Glycoside Hydrolase Family 7

Activities in Familyendo-β-1,4-glucanase (EC 3.2.1.4); reducing end-acting cellobiohydrolase (EC 3.2.1.176); chitosanase (EC 3.2.1.132); endo-β-1,3-1,4-glucanase (EC 3.2.1.73)
Mechanism Retaining
ClanGH-B
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (10567); Uniprot accession (528); PDB accession (84); 3D entries (17); cryst (0)
All (5102) Bacteria (10) Eukaryota (5088) unclassified (4) Structure (17) Characterized (84)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 51 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 glycoside hydrolase family 7 protein   Achaetomium luteum AGV05131.1    
 unnamed protein product   Acremonium sp. CAD79794.1    
 unnamed protein product   Acremonium thermophilum CAD79778.1    
 cellobiohydrolase (Cbh1;ActCbh1) (Cel7A) 3.2.1.176 Acremonium thermophilum ALKO4245 CAM98445.1 A7WNT9  
 cellobiohydrolase (Cel7B) 3.2.1.176 Acremonium thermophilum ALKO4245 CAM98446.1 A7WNU0  
 cellobiohydrolase I (Cel2)   Agaricus bisporus D649 CAA90422.1 Q92400  
 CBH1 (fragment)   Agrocybe aegerita DSMZ1004 AEN99784.1    
 CBH1 (fragment)   Agrocybe aegerita DSMZ1004 AEO14787.1    
 ALNC14_078290 (Alnc14c130g6935)   Albugo laibachii Nc14 CCA21686.1    
 exoglucanase C1 (AaC1) (fragment)   Alternaria alternata AAF05699.1 Q9UVP4  
 exoglucanase C2 (AaC2) (fragment)   Alternaria alternata AAK69517.1 Q96WK0  
 cellobiohydrolase I (fragment)   Alternaria japonica AGU16948.1    
 CBH1 (fragment)   Amanita armillariiformis DSMZ62950 AEN92175.1    
 CBH1 (fragment)   Amanita armillariiformis DSMZ62950 AEN92178.1    
 CBH1 (fragment)   Amanita grallipes DSMZ62950 AEN92181.1    
 CBH1 (fragment)   Amanita grallipes DSMZ62950 AEN92190.1    
 CBH1 (fragment)   Amanita manicata 1 AEO14759.1    
 CBH1 (fragment)   Amanita manicata DSMZ62950 AEN92183.1    
 CBH1 (fragment)   Amanita manicata DSMZ62950 AEN92191.1    
 CBH1 (fragment)   Amanita manicata DSMZ62950 AEN92193.1    
 CBH1 (fragment)   Amanita nauseosa DSMZ62950 AEN92182.1    
 CBH1 (fragment)   Amanita nauseosa DSMZ62950 AEN92184.1    
 CBH1 (fragment)   Amanita prairiicola DSMZ62950 AEN92189.1    
 CBH1 (fragment)   Amanita prairiicola DSMZ62950 AEN92192.1    
 CBH1 (fragment)   Amanita prairiicola DSMZ62950 AEN92194.1    
 CBH1 (fragment)   Amanita sp. sp-Ridley-2 DSMZ62950 AEN92179.1    
 CBH1 (fragment)   Amanita sp. sp-Ridley-2 DSMZ62950 AEN92180.1    
 CBH1 (fragment)   Amanita sp. sp-Ridley-2 DSMZ62950 AEN92195.1    
 CBH1 (fragment)   Amanita subcaligata DSMZ62950 AEN92176.1    
 CBH1 (fragment)   Amanita subcaligata DSMZ62950 AEN92177.1    
 CBH1 (fragment)   Amanita vittadinii DSMZ62950 AEN92185.1    
 CBH1 (fragment)   Amanita vittadinii DSMZ62950 AEN92186.1    
 CBH1 (fragment)   Amanita vittadinii DSMZ62950 AEN92187.1    
 CBH1 (fragment)   Amanita vittadinii DSMZ62950 AEN92188.1    
 CBH1 (fragment)   Armillaria sp. specimenA AEO14764.1    
 EGX51407.1   Arthrobotrys oligospora ATCC 24927 EGX51407.1    
 EGX46129.1   Arthrobotrys oligospora ATCC 24927 EGX46129.1    
 EGX42952.1   Arthrobotrys oligospora ATCC 24927 EGX42952.1    
 EGX44941.1 (fragment)   Arthrobotrys oligospora ATCC 24927 EGX44941.1    
 EGX44940.1 (fragment)   Arthrobotrys oligospora ATCC 24927 EGX44940.1    
 EGX43992.1   Arthrobotrys oligospora ATCC 24927 EGX43992.1    
 cellobiohydrolase I / chitosanase (CBHI) 3.2.1.176
3.2.1.132
Aspergillus aculeatus F-50 BAA25183.1 O59843  
 hydrocellulase (Cel7B)   Aspergillus aculeatus No. F-50 BAO79778.1    
 Cel7A, partial   Aspergillus fischeri ALE19913.1    
 cellobiohydrolase (Cbh1;NFIA_057300) 3.2.1.176 Aspergillus fischeri NRRL 181 EAW16381.1
XP_001258278.1
A1DNL0  
 endo-β-1,4-glucanase   Aspergillus fumigatus 212SM AGU68559.1    
 cellobiohydrolase B (CbhB;AFUA_6G11610) (Cel7A) 3.2.1.176 Aspergillus fumigatus Af293 EAL89006.1 Q4WM08 4V1Z[A]
4V20[A]
 endoglucanase I   Aspergillus fumigatus MKU1 AFJ54162.1    
 cellobiohydrolase I (CbhI) (probable frameshift)   Aspergillus glaucus XC9 ADC91991.1 D3Y1L7  
 CBH1 (fragment)   Aspergillus muricatus USDA35674 AEO14766.1    
 cellobiohydrolase (CbhA)   Aspergillus nidulans AAM54069.1 Q5B2Q4
Q8NK03
 
 cellobiohydrolase (CbhB) 3.2.1.176 Aspergillus nidulans AAM54070.1 Q8NK02  
 endo-β-1,4-glucanase (EglB) 3.2.1.4 Aspergillus nidulans AAM54071.1 Q5B7R2
Q8NK01
 
 AN5176.2 (CbhA)   Aspergillus nidulans FGSC A4 EAA62357.1
ABF50871.1
Q5B2Q4  
 cellobiohydrolase I (CBHI;CbhB;AN0494.2) 3.2.1.176 Aspergillus nidulans FGSC A4 EAA66593.1 Q8NK02  
 endo-β-1,4-glucanase (EglB;AN3418.2) 3.2.1.4 Aspergillus nidulans FGSC A4 EAA63386.1 C8VHK3
Q5B7R2
 
 CBH1   Aspergillus niger ADZ46377.1    
 cellobiohydrolase B (CbhB)   Aspergillus niger AN524 AEF58998.1    
 1,4-β-D-glucan cellobiohydrolase A (CbhA)   Aspergillus niger AS3.316 AMQ67175.1    
 cellobiohydrolase B (CbhB)   Aspergillus niger ATCC 10574 AKH61141.1    
 cellobiohydrolase A (CbhA)   Aspergillus niger BCRC 31494 ACT65727.1 Q9UVS9  
 cellobiohydrolase B (CbhB;An01g11660) 3.2.1.176 Aspergillus niger CBS 513.88 AAF04492.1
AAP66264.1
CAK44068.1
Q9UVS8  
 cellobiohydrolase A (CbhA;An07g09330) 3.2.1.176 Aspergillus niger CBS 513.88 AAF04491.1
AAP66263.1
AAR79028.1
CAK39699.1
Q9UVS9  
 exoglucanase II (CBHII) (partial)   Aspergillus niger nl-1 ADO21450.1 E3V047  
 cellobiohydrolase C (CelC)   Aspergillus oryzae KBN616 BAC07255.1 Q8NK82  
 cellobiohydrolase D (CelD)   Aspergillus oryzae KBN616 BAC07256.1 Q2UBM3
Q8NK81
 
 endo-β-1,4-glucanase (CelB) 3.2.1.4 Aspergillus oryzae KBN616 BAA22589.1 F5BB84
O13455
Q2TX26
 
 cellobiohydrolase C (CelC;CbhB;AO090001000348)   Aspergillus oryzae RIB40 BAE56877.1 Q2UNI8  
 cellobiohydrolase D (CelD;CbhA;AO090012000941)   Aspergillus oryzae RIB40 BAE61042.1 Q2UBM3  
 endo-β-1,4-glucanase (CelB;AO090010000314) 3.2.1.4 Aspergillus oryzae RIB40 BAE66197.1
AEB00821.1
Q2TX26  
 CBH1 (fragment)   Aspergillus sp. mg175 AEN99780.1    
 CBH1 (fragment)   Aspergillus sp. mg175 AEO14772.1    
 endo-β-1,4-glucanase I   Aspergillus terreus MS-31 ADR78837.1 E5Q901  
 ATEG_05002 (Cbh1)   Aspergillus terreus NIH2624 EAU34071.1
XP_001214180.1
Q0CMT2  
 cellobiohydrolase   Aspergillus terreus SUK-1 AAW68437.2    
 cellobiohydrolase (Cbh-1)   Athelia rolfsii BAC81967.1 Q76G53  
 CBH1 (fragment)   Aureobasidium pullulans USDA58013 AEO14771.1    
 Cbh1 (fragment)   Auricularia fuscosuccinea MG01 AFJ04528.1    
 cellobiohydrolase I (Cel1) 3.2.1.176 Bipolaris zeicola AAC49089.1 Q00328  
 cellulase (Cel2)   Bipolaris zeicola AAK19621.1 Q9C1F9  
 endo-β-1,3-1,4-glucanase (Bgl7A) 3.2.1.4
3.2.1.73
Bispora sp. MEY-1 / CGMCC 2500 ACT53749.1 D2DRB6  
 glycoside hydrolase family 7 protein (Bofut4_p150570.1)   Botrytis cinerea T4 CCD55925.1    
 glycoside hydrolase family 7 protein (Bofut4_p125090.1)   Botrytis cinerea T4 CCD54461.1    
 CBH1 (fragment)   Cadophora luteo-olivacea MH301 ADY89572.1    
 CBH1 (fragment)   Cadophora luteo-olivacea MH301 ADY89593.1    
 CBH1 (fragment)   Cadophora luteo-olivacea MH301 ADY89595.1    
 CBH1 (fragment)   Cadophora luteo-olivacea MH301 ADY89599.1    
 CBH1 (fragment)   Cadophora luteo-olivacea MH301 ADY89600.1    
 CBH1 (fragment)   Cadophora malorum CCF1366 ADY89577.1    
 CBH1 (fragment)   Cadophora malorum CCF1366 ADY89584.1    
 CbhI (fragment)   Cadophora malorum CCF3784 CBX31941.1 E3Q0C8  
 CbhI (fragment)   Cadophora malorum CCF3784 CBX31945.1 E3Q0D1  
 CBH1 (fragment)   Cadophora malorum CCF3784 ADY89571.1    
 CBH1 (fragment)   Cadophora malorum MH538 ADY89592.1    
 CbhI (fragment)   Ceuthospora pinastri ZK205/08 CBX31940.1 E3Q0C7  
 CBH1 (fragment)   Ceuthospora pinastri ZK205/08 ADY89578.1
AEQ59475.1
   
 CBH1 (fragment)   Ceuthospora pinastri ZK207/08 ADY89585.1    
 unnamed protein product   Chaetomidium pingtungium CAD79795.1    
 CBH1 (fragment)   Chaetomium globosum AEO14779.1    
 CBH1 (fragment)   Chaetomium globosum AEO14799.1    
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