Glycoside Hydrolase Family 83

Activities in Familyneuraminidase (EC 3.2.1.18)
Mechanism retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton Donornot known
External resourcesCAZypedia;
Statistics GenBank accession (7136); Uniprot accession (13); PDB accession (56); 3D entries (14); cryst (0)
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 hemagglutinin-neuraminidase 3.2.1.18 Avian avulavirus 1 (KENSAS) AAF19984.1 P32884
Q9Q2W5
1E8T[A,B] 2.5
1E8U[A,B] α-D-GlcpNAc
β-D-GlcpNAc
β-D-Neup5Ac
2.0
1E8V[A,B] <carb_like_DAN>
2.0
1USR[A,B] α-D-GlcpNAc
α-D-Neup5Ac
α-D-Neup5Ac-(2-6)-β-D-Galp6SH-(1-1)-methyl
<carb_like_DAN>
2.0
1USX[A,B,C] α-D-Neup5Ac-(2-6)-β-D-Galp6SH-(1-1)-methyl
<carb_like_DAN>
2.7
 hemagglutinin-neuraminidase (fragment)   Avian avulavirus 1 JG97 ABQ14808.1  
7BWU[A,B,C,D] 1.87
 glycoprotein (G;GhV-G)   Bat Paramyxovirus Eid_hel/GH-M74a/GHA/2009 AFH96011.1  
4UF7[A,B] 1.70
 attachment glycoprotein G   Cedar virus AFP87279.1  
6P72[A,C] 3.28
6P7S[A,C] 3.49
6P7Y[A,C] 2.84
6THB[A,B] 2.78
6THG[A,B,E,G,I] 4.07
 attachment glycoprotein (G)   Hendra henipavirus AAC83193.2
AEB21198.1
AEB21234.1
AEQ38062.1
AEQ38071.1
AEQ38080.1
AEQ38133.1
AEQ38141.1
APT69530.1
NP_047112.2
 
2VSK[A,C] 3.3
2X9M[A,B,C,D] 2.90
6CMG[A] 2.70
6CMI[B] 2.72
6PD4[A,B] 2.20
6PDL[A,C,E,G] 2.70
6VY4[A] 2.00
6VY6[A] 2.60
7SYY[A]
7SYZ[A]
 hemagglutinin-neuraminidase (hPIV-3 HN) 3.2.1.18 Human parainfluenza 3 virus (strain NIH 47885) AAA46846.1
ACS10163.1
AET35008.1
AGW48004.1
AGW48007.1
G8G134
P08492
U3PI42
U3PLY2
4MZA[A,B] 1.65
4MZE[A,B] 1.80
4XJQ[A,B] 1.90
4XJR[A,B] <non_carb>-(1-5)-α-L-Glcp3F4N5N-(2-0)-TYR
3.00
5KV8[A] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
1.95
5KV9[B] 2.00
6C0M[A,B] 1.83
 hemagglutinin-neuraminidase (HN)   Human respirovirus 3 AAP35240.1  
1V2I[A,B] 2.20
1V3B[A,B] 2.00
1V3C[A,B] β-D-Neup5Ac
2.30
1V3D[A,B] <carb_like_DAN>
2.28
1V3E[A,B] <carb_like_ZMR>
1.89
 neuraminidase (HN) (partial)   Human respirovirus 3 AGW47993.1
AGW47994.1
AGW47995.1
AGW47999.1
AGW48000.1
AGW48005.1
 
4WEF[A,B] α-L-Manp3F5Ac-(2-0)-TYR
2.50
 hemagglutinin-neuraminidase 3.2.1.18 Mumps virus Miyahara vaccine (MIYAHARA VACCINE) BAG84572.1
BAA94390.1
BAJ15035.1
CAA33358.1
E0D873
P11235
Q9WAF5
5B2C[A,B] 2.24
5B2D[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-α-D-Glcp
2.18
6JJM[A] β-D-GlcpNAc-(1-4)[α-D-Neup5Ac-(2-3)]-β-D-Galp-(1-4)-β-D-Glcp
2.05
6JJN[A] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc-(1-3)-β-D-Galp
2.50
 hemagglutinin-neuraminidase (HN) 3.2.1.18 Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32) VIRUS (AUSTRALIA-VICTORIA/32)   P12554
3T1E[A,B] 3.30
 hemagglutinin-neuraminidase   Newcastle disease virus Ulster/67 VIRUS (ULSTER/67) BAA00174.1  
4FZH[A,B,C,D] 3.50
 glycoprotein   Nipah henipavirus AAF73957.1
AAK29088.1
AAK50545.1
AAK50554.1
AAM13406.1
APT69634.1
APT69701.1
CAD92351.1
CAD92357.1
CAD92363.1
NP_112027.1
 
2VSM[A] 1.80
2VWD[A,B] 2.25
3D11[A] 2.31
3D12[A,D] 3.00
6VY5[A] 3.40
7TXZ[A] 3.20
7TY0[A] 3.50
 hemagglutinin-neuraminidase F 3.2.1.18 Simian virus 5 (strain W3) 5 (W3) AAA47878.1
AAB21114.1
AAC95517.1
P04850
1Z4V[A] <carb_like_DAN>
2.30
1Z4W[A] <carb_like_DAN>
2.70
1Z4X[A] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-α-D-Glcp
2.50
1Z4Y[A] 2.60
1Z4Z[A] <carb_like_DAN>
2.50
1Z50[A] <carb_like_DAN>
2.80
4JF7[A,B,C,D] 2.50
 neuraminidase   Sosuga virus AHH02040.1  
6SG8[A,B] 2.50
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