Glycoside Hydrolase Family 8

Activities in Familychitosanase (EC 3.2.1.132); cellulase (EC 3.2.1.4); licheninase (EC 3.2.1.73); endo-1,4-β-xylanase (EC 3.2.1.8); reducing-end-xylose releasing exo-oligoxylanase (EC 3.2.1.156); endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseAsp (inferred)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family D
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)NZYTech; PROZOMIX;
Statistics GenBank accession (9145); Uniprot accession (83); PDB accession (49); 3D entries (18); cryst (1)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 endo-β-1,4-glucanase A (CelA;Cthe_0269) (Cel8A) 3.2.1.4 pubmed
Acetivibrio thermocellus ATCC 27405 ABN51508.1 A3DC29  
 endo-β-1,4-glucanase A (CelA) (Cel8A) 3.2.1.4 pubmed
Acetivibrio thermocellus NCIB 10682 / JW20 AAA83521.1 A3DC29
P04955
1CEM[A]
1IS9[A]
1KWF[A]
 endoglucanase (CelY;Aq_1401) (Cel8Y) 3.2.1.4 pubmed
Aquifex aeolicus VF5 AAC07361.1
NP_213966.1
O67401  
 chitosanase (BC2682) 3.2.1.132 doi
Bacillus cereus ATCC 14579 AAP09638.1
NP_832437.1
Q81CR5  
 chitosanase (ChoK) 3.2.1.132 pubmed
Bacillus cereus BAG1O-3 K17-2   Q9ALZ1
S3JG56
1V5C[A]
1V5D[A,B]
7CJU[A,B]
7XGQ[A,B]
 chitosanase (ChoA) 3.2.1.132 URL
Bacillus cereus H-1 AAO49750.1 Q849S1  
 chitosanase (Csn) 3.2.1.132 doi
Bacillus cereus KNUC51 AAQ19678.1 Q6WCD7  
 chitosanase (Csn) 3.2.1.132 pubmed
Bacillus cereus KNUC55 AAQ75086.1 Q6JUT6  
 endo-1,4-glucanase 3.2.1.4 pubmed
Bacillus sp. (in: firmicutes) KSM-330 AAA22409.1 P29019  
 chitosanase (Csn45) 3.2.1.132 pubmed
Bacillus sp. KCTC 0377BP AAK07481.1 Q9ALZ1  
 xylanase Y (XylY) 3.2.1.8 pubmed
Bacillus sp. KK-1 AAC27700.1 O52730  
 chitosanase (Cho-GG) 3.2.1.132 pubmed
Bacillus thuringiensis JAM-GG01 BAJ05248.1 D4QGQ4  
 chitosanase (BTC11) 3.2.1.132 pubmed
Bacillus thuringiensis serovar alesti ABO61887.1 A9P7F5  
 chitosanase (BTC19) 3.2.1.132 pubmed
Bacillus thuringiensis serovar canadensis ABO61894.1 A9P7G2  
 chitosanase (BTC36) 3.2.1.132 pubmed
Bacillus thuringiensis serovar darmstadiensis ABO61891.1 A9P7F9  
 chitosanase (BTC42) 3.2.1.132 pubmed
Bacillus thuringiensis serovar israelensis ABO61892.1 A9P7G0  
 chitosanase (BTC30) 3.2.1.132 pubmed
Bacillus thuringiensis serovar morrisoni ABO61890.1 A9P7F8  
 chitosanase (BTC31) 3.2.1.132 pubmed
Bacillus thuringiensis serovar san diego ABO61888.1 A9P7F6  
 chitosanase (BTC13) 3.2.1.132 pubmed
Bacillus thuringiensis serovar sotto ABO61893.1 A9P7G1  
 chitosanase (BTC40) 3.2.1.132 pubmed
Bacillus thuringiensis serovar thompsoni ABO61889.1 A9P7F7  
 chitosanase (BTC50) 3.2.1.132 pubmed
Bacillus thuringiensis serovar tochigiensis ABO61895.1 A9P7G3  
 xylose-releasing exo-oligoxylanase (BiRex8A;BACINT_00927) (Rex8A) 3.2.1.156 pubmed
Bacteroides intestinalis DSM 17393 EDV05843.1 B3C8W4  
 endo-β-1,4-xylanase (BiXyn8A;BACINT_04210) (Xyn8A) 3.2.1.8 pubmed
Bacteroides intestinalis DSM 17393 EDV05067.1 B3CES9  
 reducing end xylose-releasing exo-oligoxylanase (RexA;XylA) 3.2.1.156 pubmed
Bifidobacterium adolescentis ATCC 15703 AAO67498.1 A1A048
Q5JB57
 
 reducing end xylose-releasing exo-oligoxylanase (RexA;BAD_0300) 3.2.1.156 pubmed
Bifidobacterium adolescentis ATCC 15703 BAF39081.1 A1A048  
 endo-β-1,4-glucanase (BpEG) 3.2.1.4 pubmed
Burkholderia pyrrocinia JK-SH007 QBY06320.1    
 endo-β-1,4-glucanase (CMCase) (fragment) 3.2.1.4 doi
Cellulomonas uda CB4 AAA23090.1 P18336  
 endoglucanase 8Y (Cel8Y) 3.2.1.4 pubmed
Dickeya chrysanthemi PY35 AAG49556.1 Q9APJ5  
 endo-β-1,4-glucanase Y (CelY) 3.2.1.4 pubmed
Dickeya dadantii 3937 AAA24818.1
ADM96331.1
P27032  
 endoglucanase 3.2.1.4 pubmed
Enterobacter cloacae JV ACU11859.1 C7FFS4  
 endo-β-1,4-glucanase (BcsZ) 3.2.1.4 doi
Enterobacter sp. CJF-002 BAM44856.1 K0IUV6 7F81[A,B,C,D]
7F82[A,B,C,D]
 endoglucanase (D8M09_02670) 3.2.1.73 pubmed
Enterobacter sp. R1(2018) RKQ41256.1 A0A495AMI2  
 endoglucanase (CelA) 3.2.1.4 pubmed
Erwinia rhapontici NCPPB2989 CAB89803.1 Q9L3G9  
 endo-β-1,4-glucanase (YhjM;BcsC;b3531) (periplasmic) 3.2.1.4 pubmed
Escherichia coli str. K-12 substr. MG1655 AAC76556.1
AAB18508.1
AIZ89469.1
ALI38788.1
AMC96411.1
AUG18236.1
AVI53692.1
AYG17530.1
NP_417988.1
P37651 3QXF[A,B,C,D]
3QXQ[A,B,C,D]
 endo-β-1,3(4)-glucanase (Fisuc_0471 / FSU_0889) 3.2.1.6 pubmed
Fibrobacter succinogenes subsp. succinogenes S85 ACX74083.1
ADL26516.1
C9RLD6
D9S8P6
 
 endo-β-1,3(4)-glucanase (Fisuc_2579 / FSU_3149) 3.2.1.6 pubmed
Fibrobacter succinogenes subsp. succinogenes S85 ACX76164.1
ADL25931.1
C9RMD2  
 Fisuc_0241 / FSU_0651 3.2.1.4 pubmed
Fibrobacter succinogenes subsp. succinogenes S85 ACX73853.1
ADL26708.1
C9RJZ0  
 endoglucanase (Fisuc_1802;FSU_2303) (Cel8B) 3.2.1.4 pubmed
Fibrobacter succinogenes subsp. succinogenes S85 ABU45499.1
ACX75395.1
ADL24942.1
A7UG68  
 [inverting] oligosaccharide reducing-end xylanase (FjXyn8; Fjoh_3868) 3.2.1.156 pubmed
Flavobacterium johnsoniae UW101 ABQ06879.1 A5FD37  
 reducing-end-xylose releasing exo-oligoxylanase (Rex;BH2105) 3.2.1.156 pubmed
Halalkalibacterium halodurans C-125 BAB05824.1
NP_242971.1
Q9KB30 1WU4[A]
1WU5[A]
1WU6[A]
2DRO[A]
2DRQ[A]
2DRR[A]
2DRS[A]
3A3V[A]
 endo-β-1,4-glucanase (Cel8H) 3.2.1.4 pubmed
Halomonas sp. 1339 ACN29537.1 C0JSK6  
 endo-β-1,4-glucanase (CelG;KPK_0216) 3.2.1.4 doi
Klebsiella pneumoniae 342 ACI07560.1 B5XN19  
 endo-β-1,4-glucanase (Cel;CelJV;Cell-JV) 3.2.1.4 doi
Klebsiella pneumoniae celJV ADJ68331.1
ADK13056.1
D9ISD8  
 endo-β-1,4-glucanase (CMCase) 3.2.1.4 doi
Klebsiella pneumoniae Sc ACO70964.1 C9WB00  
 endo-β-1,4-glucanase (Cel10;Kvar_0212) 3.2.1.4 pubmed
Klebsiella variicola At-22 ADC56143.1 A0A0J4VP90
D3RD09
5GY3[A]
 endo-β-1,4-glucanase (CMCax;CMCase;Orf1) 3.2.1.4 pubmed
Komagataeibacter sucrofermentans BPR2001 BAA31461.1
AAQ38000.1
O82857 6VC5[A]
 endo-β-1,4-glucanase (GluL) 3.2.1.4 pubmed
Lichenicola cladoniae PAMC 26568 UUL70829.1    
 bifunctional endoglucanase chitosanase (Cel8A) 3.2.1.132
3.2.1.4
pubmed
pubmed
Lysobacter sp. IB-9374 BAE86850.1 Q25C15  
 endoglucanase N257 (Egl257) 3.2.1.4 pubmed
Niallia circulans KSM N257 BAB69035.1 Q93HV0  
 lichenase / chitosanase (Bgc) 3.2.1.132
3.2.1.73
pubmed
pubmed
Niallia circulans WL-12 CAA37062.1 P19254  
 endo-β-1,4-glucanase (CMCax;AEG) 3.2.1.4 pubmed
Novacetimonas hansenii ATCC 23769 AAA16969.1 P37696 1WZZ[A]
 β-xylanase (OtXyn8A;Oter_4314) (Xyn8A) 3.2.1.8 URL
Opitutus terrae PB90-1 ACB77586.1 B1ZP97  
 reducing-end xylose-releasing exo-oligoxylanase (Rex8A) 3.2.1.156 pubmed
Paenibacillus barcinonensis BP-23 ALP73600.1 A0A0S2UQQ5 6SHY[A,B]
6SRD[A,B]
6SUD[A,B]
6TO0[A,B]
6TOW[A,B]
6TPP[A,B]
6TRH[A,B,C,D]
 chitosanase / endoglycanase (Pgl8A) (Cel8A) 3.2.1.132 pubmed
Paenibacillus cookii SS-24 BAL46897.1 H3JUE1  
 chitosanase-glucanase 3.2.1.132
3.2.1.4
3.2.1.73
pubmed
pubmed
pubmed
Paenibacillus fukuinensis D2 / IK-5 BAB64835.1 Q93IE7  
 chitosanase (Csn1794) 3.2.1.132
3.2.1.4
pubmed
pubmed
Paenibacillus sp. 1794 AFP58892.1 J7G4R4  
 β-1,3-1,4-glucanase / chitosanase (BGlc8H;Lic8H) 3.2.1.132
3.2.1.73
pubmed
pubmed
Paenibacillus sp. X4 AGV55649.1 A0A088BCU2 5X3A[A,B]
5XD0[A,B]
 lichenase / endo-β-1,3-1,4-glucanase (Cel8Pa) 3.2.1.73 pubmed
Paenibacillus xylanivorans A59 WP_053779698.1 A0A0N0C5Q2  
 endo-β-xylanase (XynB) 3.2.1.8 pubmed
Paraglaciecola mesophila KMM241 AEC33258.1 H2BKX6  
 cellulase (CelC;Cel1F) (Cel1F) 3.2.1.4 URL
Pectobacterium carotovorum subsp. carotovorum LY34 AAO43176.1 Q84CM2  
 endo-β-1,4-xylanase (Xyn8) 3.2.1.8 pubmed
Pseudoalteromonas arctica CBY88881.1 F2QKE3  
 Patl_1069 3.2.1.8 pubmed
Pseudoalteromonas atlantica T6c ABG39595.1 Q15WZ3  
 endo-β-1,4-xylanase (Xyl;XPH) 3.2.1.8 pubmed
Pseudoalteromonas haloplanktis TAH3A CAD20872.1
CAJ30796.1
CAJ33706.1
Q8RJN8 1H12[A]
1H13[A]
1H14[A]
1XW2[A]
1XWQ[A]
1XWT[A]
2A8Z[A]
2B4F[A]
 cellulase C2 (CelC2; CelcC2; CelC) 3.2.1.4 pubmed
Rhizobium leguminosarum bv. trifolii ANU843 CAD90973.1 Q83XK5  
 reducing-end xylose-releasing exo-oligoxylanase (RiXyl8;ROSINTL182_08196) 3.2.1.156 pubmed
Roseburia intestinalis L1-82 EEU99943.1 C7GE44  
 endo-β-1,4-glucanase C (CelC;Ccel_0730) (Cel8C) 3.2.1.4 pubmed
Ruminiclostridium cellulolyticum H10 ACL75109.1
AAA73867.1
P37699 1G4L[nd]
1G4N[nd]
 endo-β-1,4-glucanase B (CelB) (Cel8A) 3.2.1.4 doi
Ruminiclostridium josui BAA04078.1
BAI52925.1
D1MX94
P37701
 
 endo-β-1,4-glucanase (GH8A;RUM_08240) (Cel8A) 3.2.1.4 pubmed
Ruminococcus champanellensis 18P13 = JCM 17042 CBL17008.1 D4LBL3  
 endoglucanase (BcsZ) 3.2.1.4 pubmed
Salmonella typhimurium ATCC14028 CAC44017.1 Q8ZLB7  
 endoglucanase (CelC;CMCase) 3.2.1.4 pubmed
Salmonella typhimurium UR1 AAL69395.1
AAO33380.1
Q7B8Q5
Q8ZLB7
 
 xylanase active on β-1,4-xylan and mixed-linkage β-1,3-β-1,4-xylan (TERTU_4506) (TtGH8) 3.2.1.32
3.2.1.8
pubmed
pubmed
Teredinibacter turnerae T7901 ACR14722.1
ACP87281.1
ACW01909.1
C5BJ89 6G00[A]
6G09[A]
6G0B[A]
6G0N[A]
 endo-β-1,4-xylanase (XYL6806) 3.2.1.8 pubmed
uncultured bacterium AAS85781.1 Q6QHA3  
 acidic endocellulase (CEL8M) (Cel8M) 3.2.1.4 pubmed
uncultured bacterium AEI98922.1 F8V2V6  
 GH-EG1 3.2.1.4 doi
uncultured bacterium AFS18547.1 J9WUW3  
 xylanase (Xyn8) (Xyn8) 3.2.1.8 pubmed
uncultured bacterium ABB71891.1 Q0H3C1 cryst
 endoglucanase (Cen219;C8) 3.2.1.4 pubmed
uncultured Enterobacter sp. AFN65708.1
AGT36744.1
I6ZKG5
S5ZBD1
 
 endoglucanase (CelA; ZMO1086) 3.2.1.4 pubmed
Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821 AAV89710.1
AVZ42319.1
Q5NNK0  
unclassified
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-glucanase (Pm84;BN138_820) 3.2.1.6 pubmed
termite gut metagenome CCO21632.1 S0DEI5  
 β-glucanase (Pm83;BN138_828) 3.2.1.6 pubmed
termite gut metagenome CCO21640.1 S0DFW8  
 β-glucanase (Pm85;BN138_846) 3.2.1.6 pubmed
termite gut metagenome CCO21658.1 S0DEE6  
 lichenase (Mt-liC) 3.2.1.73 pubmed
uncultured microorganism AJG01769.1 A0A0B5JL75  
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