Glycoside Hydrolase Family 84

Activities in FamilyN-acetyl β-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorAsp
NoteMechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resourcesCAZypedia;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (691); Uniprot accession (107); PDB accession (63); 3D entries (6); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF   Amblyomma maculatum AEO34995.1    
 ebiP6225 (EbiG6225)   Anopheles gambiae str. PEST EAA03784.2    
 ORF   Ascaris suum ADY41227.1    
 meningioma expressed antigen 5 (Mgea5)   Bubalus bubalis AFB74088.1    
 O-GlcNAcase (OGA-1; T20B5.3)   Caenorhabditis elegans Bristol N2 ABD85013.1
AAA68333.2
AAA68333.3
ABD85014.1
ABD85015.1
ABX00798.1
ABX00799.1
CCD68585.1
CCD68586.1
NP_509573.1
Q1WBU9
Q22602
 
 ORF   Callorhinchus milii AFP02075.1    
 Dbus_chr3Rg2173   Drosophila busckii ALC47423.1    
 CG5871   Drosophila melanogaster AAF55867.1
AAN71482.1
NP_650956.1
Q9VDC9  
 ORF (fragment)   Equus caballus AEQ00174.1    
 RCJMB04_20o15 (fragment)   Gallus gallus CAH65349.1 Q5F3D5  
 O-glycoprotein β-N-acetylglucosaminidase / O-GlcNAcase (OGA;hOGA;Mea5;Mgea5;NCOAT) 3.2.1.169 Homo sapiens AAD05385.2
AAG21428.1
AAH39583.2
AAH47877.1
BAA31654.2
BAA31654.3
BAG63869.1
NP_036347.1
D3DR79
O60502
O75166
Q86WV0
Q9HAR0
5M7R[A,B]
5M7S[A,B]
5M7T[A,A,B,B]
5M7U[A,B]
5TKE[A,B]
5UHK[A,C]
5UHL[A,C]
5UHO[A,C]
5UHP[A,B,C,D]
5UN8[A,B,C,D]
5UN9[A,B]
5VVO[A,B]
5VVT[A,C]
5VVU[A,C]
5VVV[A,C]
5VVX[A,C]
 ORF (Mgea5)   Ictalurus punctatus AHH42339.1    
 bifunctional protein NCOAT isoform a (Mgea5)   Macaca mulatta AFE64047.1
AFH29243.1
AFI33849.1
   
 bifunctional protein NCOAT isoform b (Mgea5)   Macaca mulatta AFE64048.1    
 O-GlcNAcase (Mgea5;NCOAT) 3.2.1.169 Mus musculus AAG43273.2
AAH20093.1
AAH41109.1
AAH54821.1
BAB28416.1
BAB31029.1
BAC40564.1
BAC97998.1
BAE26311.1
NP_076288.1
Q8BTT2
Q8CFX2
Q9CSJ4
Q9CU60
Q9EQQ9
 
 ORF (fragment)   Musca domestica ALHF AFP63519.1    
 ORF   Mustela putorius furo AES01926.1    
 O-GlcNAcase   Nilaparvata lugens AJO25058.1    
 O-GlcNAc hydrolase (OgA)   Ostrinia furnacalis AFF59208.1    
 β-N-acetylglucosaminidase (Pc12g08730) 3.2.1.52 Penicillium rubens Wisconsin 54-1255 CAP80500.1 B6GYK2  
 O-GlcNAcase (Mgea5;NCOAT) 3.2.1.169 Rattus norvegicus AAK72103.1
NP_571979.1
Q8VIJ5  
 Smp_000020   Schistosoma mansoni CAZ27676.1 C4PWV3  
 Smp_127540   Schistosoma mansoni CAZ28708.1 C4PZQ6  
 Smp_210490   Schistosoma mansoni Puerto Rico CCD78439.1    
 short O-GlcNAcase (TaOGA53) 3.2.1.169 Trichoplax adhaerens AKA09673.1    
 O-GlcNAcase (TaOGA54) 3.2.1.169 Trichoplax adhaerens AKA09674.1    
 Unknown (MGC:184804 IMAGE:7653849)   Xenopus tropicalis AAI61052.1 B1H2M0  
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