Glycoside Hydrolase Family 74

Activities in Familyendoglucanase (EC 3.2.1.4); oligoxyloglucan reducing end-specific cellobiohydrolase (EC 3.2.1.150); xyloglucanase (EC 3.2.1.151)
Mechanism Inverting
3D Structure Status7-fold β-propeller
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
External resourcesCAZypedia;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (422); Uniprot accession (70); PDB accession (12); 3D entries (8); cryst (1)
All (384) Bacteria (360) Eukaryota (21) unclassified (3) Structure (8 - 1 cryst) Characterized (17)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 avicelase (AviIII;AcGH74;Acel_0618) (Cel74A) 3.2.1.- Acidothermus cellulolyticus 11B ABK52391.1
ACE14916.1
ACE14917.1
ACE14920.1
ACS09146.1
ACS09147.1
ACS09150.1
A0LSI1
4LGN[A] 1.82
 CJA_2477 (Gly74A)   Cellvibrio japonicus Ueda107 ACE84745.1 B3PKK9
5FKQ[A,B] 1.71
5FKR[A] 2.28
5FKS[A] α-D-Xylp-(1-6)[β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Galp-(1-2)-α-D-Xylp-(1-6)[α-D-Xylp-(1-6)-β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
1.99
5FKT[A,B] 1.52
 β-1,4-xyloglucan hydrolase / xyloglucanase (XghA) (Xgh74A) 3.2.1.151 Ruminiclostridium thermocellum F7/YS CAE51306.1 Q70DK5
2CN2[A,B,C,D] 2.1
2CN3[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Galp-(1-2)-α-D-Xylp-(1-6)[α-D-Xylp-(1-6)-β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
1.95
 SACTE_0562   Streptomyces sp. SirexAA-E AEN08502.1  
5JWZ[A,B] 1.70
 xyloglucanase (Tfu_1612) (Xeg74) 3.2.1.151 Thermobifida fusca YX AAZ55647.1
ZP_00056977.1
Q47PH2
1WWO[nd]
 xyloglucanase (Xgh;Xcc-Xgh;XCC1752)   Xanthomonas campestris pv. campestris str. ATCC 33913 AAM41043.1
NP_637119.1
Q8P9U5
cryst    
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 oligoxyloglucan reducing end-specific cellobiohydrolase (OXG-RCBH) 3.2.1.150 Geotrichum sp. M128 BAC22065.1
CAF02212.1
CAF02249.1
Q8J0D2
1SQJ[A,B] 2.20
2EBS[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
2.40
 xyloglucanase M128 (Xeg;XEG) 3.2.1.151 Geotrichum sp. M128 BAD11543.1 Q764N8
3A0F[A] 2.50
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