Glycoside Hydrolase Family 77

Known Activities	amylomaltase or 4-α-glucanotransferase (EC 2.4.1.25)
Mechanism	Retaining
Clan	GH-H
3D Structure Status	( β / α ) ₈
Catalytic Nucleophile/Base	Asp (inferred)
Catalytic Proton Donor	Glu (inferred)
External resources	InterPro; PFAM;
Statistics	GenBank accession (1266); Uniprot accession (769); PDB accession (10); 3D entries (5); cryst (0)

Summary

All (1133) Archaea (20) Bacteria (1086) Eukaryota (25) unclassified (2) Structure (5 ) Characterized (21)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
amylomaltase (MalQ;PAE1209)	2.4.1.25	Pyrobaculum aerophilum str. IM2	AAL63326.1 NP_559144.1	Q8ZXM0
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
amylomaltase (MalM;Aq_723)	2.4.1.25	Aquifex aeolicus VF5	AAC06897.1 CAE51853.1 NP_213497.1	O66937.1	1TZ7[A,B]
amylomaltase (MalQ;BB0166)	2.4.1.25	Borrelia burgdorferi B31	AAC66547.1 ABR29563.1 ABR29563.2 NP_212300.1	O51188
4-α-glucanotransferase (MalQ) (possible fragment)	2.4.1.25	Clostridium butyricum NCIMB 7423	AAB84229.1	Q59266
4-α-glucanotransferase (MalQ;b3416)	2.4.1.25	Escherichia coli K-12 MG1655	AAA24106.1 AAA58214.1 AAC76441.1 NP_417875.1	P15977.2
4-α-glucanotransferase (MalQ)	2.4.1.25	Escherichia coli str. K-12 substr. W3110	BAE77875.1
MalQ	2.4.1.25	Salmonella typhimurium LT2 SGSC 1412; ATCC 700720	AAL22375.1 NP_462416.1	Q8ZLI5
4-α-glucanotransferase (Sp2107)	2.4.1.25	Streptococcus pneumoniae TIGR4	AAA26923.1 AAK76166.1 NP_346526.1	P29851
4-α-glucanotransferase (MalQ;sll1676)	2.4.1.25	Synechocystis sp. PCC 6803	BAA16800.1 BAK48972.1 NP_440120.1	P72785
amylomaltase (MalQ)	2.4.1.25	Thermus aquaticus ATCC 33923	BAA33728.1	O87172.1	1CWY[A] 1ESW[A]
4-α-glucanotransferase (4α-GTase)	2.4.1.25	Thermus aquaticus YT-1	AAR23242.1	Q6JHX9
4-α-glucanotransferase / amylomaltase (TBGT)	2.4.1.25	Thermus brockianus	AAY89060.1	Q2VJA0	2X1I[A]
4-α-glucanotransferase	2.4.1.25	Thermus scotoductus ATCC 27978	AAR23241.1	Q6JHY0
amylomaltase (TTC0897;TT_C0897)	2.4.1.25	Thermus thermophilus HB27	AAS81241.1 YP_004868.1	Q72J82
4-α-glucanotransferase / amylomaltase (TTHA1261)	2.4.1.25	Thermus thermophilus HB8	BAD71084.1 CAE51852.1	Q5SIV3	1FP8[A] 1FP9[A] 2OWC[A] 2OWW[A] 2OWX[A]
4-α-glucanotransferase (MalQ;YPO0126)	2.4.1.25	Yersinia pestis CO92 Biovar Orientalis	CAC88989.1 CAL18812.1 NP_403782.1	Q8ZJI1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
4-α-glucanotransferase (Dpe2;Dpe2-1;At2g40840/T20B5.4) (cytosolic)	2.4.1.25	Arabidopsis thaliana	AAB86444.1 AAL91204.1 AAQ56807.1 AEC09889.1	O22198 Q8RXD9
4-α-glucanotransferase (Dpe1;At5g64860/MXK3.9) (plastidial)	2.4.1.25	Arabidopsis thaliana	AAK59831.1 AAL87397.1 AED97962.1 BAA97298.1 NP_201291.1	Q9LV91
4-α-glucanotransferase (D-enzyme) (Sta11)	2.4.1.25	Chlamydomonas reinhardtii 137C	AAG29839.1 AAG29840.1	Q9FDV9
4-α-glucanotransferase / disproportionating enzyme (DE2;Dpe2)	2.4.1.25	Solanum tuberosum	AAR99599.1	Q6R608
4-α-glucanotransferase (DpeP; D-enzyme)	2.4.1.25	Solanum tuberosum	CAA48630.1	Q06801	1X1N[A]

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.