Glycoside Hydrolase Family 74

Activities in Familyendoglucanase (EC 3.2.1.4); oligoxyloglucan reducing end-specific cellobiohydrolase (EC 3.2.1.150); xyloglucanase (EC 3.2.1.151)
Mechanism Inverting
3D Structure Status7-fold β-propeller
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
External resourcesCAZypedia;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (408); Uniprot accession (70); PDB accession (12); 3D entries (8); cryst (1)
All (370) Bacteria (346) Eukaryota (21) unclassified (3) Structure (8 - 1 cryst) Characterized (17)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 avicelase (AviIII;AcGH74;Acel_0618) (Cel74A) 3.2.1.- Acidothermus cellulolyticus 11B ABK52391.1
ACE14916.1
ACE14917.1
ACE14920.1
ACS09146.1
ACS09147.1
ACS09150.1
A0LSI1 4LGN[A]
 xyloglucanase (Xeg) 3.2.1.151 Jonesia DSM 14140 CAD58415.1    
 xyloglucanase (XEG74) (Xeg74) 3.2.1.151 Paenibacillus sp. KM21 BAE44527.1 Q3MUH7  
 β-1,4-xyloglucan hydrolase / xyloglucanase (XghA) (Xgh74A) 3.2.1.151 Ruminiclostridium thermocellum F7/YS CAE51306.1 Q70DK5 2CN2[A,B,C,D]
2CN3[A,B]
 xyloglucanase (GH74A;RUM_02790) (Xeg74A) 3.2.1.151 Ruminococcus champanellensis 18P13 = JCM 17042 CBL16522.1 D4LA77  
 processive endoxyloglucanase (SaGH74A;SAV1856;SAV_1856) 3.2.1.151 Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69567.1
NP_823032.1
   
 endoxyloglucanase (SaGH74B;SAV2574;SAV_2574) 3.2.1.151 Streptomyces avermitilis MA-4680 = NBRC 14893 BAC70285.1
NP_823750.1
   
 xyloglucan-specific endo-β-1,4-glucanase (SCO6545) 3.2.1.151 Streptomyces coelicolor A3(2) CAA20642.1
NP_630626.1
O86727  
 xyloglucanase (Tfu_1612) (Xeg74) 3.2.1.151 Thermobifida fusca YX AAZ55647.1
ZP_00056977.1
Q47PH2 1WWO[nd]
 endo-β-1,4-glucanase (TM0305) (Cel74) 3.2.1.4 Thermotoga maritima MSB8 AAD35393.1
AGL49229.1
AHD17931.1
AKE28106.1
NP_228117.1
Q9WYE1  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 avicelase III (Cmc2;AviIII;FIII Avicelase) 3.2.1.4 Aspergillus aculeatus F-50 BAA29031.1
ACE14921.1
ACS09151.1
O74170  
 oligoxyloglucan reducing end-specific xyloglucanobiohydrolase (OREX;AN1542.2) 3.2.1.150 Aspergillus nidulans FGSC A4 EAA64249.1 Q5BD38  
 xyloglucanase C (EglC) 3.2.1.151 Aspergillus niger CBS 120.49 / N400 AAK77227.1 Q8TFP1  
 oligoxyloglucan reducing end-specific cellobiohydrolase (OXG-RCBH) 3.2.1.150 Geotrichum sp. M128 BAC22065.1
CAF02212.1
CAF02249.1
Q8J0D2 1SQJ[A,B]
2EBS[A,B]
 xyloglucanase M128 (Xeg;XEG) 3.2.1.151 Geotrichum sp. M128 BAD11543.1 Q764N8 3A0F[A]
 xyloglucanase (Xgh74B) 3.2.1.151 Phanerochaete chrysosporium K-3 BAF95189.1 A9CSH7  
 xyloglucanase (Egl6) (formerly TrEGII) (Cel74A) 3.2.1.151 Trichoderma reesei QM6A AAP57752.1
ABH71452.1
ABJ18610.1
Q7Z9M8  
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