Activities in Family	α-1,4-mannosidase (EC 3.2.1.-); Mannosyl-1-phosphodiester α-1,P-mannosidase (EC 3.2.1.-); Mannosyl-oligosaccharide α-1,3-mannosidase (EC 3.2.1.-); Mannosyl-oligosaccharide α-1,2-mannosidase (EC 3.2.1.113); α-mannosidase (EC 3.2.1.24);
Mechanism	Inverting a
3D Structure Status	( α / α ) 6 barrel
Catalytic Nucleophile/Base	Asp
Catalytic Proton Donor	Glu
External resources	CAZypedia;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (14158); Uniprot accession (37); PDB accession (20); 3D entries (10); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
mannosyl-oligosaccharide α-1,2-mannosidase (BtGH92; BT3990; BT_3990)	3.2.1.113	Bacteroides thetaiotaomicron VPI-5482	AAO79095.1 NP_812901.1	Q8A0N1	2WVX[A,B,C,D] 1.90 2WVZ[A,B,C,D] <carb_like_KIF> 2.40 2WW0[A,B,C,D,E,F,G,H] <carb_like_SWA> 2.80 2WW1[A,B,C,D] α-D-Manp-(1-2)-α-D-Manp2S-(1-1)-methyl 2.25 2WW3[A,B,C,D,E,F] α-D-Manp-(1-2)-α-D-Manp2S-(1-1)-methyl 2.10 2WZS[A,B,C,D,E,F,G,H] <carb_like_MVL> 2.25
mannosyl-oligosaccharide α-1,2-mannosidase (BT2199)	3.2.1.113	Bacteroides thetaiotaomicron VPI-5482	AAO77306.1 NP_811112.1	Q8A5N9	2WVY[A,B,C] 2.26 2WW2[A,B,C] <carb_like_SWA> 1.90
α-1,3-mannosidase (BT3130)	3.2.1.-	Bacteroides thetaiotaomicron VPI-5482	AAO78236.1 NP_812042.1	Q8A325	6F8Z[A,B,C] 2.50 6F90[A,B,C] <carb_like_MVL> 2.40
α-1,4-mannosidase (BT3965)	3.2.1.-	Bacteroides thetaiotaomicron VPI-5482	AAO79070.1 NP_812876.1	Q8A0Q6	6F91[A,B,C,D,E,F,G,H] 1.80 6F92[A,B,C,D] <carb_like_MVL> 1.90
[N-glycan] (Man-1-Pi-6-Man-specific) uncapping α-mannosidase (CcGH92_5;CcMan5)	3.2.1.-	Cellulosimicrobium cellulans	AFK83609.1	K7PDX3 M1E1E9	2XSG[A,B] 2.00 4AQ0[A,B] <carb_like_DMJ> 2.09
exo?α-1,2-mannosidase (EfGH92; WOW_02008)	3.2.1.113	Enterococcus faecalis ATCC 10100	EOK07369.1	A0A125W3X8	7FE1[A,B,C,D] D-1-deoxy-Manp α-D-2-deoxy-Manp-(1-1)-methyl 1.72 7FE2[A,B,C,D] α-D-Manp-(1-2)-β-D-Manp 1.75
[N-glycan] exo-α-1,2-mannosidase (EfMan-I; EF2217)	3.2.1.113	Enterococcus faecalis V583	AAO81948.1 NP_815878.1	Q832K9	6DWO[A,B,C,D] 2.15
exo-α-1,2-mannosidase (NnGH92)	3.2.1.113	Neobacillus novalis	CAD7619346.1	A0A7R9KAR8	7NSN[A,B] <carb_like_MVL> 2.29
mannosyl-oligosaccharide α-1,3-mannosidase	3.2.1.-	Phocaeicola massiliensis	WP_005941513.1	U6RD63	7ZGM[A] 1.43
mannosyl-oligosaccharide α-1,2-mannosidase (SpGH92;SP_2145;SP2145)	3.2.1.113	Streptococcus pneumoniae TIGR4	AAK76202.1 NP_346562.1	A0A0H2US35 A0A0Y0HIE3 Q97NA7	5SWI[A,B,C,D] β-D-Manp 2.15
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