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Glycoside Hydrolase Family 6

Activities in FamilyEndo-β-1,4-glucanase (EC 3.2.1.4);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Inverting e
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
Noteformerly known as cellulase family B. The cellobiohydrolases of this family are widely believed to act processively from the non-reducing ends of cellulose chains to generate cellobiose.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (4322); Uniprot accession (85); PDB accession (56); 3D entries (15); cryst (0)
Summary
Download GH6 (5627) Taxonomic display Structure (15) Characterized (78)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 cellobiohydrolase A (CbhA;Celf_1925) (Cel6B) 3.2.1.91 Cellulomonas fimi ATCC 484 AAC36898.1
ABH87631.1
AEE46055.1		 P50401
7CBD[A] 1.30
 endoglucanase (CelA1;CelA;Rv0062;MTV030.05) (Cel6) 3.2.1.4 Mycobacterium tuberculosis H37Rv CAA16243.1
AFN47905.1
CAE55238.1
CCP42784.1
NP_214576.1		 Q79G13
1UOZ[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp1SH
 1.10
1UP0[A] β-D-Glcp-(1-4)-β-D-Glcp
 1.75
1UP2[A] β-D-Glcp-(1-1)-<non_carb>
β-D-Glcp-(1-4)-<carb_like_IFM>
<carb_like_IFM>
 1.9
1UP3[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
 1.6
 cellobiohydrolase 6B / exoglucanase (E3;Ex;Tfu_0620) (Cel6B) 3.2.1.91 Thermobifida fusca YX AAA62211.1
AAF75786.1
AAZ54658.1
ABH87632.1		 Q47SA9
Q60029
Q9KH72
4AVN[A] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.00
4AVO[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.80
4B4F[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.20
4B4H[A,B] 1.50
 endo-β-1,4-glucanase (E2; CelB; TfCel6A; Tfu_1074) (Cel6A) 3.2.1.4 Thermobifida fusca YX AAC06388.1
AAE59940.1
AAZ55112.1		 P26222
Q47R05
1TML[A] 1.80
2BOD[X] <non_carb>-(1-4)-β-D-Glcp4SH-(1-4)-β-D-Glcp-(1-1)-methyl
 1.5
2BOE[X] 1.15
2BOF[X] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.64
2BOG[X] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
 1.04
 endoglucanase (MgCel6A) (Cel6A) 3.2.1.4 uncultured bacterium    
6FAO[A] 1.88
 exoglucanase (CbsA) (fragment) 3.2.1.4 Xanthomonas oryzae pv. oryzae BXO43 AAT35586.1 A0A384E106
Q6IT74
5XYH[A] 1.86
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 cellobiohydrolase (CcCel6A) (Cel6A) 3.2.1.91 Coprinopsis cinerea 5338 BAH08702.1 B7X9Z0
3VOG[A] 1.45
3VOH[A] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.40
3VOI[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 2.00
3VOJ[A] 2.29
 cellobiohydrolase (CcCel6C) (Cel6C) 3.2.1.91 Coprinopsis cinerea 5338 BAH08704.1 B7X9Z2
3A64[A] 1.60
3A9A[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 1.40
3A9B[A] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
 1.20
3ABX[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 1.40
3VOF[A] β-D-Glcp
 1.60
 cellobiohydrolase / avicelase 2 (CBHII;Avi2) (Cel6A) 3.2.1.91 Humicola insolens BAB39154.1
AAN19008.1		 Q9C1S9
1BVW[A] 1.92
1GZ1[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
 1.9
1OC5[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
 1.7
1OC6[A] 1.5
1OC7[A] β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-α-D-Glcp4S-(1-1)-methyl
 1.11
1OCB[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-methyl
β-D-Glcp4N-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-methyl
 1.75
1OCJ[A] β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-α-D-Glcp4S-(1-1)-methyl
 1.3
1OCN[A] β-D-Glcp-(1-1)-<non_carb>
<carb_like_IFM>
 1.31
2BVW[A] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.70
 endo-β-1,4-glucanase B (EG VI) (Cel6B) 3.2.1.4 Humicola insolens   Q7SIG5
1DYS[A] 1.6
 β-glucanase C7 (CelC7;Cbhc7) 3.2.1.73 Orpinomyces sp. Y102 AIK03053.1 A0A076U926
5JX5[A,B,C,D] 1.80
6IDW[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
 2.78
 cellobiohydrolase II (CbhII;Cbh2) (Cel6A) 3.2.1.91 Phanerochaete chrysosporium AAB32942.1 Q02321
5XCY[A] 1.20
5XCZ[A] β-D-Glcp-(1-4)-α-D-Glcp
 2.10
 cellobiohydrolase (Cbh2;CtCbh2) (Cel6A) 3.2.1.91 Thermochaetoides thermophila CT2 AAW64927.1
AAY88915.1		 G0SD43
Q4JQF8
Q5G2D4
4A05[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.90
 cellobiohydrolase II (CBHII; Cbh2; CBH-II; TrCel6A; HjCel6A; TrCbh2) (Cel6A) 3.2.1.91 Trichoderma reesei QM9414 AAA34210.1
AAA72922.1
AAE59936.1
AAG39980.1
AAR60513.1
CAR96032.1
CAR96033.1
CAV28333.1		 P07987
Q9HEY8
1CB2[A,B] 2.00
1HGW[A,B] 2.1
1HGY[A,B] β-D-Glcp
 2.2
1LG8[nd]
1LLX[nd]
1QJW[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
 1.90
1QK0[A,B] β-D-Glcp-(1-4)-α-D-Xylp-(1-1)-<non_carb>
β-D-Glcp-(1-4)-β-D-Xylp-(1-1)-<non_carb>
 2.10
1QK2[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
 2.00
3CBH[A] 2.00
4AU0[A,B] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 1.70
4AX6[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 2.30
4AX7[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 1.70
unclassified
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 cellobiohydrolase (HmCel6A-3SNP) 3.2.1.91 metagenome   A0A4Y1YS11
6K53[A] 1.89
6K54[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
 1.91
6K55[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.88
6K52[A] 1.68
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