Glycoside Hydrolase Family 6

Activities in Familyendoglucanase (EC 3.2.1.4); cellobiohydrolase (EC 3.2.1.91)
Mechanism Inverting
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
Noteformerly known as cellulase family B. The cellobiohydrolases of this family are widely believed to act processively from the non-reducing ends of cellulose chains to generate cellobiose.
External resourcesCAZypedia; HOMSTRAD; MEGAZYME; PRINTS; PROSITE;
Statistics GenBank accession (1224); Uniprot accession (242); PDB accession (50); 3D entries (12); cryst (1)
All (1135) Bacteria (949) Eukaryota (183) unclassified (3) Structure (12 - 1 cryst) Characterized (65)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endoglucanase (GuxA) 3.2.1.4 Acidothermus cellulolyticus ABH87623.1
ABH87625.1
ABH87627.1
ABH87630.1
   
 endoglucanase (GuxA;Acel_0615) 3.2.1.4 Acidothermus cellulolyticus 11B ABK52388.1 A0LSH8  
 cellobiohydrolase A (CbhA;Celf_1925) (Cel6B) 3.2.1.91 Cellulomonas fimi ATCC 484 AAC36898.1
ABH87631.1
AEE46055.1
P50401  
 endo-β-1,4-glucanase A (CenA;Celf_3184) (Cel6A) 3.2.1.4 Cellulomonas fimi ATCC 484 AEE47298.1
AAA23084.1
AAE59939.1
P07984  
 endo-β-1,4-glucanase (CelL) 3.2.1.4
3.2.1.73
Cellulosimicrobium funkei HY-13 ALK04194.1    
 cellobiohydrolase 6A (CJA_2473) (Cel6A) 3.2.1.91 Cellvibrio japonicus Ueda107 ACE85978.1 B3PKK5  
 endo-β-1,4-glucanase (CenA;MCenA) 3.2.1.4 Micromonospora cellulolyticum AAC60491.1 Q53488  
 endoglucanase (CelA1;CelA;Rv0062;MTV030.05) (Cel6) 3.2.1.4 Mycobacterium tuberculosis H37Rv CAA16243.1
AFN47905.1
CAE55238.1
CCP42784.1
NP_214576.1
  1UOZ[A]
1UP0[A]
1UP2[A]
1UP3[A]
 endo-β-1,4-glucanase I (EGI;EGII) 3.2.1.4 Neisseria sicca SB BAJ21449.1 E1CAJ8  
 endo-β-1,4-glucanase 6A (Sde_2272) (Cel6A) 3.2.1.4 Saccharophagus degradans 2-40 ABD81532.1 Q21IE7  
 endo-β-1,4-glucanase (fragment) 3.2.1.4 Stigmatella aurantiaca CAA54143.1 Q53652  
 endo-β-1,4-glucanase A (CelA1;Cel1;CMCASE I) 3.2.1.4 Streptomyces halstedii JM8 CAA78145.1 P33682  
 endo-1,4-glucanase A 3.2.1.4 Streptomyces sp. KSM-9 AAA26713.1
AAA26776.1
AAE59941.1
CAA43330.1
P13933  
 exoglucanase (CbhII) 3.2.1.91 Streptomyces sp. M23 BAB83928.1 Q8VLR1  
 bifunctional β-1,4-endoglucanase / cellobiohydrolase (CelAB) 3.2.1.4
3.2.1.91
Teredinibacter turnerae T7901 ABS72374.1 A9Q634  
 cellobiohydrolase 6B / exoglucanase (E3;Ex;Tfu_0620) (Cel6B) 3.2.1.91 Thermobifida fusca YX AAA62211.1
AAF75786.1
AAZ54658.1
ABH87632.1
Q47SA9
Q60029
Q9KH72
4AVN[A]
4AVO[A]
4B4F[A,B]
4B4H[A,B]
 endo-β-1,4-glucanase (E2;CelB;Tfu_1074) (Cel6A) 3.2.1.4 Thermobifida fusca YX AAC06388.1
AAE59940.1
AAZ55112.1
P26222
Q47R05
1TML[A]
2BOD[X]
2BOE[X]
2BOF[X]
2BOG[X]
3RU8[X]
 endoglucanase (ThCel6A) (alkali-stable) (Cel6A) 3.2.1.4 Thermobifida halotolerans YIM 90462T AHN09982.1    
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Thermobispora bispora / Microbispora bispora   P26414  
 cellulase (Cel6H) (partial) (Cel6H) 3.2.1.4 uncultured bacterium AEK21789.1    
 cellulase (Lc-CelB) 3.2.1.4 uncultured bacterium AHL27895.1    
 cellulase (Lc-CelJ) 3.2.1.4 uncultured bacterium AHL27903.1    
 endo-β-1,4-glucanase (Cel6A) 3.2.1.4 Xylanimicrobium pachnodae DSM 12657 AAD54679.1 Q9RQE6  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 cellobiohydrolase II (Cel3;Cel3A) 3.2.1.91 Agaricus bisporus D649 AAA50607.1
AAA50608.1
AAE59938.1
CAA83971.1
P49075  
 cellulase (CelA) 3.2.1.91 Anaeromyces sp. W-98 AAQ09258.1 Q6A4K7  
 cellobiohydrolase II (CBHII;AN5282.2) 3.2.1.91 Aspergillus nidulans FGSC A4 ABF50873.1
EAA62442.1
Q5B2E8  
 cellobiohydrolase (Cbh2;CtCbh2) (Cel6A) 3.2.1.91 Chaetomium thermophilum CT2 AAW64927.1
AAY88915.1
Q5G2D4 4A05[A]
 cellobiohydrolase (EG6;CBH IIa) (Cel6A) 3.2.1.91 Chrysosporium lucknowense AAQ38151.1
ACH15009.1
   
 cellulose synthase 2.4.1.12 Ciona savignyi AAR89623.1 Q6RCS2  
 cellobiohydrolase (CcCel6A) (Cel6A) 3.2.1.91 Coprinopsis cinerea 5338 BAH08702.1 B7X9Z0 3VOG[A]
3VOH[A]
3VOI[A]
3VOJ[A]
 cellobiohydrolase (CcCel6B) (Cel6B) 3.2.1.91 Coprinopsis cinerea 5338 BAH08703.1 B7X9Z1  
 cellobiohydrolase (CcCel6C) (Cel6C) 3.2.1.91 Coprinopsis cinerea 5338 BAH08704.1 B7X9Z2 3A64[A]
3A9A[A]
3A9B[A]
3ABX[A]
3VOF[A]
 cellobiohydrolase / avicelase 2 (CBHII;Avi2) (Cel6A) 3.2.1.91 Humicola insolens BAB39154.1
AAN19008.1
Q9C1S9 1BVW[A]
1GZ1[A]
1OC5[A]
1OC6[A]
1OC7[A]
1OCB[A,B]
1OCJ[A]
1OCN[A]
2BVW[A]
 endo-β-1,4-glucanase B (EG VI) (partial) (Cel6B) 3.2.1.4 Humicola insolens   Q7SIG5 1DYS[A]
 cellobiohydrolase II (Cel4;Ex-4;Cex3) 3.2.1.91 Irpex lacteus MC-2 BAG48183.1 B2ZZ24  
 cellobiohydrolase (CbhII-1) 3.2.1.91 Lentinula edodes L54 AAK28357.1 Q9C1R4  
 cellobiohydrolase (MoCel6A;MG05520.4) (Cel6A) 3.2.1.91 Magnaporthe oryzae 70-15 XP_360146.1 G4MM92  
 cellobiohydrolase (Cel6A) 3.2.1.91 Malbranchea cinnamomea CAH05679.1
ACC29930.1
   
 cellobiohydrolase A (CelA;Cbh6) (Cel6A) 3.2.1.91 Neocallimastix patriciarum ABY52793.1
AAC49315.1
AAE59935.1
ACI26721.1
B0FEV4
Q12646
 
 cellobiohydrolase (CelA) 3.2.1.91 Neocallimastix patriciarum J11 AAR08200.1 Q6EIY8  
 1,4-β-D-glucan-cellobiohydrolase (CelD) 3.2.1.91 Orpinomyces sp. PC-2 AAC09066.1 Q874E1  
 endo-β-1,4-glucanase / cellobiohydrolase (CelA) 3.2.1.4
3.2.1.91
Orpinomyces sp. PC-2 AAB92678.1
AAE59921.1
P78720  
 endo-β-1,4-glucanase/cellobiohydrolase (CelC) 3.2.1.4
3.2.1.91
Orpinomyces sp. PC-2 AAB92679.1
AAE59922.1
P78721  
 cellobiohydrolase II (CelF) 3.2.1.91 Orpinomyces sp. PC-2 AAC09228.1
AAC09067.1
AAE50374.1
Q874D8
Q874E0
 
 exp-cellulase C16 (CelC16) 3.2.1.- Orpinomyces sp. Y102 AEH95579.1    
 exo-cellulase C7 (CelC7;Cbhc7) 3.2.1.- Orpinomyces sp. Y102 AIK03053.1   5JX5[A,B,C,D]
5JX6[A,B,C,D]
 cellobiohydrolase II (Cbh2;CbhII;PdCel6A) (Cel6A) 3.2.1.91 Penicillium decumbens 114-2 / JU-A10 ADX86895.1    
 cellobiohydrolase 3 (Cbh3;PoCel6A) (Cel6A) 3.2.1.91 Penicillium oxalicum GZ-2 AIO06741.1    
 cellobiohydrolase II (CbhII;Cbh2) (Cel6A) 3.2.1.91 Phanerochaete chrysosporium AAB32942.1 Q02321 5XCY[A]
5XCZ[A]
 exoglucanase 6A (Cel6A) 3.2.1.91 Piromyces equi AAM94167.1 Q7Z7X6  
 cellobiohydrolase (Cbh6) (Cel6A) 3.2.1.91 Piromyces rhizinflatus 2301 AAD51055.1 Q9UW10  
 exoglucanase 6A (Cel6A) 3.2.1.91 Piromyces sp. E2 AAL92497.1 Q874K3  
 cellobiohydrolase (PaCel6A;Pa_0_1250) (Cel6A) 3.2.1.91 Podospora anserina S mat+ CAP60942.1
CDP24957.1
B2ABX7  
 endo-β-1,4-glucanase (PaCel6B;Pa_2_13800) (Cel6B) 3.2.1.4 Podospora anserina S mat+ CAP60981.1
CDP26446.1
B2AC20  
 processive endo-β-1,4-glucanase (PaCel6C;Pa_4_2420) (Cel6C) 3.2.1.4
3.2.1.91
Podospora anserina S mat+ CAP61669.1
CDP28020.1
B2AE04  
 cellobiohydrolase II (CbhII;Cbh2) 3.2.1.91 Rasamsonia emersonii IMI 392299 AAL78165.2
AAL33604.4
Q8NIB5  
 cellobiohydrolase (Cel6A) 3.2.1.91 Stilbella annulata CAH05678.1    
 cellobiohydrolase II (Acc2) (Cel6A) 3.2.1.91 Talaromyces cellulolyticus CF-2612 AAE50824.1
BAA74458.1
O93837  
 cellobiohydrolase (CBH-II) (Cel6A) 3.2.1.91 Thielavia terrestris ABT06036.1    
 cellobiohydrolase II (Cbh2) 3.2.1.91 Trichoderma koningii AAK01367.1 Q7LSP2  
 cellobiohydrolase II (CbhII) 3.2.1.91 Trichoderma parceramosum AAU05379.2
AAV31052.1
Q66PN1  
 cellobiohydrolase II (CBHII;Cbh2;CBH-II;TrCel6A;HjCel6A;TrCbh2) (Cel6A) 3.2.1.91 Trichoderma reesei QM9414 AAA34210.1
AAA72922.1
AAE59936.1
AAG39980.1
AAR60513.1
CAR96032.1
CAR96033.1
CAV28333.1
P07987
Q9HEY8
1CB2[A,B]
1HGW[A,B]
1HGY[A,B]
1LG8[nd]
1LLX[nd]
1QJW[A,B]
1QK0[A,B]
1QK2[A,B]
3CBH[A]
4AU0[A,B]
4AX6[A,B]
4AX7[A,B,C,D]
 cellobiohydrolase II (CbhII;Cbh2) 3.2.1.91 Trichoderma viride CICC 13038 AAQ76094.1 Q6UJX9  
 cellobiohydrolase II (CbhII) (frameshift) 3.2.1.91 Volvariella volvacea V14 AAD41097.1 Q9Y894  
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 cellobiohydrolase (G10-6) (partial) 3.2.1.91 uncultured organism ACY24855.1 D8VN70  
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