Glycoside Hydrolase Family 6

Activities in Familyendoglucanase (EC 3.2.1.4); cellobiohydrolase (EC 3.2.1.91)
Mechanism Inverting
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
Noteformerly known as cellulase family B. The cellobiohydrolases of this family are widely believed to act processively from the non-reducing ends of cellulose chains to generate cellobiose.
External resourcesCAZypedia; HOMSTRAD; MEGAZYME; PRINTS; PROSITE;
Statistics GenBank accession (1189); Uniprot accession (242); PDB accession (50); 3D entries (12); cryst (1)
All (1099) Bacteria (914) Eukaryota (182) unclassified (3) Structure (12 - 1 cryst) Characterized (65)
| 1 | 2 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 1,4-β-D-glucan-cellobiohydrolase (CelG) (fragment)   Orpinomyces sp. PC-2 AAC09068.1 Q874D9  
 endo-β-1,4-glucanase / cellobiohydrolase (CelA) 3.2.1.4
3.2.1.91
Orpinomyces sp. PC-2 AAB92678.1
AAE59921.1
P78720  
 endo-β-1,4-glucanase/cellobiohydrolase (CelC) 3.2.1.4
3.2.1.91
Orpinomyces sp. PC-2 AAB92679.1
AAE59922.1
P78721  
 cellobiohydrolase II (CelF) 3.2.1.91 Orpinomyces sp. PC-2 AAC09228.1
AAC09067.1
AAE50374.1
Q874D8
Q874E0
 
 cellobiohydrolase C8 (Cbhc8)   Orpinomyces sp. Y102 ADN44280.1    
 exp-cellulase C16 (CelC16) 3.2.1.- Orpinomyces sp. Y102 AEH95579.1    
 cellobiohydrolase C24 (CbhC24)   Orpinomyces sp. Y102 AEH95580.1    
 exo-cellulase C7 (CelC7;Cbhc7) 3.2.1.- Orpinomyces sp. Y102 AIK03053.1   5JX5[A,B,C,D]
5JX6[A,B,C,D]
 cellobiohydrolase II (Cbh2;CbhII;PdCel6A) (Cel6A) 3.2.1.91 Penicillium decumbens 114-2 / JU-A10 ADX86895.1    
 cellobiohydrolase 3 (Cbh3;PoCel6A) (Cel6A) 3.2.1.91 Penicillium oxalicum GZ-2 AIO06741.1    
 cellobiohydrolase II (CbhII)   Penicillium oxalicum HP7-1 ALO81610.1    
 cellobiohydrolase II (CbhII)   Penicillium oxalicum Z1-3 ALO81611.1    
 Pc16g05630   Penicillium rubens Wisconsin 54-1255 CAP93233.1 B6H8F7  
 cellobiohydrolase II (CbhII;Cbh2) (Cel6A) 3.2.1.91 Phanerochaete chrysosporium AAB32942.1 Q02321 5XCY[A]
5XCZ[A]
 cellobiohydrolase II, partial (Cel6A)   Phanerochaete chrysosporium K-3 BAL63102.1    
 cellobiohydrolase II (Cbh6A)   Phialophora sp. G5 / CGMCC 3328 ADZ99361.1    
 exoglucanase 6A (Cel6A) 3.2.1.91 Piromyces equi AAM94167.1 Q7Z7X6  
 CbhB (Cel6B)   Piromyces rhizinflatus AAF34679.1
AAN26159.1
Q9P8Q8  
 Sequence 4 from patent US 6428996 (CbhA)   Piromyces rhizinflatus AAN26160.1    
 cellobiohydrolase (cbhYW23-1)   Piromyces rhizinflatus ABY52797.1 B0FEV8  
 β-glucanase (CbhYW23-2)   Piromyces rhizinflatus ABY52798.1 B0FEV9  
 1,4-β-D-glucan-cellobiohydrolase (cbhYW23-4) (fragment)   Piromyces rhizinflatus ABY52799.1 B0FEW0  
 cellobiohydrolase (fragment) (Cel6D)   Piromyces rhizinflatus 2301 AAD02028.1 O93860  
 cellobiohydrolase (Cbh6) (Cel6A) 3.2.1.91 Piromyces rhizinflatus 2301 AAD51055.1 Q9UW10  
 cellobiohydrolase (Cbh120) (Cel6C)   Piromyces rhizinflatus 2301 AAD51054.2 Q9UW11  
 exoglucanase   Piromyces sp. AF-CTS-EMP1 ADO33720.1 E3W3U5  
 1,4-β-glucanase (Cel6G) (partial)   Piromyces sp. BTrP1 ACX32999.1 D0ET40  
 Cel6E (fragment)   Piromyces sp. E2 AAM13921.1 Q874K1  
 exoglucanase 6A (Cel6A) 3.2.1.91 Piromyces sp. E2 AAL92497.1 Q874K3  
 cellobiohydrolase Cel6B (fragment) (Cel6B)   Piromyces sp. E2 AAP30749.1 Q870B2  
 cellobiohydrolase Cel6C (fragment) (fragment) (Cel6C)   Piromyces sp. E2 AAP30750.1 Q870B1  
 1,4-β-glucanase (Cel6G) (partial) (Cel6G)   Piromyces sp. KS11 AAO47726.1 Q874B0  
 endo-1,4-glucanase (fragment)   Plasmopara viticola CCD28124.1    
 ORF (fragment)   Plasmopara viticola CCD28134.1    
 cellobiohydrolase (PaCel6A;Pa_0_1250) (Cel6A) 3.2.1.91 Podospora anserina S mat+ CAP60942.1
CDP24957.1
B2ABX7  
 endo-β-1,4-glucanase (PaCel6B;Pa_2_13800) (Cel6B) 3.2.1.4 Podospora anserina S mat+ CAP60981.1
CDP26446.1
B2AC20  
 Pa_4_550 (PaCel6D) (Cel6D)   Podospora anserina S mat+ CAP61420.1
CDP27774.1
B2ADA5  
 processive endo-β-1,4-glucanase (PaCel6C;Pa_4_2420) (Cel6C) 3.2.1.4
3.2.1.91
Podospora anserina S mat+ CAP61669.1
CDP28020.1
B2AE04  
 cellobiohydrolase II (Cel2;CBH II)   Polyporus arcularius 69B-8 BAF80327.1 A8CED8  
 GH6 (fragment)   Rasamsonia byssochlamydoides CBS 151.75 CDF76447.1    
 cellobiohydrolase II (CbhII;Cbh2) 3.2.1.91 Rasamsonia emersonii IMI 392299 AAL78165.2
AAL33604.4
Q8NIB5  
 GH6 (fragment)   Remersonia thermophila CBS 540.69 CDF76450.1    
 cellobiohydrolase II (Cbh2) (fragment)   Rhizopus stolonifer var. reflexus AHI87691.1    
 sscle_03g023650   Sclerotinia sclerotiorum 1980 UF-70 APA07595.1    
 GH6   Scytalidium indonesiacum CBS 259.81 CDF76451.1    
 PIIN_00353   Serendipita indica DSM 11827 CCA66672.1    
 PIIN_02752   Serendipita indica DSM 11827 CCA68892.1    
 cellobiohydrolase (Cel6A) 3.2.1.91 Stilbella annulata CAH05678.1    
 cellobiohydrolase II (Acc2) (Cel6A) 3.2.1.91 Talaromyces cellulolyticus CF-2612 AAE50824.1
BAA74458.1
O93837  
 cellulase   Talaromyces funiculosus ACH91035.1 B5TMG4  
 GH6   Talaromyces leycettanus CBS 398.68 CDF76448.1    
 cellulase   Talaromyces pinophilus WT10 AKU20093.1    
 celloobiohydrolase II (CbhII)   Talaromyces verruculosus APE61639.1    
 ORF (fragment)   Termitomyces albuminosus AEK06446.1    
 MYCTH_51545   Thermothelomyces thermophila ATCC 42464 AEO59280.1    
 cellobiohydrolase (Cbh2b;ClCbh2;MYCTH_66729)   Thermothelomyces thermophila ATCC 42464 AEO55787.1    
 MYCTH_2303045   Thermothelomyces thermophila ATCC 42464 AEO57190.1    
 unnamed protein product (fragment)   Thielavia australiensis CAH05674.1    
 unnamed protein product (fragment)   Thielavia microspora CAH05672.1    
 cellobiohydrolase (CBH-II) (Cel6A) 3.2.1.91 Thielavia terrestris ABT06036.1    
 THITE_126432   Thielavia terrestris NRRL 8126 AEO62210.1    
 THITE_74712   Thielavia terrestris NRRL 8126 AEO64572.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55776.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55492.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55493.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55582.1    
 cellobiohydrolase (Cor1) (partial)   Trametes versicolor AAF35251.1 Q9P8N1  
 cellobiohydrolase II, partial (fragment)   Trichoderma harzianum AFD53812.1    
 cellobiohydrolase II (Cbh2) 3.2.1.91 Trichoderma koningii AAK01367.1 Q7LSP2  
 cellobiohydrolase II (Cbh2;CbhII)   Trichoderma koningii 3.2774 ABF56208.1 Q1HCL5  
 Cbh2   Trichoderma koningii AS3.2774 ABG48766.1 Q0Z8U3  
 cellobiohydrolase II   Trichoderma longibrachiatum FU05 ACZ34301.1 D1MGM6  
 cellobiohydrolase II (CbhII) 3.2.1.91 Trichoderma parceramosum AAU05379.2
AAV31052.1
Q66PN1  
 cellbiohydrolase II (CbhII)   Trichoderma reesei M5 ADC83999.1 D3YNY1  
 cellobiohydrolase II (CBHII;Cbh2;CBH-II;TrCel6A;HjCel6A;TrCbh2) (Cel6A) 3.2.1.91 Trichoderma reesei QM9414 AAA34210.1
AAA72922.1
AAE59936.1
AAG39980.1
AAR60513.1
CAR96032.1
CAR96033.1
CAV28333.1
P07987
Q9HEY8
1CB2[A,B]
1HGW[A,B]
1HGY[A,B]
1LG8[nd]
1LLX[nd]
1QJW[A,B]
1QK0[A,B]
1QK2[A,B]
3CBH[A]
4AU0[A,B]
4AX6[A,B]
4AX7[A,B,C,D]
 exoglucanase   Trichoderma reesei SJVTR AHK23048.1    
 cellobiohydrolase II   Trichoderma sp. XST1 ACH96126.1 B5TWC7  
 cellobiohydrolase II (CbhII;Cbh2) 3.2.1.91 Trichoderma viride CICC 13038 AAQ76094.1 Q6UJX9  
 cellobiohydrolase (CBH)   Trichoderma viride wdf1 ADJ10628.1 D9I7P6  
 unnamed protein product (fragment)   Trichophaea saccata CAH05677.1    
 cellobiohydrolase II-I (CbhII-I;Cbh2;VvCbh2)   Volvariella volvacea V14 AAT64008.1 Q6E5B1  
 cellobiohydrolase II (CbhII) (frameshift) 3.2.1.91 Volvariella volvacea V14 AAD41097.1 Q9Y894  
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