Known Activities	α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22)
Mechanism	inverting and retain
3D Structure Status	( β / α ) 8
Catalytic Nucleophile/Base	Glu for inverting members; Asp for retaining members
Catalytic Proton Donor	Glu
Note	Created based on a paper by Hughes et al. (2003) Oral Microbiol Immunol. 18:309-312 (PMID: 12930523); *Mechanistic and structural elucidation by Gloster et al. (2008) Chem. Biol., Oct 8 (PMID:18848471); the inverting a-glucosidases (EC 3.2.1.20) could be renamed glucoamylases (EC 3.2.1.3 according to Kitamura et al. (2008) J. Biol. Chem., Nov 3 (PMID:18981178)
External resources	CAZypedia;
Statistics	GenBank accession (251); Uniprot accession (146); PDB accession (6); 3D entries (2); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
Amuc_1420		Akkermansia muciniphila ATCC BAA-835	ACD05243.1	B2UKX0
AL1_00490		Alistipes shahii WAL 8301	CBK62784.1	D4IIM6
AL1_13810		Alistipes shahii WAL 8301	CBK63835.1	D4ILM3
AL1_16660		Alistipes shahii WAL 8301	CBK64059.1	D4IM97
AL1_27120		Alistipes shahii WAL 8301	CBK64867.1	D4IPK5
RAM_04360		Amycolatopsis mediterranei S699	AEK39364.1
AMED_0854 (MalZ)		Amycolatopsis mediterranei U32	ADJ42674.1	D8I273
Astex_0006		Asticcacaulis excentricus CB 48 CS 48	ADU11710.1	C5SHW3
Astex_2590		Asticcacaulis excentricus CB 48 CS 48	ADU14235.1	C5SKS4
Astex_3626		Asticcacaulis excentricus CB 48 CS 48	ADU15254.1	C5SMW1
Avin_51780		Azotobacter vinelandii DJ ATCC BAA-1303	ACO81253.1	C1DMH6
BXY_19700		Bacteriodes xylanisolvens XB1A	CBK67060.1	D6CY08
BXY_29220		Bacteriodes xylanisolvens XB1A	CBK67945.1	D6D0J3
BXY_18030		Bacteriodes xylanisolvens XB1A	CBK66902.1	D6CXK0
BXY_29690		Bacteriodes xylanisolvens XB1A	CBK67992.1	D6D0P0
BXY_36920		Bacteriodes xylanisolvens XB1A	CBK68657.1	D6D2K5
BXY_47650		Bacteriodes xylanisolvens XB1A	CBK69612.1	D6D6A9
BF638R_1322		Bacteroides fragilis 638R	CBW21867.1	E1WRU8
BF638R_3329		Bacteroides fragilis 638R	CBW23797.1	E1WUZ3
BF638R_3837		Bacteroides fragilis 638R	CBW24286.1	E1WNB0
BF638R_1205 (SusB)		Bacteroides fragilis 638R	CBW21755.1	E1WQY7
BF1158 (SusB)		Bacteroides fragilis NCTC 9343	CAH06880.1	Q5LG61
BF1307		Bacteroides fragilis NCTC 9343	CAH07024.1	Q5LFR9
BF3302		Bacteroides fragilis NCTC 9343	CAH08997.1	Q5LA77
BF3763		Bacteroides fragilis NCTC 9343	CAH09443.1	Q5L8Y9
BF1323		Bacteroides fragilis YCH46	BAD48072.1
BF3492		Bacteroides fragilis YCH46	BAD50235.1
BF1191		Bacteroides fragilis YCH46	BAD47941.1
BF3988		Bacteroides fragilis YCH46	BAD50730.1
Bache_0240		Bacteroides helcogenes P 36-108 ATCC 35417	ADV42270.1
Bache_1672		Bacteroides helcogenes P 36-108 ATCC 35417	ADV43672.1
Bacsa_2371		Bacteroides salanitronis DSM 18170	ADY36919.1
Bacsa_0162		Bacteroides salanitronis DSM 18170	ADY34774.1
Bacsa_0975		Bacteroides salanitronis DSM 18170	ADY35564.1
Bacsa_2125		Bacteroides salanitronis DSM 18170	ADY36680.1
Bacsa_0701		Bacteroides salanitronis DSM 18170	ADY35295.1
BT4581		Bacteroides thetaiotaomicron VPI-5482	AAO79686.1 NP_813492.1
BT0683		Bacteroides thetaiotaomicron VPI-5482	AAO75790.1 NP_809596.1
BT0132		Bacteroides thetaiotaomicron VPI-5482	AAO75239.1 NP_809045.1
α-galactosidase (BtGH97b;BT1871;BT_1871)	3.2.1.22	Bacteroides thetaiotaomicron VPI-5482	AAO76978.1 NP_810784.1		3A24[A,B]
BT3294		Bacteroides thetaiotaomicron VPI-5482	AAO78400.1 NP_812206.1
BT2620		Bacteroides thetaiotaomicron VPI-5482	AAO77727.1 NP_811533.1
BT3163		Bacteroides thetaiotaomicron VPI-5482	AAO78269.1 NP_812075.1
BT3664		Bacteroides thetaiotaomicron VPI-5482	AAO78769.1 NP_812575.1
BT3661		Bacteroides thetaiotaomicron VPI-5482	AAO78766.1 NP_812572.1
α-glucosidase (SusB;BtGH97a;BT3703;BT_3703)	3.2.1.20	Bacteroides thetaiotaomicron VPI-5482	AAC44671.1 AAO78808.1 NP_812614.1	P71094	2D73[A,B] 2JKA[A,B] 2JKE[A,B] 2JKP[A,B] 2ZQ0[A,B]
BVU_0117		Bacteroides vulgatus ATCC 8482	ABR37847.1	A6KWN3
BVU_0133		Bacteroides vulgatus ATCC 8482	ABR37863.1	A6KWP9
BVU_0213		Bacteroides vulgatus ATCC 8482	ABR37940.1	A6KWX6
BVU_0620		Bacteroides vulgatus ATCC 8482	ABR38328.1	A6KY14
BVU_1004		Bacteroides vulgatus ATCC 8482	ABR38697.1	A6KZ33
BVU_1124		Bacteroides vulgatus ATCC 8482	ABR38815.1	A6KZF1
BVU_1381		Bacteroides vulgatus ATCC 8482	ABR39070.1	A6L056
Bresu_2907		Brevundimonas subvibrioides ATCC 15264	ADL02214.1	D9QNH9
BurJV3_1015		Burkholderia sp. JV3	AEM50349.1
Ccan_22260		Capnocytophaga canimorsus Cc5	AEK24341.1
Coch_0626		Capnocytophaga ochracea DSM 7271	ACU92184.1	C7M7S8
Coch_1394		Capnocytophaga ochracea DSM 7271	ACU92940.1	C7M5Y1
Coch_0928		Capnocytophaga ochracea DSM 7271	ACU92483.1	C7M9D7
CC0796		Caulobacter crescentus CB15	AAK22781.1 NP_419613.1	Q9AA15
CCNA_00838		Caulobacter crescentus NA1000	ACL94303.1	B8H1I0
Cseg_1824		Caulobacter segnis ATCC 21756	ADG10298.1	D5VGH9
CJA_0736 (Adg97B)		Cellvibrio japonicus Ueda107	ACE83851.1	B3PK74
CJA_0817 (Agd97A)		Cellvibrio japonicus Ueda107	ACE84509.1	B3PKR0
Cpin_5410		Chitinophaga pinensis DSM 2588	ACU62839.1	C7PTT2
Cpin_5767		Chitinophaga pinensis DSM 2588	ACU63188.1	C7PCX4
Cycma_1863		Cyclobacterium marinum DSM 745	AEL25615.1
Cycma_3867		Cyclobacterium marinum DSM 745	AEL27577.1
Dfer_1312		Dyadobacter fermentans DSM 18053	ACT92560.1	C6W680
ELI_03180		Erythrobacter litoralis HTCC2594	ABC62728.1	Q2NC63
FIC_00545		Flavobacteriaceae bacterium 3519-10	ACU07003.1	C6X3L5
FB2170_09306		Flavobacteriales bacterium HTCC2170	EAR00957.1	A4ASM2
FBFL15_2614 (SusB)		Flavobacterium branchiophilum FL-15	CCB70611.1
Fjoh_0777 (fragment)		Flavobacterium johnsoniae UW101	ABQ03811.1	A5FLV5
Fjoh_1209		Flavobacterium johnsoniae UW101	ABQ04241.1 ABQ04241.2	A5FKN5
Fjoh_1400		Flavobacterium johnsoniae UW101	ABQ04432.1	A5FK37
Fjoh_3805		Flavobacterium johnsoniae UW101	ABQ06816.1	A5FD99
Fjoh_3873		Flavobacterium johnsoniae UW101	ABQ06884.1	A5FD29
Fjoh_4326		Flavobacterium johnsoniae UW101	ABQ07334.1	A5FBT0
Fjoh_4429		Flavobacterium johnsoniae UW101	ABQ07433.1	A5FBI0
Fjoh_4959		Flavobacterium johnsoniae UW101	ABQ07958.1	A5FA11
orf695		Gramella forsetii KT0803	CAL65682.1	A0LZ87
orf3401		Gramella forsetii KT0803	CAL68384.1	A0M6Y9
AciX8_0852		Granulicella mallensis MP5ACTX8	AEU35201.1
Halhy_0686		Haliscomenobacter hydrossis DSM 1100	AEE48594.1
Hore_23190		Halothermothrix orenii H 168 H 168; DSM 9562	ACL71064.1	B8D1B2
Hbal_2466		Hirschia baltica ATCC 49814 ATCC 59814	ACT60144.1	C6XNK0
Isova_1907		Isoptericola variabilis 225	AEG44646.1
Kfla_2837		Kribbella flavida DSM 17836	ADB31902.1	D2Q0B0
Lbys_2514		Leadbetterella byssophila DSM 17132	ADQ18177.1	E4RYE1
Lbys_3382		Leadbetterella byssophila DSM 17132	ADQ19033.1	E4RXT6
Mahau_2569		Mahella australiensis 50-1 BON	AEE97714.1
Mmar10_2740		Maricaulis maris MCS10	ABI67026.1	Q0AL17
Ftrac_2238		Marivirga tractuosa DSM 4126	ADR22217.1	E4TVW9
Niako_1659		Niastella koreensis GR20-10	AEV98026.1
Niako_2410		Niastella koreensis GR20-10	AEV98754.1
Niako_2424		Niastella koreensis GR20-10	AEV98766.1
Niako_3108		Niastella koreensis GR20-10	AEV99438.1
Niako_3111		Niastella koreensis GR20-10	AEV99441.1
Niako_5387		Niastella koreensis GR20-10	AEW01624.1
Niako_6416		Niastella koreensis GR20-10	AEW02640.1
Saro_1892		Novosphingobium aromaticivorans DSM 12444	ABD26332.1	Q2G741
PP1Y_AT20820		Novosphingobium sp. PP1Y	CCA92954.1
Odosp_3219		Odoribacter splanchnicus DSM 20712	ADY34178.1
Odosp_3663		Odoribacter splanchnicus DSM 20712	ADY34607.1
Oter_0169		Opitutus terrae PB90-1	ACB73460.1	B1ZN91
Oter_3217		Opitutus terrae PB90-1	ACB76497.1	B1ZN46
Palpr_0339		Paludibacter propionicigenes WB4	ADQ78500.1	E4T1A6
Palpr_0667		Paludibacter propionicigenes WB4	ADQ78823.1	E4T279
Palpr_1636		Paludibacter propionicigenes WB4	ADQ79777.1	E4T4Y3
BDI_3129		Parabacteroides distasonis ATCC 8503	ABR44835.1	A6LGM1
BDI_2880		Parabacteroides distasonis ATCC 8503	ABR44588.1	A6LFX4
BDI_0535		Parabacteroides distasonis ATCC 8503	ABR42311.1	A6L9E7
Phep_2708		Pedobacter heparinus DSM 2366	ACU04909.1	C6Y0Y2
Phep_3590		Pedobacter heparinus DSM 2366	ACU05781.1	C6XTK3
Pedsa_2572		Pedobacter saltans DSM 12145	ADY53116.1
Pedsa_2577		Pedobacter saltans DSM 12145	ADY53121.1
Pedsa_3749		Pedobacter saltans DSM 12145	ADY54278.1
ORF2350		Prevotella bryantii B14	ADI70679.1	D7SFH5
ORF2001		Prevotella bryantii B14	ADI70675.1	D7SFH1
HMPREF9137_0675		Prevotella denticola F0289	AEA21821.1
HMPREF9137_0994		Prevotella denticola F0289	AEA22033.1
HMPREF0659_A5100		Prevotella melaninogenica ATCC 25845	ADK95403.1	D9RR62
HMPREF0659_A6410		Prevotella melaninogenica ATCC 25845	ADK96325.1	D9RT76
PRU_2314		Prevotella ruminicola 23	ADE81436.1	D5EVR5
PRU_2838		Prevotella ruminicola 23	ADE81739.1	D5EYP6
PRU_1635		Prevotella ruminicola 23	ADE82129.1	D5ETH7
PRU_0117		Prevotella ruminicola 23	ADE82389.1	D5EVI3
PRU_0270		Prevotella ruminicola 23	ADE83469.1	D5EWA6
PRU_2750 (SusB)		Prevotella ruminicola 23	ADE83522.1	D5EY34
PSHAa2848		Pseudoalteromonas haloplanktis TAC125	CAI87884.1	Q3IJP2
PSM_A2915		Pseudoalteromonas sp. SM9913	ADT69828.1
DSC_12445 (short fragment)		Pseudoxanthomonas spadix BD-a59	AER57133.1
Psesu_0476		Pseudoxanthomonas suwonensis 11-1	ADV26334.1
Psesu_0888		Pseudoxanthomonas suwonensis 11-1	ADV26739.1
Psesu_1110		Pseudoxanthomonas suwonensis 11-1	ADV26960.1
RB10507		Rhodopirellula baltica SH 1	CAD78916.1 NP_869459.1
Rmar_0476		Rhodothermus marinus DSM 4252	ACY47378.1	D0MES8
Rmar_0367		Rhodothermus marinus DSM 4252	ACY47271.1	D0ME47
Rhom172_0473		Rhodothermus marinus SG0.5JP17-172	AEN72417.1
Rhom172_0363		Rhodothermus marinus SG0.5JP17-172	AEN72309.1
Riean_0026		Riemerella anatipestifer DSM 15868	ADQ81208.1	E4TAX2
RIA_0120		Riemerella anatipestifer RA-GD	ADZ11307.1
Sde_0590 (Gly97A)		Saccharophagus degradans 2-40	ABD79854.1	Q21N75
Sde_0790 (Gly97C)		Saccharophagus degradans 2-40	ABD80052.1	Q21MM7
Sde_2360 (Gly97D)		Saccharophagus degradans 2-40	ABD81620.1	Q21I59
Sde_2499 (Gly97B)		Saccharophagus degradans 2-40	ABD81759.1	Q21HS0
SACE_3274		Saccharopolyspora erythraea NRRL 2338	CAM02549.1	A4FES4
SRU_2253 (SusB)		Salinibacter ruber DSM 13855 M31	ABC45950.1	Q2S0C3
SRM_02480 (SusB)		Salinibacter ruber M8	CBH25401.1
Sama_1108		Shewanella amazonensis SB2B	ABL99315.1	A1S4K9
Sbal175_2079		Shewanella baltica BA175	AEG11343.1
Sbal117_2461		Shewanella baltica OS117	AEH14171.1
Sbal_2329		Shewanella baltica OS155	ABN61822.1	A3D509
Shew185_2329		Shewanella baltica OS185	ABS08467.1	A6WNS8
Sbal195_2445		Shewanella baltica OS195	ABX49613.1	A9L3K3
Sbal223_2017		Shewanella baltica OS223	ACK46521.1	B8EA48
Sbal223_2159		Shewanella baltica OS223	ACK46661.1	B8EEQ3
Sbal678_2446		Shewanella baltica OS678	ADT94598.1	D8CST8
Sden_2002		Shewanella denitrificans OS217	ABE55285.1	Q12MP1
Sfri_1777		Shewanella frigidimarina NCIMB 400	ABI71627.1	Q083D8
Shew_1876		Shewanella loihica PV-4	ABO23742.1	A3QE44
Shew_2298		Shewanella loihica PV-4	ABO24164.1	A3QFB6
SusB		Shewanella oneidensis MR-1	AAN55484.1 NP_718040.1
Spea_1628		Shewanella pealeana ATCC 700345	ABV86953.1	A8H316
swp_2453		Shewanella piezotolerans WP3	ACJ29196.1	B8CMD9
swp_2676		Shewanella piezotolerans WP3	ACJ29409.1	B8CML9
Shewana3_1931		Shewanella sp. ANA-3	ABK48162.1	A0KWJ3
Shewmr4_1876		Shewanella sp. MR-4	ABI38950.1	Q0HJ17
Shewmr7_2102		Shewanella sp. MR-7	ABI43090.1	Q0HUW5
Acid_3433		Solibacter usitatus Ellin6076	ABJ84406.1	Q021I3
Sph21_1022		Sphingobacterium sp. 21	ADZ77593.1
α-1,3-polybranched dextran hydrolase (hbd) (fragment)		Sphingobacterium sp. V-54	BAE92748.1	Q1XGE3
Sala_0185		Sphingopyxis alaskensis RB2256	ABF51909.1
Spico_1069		Spirochaeta coccoides DSM 17374	AEC02290.1
Slin_1419		Spirosoma linguale DSM 74	ADB37469.1	D2QMY5
Slin_0058		Spirosoma linguale DSM 74	ADB36131.1	D2QBE9
Slin_5726		Spirosoma linguale DSM 74	ADB41691.1	D2QSA9
Slin_2469		Spirosoma linguale DSM 74	ADB38488.1	D2QGI0
Smlt1176		Stenotrophomonas maltophilia K279a	CAQ44732.1	B2FSK0
Smal_1019		Stenotrophomonas maltophilia R551-3	ACF50724.1	B4SN79
STAUR_1514 (SusB)		Stigmatella aurantiaca DW4/3-1	ADO69318.1	Q09DJ4
SBI_02312		Streptomyces bingchenggensis BCW-1	ADI05433.1	D7BV54
SBI_02834		Streptomyces bingchenggensis BCW-1	ADI05955.1	D7C2S2
SBI_01652		Streptomyces bingchenggensis BCW-1	ADI04773.1	D7CFN7
SHJG_8385 (fragment)		Streptomyces hygroscopicus subsp. jinggangensis 5008	AEY93650.1
Strvi_2503		Streptomyces violaceusniger Tu 4113	AEM82223.1
Strvi_2739		Streptomyces violaceusniger Tu 4113	AEM82447.1
Strvi_4297		Streptomyces violaceusniger Tu 4113	AEM83948.1
α-glucosidase (SusB)	3.2.1.20	Tannerella forsythia ATCC 43037	AAO33827.1	Q84FT4
BFO_2272		Tannerella forsythia ATCC 43037	AEW20125.1
AciPR4_1547		Terriglobus saanensis SP1PR4	ADV82368.1	E1N698
ORF		uncultured murine large bowel bacterium BAC 31B	AAX16382.1	Q58WU4
XAC2599 (AglA)		Xanthomonas axonopodis pv. citri str. 306	AAM37448.1 NP_642912.1
XAC3313 (SusB)		Xanthomonas axonopodis pv. citri str. 306	AAM38156.1 NP_643620.1
XACM_2581		Xanthomonas axonopodis pv. citrumelo F1	AEO42839.1
XACM_3207		Xanthomonas axonopodis pv. citrumelo F1	AEO43455.1
xcc-b100_1014		Xanthomonas campestris pv. campestris B100	CAP50362.1
xcc-b100_1699		Xanthomonas campestris pv. campestris B100	CAP51049.1
XC_1002		Xanthomonas campestris pv. campestris str. 8004	AAY48076.1	Q4UXZ7
XC_1645		Xanthomonas campestris pv. campestris str. 8004	AAY48711.1	Q4UW62
AglA		Xanthomonas campestris pv. campestris str. ATCC 33913	AAM41744.1 NP_637820.1
SusB		Xanthomonas campestris pv. campestris str. ATCC 33913	AAM42433.1 NP_638509.1
XCR_3501		Xanthomonas campestris pv. raphani 756C	AEL08362.1
XCR_2782		Xanthomonas campestris pv. raphani 756C	AEL07652.1
XCV2800		Xanthomonas campestris pv. vesicatoria str. 85-10	CAJ24479.1	Q3BRT2
XCV3431		Xanthomonas campestris pv. vesicatoria str. 85-10	CAJ25162.1	Q3BQ01
zobellia_314		Zobellia galactanivorans DsiJT	CAZ94387.1
zobellia_355		Zobellia galactanivorans DsiJT	CAZ94428.1
zobellia_368 (SusB)		Zobellia galactanivorans DsiJT	CAZ94441.1
zobellia_2429		Zobellia galactanivorans DsiJT	CAZ96581.1
zobellia_316		Zobellia galactanivorans DsiJT	CAZ94389.1
zobellia_3602		Zobellia galactanivorans DsiJT	CAZ97740.1
ZPR_1029		Zunongwangia profunda SM-A87 SMA-87	ADF51374.1	D5BHY6
ZPR_1031		Zunongwangia profunda SM-A87 SMA-87	ADF51376.1	D5BHY8
ZPR_2817		Zunongwangia profunda SM-A87 SMA-87	ADF53137.1	D5BG24
ZPR_2875		Zunongwangia profunda SM-A87 SMA-87	ADF53195.1	D5BGL4
ZPR_4647		Zunongwangia profunda SM-A87 SMA-87	ADF54947.1	D5BEG2
ZPR_2493		Zunongwangia profunda SM-A87 SMA-87	ADF52817.1	D5BE58

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