Glycoside Hydrolase Family 6

Activities in Familyendoglucanase (EC 3.2.1.4); cellobiohydrolase (EC 3.2.1.91)
Mechanism Inverting
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
Noteformerly known as cellulase family B. The cellobiohydrolases of this family are widely believed to act processively from the non-reducing ends of cellulose chains to generate cellobiose.
External resourcesCAZypedia; HOMSTRAD; MEGAZYME; PRINTS; PROSITE;
Statistics GenBank accession (1224); Uniprot accession (242); PDB accession (50); 3D entries (12); cryst (1)
All (1135) Bacteria (949) Eukaryota (183) unclassified (3) Structure (12 - 1 cryst) Characterized (65)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 endoglucanase (CelA1;CelA;Rv0062;MTV030.05) (Cel6) 3.2.1.4 Mycobacterium tuberculosis H37Rv CAA16243.1
AFN47905.1
CAE55238.1
CCP42784.1
NP_214576.1
 
1UOZ[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp1SH
1.10
1UP0[A] β-D-Glcp-(1-4)-β-D-Glcp
1.75
1UP2[A] β-D-Glcp-(1-1)-<non_carb>
β-D-Glcp-(1-4)-<carb_like_IFM>
<carb_like_IFM>
1.9
1UP3[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
1.6
 cellobiohydrolase 6B / exoglucanase (E3;Ex;Tfu_0620) (Cel6B) 3.2.1.91 Thermobifida fusca YX AAA62211.1
AAF75786.1
AAZ54658.1
ABH87632.1
Q47SA9
Q60029
Q9KH72
4AVN[A] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.00
4AVO[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.80
4B4F[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.20
4B4H[A,B] 1.50
 endo-β-1,4-glucanase (E2;CelB;Tfu_1074) (Cel6A) 3.2.1.4 Thermobifida fusca YX AAC06388.1
AAE59940.1
AAZ55112.1
P26222
Q47R05
1TML[A] 1.80
2BOD[X] <non_carb>-(1-4)-β-D-Glcp4SH-(1-4)-β-D-Glcp-(1-1)-methyl
1.5
2BOE[X] 1.15
2BOF[X] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.64
2BOG[X] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
1.04
3RU8[X] 2.07
 exoglucanase (CbsA) (fragment)   Xanthomonas oryzae pv. oryzae BXO43 AAT35586.1 Q6IT74
cryst    
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 cellobiohydrolase (Cbh2;CtCbh2) (Cel6A) 3.2.1.91 Chaetomium thermophilum CT2 AAW64927.1
AAY88915.1
Q5G2D4
4A05[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.90
 cellobiohydrolase (CcCel6A) (Cel6A) 3.2.1.91 Coprinopsis cinerea 5338 BAH08702.1 B7X9Z0
3VOG[A] 1.45
3VOH[A] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.40
3VOI[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
2.00
3VOJ[A] 2.29
 cellobiohydrolase (CcCel6C) (Cel6C) 3.2.1.91 Coprinopsis cinerea 5338 BAH08704.1 B7X9Z2
3A64[A] 1.60
3A9A[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.40
3A9B[A] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
1.20
3ABX[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.40
3VOF[A] β-D-Glcp
1.60
 cellobiohydrolase / avicelase 2 (CBHII;Avi2) (Cel6A) 3.2.1.91 Humicola insolens BAB39154.1
AAN19008.1
Q9C1S9
1BVW[A] 1.92
1GZ1[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
1.9
1OC5[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
1.7
1OC6[A] 1.5
1OC7[A] β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-α-D-Glcp4S-(1-1)-methyl
1.11
1OCB[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-methyl
β-D-Glcp4N-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-methyl
1.75
1OCJ[A] β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-α-D-Glcp4S-(1-1)-methyl
1.3
1OCN[A] β-D-Glcp-(1-1)-<non_carb>
<carb_like_IFM>
1.31
2BVW[A] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.70
 endo-β-1,4-glucanase B (EG VI) (partial) (Cel6B) 3.2.1.4 Humicola insolens   Q7SIG5
1DYS[A] 1.6
 exo-cellulase C7 (CelC7;Cbhc7) 3.2.1.- Orpinomyces sp. Y102 AIK03053.1  
5JX5[A,B,C,D] 1.80
5JX6[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
2.21
 cellobiohydrolase II (CbhII;Cbh2) (Cel6A) 3.2.1.91 Phanerochaete chrysosporium AAB32942.1 Q02321
5XCY[A] 1.20
5XCZ[A] β-D-Glcp-(1-4)-α-D-Glcp
2.10
 cellobiohydrolase II (CBHII;Cbh2;CBH-II;TrCel6A;HjCel6A;TrCbh2) (Cel6A) 3.2.1.91 Trichoderma reesei QM9414 AAA34210.1
AAA72922.1
AAE59936.1
AAG39980.1
AAR60513.1
CAR96032.1
CAR96033.1
CAV28333.1
P07987
Q9HEY8
1CB2[A,B] 2.00
1HGW[A,B] 2.1
1HGY[A,B] β-D-Glcp
2.2
1LG8[nd]
1LLX[nd]
1QJW[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
1.90
1QK0[A,B] β-D-Glcp-(1-4)-α-D-Xylp-(1-1)-<non_carb>
β-D-Glcp-(1-4)-β-D-Xylp-(1-1)-<non_carb>
2.10
1QK2[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
2.00
3CBH[A] 2.00
4AU0[A,B] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.70
4AX6[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
2.30
4AX7[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.70
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