Glycoside Hydrolase Family 83

Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	not known
External resources	CAZypedia;
Statistics	GenBank accession (8633); Uniprot accession (13); PDB accession (66); 3D entries (17); cryst (0)


Viruses
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
hemagglutinin-neuraminidase	3.2.1.18	pubmed	Avian avulavirus 1 (B1-HITCHNER/47)	AAA46668.1	P12559
hemagglutinin-neuraminidase	3.2.1.18	pubmed	Avian avulavirus 1 (KENSAS)	AAF19984.1	P32884 Q9Q2W5	1E8T[A,B] 1E8U[A,B] 1E8V[A,B] 1USR[A,B] 1USX[A,B,C]
hemagglutinin-neuraminidase	3.2.1.18	pubmed	Bovine respirovirus 3 (KANSAS/15626/84)	AAF28258.1 NP_037645.1	Q9J7D7
hemagglutinin-neuraminidase (hPIV-3 HN)	3.2.1.18	pubmed	Human parainfluenza 3 virus (strain NIH 47885)	AAA46846.1 ACS10163.1 AET35008.1 AGW48004.1 AGW48007.1	G8G134 P08492 U3PI42 U3PLY2	4MZA[A,B] 4MZE[A,B] 4XJQ[A,B] 4XJR[A,B] 5KV8[A,B] 5KV9[B] 6C0M[A,B] 8TQI[A,B]
hemagglutinin-neuraminidase	3.2.1.18	pubmed	Mumps virus Miyahara vaccine (MIYAHARA VACCINE)	BAG84572.1 BAA94390.1 BAJ15035.1 CAA33358.1	E0D873 P11235 Q9WAF5	5B2C[A,B] 5B2D[A,B] 6JJM[A,B] 6JJN[A,B]
hemagglutinin-neuraminidase (HN)	3.2.1.18	pubmed	Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32) VIRUS (AUSTRALIA-VICTORIA/32)		P12554	3T1E[A,B]
hemagglutinin-neuraminidase F	3.2.1.18	pubmed	Simian virus 5 (strain W3) 5 (W3)	AAA47878.1 AAB21114.1 AAC95517.1	P04850	1Z4V[A] 1Z4W[A] 1Z4X[A] 1Z4Y[A] 1Z4Z[A] 1Z50[A] 4JF7[A,B,C,D]
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