Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	not known
External resources	CAZypedia;
Statistics	GenBank accession (8633); Uniprot accession (13); PDB accession (66); 3D entries (17); cryst (0)

Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
hemagglutinin-neuraminidase	3.2.1.18	Avian avulavirus 1 (KENSAS)	AAF19984.1	P32884 Q9Q2W5	1E8T[A,B] 2.5 1E8U[A,B] α-D-GlcpNAc β-D-GlcpNAc β-D-Neup5Ac 2.0 1E8V[A,B] <carb_like_DAN> 2.0 1USR[A,B] α-D-GlcpNAc α-D-Neup5Ac α-D-Neup5Ac-(2-6)-β-D-Galp6SH-(1-1)-methyl <carb_like_DAN> 2.0 1USX[A,B,C] α-D-Neup5Ac-(2-6)-β-D-Galp6SH-(1-1)-methyl <carb_like_DAN> 2.7
hemagglutinin-neuraminidase (fragment)		Avian avulavirus 1 JG97	ABQ14808.1		7BWU[A,B,C,D] 1.87
glycoprotein (G;GhV-G)		Bat Paramyxovirus Eid_hel/GH-M74a/GHA/2009	AFH96011.1		4UF7[A,B] 1.70
attachment glycoprotein G		Cedar virus	AFP87279.1		6P72[A,C] 3.28 6P7S[A,C] 3.49 6P7Y[A,C] 2.84 6THB[A,B] 2.78 6THG[A,B,E,G,I] 4.07
attachment glycoprotein (G)		Hendra henipavirus	AAC83193.2 AEB21198.1 AEB21234.1 AEQ38062.1 AEQ38071.1 AEQ38080.1 AEQ38133.1 AEQ38141.1 APT69530.1 NP_047112.2		2VSK[A,C] 3.3 2X9M[A,B,C,D] 2.90 6CMG[A] 2.70 6CMI[B] 2.72 6PD4[A,B] 2.20 6PDL[A,C,E,G] 2.70 6VY4[A,B] 2.00 6VY6[A] 2.60 7SYY[A] 2.74 7SYZ[A] 2.86 8JR3[A,B] 3.22 8JR5[A,B] 3.30
hemagglutinin-neuraminidase (hPIV-3 HN)	3.2.1.18	Human parainfluenza 3 virus (strain NIH 47885)	AAA46846.1 ACS10163.1 AET35008.1 AGW48004.1 AGW48007.1	G8G134 P08492 U3PI42 U3PLY2	4MZA[A,B] 1.65 4MZE[A,B] 1.80 4XJQ[A,B] 1.90 4XJR[A,B] <non_carb>-(1-5)-α-L-Glcp3F4N5N-(2-0)-TYR 3.00 5KV8[A,B] D-1-deoxy-GlcpNAc D-1-deoxy-Manp 1.95 5KV9[B] 2.00 6C0M[A,B] 1.83 8TQI[A,B] 3.24
hemagglutinin-neuraminidase (HN)		Human respirovirus 3	AAP35240.1		1V2I[A,B] 2.20 1V3B[A,B] 2.00 1V3C[A,B] β-D-Neup5Ac 2.30 1V3D[A,B] <carb_like_DAN> 2.28 1V3E[A,B] <carb_like_ZMR> 1.89
neuraminidase (HN) (partial)		Human respirovirus 3	AGW47993.1 AGW47994.1 AGW47995.1 AGW47999.1 AGW48000.1 AGW48005.1		4WEF[A,B] α-L-Manp3F5Ac-(2-0)-TYR 2.50
attachment glycoprotein (G)		Mossman virus	AAQ23992.1		7ZM5[A,B] 1.62
hemagglutinin-neuraminidase	3.2.1.18	Mumps virus Miyahara vaccine (MIYAHARA VACCINE)	BAG84572.1 BAA94390.1 BAJ15035.1 CAA33358.1	E0D873 P11235 Q9WAF5	5B2C[A,B] 2.24 5B2D[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-α-D-Glcp 2.18 6JJM[A,B] β-D-GlcpNAc-(1-4)[α-D-Neup5Ac-(2-3)]-β-D-Galp-(1-4)-β-D-Glcp 2.05 6JJN[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc-(1-3)-β-D-Galp 2.50
attachment protein (H)		Nariva virus	ACL97359.1		7ZM6[A,B] 2.07
hemagglutinin-neuraminidase (HN)	3.2.1.18	Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32) VIRUS (AUSTRALIA-VICTORIA/32)		P12554	3T1E[A,B] 3.30
hemagglutinin-neuraminidase		Newcastle disease virus Ulster/67 VIRUS (ULSTER/67)	BAA00174.1		4FZH[A,B,C,D] 3.50
glycoprotein		Nipah henipavirus	UEK26006.1		8XC4[A,B] 3.24
glycoprotein		Nipah henipavirus	AAF73957.1 AAK29088.1 AAK50545.1 AAK50554.1 AAM13406.1 APT69634.1 APT69701.1 CAD92351.1 CAD92357.1 CAD92363.1 NP_112027.1		2VSM[A] 1.80 2VWD[A,B] 2.25 3D11[A] 2.31 3D12[A,D] 3.00 6VY5[A] 3.40 7TXZ[A,B,G,H] 3.20 7TY0[A,B,G,H] 3.50 8JA5[C,F] 2.79 8K0C[C,G] 3.18 8K0D[C,F] 2.94 8K3C[C,D] 2.88
hemagglutinin-neuraminidase F	3.2.1.18	Simian virus 5 (strain W3) 5 (W3)	AAA47878.1 AAB21114.1 AAC95517.1	P04850	1Z4V[A] <carb_like_DAN> 2.30 1Z4W[A] <carb_like_DAN> 2.70 1Z4X[A] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-α-D-Glcp 2.50 1Z4Y[A] 2.60 1Z4Z[A] <carb_like_DAN> 2.50 1Z50[A] <carb_like_DAN> 2.80 4JF7[A,B,C,D] 2.50
neuraminidase		Sosuga virus	AHH02040.1		6SG8[A,B] 2.50
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