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Glycoside Hydrolase Family 83

Known Activitiesneuraminidase (EC 3.2.1.18)
Mechanism Retaining (probable)
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu (probable)
Catalytic Proton Donornot known
External resourcesInterPro; PFAM;
Statistics GenBank accession (1217); Uniprot accession (432); PDB accession (23); 3D entries (6); cryst (0)
Summary
All (561) Viruses (560) unclassified (1) Structure (6 ) Characterized (57)
Viruses
Protein Name EC#OrganismGenBankUniprotPDB/3D
 hemagglutinin-neuraminidase 3.2.1.18 Avian paramyxovirus 2 (CHICK/CALIFORNIA/YUCAIPA/56) ACA49109.1
BAA03119.1		 Q65033  
 hemagglutinin-neuraminidase 3.2.1.18 Avian paramyxovirus 4 (DUCK/HK/D3/75) ACF60578.1
ACJ06715.1
AEP44006.1
AEP44018.1
BAA03120.1		 Q65034  
 hemagglutinin-neuraminidase 3.2.1.18 Bovine parainfluenza virus 3 ABZ85924.1
BAA12218.1
CAA68298.1		 P06167.1  
 hemagglutinin-neuraminidase 3.2.1.18 Bovine parainfluenza virus 3 (KANSAS/15626/84) AAF28258.1
NP_037645.1		 Q9J7D7  
 hemagglutinin-neuraminidase 3.2.1.18 HPIV-1 (human/Washington/1957) 1 VIRUS (WASHINGTON/1957) AAA46798.1
BAK09330.1		 P16071.2  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza 3 virus (strain AUS/124854/74) 3 VIRUS (AUS/124854/74) AAA46847.1 P12561.1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza 3 virus (strain NIH 47885) 3 VIRUS (NIH 47885) AAA46846.1
ACS10163.1
AET35008.1		 P08492.1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza 3 virus (strain TEX/12677/83) 3 VIRUS (TEX/12677/83) AAA46851.1 P12564.1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza 3 virus (strain TEX/545/80) 3 VIRUS (TEX/545/80) AAA46849.1 P12562.1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza 3 virus (strain TEX/9305/82) 3 VIRUS (TEX/9305/82) AAA46850.1 P12563.1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza 3 virus (strain WASH/1511/73) 3 VIRUS (WASH/1511/73) AAA46844.1
BAA32574.1		 P12566.1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza 3 virus (strain WASH/641/79) 3 VIRUS (WASH/641/79) AAA46848.1 P12565.1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 1 CAA26576.1 P06863  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 1 CAA27274.1 P04853.1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 1 (MIL-51/91) AAB17173.1
BAK41441.1
BAK41442.1
BAK41487.1
BAK41491.1		 Q98008  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 1 (MIL-52/91) AAB17174.1 Q98009  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 1 (MIL-53/91) AAB17175.1 Q98010  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 1 (MIL-55/91) AAB17177.1 Q98012  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 1 (MIL-58/91) AAB17178.1 Q98013  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 1 (MIL-62/91) AAB17181.1 Q98016  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 2 (PIV2/V9412-6) AAG10684.1
AEQ39010.1
AEQ39011.1		 Q9E7N1  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 2 (strain Toshiba) VIRUS 2 (TOSHIBA) CAA40787.1 P25466.1  
 hemagglutinin-neuramindase (HN) 3.2.1.18 Human parainfluenza virus 2 Riyadh 105/2009 ADO60289.1
AEQ39009.1		 E3ULT3  
 hemagglutinin-neuraminidase 3.2.1.18 Human parainfluenza virus 4a (strain Toshiba) VIRUS 4A (TOSHIBA) AAA46799.1
BAJ11746.1		 P21526.1  
 hemagglutinin-neuraminidase protein (HN) 3.2.1.18 Menangle virus AAK62284.1 Q91MJ8  
 hemagglutinin-neuraminidase 3.2.1.18 Mumps virus (EUROPE-1) CAA67378.1 Q83651  
 hemagglutinin-neuraminidase 3.2.1.18 Mumps virus (STRAIN MIYAHARA VACCINE) BAA94390.1
BAG84572.1
BAJ15035.1
CAA33358.1		 P11235.1  
 hemagglutinin-neuraminidase 3.2.1.18 Mumps virus (STRAIN RW) AAA46609.1
AEB92303.1		 P10866.1  
 hemagglutinin-neuraminidase 3.2.1.18 Mumps virus (STRAIN SBL-1) AAA74751.1 P19762.1  
 hemagglutinin-neuraminidase 3.2.1.18 Mumps virus GLOUC1/UK96 AAG37832.1 Q9DQA1  
 hemaglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (B1(SEPRL)) AAC55047.1
AAK55551.1
AAO95266.1
AAQ77501.1
ABZ80390.1		 Q83846
Q91AH7		  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (B1-HITCHNER/47) AAA46668.1 P12559.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (BEAUDETTE C/45). AAA46660.1
AAG30929.1
CAA00289.1
CAA27880.1		 P32884.1
Q71SA4		  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (KENSAS) AAF19984.1 Q9Q2W5 1E8T[A,B]
1E8U[A,B]
1E8V[A,B]
1USR[A,B]
1USX[A,B,C]
 hemagglutinin-neuraminidase (HN) 3.2.1.18 Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32) VIRUS (AUSTRALIA-VICTORIA/32)   P12554.2 3T1E[A,B,E,F]
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (STRAIN HER/33) VIRUS (HER/33) AAA46664.1 P35741.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (STRAIN IBA/85) VIRUS (IBA/85) AAA46667.1 P35742.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (STRAIN LAS/46) VIRUS (LAS/46) AAA46659.1
ACT34824.1
ACT34831.1
ACT34835.1
AEL75044.1
AEO72344.1		 P35743.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (TEXAS G.B./48) AAA46669.1
AEW24450.1
AEW24462.1
AEW24468.1
AEW24474.1
AEW24480.1
AEX01230.1
AEY80140.1		 P12553.1  
 hemaglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (VACCINE 1 (B1 TYPE)) AAC55041.1 Q83842  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus (VACCINE 5 (B1 TYPE)) AAC55045.1 Q83845  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus B1 AAG36979.1 Q91UL0  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus CHI/85 VIRUS (CHI/85) AAA46666.1
ACD44598.1		 P35740.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus Miyadera/51 VIRUS (MIYADERA/51) AAA46674.1 P12557.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus strain D26/76 VIRUS (D26/76) AAA46638.1
AAA46655.1
ACM45086.1
ACT22814.1
ACT22820.1
ACT22826.1
ACT22832.1
ACT22886.1
ACT22892.1
ACT22898.1
ACT22904.1
ACT34822.1
ADF59224.1
ADF59235.1		 P12555.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus strain Italien/45 VIRUS (ITALIEN/45) AAA46671.1
ADQ64402.1
ADU52867.1		 P12556.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus strain Queensland/66 VIRUS (QUEENSLAND/66) AAA46654.1
ACT34823.1		 P13850.1  
 hemagglutinin-neuraminidase 3.2.1.18 Newcastle disease virus Ulster/67 VIRUS (ULSTER/67) BAA00174.1 P12558.1  
 hemagglutinin-neuraminidase 3.2.1.18 Sendai virus AAB06200.1
AAB06282.1
AAB06288.1
AAB06294.1		    
 hemagglutinin-neuraminidase 3.2.1.18 Sendai virus (strain Fushimi) (FUSHIMI) CAA39596.1 P19758.1  
 hemagglutinin-neuraminidase 3.2.1.18 Sendai virus (strain Harris) (HARRIS) AAA47810.1 P03425.1  
 hemagglutinin-neuraminidase 3.2.1.18 Sendai virus HAMAMATSU BAB20025.1
BAC07511.1
BAC79131.1
BAC79139.1
BAC79147.1		    
 hemagglutinin-neuraminidase 3.2.1.18 Simian virus 41 AAA47451.1
CAA45568.1		 P25180.1  
 hemagglutinin-neuraminidase 3.2.1.18 Simian virus 5 (isolate canine/CPI+) 5 (CANINE/CPI POSITIVE)   P28884.1  
 hemagglutinin-neuraminidase 3.2.1.18 Simian virus 5 (isolate canine/CPI-) 5 (CANINE/CPI NEGATIVE)   P28883.1  
 hemagglutinin-neuraminidase 3.2.1.18 Simian virus 5 (isolate human/LN) 5 (HUMAN/LN)   P28885.1  
 hemagglutinin-neuraminidase F 3.2.1.18 Simian virus 5 (strain W3) 5 (W3) AAA47878.1
AAB21114.1
AAC95517.1		 P04850.1 1Z4V[A]
1Z4W[A]
1Z4X[A]
1Z4Y[A]
1Z4Z[A]
1Z50[A]

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.





Last update: 2012-01-31 © Copyright 1998-2012
AFMB - CNRS - Universités Aix-Marseille I & II