Glycoside Hydrolase Family 63

Activities in Familyprocessing α-glucosidase (EC 3.2.1.106); α-1,3-glucosidase (EC 3.2.1.84); α-glucosidase (EC 3.2.1.20); mannosylglycerate α-mannosidase / mannosylglycerate hydrolase (EC 3.2.1.170)
Mechanism Inverting
ClanGH-G
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorAsp (inferred)
Statistics GenBank accession (2052); Uniprot accession (205); PDB accession (18); 3D entries (3); cryst (0)
All (1800) Archaea (3) Bacteria (1269) Eukaryota (528) Structure (3) Characterized (19)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF (fragment)   Citharoides macrolepis AGD95990.1    
 ORF (fragment)   Citharus linguatula AGD96038.1    
 ORF (fragment)   Coryphaena hippurus AGD95878.1    
 GCS1, partial (fragment)   Craterocephalus eyresii AKE13553.1    
 GCS1, partial (fragment)   Craterocephalus honoriae AKE13554.1    
 GCS1, partial (fragment)   Craterocephalus stramineus AKE13555.1    
 α-glucosidase I (partial)   Cricetulus griseus BAC80205.1 Q7TNW2  
 ORF (fragment)   Ctenopoma acutirostre AGD95937.1    
 CYME_CMF070C   Cyanidioschyzon merolae strain 10D BAM79451.1    
 CYFA0S_01e09560g   Cyberlindnera fabianii YJS4271 CDR37315.1    
 ORF (fragment)   Cyclopsetta chittendeni AGD95996.1    
 ORF (fragment)   Cynoglossus interruptus AGD95991.1    
 ORF (fragment)   Dactyloptena orientalis AGD95927.1    
 Unknown (protein for MGC:158312)   Danio rerio AAI29198.1
CAX13029.1
A1L1S8  
 DEHA0D13486g   Debaryomyces hansenii CBS767 CAG87171.1 Q6BS17  
 ORF (fragment)   Decapterus macarellus AGD95947.1    
 ORF (fragment)   Decapterus punctatus AGD95948.1    
 ORF (fragment)   Dicentrarchus labrax AGD95892.1    
 ORF (fragment)   Drepane punctata AGD95879.1    
 Dbus_chrXg267   Drosophila busckii ALC48411.1    
 CG1597   Drosophila melanogaster AAF48028.2
AAF48028.3
AAF48028.4
AAL29139.1
ABY20525.1
AFH07335.1
NP_572707.2
Q95R68
Q9VZ04
 
 ORF (fragment)   Echeneis naucratoides AGD95880.1    
 ORF (fragment)   Elagatis bipinnulata AGD95949.1    
 ORF (fragment)   Elassoma evergladei AGD95916.1    
 ORF (fragment)   Eleutheronema tetradactylum AGD95971.1    
 ORF (fragment)   Embassichthys bathybius AGD96003.1    
 gcs1a   Enchytraeus japonensis BAE93517.1 Q1MX36  
 gcs1b   Enchytraeus japonensis BAE93518.1 Q1MX35  
 ORF (fragment)   Eopsetta jordani AGD96004.1    
 ORF (fragment)   Epigonus telescopus AGD95881.1    
 ORF (fragment)   Epinephelus maculatus AGD95907.1    
 Ecym_1427   Eremothecium cymbalariae DBVPG#7215 AET37655.1    
 AFR483C   Eremothecium gossypii ATCC 10895 AAS53854.1
AAS53854.2
Q752U0  
 FAGOS_FAFR483C   Eremothecium gossypii FDAG1 AEY98167.1    
 AW171_hschr53438   Eremothecium sinecaudum ATCC 58844 AMD21486.1    
 ORF (fragment)   Etropus crossotus AGD95997.1    
 ORF (fragment)   Etropus microstomus AGD95998.1    
 FFUJ_13448   Fusarium fujikuroi IMI 58289 CCT67252.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF88883.1    
 ORF (fragment)   Gadopsis marmoratus AGD95939.1    
 ORF (fragment)   Gerres cinereus AGD95882.1    
 GCS1, partial (fragment)   Glossolepis incisus AKE13556.1    
 ORF (fragment)   Glyptocephalus zachirus AGD96005.1    
 ORF (fragment)   Gnathanodon speciosus AGD95952.1    
 ORF (fragment)   Gramma loreto AGD95883.1    
 ORF (fragment)   Gymnachirus melas AGD95980.1    
 ORF (fragment)   Gymnachirus texae AGD95981.1    
 ORF (fragment)   Haemulon sciurus AGD95884.1    
 ORF (fragment)   Haemulon vittatum AGD95885.1    
 ORF (fragment)   Halidesmus scapularis AGD95904.1    
 ORF (fragment)   Hemicaranx amblyrhynchus AGD95953.1    
 ORF (fragment)   Heteromycteris japonicus AGD96027.1    
 ORF (fragment)   Hexagrammos decagrammus AGD95928.1    
 ORF (fragment)   Hippoglossoides elassodon AGD96006.1    
 ORF (fragment)   Hippoglossus hippoglossus AGD96007.1    
 α-glucosidase (processing) (Gcs1) 3.2.1.106 Homo sapiens AAI17253.1
AAH28337.1
AAI17251.1
BAF85242.1
BAF85408.1
CAA60683.1
CAD19636.1
NP_006293.1
A8K938
Q13724
Q13724
 
 predicted protein   Hordeum vulgare subsp. vulgare BAK00788.1    
 ORF (fragment)   Howella brodiei AGD95897.1    
 ORF (fragment)   Hypoclinemus sp. GO328 AGD96031.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56438.1    
 ORF (fragment)   Hypsopsetta guttulata AGD96008.1    
 ORF (MogS)   Ictalurus punctatus AHH42042.1    
 ORF (fragment)   Indostomus paradoxus AGD95973.1    
 GCS1, partial (fragment)   Iriatherina werneri AKE13557.1    
 GCS1, partial (fragment)   Iso natalensis AKE13558.1    
 ORF (fragment)   Isopsetta isolepis AGD96009.1    
 ORF (fragment)   Istiophorus platypterus AGD95936.1    
 GCS1, partial (fragment)   Kalyptatherina helodes AKE13559.1    
 KAFR_0F03510 (Kafr0f03510)   Kazachstania africana CBS 2517 CCF58947.1    
 KNAG_0D03680 (Knag0d03680)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK70114.1    
 GCS1, partial (fragment)   Kestratherina esox AKE13560.1    
 GCS1, partial (fragment)   Kiunga ballochi AKE13561.1    
 KLLA0E10681g   Kluyveromyces lactis NRRL Y-1140 CAG99520.1 Q6CNQ6  
 KLMA_20048   Kluyveromyces marxianus DMKU3-1042 BAO38506.1    
 KMAR_20044   Kluyveromyces marxianus NBRC 1777 BAP70056.1    
 ATY40_BA7501322 (Cwh41)   Komagataella pastoris ATCC 28485 ANZ73297.1    
 PP7435_Chr1-0530   Komagataella phaffii CBS 7435 CCA36680.1    
 PAS_chr1-1_0215   Komagataella phaffii GS115 CAY67585.1
AOA66000.1
C4QWG2  
 AT249_GQ6702798 (Cwh41)   Komagataella phaffii WT AOA61544.1    
 ORF (fragment)   Kuhlia mugil AGD95886.1    
 ORF (fragment)   Kurtus gulliveri AGD95917.1    
 ORF (fragment)   Kyphosus sectatrix AGD95887.1    
 GCS1, partial (fragment)   Labidesthes sicculus AKE13562.1    
 KLTH0E07304g   Lachancea thermotolerans CBS 6340 CAR23360.1    
 ORF (fragment)   Laeops kitaharae AGD95987.1    
 ORF (fragment)   Lates japonicus AGD95965.1    
 LbrM28_V2.2400   Leishmania braziliensis MHOM/BR/75/M2904 CAM39770.1 A4HGS4  
 LDBPK_282350   Leishmania donovani BPK282A1 CBZ35640.1    
 LinJ28.2290   Leishmania infantum JPCM5 CAM69456.1    
 LmjF28.2200   Leishmania major strain Friedlin CAJ05671.1 Q4Q845  
 LMXM_28_2200   Leishmania mexicana MHOM/GT/2001/U1103 CBZ28592.1    
 LPMP_282330   Leishmania panamensis MHOM/PA/94/PSC-1 AIN99866.1    
 ORF (fragment)   Lepidopsetta bilineata AGD96010.1    
 ORF (fragment)   Lepidorhombus boscii AGD96023.1    
 ORF (fragment)   Leptobrama muelleri AGD95967.1    
 ORF (fragment)   Leptomelanosoma indicum AGD95954.1    
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX90523.1 E4ZGV3  
 ORF (fragment)   Leptosphaeria maculans JN3 v23.1.3 CBX92013.1 E5R543  
 ORF (fragment)   Leptosphaeria maculans JN3 v23.1.3 CBX98860.1 E5A5G2  
 ORF (fragment)   Lethrinus harak AGD95888.1    
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