Activities in Family	Acholetin phosphorylase (EC 2.4.1.-); β-1,4-glucosyl-N-acetylglucosamine phosphorylase (EC 2.4.1.-); β-1,4-glucosylgalactose phosphorylase (EC 2.4.1.-); Mixed-linkage β-glucooligosaccharide phosphorylase (EC 2.4.1.-); Cellobiose phosphorylase (EC 2.4.1.20); Chitobiose phosphorylase (EC 2.4.1.280); Laminaribiose phosphorylase (EC 2.4.1.31); Cellobionic acid phosphorylase (EC 2.4.1.321); β-1,2-oligoglucan phosphorylase (EC 2.4.1.333); Solabiose phosphorylase (EC 2.4.1.389); 3-O-β-D-glucopyranosyl β-D-glucuronide phosphorylase (EC 2.4.1.392); Cellodextrin phosphorylase (EC 2.4.1.49);
Mechanism	Inverting e
Clan	GH-Q
3D Structure Status	( α / α ) 6 barrel
Catalytic Nucleophile/Base	phosphate
Catalytic Proton Donor	Asp
Note	Formerly known as glycosyltransferase family GT36; Assigned to a GH family following a paper by Hidaka, Honda, Kitaoka, Nirasawa, Hayashi, Wakagi, Shoun and Fushinobu (Structure (Camb). 2004 Jun;12(6):937-947) (PMID: 15274915) that revealed the evolutionary, structural and mechanistic relationship of these phosphorylases with glycoside hydrolases of clan GH-L.
External resources	CAZypedia;
Statistics	GenBank accession (5971); Uniprot accession (46); PDB accession (40); 3D entries (9); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
cellodextrin-phosphorylase (Cdp; CtCDP; RtCDP; Cthe_2989)	2.4.1.49	Acetivibrio thermocellus ATCC 27405	ABN54185.1 BAA22081.1	A3DJQ6 O24780 Q93HT8	5NZ7[A,B] 2.30 5NZ8[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 3.00 8H2K[A,B] 1.37 8H2V[A,B] β-D-Glcp 1.68 8H2W[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.21 8H6H[A,B] 2.30 8HNU[A,B] 2.28
cellobiose phosphorylase (Cbp)	2.4.1.20	Acetivibrio thermocellus YM4	AAL67138.1	Q8VP44	3QDE[A,B] 2.40 8HO7[A,B] 2.59 8HO8[A,B] β-D-Glcp-(1-4)-β-D-Glcp 2.24 8HO9[A,B] 2.25
mixed-linkage β-glucooligosaccharide phosphorylase (BpGH94MLG; E5259_00910)	2.4.1.-	Blautia producta DSM 2950	QMW76265.1		8BOU[A,B] 2.32
cellobiose phosphorylase (Cbp;CgCBP)	2.4.1.20	Cellulomonas gilvus ATCC13127	BAA28631.1	O66264	2CQS[A,B] β-D-Glcp 2.00 2CQT[A,B] β-D-Glcp 2.10 3ACS[A,B] β-D-Glcp 2.51 3ACT[A,B] β-D-Glcp 1.85 3AFJ[A,B] β-D-Glcp 1.90 3QFY[A,B] β-D-Glcp <carb_like_IFM> 2.30 3QFZ[A,B] β-D-Glcp <carb_like_NOJ> 2.39 3QG0[A,B] β-D-Glcp <carb_like_NOJ> 2.70
cellobiose phosphorylase (CbP)	2.4.1.20	Cellulomonas uda DSM 20108	AAQ20920.1	Q7WTR6	3RRS[A,B] 1.70 3RSY[A,B] 1.81 3S4A[A,B] β-D-Glcp-(1-4)-β-D-Glcp 1.99 3S4B[A,B] β-D-Glcp 2.40 3S4C[A] 2.40 3S4D[A] β-D-Glcp-(1-4)-β-D-Glcp 3.30
β-1,2-oligoglucan phosphorylase (LpSOGP;Cphy_0694)	2.4.1.333	Lachnoclostridium phytofermentans ISDg	ABX41081.1	A9KJS6	5H3Z[A,B] 2.00 5H40[A,B] β-D-Glcp-(1-2)-β-D-Glcp 2.20 5H41[A,B] β-D-Glcp-(1-2)-α-D-Glcp <carb_like_IFM> 2.00 5H42[A,B] α-D-Glcp 2.10
laminaribiose phosphorylase (LbpA)	2.4.1.31	Paenibacillus sp. YM1	BAJ10826.1	D7UT17	6GGY[A,B] 1.95 6GH2[A,B] α-D-Glcp 2.50 6GH3[A,B] α-D-Manp 1.82
cellobionic acid phosphorylase 94B (Cep94B;CBAP;SdCBAP;Sde_0906) (Cep94B)	2.4.1.321	Saccharophagus degradans 2-40	ABD80168.1	Q21MB1	4ZLE[A] 2.10 4ZLF[A] β-D-Glcp-(1-1)-<non_carb> 1.60 4ZLG[A] β-D-Glcp 1.75 4ZLI[A] β-D-Glcp-(1-3)-α-D-GlcpA 1.80
chitobiose phosphorylase (ChbP;VpChBP)	2.4.1.280	Vibrio proteolyticus	BAC87867.1	Q76IQ9	1V7V[A] 1.80 1V7W[A] α-D-GlcpNAc β-D-GlcpNAc 1.60 1V7X[A] α-D-GlcpNAc β-D-GlcpNAc 2.00
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