Glycoside Hydrolase Family 8

Activities in Familychitosanase (EC 3.2.1.132); cellulase (EC 3.2.1.4); licheninase (EC 3.2.1.73); endo-1,4-β-xylanase (EC 3.2.1.8); reducing-end-xylose releasing exo-oligoxylanase (EC 3.2.1.156)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseAsp (inferred)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family D
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)NZYTech; PROZOMIX;
Statistics GenBank accession (3047); Uniprot accession (356); PDB accession (31); 3D entries (13); cryst (1)
All (2941) Bacteria (2916) Eukaryota (7) unclassified (18) Structure (13 - 1 cryst) Characterized (74)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 reducing-end-xylose releasing exo-oligoxylanase (Rex;BH2105) 3.2.1.156 Bacillus halodurans C-125 BAB05824.1
NP_242971.1
Q9KB30
1WU4[A] 1.35
1WU5[A] β-D-Xylp
2.20
1WU6[A] β-D-Xylp-(1-4)-β-D-Xylp
1.45
2DRO[A] 1.70
2DRQ[A] 2.10
2DRR[A] 1.60
2DRS[A] 2.10
3A3V[A] 1.39
 chitosanase (ChoK) 3.2.1.132 Bacillus sp. K17    
1V5D[A,B] 1.50
1V5C[A] 2.00
 endo-β-1,4-glucanase C (CelC;Ccel_0730) (Cel8C) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL75109.1
AAA73867.1
P37699
1G4L[nd]
1G4N[nd]
 endo-β-1,4-glucanase (YhjM;BcsC;b3531) (periplasmic) 3.2.1.4 Escherichia coli str. K-12 substr. MG1655 AAC76556.1
AAB18508.1
AIZ89469.1
ALI38788.1
AMC96411.1
NP_417988.1
P37651
3QXF[A,B,C,D] 1.85
3QXQ[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.20
 endo-β-1,4-glucanase (Cel10;Kvar_0212) 3.2.1.4 Klebsiella variicola At-22 ADC56143.1 D3RD09
5GY3[A] 1.77
 endo-β-1,4-glucanase (CMCax;AEG) 3.2.1.4 Komagataeibacter hansenii ATCC 23769 AAA16969.1 P37696
1WZZ[A] 1.65
 β-1,3-1,4-glucanase / chitosanase (BGlc8H;Lic8H) 3.2.1.132
3.2.1.73
Paenibacillus sp. X4 AGV55649.1  
5X3A[A,B] 1.79
 endo-β-1,4-xylanase (Xyl;XPH) 3.2.1.8 Pseudoalteromonas haloplanktis TAH3A CAD20872.1
CAJ30796.1
CAJ33706.1
Q8RJN8
1H12[A] β-D-Xylp
1.2
1H13[A] 1.3
1H14[A] 1.5
1XW2[A] 1.76
1XWQ[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-α-D-Xylp
1.88
1XWT[A] 1.30
2A8Z[A] 3.20
2B4F[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
1.95
 endo-β-1,4-glucanase (BcsZ;PP2637)   Pseudomonas putida KT2440 AAN68245.1
NP_744781.1
Q88JL2
4Q2B[A,B,C,D,E,F] 2.12
 TE10_01090   Raoultella ornithinolytica S12 AJF70739.1  
5CZL[A] 2.39
 endo-β-1,4-glucanase A (CelA) (Cel8A) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682 / JW20 AAA83521.1 P04955
1CEM[A] 1.65
1IS9[A] 1.03
1KWF[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
0.94
 xylanase (Xyn8) (Xyn8) 3.2.1.8 uncultured bacterium ABB71891.1 Q0H3C1
cryst    
 endo-β-1,4-glucanase (VFA0882)   Vibrio fischeri ES114 AAW87952.1 Q5DZ44
5CD2[A] 1.55
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