Activities in Family	Endo-β-1,4-glucanase (EC 3.2.1.4); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); Endo-β-1,4-xylanase (EC 3.2.1.8); Cellobiohydrolase (EC 3.2.1.91);
Mechanism	Inverting e
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp (experimental)
Catalytic Proton Donor	Asp (experimental)
Note	formerly known as cellulase family B. The cellobiohydrolases of this family are widely believed to act processively from the non-reducing ends of cellulose chains to generate cellobiose.
External resources	CAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (4642); Uniprot accession (86); PDB accession (60); 3D entries (15); cryst (0)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
cellobiohydrolase A (CbhA;Celf_1925) (Cel6B)	3.2.1.91	pubmed	Cellulomonas fimi ATCC 484	AAC36898.1 ABH87631.1 AEE46055.1	P50401	7CBD[A]
endo-β-1,4-glucanase A (CenA;Celf_3184) (Cel6A)	3.2.1.4	pubmed	Cellulomonas fimi ATCC 484	AEE47298.1 AAA23084.1 AAE59939.1	F4GZY2 P07984
endo-β-1,4-glucanase (CelL)	3.2.1.4	pubmed	Cellulosimicrobium funkei HY-13	ALK04194.1	A0A0P0IZM9
exo-β-1,4-xylanase (XylK2)	3.2.1.8	pubmed	Cellulosimicrobium sp. HY-13	ADR71224.1	E5LP78
cellobiohydrolase 6A (CJA_2473) (Cel6A)	3.2.1.91	pubmed	Cellvibrio japonicus Ueda107	ACE85978.1	B3PKK5
endo-β-1,4-glucanase (CenA;MCenA)	3.2.1.4	pubmed	Micromonospora cellulolyticum	AAC60491.1	Q53488
endoglucanase (CelA1;CelA;Rv0062;MTV030.05) (Cel6)	3.2.1.4	pubmed	Mycobacterium tuberculosis H37Rv	CAA16243.1 AFN47905.1 CAE55238.1 CCP42784.1 NP_214576.1	Q79G13	1UOZ[A] 1UP0[A] 1UP2[A] 1UP3[A]
endo-β-1,4-glucanase I (EGI;EGII)	3.2.1.4	pubmed	Neisseria sicca SB	BAJ21449.1	E1CAJ8
endo-β-1,4-glucanase 6A (Sde_2272) (Cel6A)	3.2.1.4	pubmed	Saccharophagus degradans 2-40	ABD81532.1	Q21IE7
endo-β-1,4-glucanase A (CelA1;Cel1;CMCASE I)	3.2.1.4	pubmed	Streptomyces halstedii JM8	CAA78145.1	P33682
exoglucanase (CbhII)	3.2.1.91	pubmed	Streptomyces sp. M23	BAB83928.1	Q8VLR1
bifunctional β-1,4-endoglucanase / cellobiohydrolase (CelAB)	3.2.1.91	pubmed	Teredinibacter turnerae T7901	ABS72374.1	A9Q634
cellobiohydrolase 6B / exoglucanase (E3;Ex;Tfu_0620) (Cel6B)	3.2.1.91	pubmed	Thermobifida fusca YX	AAA62211.1 AAF75786.1 AAZ54658.1 ABH87632.1	Q47SA9 Q60029 Q9KH72	4AVN[A] 4AVO[A] 4B4F[A,B] 4B4H[A,B]
endo-β-1,4-glucanase (E2; CelB; TfCel6A; Tfu_1074) (Cel6A)	3.2.1.4	pubmed	Thermobifida fusca YX	AAC06388.1 AAE59940.1 AAZ55112.1	P26222 Q47R05	1TML[A] 2BOD[X] 2BOE[X] 2BOF[X] 2BOG[X]
endoglucanase (ThCel6A) (alkali-stable) (Cel6A)	3.2.1.4	pubmed	Thermobifida halotolerans YIM 90462T	AHN09982.1	X2G0M7
endo-β-1,4-glucanase A (CelA)	3.2.1.4	pubmed	Thermobispora bispora / Microbispora bispora		P26414
endoglucanase (MgCel6A) (Cel6A)	3.2.1.4	pubmed	uncultured bacterium			6FAO[A]
cellulase (Cel6H) (partial) (Cel6H)	3.2.1.4	doi	uncultured bacterium	AEK21789.1 AEK21789.2	G1K3U8
endo-β-1,4-glucanase (ZFYN1413)	3.2.1.4	pubmed	uncultured bacterium	UFZ14339.1
cellulase (Lc-CelB)	3.2.1.4	pubmed	uncultured bacterium	AHL27895.1	W8PF16
cellulase (Lc-CelJ)	3.2.1.4	pubmed	uncultured bacterium	AHL27903.1	W8P3Q3
exoglucanase (CbsA) (fragment)	3.2.1.4	pubmed	Xanthomonas oryzae pv. oryzae BXO43	AAT35586.1	A0A384E106 Q6IT74	5XYH[A]
endo-β-1,4-glucanase (Cel6A)	3.2.1.4	pubmed	Xylanimonas pachnodae DSM 12657	AAD54679.1	Q9RQE6
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
cellobiohydrolase II (Cel3;Cel3A)	3.2.1.91	pubmed	Agaricus bisporus D649	AAA50607.1 AAA50608.1 AAE59938.1 CAA83971.1	P49075
cellobiohydrolase 6A (AfCel6A; AFUA_3G01910; Afu3g01910)	3.2.1.91	pubmed	Aspergillus fumigatus Af293	EAL86473.1	Q4WFK4
cellobiohydrolase II (CBHII;AN5282.2)	3.2.1.91	pubmed	Aspergillus nidulans FGSC A4	ABF50873.1 EAA62442.1	Q5B2E8
cellobiohydrolase 6A (AtCel6A; ATEG_00193) (Cel6A)	3.2.1.91	pubmed	Aspergillus terreus NIH2624	EAU38839.1	Q0D1J1
cellobiohydrolase II (Cel7;Cbh7;Cbh2;ChCbh2)	3.2.1.91	pubmed	Bipolaris maydis C4	AAM76664.1	Q8J215
cellobiohydrolase (EG6;CBH IIa) (Cel6A)	3.2.1.91	pubmed	Chrysosporium lucknowense	AAQ38151.1 ACH15009.1
cellobiohydrolase 6A (CgCel6A; GLRG_08518) (Cel6A)	3.2.1.91	pubmed	Colletotrichum graminicola M1.001	EFQ33589.1	E3QRV1
cellobiohydrolase 6B (CgCel6B; GLRG_00951) (Cel6B)	3.2.1.91	pubmed	Colletotrichum graminicola M1.001	EFQ25807.1	E3Q540
cellobiohydrolase (CcCel6A) (Cel6A)	3.2.1.91	pubmed	Coprinopsis cinerea 5338	BAH08702.1	B7X9Z0	3VOG[A] 3VOH[A] 3VOI[A] 3VOJ[A]
cellobiohydrolase (CcCel6B) (Cel6B)	3.2.1.91	pubmed	Coprinopsis cinerea 5338	BAH08703.1	B7X9Z1
cellobiohydrolase (CcCel6C) (Cel6C)	3.2.1.91	pubmed	Coprinopsis cinerea 5338	BAH08704.1	B7X9Z2	3A64[A] 3A9A[A] 3A9B[A] 3ABX[A] 3VOF[A]
cellobiohydrolase II (Cel6A)	3.2.1.91	pubmed	Dichomitus squalens FBCC312	ALT57232.1	A0A0U3CB12
cellobiohydrolase / avicelase 2 (CBHII;Avi2) (Cel6A)	3.2.1.91	pubmed	Humicola insolens	BAB39154.1 AAN19008.1	Q9C1S9	1BVW[A] 1GZ1[A] 1OC5[A] 1OC6[A] 1OC7[A] 1OCB[A,B] 1OCJ[A] 1OCN[A] 2BVW[A]
endo-β-1,4-glucanase B (EG VI) (Cel6B)	3.2.1.4	pubmed	Humicola insolens		Q7SIG5	1DYS[A]
cellobiohydrolase II (Cel4;Ex-4;Cex3)	3.2.1.91	doi	Irpex lacteus MC-2	BAG48183.1	B2ZZ24
cellobiohydrolase (CbhII-1)	3.2.1.91	pubmed	Lentinula edodes L54	AAK28357.1	Q9C1R4
cellobiohydrolase II (LsCel6A) (Cel6A)	3.2.1.91	pubmed	Lentinus sajor-caju	AAL15037.1 AAL15038.1	Q96TP4
cellobiohydrolase (Cel6A)	3.2.1.91	doi	Malbranchea cinnamomea	CAH05679.1 ACC29930.1
cellobiohydrolase A (CelA; Cbh6) (Cel6A)	3.2.1.91	pubmed	Neocallimastix patriciarum	ABY52793.1 AAC49315.1 AAE59935.1 ACI26721.1	B0FEV4 B6EA50 Q12646
cellobiohydrolase (CelA)	3.2.1.91	pubmed	Neocallimastix patriciarum J11	AAR08200.1	Q6EIY8
exoglucanase (W5-CAT6-9)	3.2.1.91	pubmed	Neocallimastix patriciarum W5	AEX92709.1	H2BPT3
exoglucanase (W5-10151-39)	3.2.1.91	pubmed	Neocallimastix patriciarum W5	AEX92714.1	H2BPT8
exoglucanase (W5-10151-38)	3.2.1.91	pubmed	Neocallimastix patriciarum W5	AEX92715.1	H2BPT9
exoglucanase (W5-10151-5)	3.2.1.91	pubmed	Neocallimastix patriciarum W5	AEX92716.1	H2BPU0
exoglucanase (W5-10151-6)	3.2.1.91	pubmed	Neocallimastix patriciarum W5	AEX92717.1	H2BPU1
endo-β-1,4-glucanase / cellobiohydrolase (CelA)	3.2.1.4 3.2.1.91	pubmed pubmed	Orpinomyces sp. PC-2	AAB92678.1 AAE59921.1	P78720
endo-β-1,4-glucanase/cellobiohydrolase (CelC)	3.2.1.4 3.2.1.91	pubmed pubmed	Orpinomyces sp. PC-2	AAB92679.1 AAE59922.1	P78721
cellobiohydrolase II (CelF)	3.2.1.91	pubmed	Orpinomyces sp. PC-2	AAC09228.1 AAC09067.1 AAE50374.1	Q874D8 Q874E0
exp-cellulase C16 (CelC16)	3.2.1.91	doi	Orpinomyces sp. Y102	AEH95579.1	V9I1G2
β-glucanase C7 (CelC7;Cbhc7)	3.2.1.73	pubmed	Orpinomyces sp. Y102	AIK03053.1	A0A076U926	5JX5[A,B,C,D] 6IDW[A,B,C,D]
cellobiohydrolase II (Cbh2;CbhII;PdCel6A) (Cel6A)	3.2.1.91	pubmed	Penicillium decumbens 114-2 / JU-A10	ADX86895.1	F1CHI2
cellobiohydrolase 3 (Cbh3;PoCel6A) (fragment) (Cel6A)	3.2.1.91	pubmed	Penicillium oxalicum GZ-2	AIO06741.1	A0A088STL5
cellobiohydrolase II (CbhII;Cbh2) (Cel6A)	3.2.1.91	doi	Phanerochaete chrysosporium	AAB32942.1	Q02321	5XCY[A] 5XCZ[A] 8WUP[A] 8WW5[A] 8WWT[A] 8WX6[A]
cellobiohydrolase II (Cbh6A)	3.2.1.91	pubmed	Phialophora sp. G5 / CGMCC 3328	ADZ99361.1	F2VRZ0
β-glucanase (CbhYW23-2)	3.2.1.4	pubmed	Piromyces rhizinflatus	ABY52798.1	B0FEV9
cellobiohydrolase (Cbh6) (Cel6A)	3.2.1.91	pubmed	Piromyces rhizinflatus 2301	AAD51055.1	Q9UW10
exoglucanase 6A (Cel6A)	3.2.1.91	pubmed	Piromyces sp. E2	AAL92497.1	Q874K3
exoglucanase 6A (Cel6A)	3.2.1.91	pubmed	Piromyces sp. equi	AAM94167.1	Q7Z7X6
cellobiohydrolase (PaCel6A;Pa_0_1250) (Cel6A)	3.2.1.91	pubmed	Podospora anserina S mat+	CAP60942.1 CDP24957.1	B2ABX7
endo-β-1,4-glucanase (PaCel6B;Pa_2_13800) (Cel6B)	3.2.1.4	pubmed	Podospora anserina S mat+	CAP60981.1 CDP26446.1	B2AC20
processive endo-β-1,4-glucanase (PaCel6C;Pa_4_2420) (Cel6C)	3.2.1.4 3.2.1.91	pubmed pubmed	Podospora anserina S mat+	CAP61669.1 CDP28020.1	B2AE04
cellobiohydrolase (MoCel6A;MG05520.4) (Cel6A)	3.2.1.91	pubmed	Pyricularia oryzae 70-15	XP_360146.1	G4MM92
cellobiohydrolase II (CbhII;Cbh2)	3.2.1.91	pubmed	Rasamsonia emersonii IMI 392299	AAL78165.2 AAL33604.4	Q8NIB5
cellobiohydrolase (Cel6A)	3.2.1.91	doi	Stilbella annulata	CAH05678.1
cellulase / cellobiohydrolase 6A (TfCel6A) (Cel6A)	3.2.1.91	pubmed	Talaromyces funiculosus	ACH91035.1	B5TMG4
cellobiohydrolase II (Acc2) (Cel6A)	3.2.1.91	pubmed	Talaromyces pinophilus CF-2612	AAE50824.1 BAA74458.1	O93837
cellobiohydrolase (Cbh2;CtCbh2) (Cel6A)	3.2.1.91	pubmed	Thermochaetoides thermophila CT2	AAW64927.1 AAY88915.1	G0SD43 Q4JQF8 Q5G2D4	4A05[A]
cellobiohydrolase (Cbh2b;ClCbh2;MYCTH_66729)	3.2.1.91	pubmed	Thermothelomyces thermophilus ATCC 42464	AEO55787.1	G2QA39
cellobiohydrolase (CBH-II) (Cel6A)	3.2.1.91	doi	Thielavia terrestris	ABT06036.1
cellobiohydrolase II (CbhII)	3.2.1.91	URL	Trichoderma parceramosum	AAU05379.2 AAV31052.1	Q66PN1
cellobiohydrolase II (CBHII; Cbh2; CBH-II; TrCel6A; HjCel6A; TrCbh2) (Cel6A)	3.2.1.91	pubmed	Trichoderma reesei QM9414	AAA34210.1 AAA72922.1 AAE59936.1 AAG39980.1 AAR60513.1 CAR96032.1 CAR96033.1 CAV28333.1	P07987 Q9HEY8	1CB2[A,B] 1HGW[A,B] 1HGY[A,B] 1LG8[nd] 1LLX[nd] 1QJW[A,B] 1QK0[A,B] 1QK2[A,B] 3CBH[A] 4AU0[A,B] 4AX6[A,B] 4AX7[A,B,C,D]
cellobiohydrolase II (CbhII;Cbh2)	3.2.1.91	pubmed	Trichoderma viride CICC 13038	AAQ76094.1	Q6UJX9
cellobiohydrolase II-I (CbhII-I;Cbh2;VvCbh2)	3.2.1.91	pubmed	Volvariella volvacea V14	AAT64008.1	Q6E5B1
unclassified
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
cellobiohydrolase (HmCel6A-3SNP)	3.2.1.91	pubmed	metagenome		A0A4Y1YS11	6K53[A] 6K54[A,B,C] 6K55[A,B,C] 6K52[A]
cellobiohydrolase (G10-6) (partial)	3.2.1.91	pubmed	uncultured organism	ACY24855.1	D8VN70
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