Glycoside Hydrolase Family 6

Activities in Familyendoglucanase (EC 3.2.1.4); cellobiohydrolase (EC 3.2.1.91); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Mechanism Inverting
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
Noteformerly known as cellulase family B. The cellobiohydrolases of this family are widely believed to act processively from the non-reducing ends of cellulose chains to generate cellobiose.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (3101); Uniprot accession (79); PDB accession (56); 3D entries (15); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 cellobiohydrolase A (CbhA;Celf_1925) (Cel6B) 3.2.1.91 pubmed
Cellulomonas fimi ATCC 484 AAC36898.1
ABH87631.1
AEE46055.1
P50401 7CBD[A]
 endo-β-1,4-glucanase A (CenA;Celf_3184) (Cel6A) 3.2.1.4 pubmed
Cellulomonas fimi ATCC 484 AEE47298.1
AAA23084.1
AAE59939.1
F4GZY2
P07984
 
 endo-β-1,4-glucanase (CelL) 3.2.1.4 pubmed
Cellulosimicrobium funkei HY-13 ALK04194.1 A0A0P0IZM9  
 exo-β-1,4-xylanase (XylK2) 3.2.1.8 pubmed
Cellulosimicrobium sp. HY-13 ADR71224.1 E5LP78  
 cellobiohydrolase 6A (CJA_2473) (Cel6A) 3.2.1.91 pubmed
Cellvibrio japonicus Ueda107 ACE85978.1 B3PKK5  
 endo-β-1,4-glucanase (CenA;MCenA) 3.2.1.4 pubmed
Micromonospora cellulolyticum AAC60491.1 Q53488  
 endoglucanase (CelA1;CelA;Rv0062;MTV030.05) (Cel6) 3.2.1.4 pubmed
Mycobacterium tuberculosis H37Rv CAA16243.1
AFN47905.1
CAE55238.1
CCP42784.1
NP_214576.1
Q79G13 1UOZ[A]
1UP0[A]
1UP2[A]
1UP3[A]
 endo-β-1,4-glucanase I (EGI;EGII) 3.2.1.4 pubmed
Neisseria sicca SB BAJ21449.1 E1CAJ8  
 endo-β-1,4-glucanase 6A (Sde_2272) (Cel6A) 3.2.1.4 pubmed
Saccharophagus degradans 2-40 ABD81532.1 Q21IE7  
 endo-β-1,4-glucanase A (CelA1;Cel1;CMCASE I) 3.2.1.4 pubmed
Streptomyces halstedii JM8 CAA78145.1 P33682  
 exoglucanase (CbhII) 3.2.1.91 pubmed
Streptomyces sp. M23 BAB83928.1 Q8VLR1  
 bifunctional β-1,4-endoglucanase / cellobiohydrolase (CelAB) 3.2.1.91 pubmed
Teredinibacter turnerae T7901 ABS72374.1 A9Q634  
 cellobiohydrolase 6B / exoglucanase (E3;Ex;Tfu_0620) (Cel6B) 3.2.1.91 pubmed
Thermobifida fusca YX AAA62211.1
AAF75786.1
AAZ54658.1
ABH87632.1
Q47SA9
Q60029
Q9KH72
4AVN[A]
4AVO[A]
4B4F[A,B]
4B4H[A,B]
 endo-β-1,4-glucanase (E2;CelB;Tfu_1074) (Cel6A) 3.2.1.4 pubmed
Thermobifida fusca YX AAC06388.1
AAE59940.1
AAZ55112.1
P26222
Q47R05
1TML[A]
2BOD[X]
2BOE[X]
2BOF[X]
2BOG[X]
 endoglucanase (ThCel6A) (alkali-stable) (Cel6A) 3.2.1.4 pubmed
Thermobifida halotolerans YIM 90462T AHN09982.1 X2G0M7  
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 pubmed
Thermobispora bispora / Microbispora bispora   P26414  
 endoglucanase mgCel6A (mgCel6A) 3.2.1.4 pubmed
uncultured bacterium     6FAO[A]
 cellulase (Cel6H) (partial) (Cel6H) 3.2.1.4 doi
uncultured bacterium AEK21789.1
AEK21789.2
G1K3U8  
 cellulase (Lc-CelB) 3.2.1.4 pubmed
uncultured bacterium AHL27895.1 W8PF16  
 cellulase (Lc-CelJ) 3.2.1.4 pubmed
uncultured bacterium AHL27903.1 W8P3Q3  
 exoglucanase (CbsA) (fragment) 3.2.1.4 pubmed
Xanthomonas oryzae pv. oryzae BXO43 AAT35586.1 A0A384E106
Q6IT74
5XYH[A]
 endo-β-1,4-glucanase (Cel6A) 3.2.1.4 pubmed
Xylanimicrobium pachnodae DSM 12657 AAD54679.1 Q9RQE6  
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 cellobiohydrolase II (Cel3;Cel3A) 3.2.1.91 pubmed
Agaricus bisporus D649 AAA50607.1
AAA50608.1
AAE59938.1
CAA83971.1
P49075  
 cellobiohydrolase 6A (AfCel6A; AFUA_3G01910; Afu3g01910) 3.2.1.91 pubmed
Aspergillus fumigatus Af293 EAL86473.1    
 cellobiohydrolase II (CBHII;AN5282.2) 3.2.1.91 pubmed
Aspergillus nidulans FGSC A4 ABF50873.1
EAA62442.1
Q5B2E8  
 cellobiohydrolase 6A (AtCel6A; ATEG_00193) (Cel6A) 3.2.1.91 pubmed
Aspergillus terreus NIH2624 EAU38839.1    
 cellobiohydrolase II (Cel7;Cbh7;Cbh2;ChCbh2) 3.2.1.91 pubmed
Bipolaris maydis C4 AAM76664.1 Q8J215  
 cellobiohydrolase (EG6;CBH IIa) (Cel6A) 3.2.1.91 pubmed
Chrysosporium lucknowense AAQ38151.1
ACH15009.1
   
 cellobiohydrolase 6A (CgCel6A; GLRG_08518) (Cel6A) 3.2.1.91 pubmed
Colletotrichum graminicola M1.001 EFQ33589.1    
 cellobiohydrolase 6B (CgCel6B; GLRG_00951) (Cel6B) 3.2.1.91 pubmed
Colletotrichum graminicola M1.001 EFQ25807.1    
 cellobiohydrolase (CcCel6A) (Cel6A) 3.2.1.91 pubmed
Coprinopsis cinerea 5338 BAH08702.1 B7X9Z0 3VOG[A]
3VOH[A]
3VOI[A]
3VOJ[A]
 cellobiohydrolase (CcCel6B) (Cel6B) 3.2.1.91 pubmed
Coprinopsis cinerea 5338 BAH08703.1 B7X9Z1  
 cellobiohydrolase (CcCel6C) (Cel6C) 3.2.1.91 pubmed
Coprinopsis cinerea 5338 BAH08704.1 B7X9Z2 3A64[A]
3A9A[A]
3A9B[A]
3ABX[A]
3VOF[A]
 cellobiohydrolase II (Cel6A) 3.2.1.91 pubmed
Dichomitus squalens FBCC312 ALT57232.1 A0A0U3CB12  
 cellobiohydrolase / avicelase 2 (CBHII;Avi2) (Cel6A) 3.2.1.91 pubmed
Humicola insolens BAB39154.1
AAN19008.1
Q9C1S9 1BVW[A]
1GZ1[A]
1OC5[A]
1OC6[A]
1OC7[A]
1OCB[A,B]
1OCJ[A]
1OCN[A]
2BVW[A]
 endo-β-1,4-glucanase B (EG VI) (Cel6B) 3.2.1.4 pubmed
Humicola insolens   Q7SIG5 1DYS[A]
 cellobiohydrolase II (Cel4;Ex-4;Cex3) 3.2.1.91 doi
Irpex lacteus MC-2 BAG48183.1 B2ZZ24  
 cellobiohydrolase (CbhII-1) 3.2.1.91 pubmed
Lentinula edodes L54 AAK28357.1 Q9C1R4  
 cellobiohydrolase II (LsCel6A) (Cel6A) 3.2.1.91 pubmed
Lentinus sajor-caju AAL15037.1
AAL15038.1
   
 cellobiohydrolase (Cel6A) 3.2.1.91 doi
Malbranchea cinnamomea CAH05679.1
ACC29930.1
   
 cellobiohydrolase A (CelA;Cbh6) (Cel6A) 3.2.1.91 pubmed
Neocallimastix patriciarum ABY52793.1
AAC49315.1
AAE59935.1
ACI26721.1
B0FEV4
B6EA50
Q12646
 
 cellobiohydrolase (CelA) 3.2.1.91 pubmed
Neocallimastix patriciarum J11 AAR08200.1 Q6EIY8  
 exoglucanase (W5-CAT6-9) 3.2.1.91 pubmed
Neocallimastix patriciarum W5 AEX92709.1 H2BPT3  
 exoglucanase (W5-10151-39) 3.2.1.91 pubmed
Neocallimastix patriciarum W5 AEX92714.1 H2BPT8  
 exoglucanase (W5-10151-38) 3.2.1.91 pubmed
Neocallimastix patriciarum W5 AEX92715.1 H2BPT9  
 exoglucanase (W5-10151-5) 3.2.1.91 pubmed
Neocallimastix patriciarum W5 AEX92716.1 H2BPU0  
 exoglucanase (W5-10151-6) 3.2.1.91 pubmed
Neocallimastix patriciarum W5 AEX92717.1 H2BPU1  
 endo-β-1,4-glucanase / cellobiohydrolase (CelA) 3.2.1.4
3.2.1.91
pubmed
pubmed
Orpinomyces sp. PC-2 AAB92678.1
AAE59921.1
P78720  
 endo-β-1,4-glucanase/cellobiohydrolase (CelC) 3.2.1.4
3.2.1.91
pubmed
pubmed
Orpinomyces sp. PC-2 AAB92679.1
AAE59922.1
P78721  
 cellobiohydrolase II (CelF) 3.2.1.91 pubmed
Orpinomyces sp. PC-2 AAC09228.1
AAC09067.1
AAE50374.1
Q874D8
Q874E0
 
 exp-cellulase C16 (CelC16) 3.2.1.91 doi
Orpinomyces sp. Y102 AEH95579.1 V9I1G2  
 β-glucanase C7 (CelC7;Cbhc7) 3.2.1.73 pubmed
Orpinomyces sp. Y102 AIK03053.1 A0A076U926 5JX5[A,B,C,D]
6IDW[A,B,C,D]
 cellobiohydrolase II (Cbh2;CbhII;PdCel6A) (Cel6A) 3.2.1.91 pubmed
Penicillium decumbens 114-2 / JU-A10 ADX86895.1 F1CHI2  
 cellobiohydrolase 3 (Cbh3;PoCel6A) (fragment) (Cel6A) 3.2.1.91 pubmed
Penicillium oxalicum GZ-2 AIO06741.1 A0A088STL5  
 cellobiohydrolase II (CbhII;Cbh2) (Cel6A) 3.2.1.91 doi
Phanerochaete chrysosporium AAB32942.1 Q02321 5XCY[A]
5XCZ[A]
 cellobiohydrolase II (Cbh6A) 3.2.1.91 pubmed
Phialophora sp. G5 / CGMCC 3328 ADZ99361.1 F2VRZ0  
 β-glucanase (CbhYW23-2) 3.2.1.4 pubmed
Piromyces rhizinflatus ABY52798.1 B0FEV9  
 cellobiohydrolase (Cbh6) (Cel6A) 3.2.1.91 pubmed
Piromyces rhizinflatus 2301 AAD51055.1 Q9UW10  
 exoglucanase 6A (Cel6A) 3.2.1.91 pubmed
Piromyces sp. E2 AAL92497.1 Q874K3  
 exoglucanase 6A (Cel6A) 3.2.1.91 pubmed
Piromyces sp. equi AAM94167.1 Q7Z7X6  
 cellobiohydrolase (PaCel6A;Pa_0_1250) (Cel6A) 3.2.1.91 pubmed
Podospora anserina S mat+ CAP60942.1
CDP24957.1
B2ABX7  
 endo-β-1,4-glucanase (PaCel6B;Pa_2_13800) (Cel6B) 3.2.1.4 pubmed
Podospora anserina S mat+ CAP60981.1
CDP26446.1
B2AC20  
 processive endo-β-1,4-glucanase (PaCel6C;Pa_4_2420) (Cel6C) 3.2.1.4
3.2.1.91
pubmed
pubmed
Podospora anserina S mat+ CAP61669.1
CDP28020.1
B2AE04  
 cellobiohydrolase (MoCel6A;MG05520.4) (Cel6A) 3.2.1.91 pubmed
Pyricularia oryzae 70-15 XP_360146.1 G4MM92  
 cellobiohydrolase II (CbhII;Cbh2) 3.2.1.91 pubmed
Rasamsonia emersonii IMI 392299 AAL78165.2
AAL33604.4
Q8NIB5  
 cellobiohydrolase (Cel6A) 3.2.1.91 doi
Stilbella annulata CAH05678.1    
 cellobiohydrolase II (Acc2) (Cel6A) 3.2.1.91 pubmed
Talaromyces cellulolyticus CF-2612 AAE50824.1
BAA74458.1
O93837  
 cellulase / cellobiohydrolase 6A (TfCel6A) (Cel6A) 3.2.1.91 pubmed
Talaromyces funiculosus ACH91035.1    
 cellobiohydrolase (Cbh2;CtCbh2) (Cel6A) 3.2.1.91 pubmed
Thermochaetoides thermophila CT2 AAW64927.1
AAY88915.1
G0SD43
Q4JQF8
Q5G2D4
4A05[A]
 cellobiohydrolase (Cbh2b;ClCbh2;MYCTH_66729) 3.2.1.91 pubmed
Thermothelomyces thermophilus ATCC 42464 AEO55787.1 G2QA39  
 cellobiohydrolase (CBH-II) (Cel6A) 3.2.1.91 doi
Thielavia terrestris ABT06036.1    
 cellobiohydrolase II (CbhII) 3.2.1.91 URL
Trichoderma parceramosum AAU05379.2
AAV31052.1
Q66PN1  
 cellobiohydrolase II (CBHII; Cbh2; CBH-II; TrCel6A; HjCel6A; TrCbh2) (Cel6A) 3.2.1.91 pubmed
Trichoderma reesei QM9414 AAA34210.1
AAA72922.1
AAE59936.1
AAG39980.1
AAR60513.1
CAR96032.1
CAR96033.1
CAV28333.1
P07987
Q9HEY8
1CB2[A,B]
1HGW[A,B]
1HGY[A,B]
1LG8[nd]
1LLX[nd]
1QJW[A,B]
1QK0[A,B]
1QK2[A,B]
3CBH[A]
4AU0[A,B]
4AX6[A,B]
4AX7[A,B,C,D]
 cellobiohydrolase II (CbhII;Cbh2) 3.2.1.91 pubmed
Trichoderma viride CICC 13038 AAQ76094.1 Q6UJX9  
 cellobiohydrolase II-I (CbhII-I;Cbh2;VvCbh2) 3.2.1.91 pubmed
Volvariella volvacea V14 AAT64008.1 Q6E5B1  
unclassified
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 cellobiohydrolase (hmcel6α-3snp) 3.2.1.91 doi
metagenome     6K53[A]
6K54[A,B,C]
6K55[A,B,C]
6K52[A]
 cellobiohydrolase (G10-6) (partial) 3.2.1.91 pubmed
uncultured organism ACY24855.1 D8VN70  
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