Glycoside Hydrolase Family 65

Activities in Familyα,α-trehalase (EC 3.2.1.28); maltose phosphorylase (EC 2.4.1.8); trehalose phosphorylase (EC 2.4.1.64); kojibiose phosphorylase (EC 2.4.1.230); trehalose-6-phosphate phosphorylase (EC 2.4.1.216); nigerose phosphorylase (EC 2.4.1.279); 3-O-α-glucopyranosyl-L-rhamnose phosphorylase (EC 2.4.1.282); 2-O-α-glucopyranosylglycerol: phosphate β-glucosyltransferase (EC 2.4.1.-); α-glucosyl-1,2-β-galactosyl-L-hydroxylysine α-glucosidase (EC 3.2.1.107)
Mechanism Inverting
ClanGH-L
3D Structure Status( α / α ) 6
Catalytic Nucleophile/Basephosphate for phosphorylases; water for hydrolases
Catalytic Proton DonorGlu
External resourcesCAZypedia;
Statistics GenBank accession (3623); Uniprot accession (456); PDB accession (5); 3D entries (4); cryst (1)
All (3484) Archaea (10) Bacteria (3280) Eukaryota (192) unclassified (2) Structure (4 - 1 cryst) Characterized (23)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 maltose phosphorylase (Bsel2056;Bsel_2056) 2.4.1.8 [Bacillus] selenitireducens MLS10 ADH99560.1 D6XUS4  
 2-O-α-glucopyranosylglycerol: phosphate β-glucosyltransferase / 2-O-α-glucosylglycerol phosphorylase (GGP;Bsel_2816) 2.4.1.- [Bacillus] selenitireducens MLS10 ADI00307.1 D6XZ22 4KTP[A,B]
4KTR[A,B,C,D,E,F,G,H]
 maltose phosphorylase (MPase) 2.4.1.8 Bacillus sp. RK-1 BAC54904.1 Q84IX5  
 kojibiose phosphorylase (CsKP;Csac_0439) 2.4.1.230 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66077.1 A4XGP2 3WIQ[A]
3WIR[A,B,C,D]
 maltose phosphorylase (MalP;EF0957) 2.4.1.8 Enterococcus faecalis V583 AAO80764.1
AAR57274.1
NP_814694.1
Q836Y7  
 trehalose phosphorylase (TPase) 2.4.1.64 Geobacillus stearothermophilus SK-1 BAC20640.1 Q8GRC3  
 3-O-α-glucopyranosyl-L-rhamnose phosphorylase (Cphy_1019) 2.4.1.282 Lachnoclostridium phytofermentans ISDg ABX41399.1 A9KM56  
 nigerose phosphorylase (Cphy_1874) 2.4.1.279 Lachnoclostridium phytofermentans ISDg ABX42243.1 A9KT32  
 maltose phosphorylase (MalP;LBA1870) 2.4.1.8 Lactobacillus acidophilus NCFM AAV43670.1
CAN87417.1
Q5FI04  
 maltose phosphorylase 2.4.1.8 Lactobacillus brevis ATCC 8287   Q7SIE1 1H54[A]
 maltose phosphorylase 2.4.1.8 Lactobacillus sanfranciscensis DSM 20451(T) CAA11905.1 O87772  
 trehalose-6-phosphate phosphorylase (TrePP;YeeA;L39593;LL0428) 2.4.1.216 Lactococcus lactis subsp. lactis Il1403 AAK04526.1
NP_266584.1
Q9CID5  
 maltose phosphorylase (MapA) 2.4.1.8 Paenibacillus sp. SH-55 BAD97810.1
BAJ22988.1
Q50LH0  
 trehalose phosphorylase (TreP) 2.4.1.64 Thermoanaerobacter brockii ATCC 35047 BAB97299.1
AAE18727.1
AAE24711.1
Q8L164 cryst
 kojibiose phosphorylase (KojP;KPase) 2.4.1.230 Thermoanaerobacter brockii ATCC 35047 AAE30762.1
BAB97300.1
Q8L163  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 acid trehalase (TreA) 3.2.1.28 Aspergillus nidulans AAB57642.1 P78617  
 AN9340.2 (TreA) 3.2.1.28 Aspergillus nidulans FGSC A4 EAA66407.1 P78617  
 acid trehalase (Atc1;CaATC1) 3.2.1.28 Candida albicans AAV05390.1    
 acid trehalase (Ath1;CgATH1;CAGLOK05137g) 3.2.1.28 Candida glabrata Bg14 AGG12634.1    
 trehalase (Atc1;CpATC1;CPAR2_208980) 3.2.1.28 Candida parapsilosis CDC317 CCE43253.1    
 protein α-glucosyl-1,2-β-galactosyl-L-hydroxylysine α-glucosidase (Athl1;PGGHG) 3.2.1.107 Gallus gallus BAR88294.1
BAR88295.1
   
 acid trehalase (Atm1) 3.2.1.28 Metarhizium acridum CQMA102 ABO93464.1
ABB51158.1
ABB51159.1
   
 acid trehalase (vacuolar) (Ath1;YPR026w;YP9367.06) 3.2.1.28 Saccharomyces cerevisiae S288c CAA89280.1
CAA58961.1
CAA95022.1
NP_015351.1
P48016  
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