Glycoside Hydrolase Family 65

Activities in Familyα,α-trehalase (EC 3.2.1.28); maltose phosphorylase (EC 2.4.1.8); trehalose phosphorylase (EC 2.4.1.64); kojibiose phosphorylase (EC 2.4.1.230); trehalose-6-phosphate phosphorylase (EC 2.4.1.216); nigerose phosphorylase (EC 2.4.1.279); 3-O-α-glucopyranosyl-L-rhamnose phosphorylase (EC 2.4.1.282); 1,2-α-glucosylglycerol phosphorylase (EC 2.4.1.332); α-glucosyl-1,2-β-galactosyl-L-hydroxylysine α-glucosidase (EC 3.2.1.107); 1,3-α-oligoglucan phosphorylase (EC 2.4.1.334); α-1,2-glucosidase (EC 3.2.1.-); α-glucan phosphorylase (EC 2.4.1.-); kojibiose glucohydrolase (α-1,2-glucosidase) (configuration inverting) (EC 3.2.1.216)
Mechanism Inverting
ClanGH-L
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/Basephosphate for phosphorylases; water for hydrolases
Catalytic Proton DonorGlu
External resourcesCAZypedia;
Statistics GenBank accession (9413); Uniprot accession (30); PDB accession (9); 3D entries (6); cryst (1)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 maltose phosphorylase (Bsel2056;Bsel_2056) 2.4.1.8 pubmed
[Bacillus] selenitireducens MLS10 ADH99560.1 D6XUS4  
 2-O-α-glucopyranosylglycerol: phosphate β-glucosyltransferase / 2-O-α-glucosylglycerol phosphorylase (GGP;Bsel_2816) 2.4.1.332 pubmed
[Bacillus] selenitireducens MLS10 ADI00307.1 D6XZ22 4KTP[A,B]
4KTR[A,B,C,D,E,F,G,H]
 maltose phosphorylase (MPase) 2.4.1.8 pubmed
Bacillus sp. RK-1 BAC54904.1 Q84IX5  
 1,3-α-oligoglucan phosphorylase (ChGP;Calhy_0070) 2.4.1.334 pubmed
Caldicellulosiruptor hydrothermalis 108 ADQ05832.1    
 kojibiose phosphorylase (CsKP;Csac_0439) 2.4.1.230 pubmed
Caldicellulosiruptor saccharolyticus DSM 8903 ABP66077.1 A4XGP2 3WIQ[A]
3WIR[A,B,C,D]
  a,α-trehalose-6-phosphate phosphorylase (CaGP;Cabys_1845) 2.4.1.216 pubmed
Caldithrix abyssi DSM 13497 LF13 APF18594.1    
 maltose phosphorylase (MalP;EF0957) 2.4.1.8 pubmed
Enterococcus faecalis V583 AAO80764.1
AAR57274.1
NP_814694.1
Q836Y7  
 kojibiose phosphorylase (YcjT; b1316) 2.4.1.230 pubmed
Escherichia coli str. K-12 substr. MG1655 AAC74398.1
AIZ91569.1
ALI40905.1
AMC98527.1
AUG16095.1
AVI55835.1
AYG19605.1
NP_415832.1
P77154  
 kojibiose hydrolase (FjGH65A;Fjoh_4428) 3.2.1.216 pubmed
Flavobacterium johnsoniae UW101 ABQ07432.1   B[nd]
C[nd]
7FE3[A]
7FE4[A]
 maltose phosphorylase 2.4.1.8 pubmed
Fructilactobacillus sanfranciscensis DSM 20451(T) CAA11905.1 O87772  
 trehalose phosphorylase (TPase) 2.4.1.64 pubmed
Geobacillus stearothermophilus SK-1 BAC20640.1 Q8GRC3  
 kojibiose phosphorylase (HoGP; Hore_00420) 2.4.1.230 pubmed
Halothermothrix orenii H 168 ACL68803.1    
 3-O-α-glucopyranosyl-L-rhamnose phosphorylase (Cphy_1019) 2.4.1.282 pubmed
Lachnoclostridium phytofermentans ISDg ABX41399.1 A9KM56  
 nigerose phosphorylase (Cphy_1874) 2.4.1.279 pubmed
Lachnoclostridium phytofermentans ISDg ABX42243.1 A9KT32  
 nigerose phosphorylase (Cphy_3313) 2.4.1.279 doi
Lachnoclostridium phytofermentans ISDg ABX43667.1 A9KSL5  
 1,3-?-oligoglucan phosphorylase (Cphy_3314) 2.4.1.334 doi
Lachnoclostridium phytofermentans ISDg ABX43668.1 A9KSL6  
 maltose phosphorylase (MalP;LBA1870) 2.4.1.8 pubmed
Lactobacillus acidophilus NCFM AAV43670.1
CAN87417.1
Q5FI04  
 trehalose-6-phosphate phosphorylase (TrePP;YeeA;L39593;LL0428) 2.4.1.216 pubmed
Lactococcus lactis subsp. lactis Il1403 AAK04526.1
NP_266584.1
Q9CID5  
 maltose phosphorylase 2.4.1.8 pubmed
Levilactobacillus brevis ATCC 8287   Q7SIE1 1H54[A]
 Trisaccharide α-glucan phosphorylase (MiGP;HMPREF0868_0806) 2.4.1.- pubmed
Mageeibacillus indolicus UPII9-5 ADC90669.1    
 kojibiose hydrolase (MmGH;SAMN05216490_2434) 3.2.1.216 pubmed
Mucilaginibacter mallensis MP1X4 SDT07729.1    
 maltose phosphorylase (MapA) 2.4.1.8 doi
Paenibacillus sp. SH-55 BAD97810.1
BAJ22988.1
Q50LH0  
 trehalose phosphorylase (TreP) 2.4.1.64 pubmed
Thermoanaerobacter brockii ATCC 35047 BAB97299.1
AAE18727.1
AAE24711.1
Q8L164 cryst
 kojibiose phosphorylase (KojP;KPase) 2.4.1.230 pubmed
Thermoanaerobacter brockii ATCC 35047 AAE30762.1
BAB97300.1
Q8L163  
 α,α-trehalose phosphorylase (TbGP; Tbis_2887) 2.4.1.64 pubmed
Thermobispora bispora DSM 43833 ADG89586.1    
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 acid trehalase (TreA) 3.2.1.28 pubmed
Aspergillus nidulans AAB57642.1 P78617  
 AN9340.2 (TreA) 3.2.1.28 pubmed
Aspergillus nidulans FGSC A4 EAA66407.1 P78617  
 acid trehalase (Atc1;CaATC1) 3.2.1.28 pubmed
Candida albicans AAV05390.1    
 acid trehalase (Ath1;CgATH1;CAGLOK05137g) 3.2.1.28 pubmed
Candida glabrata Bg14 AGG12634.1 M1RNJ8  
 trehalase (Atc1;CpATC1;CPAR2_208980) 3.2.1.28 pubmed
Candida parapsilosis CDC317 CCE43253.1 G8BDA6  
 protein α-glucosyl-1,2-β-galactosyl-L-hydroxylysine α-glucosidase (Athl1;PGGHG) 3.2.1.107 pubmed
Gallus gallus BAR88294.1
BAR88295.1
F1NZI4  
 α-glucosyl-1,2-β-galactosyl-L-hydroxylysine α-glucosidase (Athl1;PGGHG) 3.2.1.107 pubmed
Homo sapiens AAI09258.1
AAI09259.1
AAY07220.1
AEE60938.1
BAB15431.1
BAB84981.1
BAC03409.1
BAG58879.1
CAC34689.1
CAH56316.1
NP_079368.1
A0A024R1Z9
B4DJL7
Q32M88
Q8NF51
Q9H635
 
 acid trehalase (Atm1) 3.2.1.28 pubmed
Metarhizium acridum CQMA102 ABO93464.1
ABB51158.1
ABB51159.1
A9XE63
Q307Q4
 
 acid trehalase (vacuolar) (Ath1;YPR026w;YP9367.06) 3.2.1.28 pubmed
Saccharomyces cerevisiae S288c CAA89280.1
CAA58961.1
CAA95022.1
NP_015351.1
P48016  
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