Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (14199); Uniprot accession (1922); PDB accession (218); 3D entries (77); cryst (0)
All (12811) Archaea (93) Bacteria (10374) Eukaryota (2215) Viruses (8) unclassified (121) Structure (77) Characterized (551)
| 1 | ... | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | ... | 104 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 β-1,4-mannanase   Streptomyces sp. s6-204 ABY90130.1 B0ZSE6   8
 A6E92_09020   Streptomyces sp. S8 ARI52309.1    
 A6E92_04910   Streptomyces sp. S8 ARI51563.1     2
 A6E92_08370   Streptomyces sp. S8 ARI52190.1     51
 A8713_28445   Streptomyces sp. SAT1 ANH94624.1     18
 CAG99_11965   Streptomyces sp. SCSIO 03032 ARQ69488.1     4
 CAG99_02395   Streptomyces sp. SCSIO 03032 ARQ67834.1     8
 CAG99_24650   Streptomyces sp. SCSIO 03032 ARQ71592.1     2
 CAG99_16915   Streptomyces sp. SCSIO 03032 ARQ70300.1     19
 B6R96_09720   Streptomyces sp. Sge12 ARE74178.1     18
 B6R96_32350   Streptomyces sp. Sge12 ARE78068.1     51
 SACTE_5461   Streptomyces sp. SirexAA-E AEN13270.1     19
 SACTE_0482   Streptomyces sp. SirexAA-E AEN08423.1     2
 β-mannanase (SACTE_2347) 3.2.1.78 Streptomyces sp. SirexAA-E AEN10237.1   4FK9[A] 8
 B9S66_30290   Streptomyces sp. SM17 AWL36215.1     19
 B9S64_11350   Streptomyces sp. SM18 AWL38642.1     8
 B9S64_28810   Streptomyces sp. SM18 AWL41642.1     1
 SAMN05216371_6717   Streptomyces sp. TLI_053 SDT81587.1     18
 SAMN05216371_2675   Streptomyces sp. TLI_053 SDT52299.1    
 SAMN05216371_0646   Streptomyces sp. TLI_053 SDS80184.1     51
 BSL84_24760   Streptomyces sp. TN58 APU42518.1     18
 BSL84_03095   Streptomyces sp. TN58 APU38900.1     51
 TK78_05020   Streptomyces sp. Tue 6075 Tue6075 APS18384.1     2
 TK78_00435   Streptomyces sp. Tue 6075 Tue6075 APS17566.1     19
 TK78_09270   Streptomyces sp. Tue 6075 Tue6075 APS19128.1     51
 TK78_09870   Streptomyces sp. Tue 6075 Tue6075 APS19238.1    
 C5L38_04485   Streptomyces sp. WAC00288 AVH94409.1     40
 C5L38_10820   Streptomyces sp. WAC00288 AVH99562.1    
 C5L38_02755   Streptomyces sp. WAC00288 AVH94115.1     2
 ORF   Streptomyces sp. WAC1438 AFO53553.1     2
 D9753_01445   Streptomyces sp. Z022 AYN37844.1     8
 D9753_02700   Streptomyces sp. Z022 AYN38038.1     43
 D9753_01650   Streptomyces sp. Z022 AYN37875.1     51
 D9753_05755   Streptomyces sp. Z022 AYN38507.1     40
 D9753_04620   Streptomyces sp. Z022 AYN38326.1    
 DN051_38390   Streptomyces sp. ZFG47 AWW41785.1     2
 DN051_28545   Streptomyces sp. ZFG47 AWW42703.1     51
 DN051_07010   Streptomyces sp. ZFG47 AWW36418.1     18
 DDQ41_09690   Streptomyces spongiicola HNM0071 AWK09149.1     18
 cellulase (Cel5A)   Streptomyces thermocarboxydus C42 BAP18991.1     2
 β-mannanase (Man;StMan) 3.2.1.78 Streptomyces thermolilacinus NBRC14274 BAK26781.1   3WSU[A,B]
4Y7E[A,B]
8
 β-mannanase (ManII;StManII) 3.2.1.78 Streptomyces thermoluteus NBRC 14269 BAM62868.1     8
 SVEN_4954 (fragment)   Streptomyces venezuelae ATCC 10712 CCA58240.1    
 SVEN_6597 (fragment)   Streptomyces venezuelae ATCC 10712 CCA59883.1     40
 SVEN_6894   Streptomyces venezuelae ATCC 10712 CCA60180.1     8
 SVEN_6970   Streptomyces venezuelae ATCC 10712 CCA60256.1     2
 SVEN_6902 (fragment)   Streptomyces venezuelae ATCC 10712 CCA60188.1    
 SVEN_6905   Streptomyces venezuelae ATCC 10712 CCA60191.1     8
 BN2537_5981   Streptomyces venezuelae ATCC 15439 CUM38508.1    
 BN2537_1935   Streptomyces venezuelae ATCC 15439 CUM36485.1     2
 BN2537_14531   Streptomyces venezuelae ATCC 15439 CUM42783.1     18
 BN2537_16313   Streptomyces venezuelae ATCC 15439 CUM43674.1     51
 BN2537_1569   Streptomyces venezuelae ATCC 15439 CUM36302.1     51
 BN2537_3229   Streptomyces venezuelae ATCC 15439 CUM37132.1     40
 AQF52_7445   Streptomyces venezuelae ATCC 15439 ALO13031.1     51
 AQF52_5395   Streptomyces venezuelae ATCC 15439 ALO10989.1    
 AQF52_7272   Streptomyces venezuelae ATCC 15439 ALO12858.1     2
 AQF52_6684   Streptomyces venezuelae ATCC 15439 ALO12277.1     40
 AQF52_0493   Streptomyces venezuelae ATCC 15439 ALO06091.1     51
 AQF52_1325   Streptomyces venezuelae ATCC 15439 ALO06921.1     18
 SVTN_01005   Streptomyces vietnamensis GIM4.0001 AJF63299.1     4
 SVTN_25570   Streptomyces vietnamensis GIM4.0001 AJF67246.1    
 SVTN_32840   Streptomyces vietnamensis GIM4.0001 AJF70118.1     40
 B1H20_29330   Streptomyces violaceoruber S21 ARF65053.1     2
 B1H20_24815   Streptomyces violaceoruber S21 ARF64240.1    
 Strvi_3247   Streptomyces violaceusniger Tu 4113 AEM82935.1     19
 Strvi_4282   Streptomyces violaceusniger Tu 4113 AEM83933.1     43
 Strvi_5490   Streptomyces violaceusniger Tu 4113 AEM85012.1     8
 Strvi_8131   Streptomyces violaceusniger Tu 4113 AEM87454.1     40
 Strvi_8930   Streptomyces violaceusniger Tu 4113 AEM88231.1     1
 Strvi_3249   Streptomyces violaceusniger Tu 4113 AEM82937.1     51
 SXIM_41680   Streptomyces xiamenensis 318 AKG45552.1    
 SXIM_49970   Streptomyces xiamenensis 318 AKG46381.1     4
 SXIM_49310   Streptomyces xiamenensis 318 AKG46315.1     8
 SXIM_16110   Streptomyces xiamenensis 318 AKG42995.1     2
 Sros_0934   Streptosporangium roseum DSM 43021 ACZ83938.1 D2B807   8
 Sros_1713   Streptosporangium roseum DSM 43021 ACZ84704.1 D2AS25   28
 Sros_5000   Streptosporangium roseum DSM 43021 ACZ87799.1 D2B8I9   18
 Sros_5302   Streptosporangium roseum DSM 43021 ACZ88069.1 D2BC46   43
 DKM19_18775   Streptosporangium sp. caverna AWS43115.1     22
 DKM19_10005   Streptosporangium sp. caverna AWS41636.1     22
 DKM19_02670   Streptosporangium sp. caverna AWS40401.1     1
 DKM19_02655   Streptosporangium sp. caverna AWS40398.1     8
 BXT84_03210   Sulfobacillus thermotolerans Kr AUW93080.1     19
 SCL_1792   Sulfuricaulis limicola HA5 BAV34090.1     1
 NIES970_21890   Synechococcus sp. NIES-970 BAW97238.1     39
 Syn6312_0711   Synechococcus sp. PCC 6312 AFY59930.1     39
 Sgly_1611   Syntrophobotulus glycolicus DSM 8271 ADY55909.1     25
 Swol_1899   Syntrophomonas wolfei subsp. wolfei str. Goettingen G311 ABI69196.1 Q0AVQ8  
 Slip_0761   Syntrophothermus lipocalidus DSM 12680 ADI01541.1 D7CLF6  
 C1A40_07415   Tamlana sp. UJ94 AUS05313.1     5
 C1A40_02195   Tamlana sp. UJ94 AUS04354.1     4
 BCB71_04995   Tannerella sp. oral taxon HOT-286 str. W11667 AOH40543.1    
 C7123_12510   Tannerella sp. oral taxon HOT-286 W11666 AVV54443.1    
 LMI_2047   Tatlockia micdadei ATCC33218 CEG61331.1    
 B6N58_05815   Tatlockia micdadei NZ2015 ARG97215.1    
 B6V88_08870   Tatlockia micdadei NZ2016 ARH00527.1    
 AUW17_07165   Tenacibaculum dicentrarchi AY7486TD ALU76135.1     42
 TJEJU_2824   Tenacibaculum jejuense KCTC 22618 SNR16498.1     42
 TJEJU_3613   Tenacibaculum jejuense KCTC 22618 SNR17256.1     7
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