGK73289.1    
 V144x_37410   Gimesia aquarii V144 QDT98255.1    
 F1728_03455   Gimesia benthica E7 QGQ21802.1    
 Enr10x_27000   Gimesia panareensis Enr10 QDT27383.1    
 Haur_3007   Herpetosiphon aurantiacus DSM 785 ABX05645.1    
 GJA_1091   Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628 CDG81746.1    
 ORF   Kibdelosporangium sp. MJ126-NF4 CTQ91594.1    
 Kole_0482   Kosmotoga olearia TBF 19.5.1 ACR79205.1 C5CEA1  
 ccbrp13_36020   Ktedonobacteria bacterium brp13 BCL81137.1    
 EPA93_38735   Ktedonosporobacter rubrisoli SCAWS-G2 QBD81593.1    
 FKV23_02920   Lysobacter alkalisoli SJ-36 QDH69163.1    
 LA76x_2943 (ManeA)   Lysobacter antibioticus 76 ALN81073.1    
 LA76x_0982   Lysobacter antibioticus 76 ALN79143.1    
 GLA29479_246   Lysobacter antibioticus ATCC 29479 ALN61132.1    
 GLA29479_2173   Lysobacter antibioticus ATCC 29479 ALN63043.1    
 C9I47_2704   Lysobacter maris HZ9B AWV08380.1    
 Mal4_55290   Maioricimonas rarisocia Mal4 QDU41164.1    
 MFFC18_04220   Mariniblastus fucicola FC18 QEG20573.1    
 MEBOL_003633   Melittangium boletus DSM 14713 ATB30178.1    
 HXZ27_18640   Micromonospora carbonacea aurantiaca QLD25982.1    
 H1D33_11835   Micromonospora sp. 28ISP2-46 QLQ39452.1    
 G7071_01355   Nocardioides sp. HDW12A QIK74283.1    
 BN4615_P5528   Nonomuraea gerenzanensis ATCC 39727 SBO96012.1    
 AY601_2188   Pedobacter cryoconitis PAMC 27485 AMP99086.1    
 CPT03_06560   Pedobacter ginsengisoli T01R-27 ATP56149.1    
 IPV69_13860   Phycisphaerales bacterium M1803 QOV87376.1    
 Pflav_004350   Phytohabitans flavus NBRC 107702 BCB74025.1    
 Pflav_039300 (fragment)   Phytohabitans flavus NBRC 107702 BCB77520.1    
 PLANPX_0769   Planctomycetales bacterium PX69 BBO31157.1    
 PLANPX_5437   Planctomycetales bacterium PX69 BBO35825.1    
 HG66A1_22370   Planctomycetes bacterium HG66A1 QDT20451.1    
 K2D_21900   Planctomycetes bacterium K2D QDV78583.1    
 K2D_27510   Planctomycetes bacterium K2D QDV79140.1    
 MalM14_28150   Planctomycetes bacterium MalM14 QDT85148.1    
 MalM25_22120   Planctomycetes bacterium MalM25 QDT69276.1    
 Pan265_03950   Planctomycetes bacterium Pan265 QDU70567.1    
 Pan265_03990   Planctomycetes bacterium Pan265 QDU70571.1    
 SV7mr_05200   Planctomycetes bacterium SV_7m_r QDT58031.1    
 V202x_28190   Planctomycetes bacterium V202 QDU09444.1    
 V6x_22780   Planctomycetes bacterium V6 QDU02573.1    
 JD969_06275   Planctomycetes bacterium ZRK32 QQE13063.1    
 JD969_05510   Planctomycetes bacterium ZRK32 QQE12917.1    
 BW723_17595   Polaribacter reichenbachii 6Alg 8T APZ47999.1    
 BW723_17590   Polaribacter reichenbachii 6Alg 8T APZ47998.1    
 BTO17_08005   Polaribacter reichenbachii KCTC 23969 AUC18633.1    
 BTO17_08000   Polaribacter reichenbachii KCTC 23969 AUC18632.1    
 KS4_30670   Poriferisphaera corsica KS4 QDU34990.1    
 KS4_13410   Poriferisphaera corsica KS4 QDU33295.1    
 CRM71_08335   Prevotella jejuni CD3_33 AUI55491.1    
 HMPREF0659_A6411   Prevotella melaninogenica ATCC 25845 ADK95453.1 D9RT77  
 CEP85_00160   Prevotella melaninogenica FDAARGOS_306 ASE16633.1    
 FIU21_11975   Prevotella melaninogenica FDAARGOS_760 QKH89593.1    
 PMEL1_01415   Prevotella melaninogenica GAI 07411 BBA29477.1    
 AXF22_01650   Prevotella scopos JCM 17725 ANR73274.1    
 Plabr_4762   Rubinisphaera brasiliensis DSM 5305 ADY62333.1    
 STSP1_00024   Sedimentisphaera salicampi ST-PulAB-D4 ARN55664.1    
 endo-α-1,2-mannosidase (Sama99;Sama_0297) 3.2.1.130 Shewanella amazonensis SB2B ABL98508.1 A1S2A2  
 Solca_2945   Solitalea canadensis DSM 3403 AFD07964.1    
 DRN02_015355   Sphingomonas paucimobilis AIMST S2 QBE93223.1    
 STHERM_c15300   Spirochaeta thermophila DSM 6192 ADN02470.1 E0RTU5  
 Spith_1563   Spirochaeta thermophila DSM 6578 AEJ61824.1    
 STAUR_3309   Stigmatella aurantiaca DW4/3-1 ADO71101.1 Q08X64  
 GXW83_18205   Streptacidiphilus sp. PB12-B1b QMU77344.1    
 DMT42_31755   Streptomyces actuosus ATCC 25421 AWT47880.1    
 G3H79_04355   Streptomyces aureoverticillatus HN6 QIB42422.1    
 BV401_08475   Streptomyces autolyticus CGMCC0516 AQA10517.1    
 SBI_00635   Streptomyces bingchenggensis BCW-1 ADI03756.1 D7C2A2  
 SBI_09400   Streptomyces bingchenggensis BCW-1 ADI12518.1 D7C5Y9  
 DN051_38445   Streptomyces cadmiisoli ZFG47 AWW41795.1    
 CP983_39790   Streptomyces chartreusis ATCC 14922 QEV73572.1    
 HUT05_42545   Streptomyces chartreusis NA02069 QKZ25171.1    
 BN159_0556   Streptomyces davaonensis JCM 4913 CCK24935.1    
 IFE09_09670   Streptomyces fulvissimus DF QQZ53865.1    
 SFUL_1990   Streptomyces fulvissimus DSM 40593 AGK76953.1    
 HUT09_09600   Streptomyces fulvissimus NA06532 QKW42807.1    
 WQO_10015   Streptomyces globisporus C-1027 ALU93662.1    
 DIJ69_24220   Streptomyces globisporus TFH56 AWL88610.1    
 SGR_5090   Streptomyces griseus subsp. griseus NBRC 13350 BAG21919.1 B1VYD4  
 SHXM_08303   Streptomyces hygroscopicus XM201 AQW54840.1    
 SIRAN8449   Streptomyces iranensis CDR14748.1    
 SMALA_0936   Streptomyces malaysiensis DSM 4137 ATL81171.1
QDL74317.1		    
 BBN63_24330   Streptomyces niveus SCSIO 3406 AQU68854.1    
 SPRI_6730   Streptomyces pristinaespiralis HCCB 10218 ALC25036.1    
 H3L99_03105   Streptomyces pristinaespiralis PR11 QMU12692.1    
 M271_42530   Streptomyces rapamycinicus NRRL 5491 AGP59881.1    
 I1A49_08165   Streptomyces solisilvae HNM0141 QPI54911.1    
 CGL27_42775   Streptomyces sp. 11-1-2 ASQ98848.1    
 HYC88_25715   Streptomyces sp. CB00271 QNQ36732.1    
 CXR04_07415   Streptomyces sp. CMB-StM0423 AUH40093.1    
 AA958_26800   Streptomyces sp. CNQ-509 AKH85244.1    
 STKY70_5504   Streptomyces sp. KY70 CAD5986556.1    
 STKY75_2100   Streptomyces sp. KY75 CAD5945000.1    
 CFP59_07654   Streptomyces sp. M56 AUA15467.1    
 HA039_31350   Streptomyces sp. QMT-12 QIQ06213.1    
 SSPS47_09440 (Xyna1)   Streptomyces sp. S4.7 QHY95346.1    
 TK78_24890   Streptomyces sp. Tue 6075 Tue6075 APS21788.1    
 DMB38_28255   Streptomyces sp. WAC 06738 AZM49161.1    
 SSPO_083680   Streptomyces sporoclivatus NBRC 100767 BBJ45650.1    
 DEJ48_34345   Streptomyces venezuelae ATCC 14584 QES37822.1    
 Strvi_5963   Streptomyces violaceusniger Tu 4113 AEM85470.1    
 Sros_3784   Streptosporangium roseum DSM 43021 ACZ86705.1 D2ATI5  
 TJEJU_3218   Tenacibaculum jejuense KCTC 22618 SNR16870.1    
 MARIT_1314   Tenacibaculum maritimum SFZ81842.1    
 B9C57_05070   Tenacibaculum maritimum TM-KORJJ QCD61957.1    
 THTE_1595   Thermogutta terrifontis R1 ASV74197.1    
 Trebr_0184   Treponema brennaborense DSM 12168 AEE15635.1    
 ORF   uncultured bacterium AIA15982.1    
 TBR22_30140   Vicinamibacteria bacterium TBR-22 BCS33817.1    
 SAMN04489797_1037   Winogradskyella sp. RHA_55 SDS17746.1    
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ENSANGG00000018734 (fragment)   Anopheles gambiae str. PEST XP_320623.1
EAA00122.2		    
 ORF (fragment)   Ascaris suum ADY46293.1    
 endo-α-mannosidase (protein for IMAGE:7984259) (fragment)   Bos taurus AAI03139.1
AEM43818.1
AFK84025.1
AFK84026.1
AFK84027.1
AFK84028.1		 Q3ZBS4  
 Unknown (protein for MGC:152422)   Bos taurus AAI51267.1 A7MB02  
 ORF (fragment)   Coptotermes formosanus AGM32803.1    
 CSTEINMANNI_LOCUS4562702   Coregonus sp. balchen CAB1350915.1    
 CSTEINMANNI_LOCUS1015889   Coregonus sp. balchen CAB1320766.1    
 CSTEINMANNI_LOCUS2529038 (fragment)   Coregonus sp. balchen CAB1333566.1    
 CSTEINMANNI_LOCUS2529039 (fragment)   Coregonus sp. balchen CAB1333567.1    
 CSTEINMANNI_LOCUS2174636   Coregonus sp. balchen CAB1331354.1    
 endomannosidase   Cricetulus griseus ABH07382.1 A7RDN7  
 CTOB1V02_LOCUS8236   Cyprideis torosa CAD7230377.1    
 Manea (fragment)   Danio rerio AAH81681.1 Q66HT9  
 CH211-30B16.2-001   Danio rerio CAK04938.1 Q1L8D2  
 DSTB1V02_LOCUS2803   Darwinula stevensoni CAD7242860.1    
 Dbus_chr2Lg2204   Drosophila busckii ALC40119.1    
 CG14015   Drosophila melanogaster AAF52260.2
AAL49145.1
NP_608937.1		 Q9VMQ2  
 GA12699   Drosophila pseudoobscura MV2-25 EAL34552.1    
 ORF (fragment)   Equus caballus AEQ00826.1    
 LOC421807   Gallus gallus XP_419831.1    
 LOC419611   Gallus gallus XP_417758.1    
 HERILL_LOCUS3385   Hermetia illucens CAD7080219.1    
 glycoprotein endo-α-1,2-mannosidase (ManeA) 3.2.1.130 Homo sapiens CAE12165.1
AAI46672.1
AAI50200.1
AAL07306.1
AAL07307.1
AAQ75077.1
ACH33940.1
BAB14298.1
BAF84629.1
CAD97640.1
CAE45927.1
CAH33902.1
CAI17346.1
CAI17347.1
NP_078917.2		 A6H8M6
Q5SRI9		 6ZDC[A]
6ZDF[A,B,C]
6ZDK[AAA]
6ZDL[AAA]
6ZFA[AAA]
6ZFN[AAA]
6ZFQ[AAA]
6ZJ1[AAA]
6ZJ5[AAA]
 ManeAL   Homo sapiens CAH70081.1
AAH09952.2
AAH31903.1
AAH63587.1
AAH77730.1
ABE14780.1
BAB71068.1
BAG62934.1
CAH70082.1
NP_689709.1		 Q5VSG8  
 ORF (ManeA)   Ictalurus punctatus AHH39207.1    
 glycoprotein endo-α-1,2-mannosidase (ManeA)   Macaca mulatta AFE66476.1
AFH27753.1		    
 ORF (fragment)   Macaca mulatta AFE70497.1    
 Manea   Mus musculus AAH67076.1
BAC26805.1
CAM23963.1
NP_766453.2		 Q6NXH2  
 Gm50 (ManeaL)   Mus musculus AAH65047.1
BAE23227.1
CAM16102.1		 Q6P1J0  
 ORF   Mustela putorius furo AES01516.1    
 ORF (fragment)   Mustela putorius furo AES01517.1    
 ORF (fragment)   Mustela putorius furo AES01518.1    
 LOC472074   Pan troglodytes XP_527453.1 H2QTF2  
 glycoprotein endo-α-1,2-mannosidase (ManeA)   Phallusia mammillata CAB3263610.1    
 DKFZp469G135   Pongo abelii CAH90264.1 Q5RD93  
 endo-α-1,2-mannosidase (Enman) 3.2.1.130 Rattus norvegicus AAT44962.1
AAB86925.1
NP_542963.1
XP_346734.1		 Q5GF25  
 LOC366466 (fragment)   Rattus norvegicus XP_345581.1    
 Smp_016880   Schistosoma mansoni Puerto Rico CAZ29389.1
CCD80792.1		 C4Q1N7  
 SMAX5B_012027   Scophthalmus maximus AWO96264.1    
 SMAX5B_016224   Scophthalmus maximus AWP04785.1    
 SRAE_2000015400   Strongyloides ratti ED321 Heterogonic CEF65474.1    
 GSTEN:00031982:G:001   Tetraodon nigroviridis CAG10373.1 Q4RMK9  
 TDIB3V08_LOCUS3194   Timema douglasi CAD7196868.1    
 TSIB3V08_LOCUS11695   Timema shepardi CAD7267690.1    
 Maneα-prov   Xenopus laevis AAH77304.1 Q6DE40  
 Unknown (protein for MGC:121847)   Xenopus tropicalis AAI35933.1
AAI52045.1		 A4IIA4  
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 BN138_675   termite gut metagenome CCO21487.1    
 BN138_915   termite gut metagenome CCO21727.1    
 BN138_935   termite gut metagenome CCO21747.1    
 BN138_955   termite gut metagenome CCO21767.1    
 BN138_1026   termite gut metagenome CCO21838.1    
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