Glycoside Hydrolase Family 65

Activities in Familyα,α-trehalase (EC 3.2.1.28); maltose phosphorylase (EC 2.4.1.8); trehalose phosphorylase (EC 2.4.1.64); kojibiose phosphorylase (EC 2.4.1.230); trehalose-6-phosphate phosphorylase (EC 2.4.1.216); nigerose phosphorylase (EC 2.4.1.279); 3-O-α-glucopyranosyl-L-rhamnose phosphorylase (EC 2.4.1.282); 2-O-α-glucopyranosylglycerol: phosphate β-glucosyltransferase (EC 2.4.1.-); α-glucosyl-1,2-β-galactosyl-L-hydroxylysine α-glucosidase (EC 3.2.1.107)
Mechanism Inverting
ClanGH-L
3D Structure Status( α / α ) 6
Catalytic Nucleophile/Basephosphate for phosphorylases; water for hydrolases
Catalytic Proton DonorGlu
External resourcesCAZypedia;
Statistics GenBank accession (3623); Uniprot accession (456); PDB accession (5); 3D entries (4); cryst (1)
All (3484) Archaea (10) Bacteria (3280) Eukaryota (192) unclassified (2) Structure (4 - 1 cryst) Characterized (23)
| 1 | 2 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ENSANGG00000018306   Anopheles gambiae str. PEST EAA10071.1    
 ENSANGG00000018265 (partial)   Anopheles gambiae str. PEST EAA10287.1    
 ENSANGG00000018285   Anopheles gambiae str. PEST EAA10072.1    
 EGX52365.1   Arthrobotrys oligospora ATCC 24927 EGX52365.1    
 acid trehalase (TreA) 3.2.1.28 Aspergillus nidulans AAB57642.1 P78617  
 AN9340.2 (TreA) 3.2.1.28 Aspergillus nidulans FGSC A4 EAA66407.1 P78617  
 An01g01540   Aspergillus niger CBS 513.88 CAK43526.1 A2Q7Q3  
 AO090120000052   Aspergillus oryzae RIB40 BAE62687.1 Q2U6X8  
 glycoside hydrolase family 65 protein (Bofut4_p056740.1)   Botrytis cinerea T4 CCD44773.1    
 BofuT4P103000008001   Botrytis cinerea T4 CCD52235.2
CCD52235.1
   
 Athl1   Callorhinchus milii AFK10199.1
AFO97544.1
   
 acid trehalase (Atc1;CaATC1) 3.2.1.28 Candida albicans AAV05390.1    
 CAALFM_C106940CA (Atc1)   Candida albicans SC5314 AOW26348.1    
 CD36_06490   Candida dubliniensis CD36 CAX44942.1 B9W888  
 acid trehalase (Ath1;CgATH1;CAGLOK05137g) 3.2.1.28 Candida glabrata Bg14 AGG12634.1    
 CAGL0K05137g   Candida glabrata CBS 138 CAG61411.1 Q6FMU4  
 SAMEA4029010_CIC11G00000002223   [Candida] intermedia CBS 141442 SGZ50539.1    
 SAMEA4029009_CIC11G00000000499   [Candida] intermedia PYCC 4715 SGZ51491.1    
 CORT_0A08250   Candida orthopsilosis Co 90-125 CCG21210.1    
 trehalase (Atc1;CpATC1;CPAR2_208980) 3.2.1.28 Candida parapsilosis CDC317 CCE43253.1    
 CYFA0S_01e13828g   Cyberlindnera fabianii YJS4271 CDR37636.1    
 Unknown (protein for MGC:154078)   Danio rerio AAI25952.1 A0JMP0  
 DEHA0D15774g   Debaryomyces hansenii CBS767 CAG87277.1 Q6BRR1  
 Dbus_chr2Lg1438   Drosophila busckii ALC39353.1    
 CG16965   Drosophila melanogaster ADC27646.2
AAF53137.1
AAF53137.2
AAF53137.3
ADC27646.1
NP_609528.1
Q9VKD9  
 Ecym_7120   Eremothecium cymbalariae DBVPG#7215 AET40970.1    
 AGL271W   Eremothecium gossypii ATCC 10895 AAS54220.1 Q751H7  
 FAGOS_FAGL271W   Eremothecium gossypii FDAG1 AEY98546.1    
 AW171_hschr42371   Eremothecium sinecaudum ATCC 58844 AMD20478.1    
 FFUJ_12835   Fusarium fujikuroi IMI 58289 CCT73100.1    
 protein α-glucosyl-1,2-β-galactosyl-L-hydroxylysine α-glucosidase (Athl1;PGGHG) 3.2.1.107 Gallus gallus BAR88294.1
BAR88295.1
   
 unnamed protein product (contains FLJ00228)   Homo sapiens CAC34689.1
AAI09258.1
AAI09259.1
AAY07220.1
BAB15431.1
BAB84981.1
BAC03409.1
BAG58879.1
CAH56316.1
NP_079368.1
Q8NF51
Q9H635
 
 ORF   Hypocrella siamensis MTCC 10142 ANH56413.1    
 KAFR_0K02080 (Kafr0k02080)   Kazachstania africana CBS 2517 CCF60562.1    
 KNAG_0C03300 (Knag0c03300)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK69438.1    
 KLLA0E06622g   Kluyveromyces lactis NRRL Y-1140 CAG99334.1 Q6CP92  
 KLMA_70139   Kluyveromyces marxianus DMKU3-1042 BAO41987.1    
 KMAR_70121   Kluyveromyces marxianus NBRC 1777 BAP73405.1    
 ATY40_BA7502948 (Ath1)   Komagataella pastoris ATCC 28485 ANZ75936.1    
 AT249_GQ6704682 (Ath1)   Komagataella phaffii ATCC 76273 AOA64536.1    
 PP7435_Chr4-0652 (Ath1)   Komagataella phaffii CBS 7435 CCA40810.1    
 PAS_chr4_0342   Komagataella phaffii GS115 CAY71585.1
AOA70274.1
C4R7L0  
 KLTH0C05676g   Lachancea thermotolerans CBS 6340 CAR22033.1    
 LbrM20_V2.1740   Leishmania braziliensis MHOM/BR/75/M2904 CAM38520.1 A4HAT6  
 LbrM35_V2.5490   Leishmania braziliensis MHOM/BR/75/M2904 CAM44301.1 A4HQ39  
 LDBPK_365470   Leishmania donovani BPK282A1 CBZ38983.1    
 LDBPK_342000   Leishmania donovani BPK282A1 CBZ37678.1    
 LinJ34.1800   Leishmania infantum JPCM5 CAM71651.1    
 LinJ36.5800   Leishmania infantum JPCM5 CAM73030.1    
 LmjF34.2240   Leishmania major strain Friedlin CAJ07937.1 Q4Q2X6  
 LmjF36.5240   Leishmania major strain Friedlin CAJ09496.1 Q4Q0N8  
 LMXM_36_5240   Leishmania mexicana MHOM/GT/2001/U1103 CBZ26383.1    
 LMXM_33_2240   Leishmania mexicana MHOM/GT/2001/U1103 CBZ30329.1    
 LPMP_355360   Leishmania panamensis MHOM/PA/94/PSC-1 AIO02666.1    
 LPMP_201920   Leishmania panamensis MHOM/PA/94/PSC-1 AIN97686.1    
 ORF (fragment)   Leptosphaeria maculans JN3 v23.1.3 CBX91091.1 E4ZIS0  
 ORF   Macaca fascicularis BAE01275.1 Q4R6K0  
 ORF (fragment)   Macaca mulatta AFE72965.1    
 acid trehalase (Atm1) 3.2.1.28 Metarhizium acridum CQMA102 ABO93464.1
ABB51158.1
ABB51159.1
   
 GNLVRS01_PISO0N01443g (Piso0_004801)   Millerozyma farinosa CBS 7064 CCE86318.1    
 GNLVRS01_PISO0M01288g (Piso0_004801)   Millerozyma farinosa CBS 7064 CCE85219.1    
 ORF   Mus musculus C57BL/6J BAC36936.1
AAH23151.1
AAH56953.1
BAD90165.1
NP_663362.1
Q8BP56
Q8R585
 
 ORF (fragment)   Mustela putorius furo AER94698.1    
 ORF (fragment)   Mustela putorius furo AER94699.1    
 NCAS_0A14660   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC68024.1    
 NDAI_0A01370 (Ndai0a01370)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD22295.1    
 ORF   Passalora fulva 0WU AQA29363.1    
 Pc16g11870   Penicillium rubens Wisconsin 54-1255 CAP93857.1 B6H9U0  
 DKFZp468O1012 (probable fragment)   Pongo abelii CAH90373.1 Q5RCY4  
 acid trehalase   Rasamsonia emersonii IMI 392299 AAQ67343.1
AAL33632.1
Q6V7X7
Q8X1C4
 
 LOC309103   Rattus norvegicus XP_219475.2    
 RHTO0S_23e02124g   Rhodotorula toruloides CECT1137 CDR49168.1    
 EC1118_1P2_3422g   Saccharomyces cerevisiae EC1118 Lalvin EC1118 CAY86981.1 C8ZJ50  
 acid trehalase (vacuolar) (Ath1;YPR026w;YP9367.06) 3.2.1.28 Saccharomyces cerevisiae S288c CAA89280.1
CAA58961.1
CAA95022.1
NP_015351.1
P48016  
 F842_YJM1078P00303 (Ath1)   Saccharomyces cerevisiae YJM1078 AJP42163.1    
 H635_YJM1083P00303 (Ath1)   Saccharomyces cerevisiae YJM1083 AJW10602.1    
 H668_YJM1129P00158 (Ath1)   Saccharomyces cerevisiae YJM1129 AJW10872.1    
 H781_YJM1133P00303 (Ath1)   Saccharomyces cerevisiae YJM1133 AJW11312.1    
 H782_YJM1190P00302 (Ath1)   Saccharomyces cerevisiae YJM1190 AJW11755.1    
 H783_YJM1199P00303 (Ath1)   Saccharomyces cerevisiae YJM1199 AJW12194.1    
 H784_YJM1202P00302 (Ath1)   Saccharomyces cerevisiae YJM1202 AJW12637.1    
 H785_YJM1208P00299 (Ath1)   Saccharomyces cerevisiae YJM1208 AJW13074.1    
 H786_YJM1242P00297 (Ath1)   Saccharomyces cerevisiae YJM1242 AJW13498.1    
 H787_YJM1244P00299 (Ath1)   Saccharomyces cerevisiae YJM1244 AJW13937.1    
 H788_YJM1248P00303 (Ath1)   Saccharomyces cerevisiae YJM1248 AJW14377.1    
 H789_YJM1250P00302 (Ath1)   Saccharomyces cerevisiae YJM1250 AJW14798.1    
 H790_YJM1252P00303 (Ath1)   Saccharomyces cerevisiae YJM1252 AJW15222.1    
 H791_YJM1273P00299 (Ath1)   Saccharomyces cerevisiae YJM1273 AJW15659.1    
 H792_YJM1304P00303 (Ath1)   Saccharomyces cerevisiae YJM1304 AJW16102.1    
 H793_YJM1307P00301 (Ath1)   Saccharomyces cerevisiae YJM1307 AJW16537.1    
 H794_YJM1311P00301 (Ath1)   Saccharomyces cerevisiae YJM1311 AJW16975.1    
 H795_YJM1326P00286 (Ath1)   Saccharomyces cerevisiae YJM1326 AJW17399.1    
 H796_YJM1332P00303 (Ath1)   Saccharomyces cerevisiae YJM1332 AJW17845.1    
 H797_YJM1336P00303 (Ath1)   Saccharomyces cerevisiae YJM1336 AJW18284.1    
 H798_YJM1338P00303 (Ath1)   Saccharomyces cerevisiae YJM1338 AJW18721.1    
 H799_YJM1341P00299 (Ath1)   Saccharomyces cerevisiae YJM1341 AJW19159.1    
 H800_YJM1342P00303 (Ath1)   Saccharomyces cerevisiae YJM1342 AJW19585.1    
 H801_YJM1355P00282 (Ath1)   Saccharomyces cerevisiae YJM1355 AJW20001.1    
 H802_YJM1356P00302 (Ath1)   Saccharomyces cerevisiae YJM1356 AJW00602.1    
 H803_YJM1381P00299 (Ath1)   Saccharomyces cerevisiae YJM1381 AJW01041.1    
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