Glycoside Hydrolase Family 6

Activities in Familyendoglucanase (EC 3.2.1.4); cellobiohydrolase (EC 3.2.1.91)
Mechanism Inverting
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
Noteformerly known as cellulase family B. The cellobiohydrolases of this family are widely believed to act processively from the non-reducing ends of cellulose chains to generate cellobiose.
External resourcesCAZypedia; HOMSTRAD; MEGAZYME; PRINTS; PROSITE;
Statistics GenBank accession (1202); Uniprot accession (242); PDB accession (50); 3D entries (12); cryst (1)
All (1112) Bacteria (927) Eukaryota (182) unclassified (3) Structure (12 - 1 cryst) Characterized (65)
| 1 | 2 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 glycoside hydrolase family 6 protein   Achaetomium luteum AGV05130.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55792.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55974.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56131.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55789.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55947.1    
 glycoside hydrolase family 6 protein, partial (fragment)   Acidomyces sp. APF32769.1    
 unnamed protein product (fragment)   Acremonium sp. CBI69363.1
ACC29920.1
CAH05670.1
   
 cellobiohydrolase II (Cel3;Cel3A) 3.2.1.91 Agaricus bisporus D649 AAA50607.1
AAA50608.1
AAE59938.1
CAA83971.1
P49075  
 ALNC14_030970 (Alnc14c28g2684)   Albugo laibachii Nc14 CCA16954.1    
 ALNC14_061950   Albugo laibachii Nc14 CCA20052.1    
 cellulase (CelA) 3.2.1.91 Anaeromyces sp. W-98 AAQ09258.1 Q6A4K7  
 EGX48837.1   Arthrobotrys oligospora ATCC 24927 EGX48837.1    
 EGX43996.1   Arthrobotrys oligospora ATCC 24927 EGX43996.1    
 cellobiohydrolase II (CBHII;AN5282.2) 3.2.1.91 Aspergillus nidulans FGSC A4 ABF50873.1
EAA62442.1
Q5B2E8  
 AN1273.2   Aspergillus nidulans FGSC A4 EAA65866.1 Q5BDV7  
 An08g01760   Aspergillus niger CBS 513.88 CAK39856.1 A2QQ99  
 An12g02220   Aspergillus niger CBS 513.88 CAK41068.1 A2QYR9  
 AO090038000439 (CbhD)   Aspergillus oryzae RIB40 BAE64227.1
BAI65845.1
Q2U2I8  
 unnamed protein product (fragment)   Aspergillus sp. CAH05673.1    
 unnamed protein product (fragment)   Aspergillus tubingensis CAH05675.1
ACC29925.1
   
 cellobiohydrolase II (Cel7;Cbh7;Cbh2;ChCbh2)   Bipolaris maydis C4 AAM76664.1 Q8J215  
 BofuT4P51000027001   Botrytis cinerea T4 CCD44345.2
CCD44345.1
   
 glycoside hydrolase family 6 protein   Chaetomium atrobrunneum AGV05123.1    
 glycoside hydrolase family 6 protein   Chaetomium gracile AGV05122.1    
 GH6 (fragment)   Chaetomium senegalense CBS 728.84 CDF76444.1    
 unnamed protein product   Chaetomium thermophilum CAH05669.1    
 cellobiohydrolase (Cbh2;CtCbh2) (Cel6A) 3.2.1.91 Chaetomium thermophilum CT2 AAW64927.1
AAY88915.1
Q5G2D4 4A05[A]
 Eg6-3 (fragment)   Chaetomium thermophilum CT2 AGY80095.1    
 cellobiohydrolase (EG6;CBH IIa) (Cel6A) 3.2.1.91 Chrysosporium lucknowense AAQ38151.1
ACH15009.1
   
 CesA (CiCesA)   Ciona intestinalis BAD10864.1 Q76G00  
 cellulose synthase 2.4.1.12 Ciona savignyi AAR89623.1 Q6RCS2  
 cellulase (Cel6A)   Coniophora puteana WD-758 BAH59082.1 C4B8I1  
 cellulase (Cel6B)   Coniophora puteana WD-758 BAH59083.1 C4B8I2  
 cellobiohydrolase (CcCel6A) (Cel6A) 3.2.1.91 Coprinopsis cinerea 5338 BAH08702.1 B7X9Z0 3VOG[A]
3VOH[A]
3VOI[A]
3VOJ[A]
 cellobiohydrolase (CcCel6B) (Cel6B) 3.2.1.91 Coprinopsis cinerea 5338 BAH08703.1 B7X9Z1  
 cellobiohydrolase (CcCel6C) (Cel6C) 3.2.1.91 Coprinopsis cinerea 5338 BAH08704.1 B7X9Z2 3A64[A]
3A9A[A]
3A9B[A]
3ABX[A]
3VOF[A]
 cellobiohydrolase (CcCel6D) (Cel6D)   Coprinopsis cinerea 5338 BAH08705.1 B7X9Z3  
 cellobiohydrolase (CcCel6E) (Cel6E)   Coprinopsis cinerea 5338 BAH08706.1 B7X9Z4  
 glycoside hydrolase family 6 protein   Corynascus sepedonium AGV05128.1    
 GH6 (fragment)   Crassicarpon thermophilum CBS 406.69 CDF76445.1    
 cellobiohydrolase II (Cel6A)   Dichomitus squalens FBCC312 ALT57232.1    
 ORF   Flammulina velutipes KACC 42777 ADX07335.1    
 FFUJ_10595   Fusarium fujikuroi IMI 58289 CCT74540.1    
 Cel6 (Cel6)   Fusarium graminearum K59 AAQ72468.1
AAR01213.1
Q6JV41  
 unnamed protein product   Fusarium graminearum PH-1 CEF78468.1    
 endoglucanase B   Fusarium oxysporum AAA65585.1
AAE59937.1
P46236  
 unnamed protein product (fragment)   Gloeophyllum trabeum CAH05676.1    
 cellulose synthase (CesA;Hr-CesA) (fragment)   Halocynthia roretzi BAJ65325.1    
 cellobiohydrolase / avicelase 2 (CBHII;Avi2) (Cel6A) 3.2.1.91 Humicola insolens BAB39154.1
AAN19008.1
Q9C1S9 1BVW[A]
1GZ1[A]
1OC5[A]
1OC6[A]
1OC7[A]
1OCB[A,B]
1OCJ[A]
1OCN[A]
2BVW[A]
 endo-β-1,4-glucanase B (EG VI) (partial) (Cel6B) 3.2.1.4 Humicola insolens   Q7SIG5 1DYS[A]
 endo-β-1,4-glucanase (Cel6C)   Humicola insolens Y1 AKI05479.1    
 cellobiohydrolase II (CbhII)   Hypocrea orientalis EU7-22 AFD50193.1    
 cellobiohydrolase II (Cel4;Ex-4;Cex3) 3.2.1.91 Irpex lacteus MC-2 BAG48183.1 B2ZZ24  
 cellobiohydrolase (CbhII-1) 3.2.1.91 Lentinula edodes L54 AAK28357.1 Q9C1R4  
 cellulase (Cel6B)   Lentinula edodes STAMETS CS-2 AAK95564.1 Q96VU2  
 cellulase, partial (fragment)   Lentinula edodes U8/1 AMB72858.1    
 cellulase, partial (fragment)   Lentinula edodes U8/1B AMB72859.1    
 cellobiohydrolase II   Lentinus sajor-caju AAL15037.1
AAL15038.1
Q96TP4  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX92025.1 E5R555  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBY00792.1 E5AAV1  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX97039.1 E5A0H9  
 cellobiohydrolase II (Cel6)   Leucoagaricus gongylophorus Ae322 CDJ79821.1    
 MG07908.4   Magnaporthe oryzae 70-15 XP_368004.1 G4N2D8  
 MG04499.4   Magnaporthe oryzae 70-15 XP_362054.1 G4MS86  
 cellobiohydrolase (MoCel6A;MG05520.4) (Cel6A) 3.2.1.91 Magnaporthe oryzae 70-15 XP_360146.1 G4MM92  
 cellobiohydrolase (Cel6A) 3.2.1.91 Malbranchea cinnamomea CAH05679.1
ACC29930.1
   
 glycoside hydrolase 6 (Gh6)   Malbranchea cinnamomea CBS 115.68 CDF76449.1    
 unnamed protein product (fragment)   Melanocarpus CAH05671.1    
 GH6 (fragment)   Melanocarpus albomyces CBS 638.94 CDF76446.1    
 cellulose synthase (CesA;Mt-CesA)   Molgula tectiformis BAJ65324.1    
 cellobiohydrolase (CelB)   Neocallimastix frontalis AAQ93324.1 Q6EH22  
 cellobiohydrolase A (CelA;Cbh6) (Cel6A) 3.2.1.91 Neocallimastix patriciarum ABY52793.1
AAC49315.1
AAE59935.1
ACI26721.1
B0FEV4
Q12646
 
 cellobiohydrolase (CelA) 3.2.1.91 Neocallimastix patriciarum J11 AAR08200.1 Q6EIY8  
 W5C-O   Neocallimastix patriciarum W5 AEX92711.1    
 W5-CAT5   Neocallimastix patriciarum W5 AEX92708.1    
 exoglucanase (W5-CAT6-9)   Neocallimastix patriciarum W5 AEX92709.1    
 W5-20147   Neocallimastix patriciarum W5 AEX92710.1    
 W5-16271   Neocallimastix patriciarum W5 AEX92712.1    
 exoglucanase (W5-10151-39)   Neocallimastix patriciarum W5 AEX92714.1    
 exoglucanase (W5-10151-38)   Neocallimastix patriciarum W5 AEX92715.1    
 exoglucanase (W5-10151-5)   Neocallimastix patriciarum W5 AEX92716.1    
 exoglucanase (W5-10151-6)   Neocallimastix patriciarum W5 AEX92717.1    
 W5-01055   Neocallimastix patriciarum W5 AEX92713.1    
 cellulase (CelA)   Neocallimastix sp. AF-CTS-CDN1 ADO33719.1 E3W3U4  
 CelC   Neocallimastix sp. W-1 AAQ09256.1 Q6EY63  
 cellobiohydrolase II   Neolentinus lepideus ADN88317.1 E2JAJ2  
 cellobiohydrolase (GH6-2;CBHII;NCU09680)   Neurospora crassa OR74A CAD70733.1
XP_330330.1
Q1K6Q5
Q872J7
 
 NCU07190 (GH6-3)   Neurospora crassa OR74A CAD71092.1
XP_327476.1
Q1K5V3
Q871B5
 
 NCU03996.1   Neurospora crassa OR74A XP_323315.1 Q7RXI7  
 cellulose synthase (CesA2;Od-CesA2)   Oikopleura dioica BAJ65326.1    
 cellulose synthase (CesA1;Od-CesA1)   Oikopleura dioica BAJ65327.1    
 cellulose synthase 1 (CesA1)   Oikopleura dioica CBA10397.1    
 cellulose synthase (CesA)   Oikopleura dioica CAJ43274.1
CAJ43275.1
A8Y5V6  
 cellulose synthase (CesA2;Ol-CesA2)   Oikopleura longicauda BAJ65323.1    
 Cel6B, partial   Orpinomyces sp. C1A ANS13823.1    
 Cel6A, partial   Orpinomyces sp. C1A ANS13822.1    
 CelI   Orpinomyces sp. PC-2 AAL01212.1 Q96V97  
 CelH   Orpinomyces sp. PC-2 AAL01211.1 Q96V98  
 1,4-β-D-glucan-cellobiohydrolase (CelD) 3.2.1.91 Orpinomyces sp. PC-2 AAC09066.1 Q874E1  
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