Glycoside Hydrolase Family 8

Known Activities	chitosanase (EC 3.2.1.132); cellulase (EC 3.2.1.4); licheninase (EC 3.2.1.73); endo-1,4-β-xylanase (EC 3.2.1.8); reducing-end-xylose releasing exo-oligoxylanase (EC 3.2.1.156)
Mechanism	Inverting
Clan	GH-M
3D Structure Status	( α / α ) ₆
Catalytic Nucleophile/Base	Asp (inferred)
Catalytic Proton Donor	Glu (experimental)
Note	formerly known as cellulase family D
External resources	CAZypedia; InterPro; PFAM; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	NZYTech; PROZOMIX;
Statistics	GenBank accession (607); Uniprot accession (348); PDB accession (26); 3D entries (8); cryst (1)

All (537) Bacteria (526) Eukaryota (1) unclassified (10) Structure (8 - 1 cryst) Characterized (55)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
reducing-end-xylose releasing exo-oligoxylanase (Rex;BH2105)	3.2.1.156	Bacillus halodurans C-125	BAB05824.1 NP_242971.1	Q9KB30	1WU4[A] 1WU5[A] 1WU6[A] 2DRO[A] 2DRQ[A] 2DRR[A] 2DRS[A] 3A3V[A]
chitosanase (ChoK)	3.2.1.132	Bacillus sp. K17			1V5C[A] 1V5D[A,B]
endo-β-1,4-glucanase C (CelC;Ccel_0730) (Cel8C)	3.2.1.4	Clostridium cellulolyticum H10 ATCC 35319	AAA73867.1 ACL75109.1	P37699	1G4L 1G4N
endo-β-1,4-glucanase A (CelA) (Cel8A)	3.2.1.4	Clostridium thermocellum NCIB 10682 / JW20	AAA83521.1	P04955	1CEM[A] 1IS9[A] 1KWF[A]
endo-β-1,4-glucanase (YhjM;BcsC;b3531) (periplasmic)	3.2.1.4	Escherichia coli K-12 MG1655	AAB18508.1 AAC76556.1 NP_417988.1	P37651	3QXF[A,B,C,D] 3QXQ[A,B,C,D]
endo-β-1,4-glucanase (CMCax;AEG)	3.2.1.4	Gluconacetobacter xylinus ATCC 23769	AAA16969.1	P37696	1WZZ[A]
endo-β-1,4-xylanase (Xyl;XPH)	3.2.1.8	Pseudoalteromonas haloplanktis TAH3A	CAD20872.1 CAJ30796.1 CAJ33706.1	Q8RJN8	1H12[A] 1H13[A] 1H14[A] 1XW2[A] 1XWQ[A] 1XWT[A] 2A8Z[A] 2B4F[A]
xylanase (Xyn8) (Xyn8)	3.2.1.8	uncultured bacterium	ABB71891.1	Q0H3C1	cryst