Glycoside Hydrolase Family 74

Activities in Familyendoglucanase (EC 3.2.1.4); oligoxyloglucan reducing end-specific cellobiohydrolase (EC 3.2.1.150); xyloglucanase (EC 3.2.1.151)
Mechanism Inverting
3D Structure Status7-fold β-propeller
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
External resourcesCAZypedia;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (940); Uniprot accession (33); PDB accession (19); 3D entries (12); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-1,4-xyloglucan hydrolase / xyloglucanase (XghA) (Xgh74A) 3.2.1.151 Acetivibrio thermocellus F7/YS CAE51306.1 Q70DK5
2CN2[A,B,C,D] 2.1
2CN3[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Galp-(1-2)-α-D-Xylp-(1-6)[α-D-Xylp-(1-6)-β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
1.95
 avicelase (AviIII;AcGH74;Acel_0618) (Cel74A)   Acidothermus cellulolyticus 11B ABK52391.1
ACE14916.1
ACE14917.1
ACE14920.1
ACS09146.1
ACS09147.1
ACS09150.1
 
4LGN[A] 1.82
 endo-xyloglucanase (Calla_2311) 3.2.1.151 Caldicellulosiruptor lactoaceticus 6A AEM74844.1 G2PXX7
6P2M[A] β-D-Galp-(1-2)-α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
1.98
 endo-xyloglucanase (CJA_2477) (Gly74A) 3.2.1.151 Cellvibrio japonicus Ueda107 ACE84745.1 B3PKK9
5FKQ[A,B] 1.71
5FKR[A] 2.28
5FKS[A] α-D-Xylp-(1-6)[β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Galp-(1-2)-α-D-Xylp-(1-6)[α-D-Xylp-(1-6)-β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
1.99
5FKT[A,B] 1.52
 endo-xyloglucanase (Niako_1751) 3.2.1.151 Niastella koreensis GR20-10 AEV98114.1 G8TAF2
6P2L[A] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-α-D-Glcp
1.08
 endo-xyloglucanase (PGRAT_12815) 3.2.1.151 Paenibacillus graminis DSM 15220 AIQ68396.1 A0A089M3R3
6P2N[A] 1.35
 endo-xyloglucanase (CD191_11325) 3.2.1.151 Paenibacillus odorifer CBA7130 AWV33160.1  
6MGJ[A,B,C,D,E,F,G,H] 2.00
6MGK[A,B,C,D] β-D-Galp-(1-2)-α-D-Xylp-(1-6)[α-D-Xylp-(1-6)-β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp
β-D-Manp
2.10
6MGL[A] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
1.50
 endo-xyloglucanase (M271_10845) 3.2.1.151 Streptomyces rapamycinicus NRRL 5491 AGP53770.1 A0A0A0NH71
6P2O[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Galp-(1-2)-α-D-Xylp-(1-6)[α-D-Xylp-(1-6)-β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
1.88
 SACTE_0562   Streptomyces sp. SirexAA-E AEN08502.1  
5JWZ[A,B] 1.70
 xyloglucanase (Xgh;Xcc-Xgh;XCC1752) 3.2.1.151 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM41043.1
NP_637119.1
Q8P9U5
7KN8[A] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)-β-D-Glcp
1.95
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 oligoxyloglucan reducing end-specific cellobiohydrolase (OXG-RCBH) 3.2.1.150 Geotrichum sp. M128 BAC22065.1
CAF02212.1
CAF02249.1
Q8J0D2
1SQJ[A,B] 2.20
2EBS[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
2.40
 xyloglucanase M128 (Xeg;XEG) 3.2.1.151 Geotrichum sp. M128 BAD11543.1 Q764N8
3A0F[A] 2.50
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