Glycoside Hydrolase Family 7

Activities in Familyendo-β-1,4-glucanase (EC 3.2.1.4); reducing end-acting cellobiohydrolase (EC 3.2.1.176); chitosanase (EC 3.2.1.132); endo-β-1,3-1,4-glucanase (EC 3.2.1.73)
Mechanism Retaining
ClanGH-B
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (10571); Uniprot accession (528); PDB accession (84); 3D entries (17); cryst (0)
All (5106) Bacteria (10) Eukaryota (5092) unclassified (4) Structure (17) Characterized (84)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 51 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 MGG_14954   Magnaporthe oryzae 70-15 XP_003720295.1
XP_364592.1
   
 GH7 (fragment)   Malbranchea cinnamomea CBS 115.68 CDF76468.1    
 CBH   Marssonina brunnea f. sp. multigermtubi S1 ADB23428.1 D2XZ25  
 cellulase (MaCel7A) (Cel7A)   Melanocarpus albomyces CAD56666.1
AAU96163.1
Q8J0K7  
 cellobiohydrolase (Gh7;MaCel7B) (Cel7B) 3.2.1.176 Melanocarpus albomyces CBS 638.94 CAD56667.1
AAU96164.1
CAD79785.1
CDF76454.1
Q8J0K6 2RFW[A,B,C,D]
2RFY[A,B,C,D]
2RFZ[A,B,C,D]
2RG0[A,B,C,D]
 CBH1 (fragment)   Melanoleuca alboflavida 1 AEO14786.1    
 CBH1 (fragment)   Melanoleuca rasilis 1 AEO14780.1    
 CBH1 (fragment)   Monosporascus sp. mg162 AEO14797.1    
 CBH1 (fragment)   Mucor hiemalis AEO14769.1    
 CBH1 (fragment)   Mucor hiemalis AEQ59461.1    
 CBH1 (fragment)   Mycena galopus AEQ59463.1    
 CbhI (fragment)   Mycena galopus ZK85/08 CBX31952.1 E3Q0D7  
 CbhI (fragment)   Mycena galopus ZK85/08 CBX31953.1 E3Q0D8  
 Cbh1 (fragment)   Mycena galopus ZK85/08 ADY89605.1
CBX31955.1
E3Q0E0  
 Sequence 9 from patent US 7459299   Mycothermus thermophilus ACK31575.1
ACK31577.1
   
 unnamed protein product   Mycothermus thermophilus CAD79797.1    
 cellobiohydrolase / cellulase I 3.2.1.176 Mycothermus thermophilus CBS 619.91 CAD79780.1    
 CBH1 (fragment)   Myrothecium sp. mg139 AEO14796.1    
 exoglucanase type C (CBH-C)   Nectria haematococca mpVI AAS82856.1
AAQ12002.1
Q5MY21  
 CBH1 (fragment)   Nectria sp. mg136 DSMZ62950 AEN99789.1    
 cellobiohydrolase I   Neolentinus lepideus ADN88316.1 E2JAJ1  
 CBH1 (fragment)   Neonectria ramulariae ZK/09 ADY89597.1
AEQ59471.1
   
 CbhI (fragment)   Neonectria ramulariae ZK151/08 CBX31958.1 E3Q0E2  
 unnamed protein product   Neotermes castaneus CAD79784.1    
 cellobiohydrolase I (Cbh-1)   Neurospora crassa 74-OR23-1A CAA02835.1
CAA54815.1
P38676  
 NCU05104.1 (B23B10.160)   Neurospora crassa OR74A CAD70429.1
XP_324461.1
Q1K5N1
Q872Y1
 
 NCU04027.1 (B10H18.030)   Neurospora crassa OR74A CAE85587.1
XP_323346.1
   
 NCU05057 (GH7-1)   Neurospora crassa OR74A EAA27195.1
XP_324414.1
Q7RXC7  
 cellobiohydrolase (Cbh-1;CBH1;NCU07340) 3.2.1.176 Neurospora crassa OR74A EAA33262.1
XP_327626.1
Q7SA23  
 NCU04854.1   Neurospora crassa OR74A XP_324211.1
EAA29875.1
   
 CBH1 (fragment)   Nidularia pulvinata AEO14776.1    
 CBH1 (fragment)   Nidularia pulvinata AEO14781.1    
 CBH1 (fragment)   Nidularia pulvinata AEO14782.1    
 CBH1 (fragment)   Nigrospora oryzae USDA54030 AEO14788.1    
 CBH1 (fragment)   Oidiodendron cerealis CCF3441 ADY89573.1    
 cellobiohydrolase I (Cbh1;CbhI;PcCel7A) (Cel7A) 3.2.1.176 Penicillium canescens F-178 / RN3-11-7 AIL95870.1    
 cellobiohydrolase 1 (CbhI) 3.2.1.176 Penicillium chrysogenum FS010 AAV65115.1
AAX84833.1
Q5S1P9  
 cellobiohydrolase (Cbh1;CBHI;CBH Ib) (Cel7A) 3.2.1.176 Penicillium decumbens 114-2 ACV95805.1 C9EI49  
 cellobiohydrolase (Cbh1)   Penicillium decumbens 114-2 / JU-A10 ABN68954.1 A3RG86  
 endoglucanase I / 7B (Eg1;Egl1) (Cel7B) 3.2.1.4 Penicillium decumbens 114-2 / JU-A10 ABY56790.1 B0FMT4  
 endoglucanase I (Egl1)   Penicillium decumbens L-06 ACJ15337.1 B6ZBT2  
 cellobiohydrolase (Cel7A)   Penicillium glabrum NA-69 AEL78901.1    
 cellobiohydrolase I (Cbh1)   Penicillium granulatum AGU16949.1    
 cellobiohydrolase I (Cbh1) 3.2.1.176 Penicillium janthinellum Biourge IMET 43733 (C41) CAA41780.1 Q06886  
 cellobiohydrolase I (Cbh1) 3.2.1.176 Penicillium occitanis Pol6 AAT99321.1 Q68HC2  
 endoglucanase I (Egl1;Eg1)   Penicillium oxalicum ACS32299.1
AEC03713.1
C5MRS3  
 exo-cellobiohydrolase (Cbh1)   Penicillium oxalicum AEF33951.1    
 CBHI   Penicillium oxalicum F67 ACE60553.1
ACB86851.1
B3GS64  
 CBHI (fragment)   Penicillium oxalicum F67 ACC93621.1 B2M126  
 exo-cellobiohydrolase (fragment)   Penicillium oxalicum F67 ACD37717.1 B2ZFJ4  
 cellobiohydrolase 2 (Cbh2)   Penicillium oxalicum GZ-2 AGW24292.1    
 cellobiohydrolase 1 (Cbh1)   Penicillium oxalicum GZ-2 AGW24291.1    
 Egl1 (fragment)   Penicillium oxalicum GZ-2 AGW24293.1    
 cellobiohydrolase I (CbhI)   Penicillium oxalicum HP7-1 ALO81606.1    
 cellobiohydrolase I (CbhI)   Penicillium oxalicum HP7-1 ALO81608.1    
 endoglucanase I (Egl1)   Penicillium oxalicum SJ1 / M AGG20186.1
AEF33952.1
AGG20187.1
   
 cellobiohydrolase   Penicillium oxalicum X10-279 AKI32221.1    
 cellobiohydrolase I (CbhI)   Penicillium oxalicum Z1-3 ALO81609.1    
 cellobiohydrolase I (CbhI)   Penicillium oxalicum Z1-3 ALO81607.1    
 Pc20g01970   Penicillium rubens Wisconsin 54-1255 CAP85526.1 B6HE71  
 Pc18g05490   Penicillium rubens Wisconsin 54-1255 CAP94773.1 B6HC69  
 endoglucanase (Bgl7C7)   Penicillium sp. C7 AEG74551.1    
 CBH1 (fragment)   Peziza sp. MDB AEO14792.1    
 CBH1 (fragment)   Phacidiopycnis sp. 19 AEQ59465.1    
 CBH1 (fragment)   Phacidiopycnis sp. ZK19/08 ZK205/08 ADY89580.1    
 CBH1 (fragment)   Phacidiopycnis sp. ZK19/08 ZK205/08 ADY89581.1    
 CbhI (fragment)   Phacidium coniferarum ZK19/08 CBX31959.1 E3Q0E3  
 unnamed protein product   Phanerochaete chrysosporium CAD79796.1    
 cellobiohydrolase I-1 (Cbh1;CBH62;PcCel7C) (Cel7C) 3.2.1.176 Phanerochaete chrysosporium CAA80253.1
AAB46373.1
P13860  
 cellobiohydrolase I-2 (CBH58;CbhI.2;CbhI-4;PcCel7D) (Cel7D) 3.2.1.176 Phanerochaete chrysosporium CAA82761.1
AAA19802.1
CAA77789.1
CAA77795.1
CAA80252.1
CAA82762.1
Q09431
Q7LHI2
1GPI[A]
1H46[X]
1Z3T[A]
1Z3V[A]
1Z3W[A]
 cellobiohydrolase (Cbh)   Phanerochaete chrysosporium 787 AGJ81161.1    
 cellobiohydrolase (Cbh1-2) (Cel7B)   Phanerochaete chrysosporium BKM-1767 CAA38275.1 Q01763  
 cellobiohydrolase (Cbh1-1) (Cel7A) 3.2.1.176 Phanerochaete chrysosporium BKM-1767 AAA09708.1
CAA38274.1
Q01762  
 CBH1 (fragment)   Phialophora cinerescens 4 ADY89591.1    
 CBH1 (fragment)   Phialophora cinerescens 4 ADY89602.1    
 CbhI (fragment)   Phialophora sp. AK47/92 CCF3784 CBX31942.1 E3Q0C9  
 CbhI (fragment)   Phialophora sp. AK47/92 CCF3784 CBX31946.1 E3Q0D2  
 CBH1 (fragment)   Phialophora sp. AK47/92 ZK/09 ADY89598.1    
 CBH1 (fragment)   Phialophora sp. AK47/92 ZK205/08 ADY89579.1    
 cellulase (CelG5)   Phialophora sp. G5 / CGMCC3328 ADZ44605.1    
 CBH1 (fragment)   Phialophora sp. MK320 AEQ59472.1    
 CBH1 (fragment)   Phlebia sp. G CFW-2011 AEN99778.1    
 CBH1 (fragment)   Phlebia sp. specimenG AEO14763.1    
 CBH1 (fragment)   Phoma sp. mg154 AEO14790.1    
 cellobiohydrolase, partial (fragment)   Piptoporus sp. TL01 AKU48238.1    
 cellobiohydrolase (Cbh;PeCbh)   Pleurotus eryngii BAQ59234.1    
 Cbh1 (fragment)   Pleurotus eryngii MG02 AFJ04530.1    
 Cbh1 (fragment)   Pleurotus giganteus MFLU100154 AFJ04529.1    
 Cbh1 (fragment)   Pleurotus ostreatus MG03 AFJ04532.1    
 cellobiohydrolase (Cbhi-1;CbhI1)   Pleurotus sp. Florida FLORIDA N001 CAK18913.1    
 cellobiohydrolase (CbhI-3;CbhI3)   Pleurotus sp. Florida FLORIDA N001 CAK18798.1    
 cellobiohydrolase (CbhI-4;CbhI4)   Pleurotus sp. Florida FLORIDA N001 CAK18799.1    
 cellobiohydrolase (Cbhi-2;CbhI2)   Pleurotus sp. Florida FLORIDA N001 CAK18800.1    
 CBH1 (fragment)   Pluteus cervinus 42 AEN99783.1    
 CBH1 (fragment)   Pluteus cervinus DSMZ62950 AEN92159.1    
 CBH1 (fragment)   Pluteus cervinus DSMZ62950 AEN92160.1    
 CBH1 (fragment)   Pluteus cervinus DSMZ62950 AEN92161.1    
 CBH1 (fragment)   Pluteus petasatus 1 AEO14752.1    
 CBH1 (fragment)   Pluteus petasatus DSMZ62950 AEN92162.1    
 CBH1 (fragment)   Pluteus petasatus DSMZ62950 AEN92163.1    
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