Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (12437); Uniprot accession (1922); PDB accession (212); 3D entries (75); cryst (0)
All (11057) Archaea (67) Bacteria (8798) Eukaryota (2066) Viruses (6) unclassified (120) Structure (75) Characterized (547)
| 1 | ... | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 |
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 XFC3_12195   Xylella fastidiosa 3124 ALQ98004.1     5
 XFC3_10855   Xylella fastidiosa 3124 ALQ97780.1     1
 endoglucanase (XF2708;EGL) Xylella fastidiosa 9a5c AAF85505.1
Q9PA12   5
 endoglucanase (XF0818) Xylella fastidiosa 9a5c AAF83628.1
Q9PF60   1
 endoglucanase (XF0810;EngXCA)   Xylella fastidiosa 9a5c AAF83620.1
 XFFB_09805   Xylella fastidiosa Fb7 ALR09440.1     5
 XFFB_11575   Xylella fastidiosa Fb7 ALR09719.1     1
 XFFB_11555   Xylella fastidiosa Fb7 ALR09716.1    
 XFHB_11215   Xylella fastidiosa Hib4 ALR07320.1     1
 XFHB_12560   Xylella fastidiosa Hib4 ALR07544.1     5
 OY18_11165   Xylella fastidiosa J1a12 ALR02660.1    
 OY18_11145   Xylella fastidiosa J1a12 ALR02657.1     1
 OY18_12500   Xylella fastidiosa J1a12 ALR02884.1     5
 Xfasm12_2037   Xylella fastidiosa M12 ACA12903.1 B0U4Y6  
 Xfasm12_2256   Xylella fastidiosa M12 ACA13105.1 B0U633   5
 XfasM23_2164   Xylella fastidiosa M23 ACB93560.1 B2IAC4   5
 XfasM23_1958   Xylella fastidiosa M23 ACB93357.1 B2I9A2  
 XfasM23_1953   Xylella fastidiosa M23 ACB93352.1 B2I997   1
 P303_00560   Xylella fastidiosa MUL0034 AIC11831.1    
 P303_12205   Xylella fastidiosa MUL0034 AIC13381.1     5
 P303_00585   Xylella fastidiosa MUL0034 AIC13500.1     1
 XFPR_10465   Xylella fastidiosa Pr8x ALR04981.1     1
 XFPR_10485   Xylella fastidiosa Pr8x ALR04984.1    
 XFPR_11535   Xylella fastidiosa Pr8x ALR05162.1     5
 XFLM_03715   Xylella fastidiosa subsp. fastidiosa GB514 ADN62717.1 E1RM63   1
 XFLM_03740   Xylella fastidiosa subsp. fastidiosa GB514 ADN62722.1 E1RM68  
 XFLM_04820   Xylella fastidiosa subsp. fastidiosa GB514 ADN62924.1 E1RN74   5
 B9J09_10430   Xylella fastidiosa subsp. pauca De Donno ARO69370.1    
 B9J09_10405   Xylella fastidiosa subsp. pauca De Donno ARO69366.1     1
 B9J09_11560   Xylella fastidiosa subsp. pauca De Donno ARO69549.1     5
 D934_00505   Xylella fastidiosa subsp. sandyi Ann-1 AIC09172.1     5
 D934_13125   Xylella fastidiosa subsp. sandyi Ann-1 AIC10796.1    
 D934_13100   Xylella fastidiosa subsp. sandyi Ann-1 AIC11675.1     1
 endo-β-1,4-glucanase (EngXCA;PD1851)   Xylella fastidiosa Temecula1 AAO29683.1
Q87AH4   1
 PD2061 (Egl)   Xylella fastidiosa Temecula1 AAO29885.1
Q879X8   5
 PD1856 (EngXCA)   Xylella fastidiosa Temecula1 AAO29688.1
 XFUD_11760   Xylella fastidiosa U24D ALQ95697.1     5
 XFUD_03465   Xylella fastidiosa U24D ALQ94365.1     1
 XFUD_03445   Xylella fastidiosa U24D ALQ94362.1    
 YE5303_39551   Yersinia enterocolitica (type O:5) str. YE53/03 CCQ42663.1     41
 CH48_1562   Yersinia enterocolitica 2516-87 AJJ26572.1     41
 CH49_3561   Yersinia enterocolitica 8081 AJJ24411.1     41
 LI89_21365   Yersinia enterocolitica FORC-002 ALG47177.1     41
 FORC2_0075   Yersinia enterocolitica FORC_002 AKF36222.1     41
 XM56_00345   Yersinia enterocolitica KNG22703 ALG76969.1     41
 YE4100   Yersinia enterocolitica subsp. enterocolitica 8081 CAL14117.1 A1JSX4   41
 YE105_C3829   Yersinia enterocolitica subsp. palearctica 105.5R(r) ADZ44323.1     41
 Y11_43230   Yersinia enterocolitica subsp. palearctica Y11 CBY29448.1     41
 YEW_DY16990   Yersinia enterocolitica W22703 CBX73276.1     41
 CH47_3631   Yersinia enterocolitica WA AJI82535.1     41
 BB936_00380   Yersinia enterocolitica YE165 AOF13160.1     41
 CRN75_14165   Yersinia frederiksenii FDAARGOS_418 ATM96404.1     41
 AW19_2483   Yersinia frederiksenii Y225 AJI87395.1     13
 CH53_3461   Yersinia intermedia Y228 AJJ21305.1     13
 DJ57_73   Yersinia kristensenii ATCC 33639 AIN17485.1     13
 CH54_3304   Yersinia kristensenii Y231 AJJ35271.1     13
 M486_2154   Yersinia pestis 1045 AKT02463.1     13
 M478_2212   Yersinia pestis 2944 AKS63812.1     13
 M477_3237   Yersinia pestis 790 AKS84007.1     13
 A1122_01260   Yersinia pestis A1122 AEL70935.1
 YPA_3393   Yersinia pestis Antiqua ABG15355.1
Q1C2G7   13
 YPC_0794   Yersinia pestis biovar Medievalis str. Harbin 35 ADV97486.1     13
 YP3444   Yersinia pestis biovar Microtus str. 91001 AAS63604.1
 BAY22_02465   Yersinia pestis Cadman ANW12914.1     13
 AK38_1817   Yersinia pestis CO92 AJJ90027.1     13
 YPD4_0658   Yersinia pestis D106004 ACY57567.1 D0JFL3   13
 YPD8_0658 (fragment)   Yersinia pestis D182038 ACY61348.1 D0JQ35   13
 CH61_3449   Yersinia pestis Dodson AJJ32882.1     13
 CH46_162   Yersinia pestis El Dorado AJJ16012.1     13
 CH55_3543   Yersinia pestis Harbin35 AJK07828.1     13
 CH62_3904   Yersinia pestis Java9 AJJ39389.1     13
 Y3438 (probable fragment)   Yersinia pestis KIM10+ AAM86987.1
 CH44_2037   Yersinia pestis KIM5 AKB89791.1     13
 CH45_128   Yersinia pestis Nairobi AJK20368.1     13
 YPN_3196   Yersinia pestis Nepal516 ABG19523.1 Q1CEQ7   13
 CH63_1298   Yersinia pestis Nicholisk 41 AJJ45062.1     13
 CH59_1109   Yersinia pestis PBM19 AJI90819.1     13
 BZ15_2819   Yersinia pestis Shasta AJJ50222.1     13
 CH60_3341   Yersinia pestis str. Pestoides B AJK12567.1     13
 BZ23_2830   Yersinia pseudotuberculosis 1 AJJ71713.1     13
 DJ40_3168   Yersinia pseudotuberculosis ATCC 6904 AIN15627.1     13
 BZ20_2845   Yersinia pseudotuberculosis EP2/+ AJJ08646.1     13
 YpsIP31758_0708   Yersinia pseudotuberculosis IP 31758 ABS49253.1 A7FEL9   13
 YPTB3269   Yersinia pseudotuberculosis IP 32953 CAH22507.1     13
 BZ17_3341   Yersinia pseudotuberculosis IP 32953 AJJ55811.1     13
 BZ21_2549   Yersinia pseudotuberculosis MD67 AJJ02299.1     13
 YPTS_3405   Yersinia pseudotuberculosis PB1/+ ACC90360.1
B2K1I7   13
 BZ19_2675   Yersinia pseudotuberculosis str. PA3606 AJK15186.1     13
 YPK_0780   Yersinia pseudotuberculosis YPIII ACA67081.1
B1JMZ8   13
 CH64_1914   Yersinia rohdei YRA AJJ09410.1     13
 BF17_03365   Yersinia similis CCUG 52882 AHK18490.1     13
 AZF00_16475   Zhongshania aliphaticivorans SM2 AMO69798.1    
 zobellia_208 (EngA)   Zobellia galactanivorans DsiJT CAZ94281.1     4
 zobellia_2986   Zobellia galactanivorans DsiJT CAZ97132.1     42
 zobellia_3703 (BglC)   Zobellia galactanivorans DsiJT CAZ97841.1     2
 ZPR_1048   Zunongwangia profunda SM-A87 ADF51393.1 D5BI05   42
 ZPR_3478   Zunongwangia profunda SM-A87 ADF53794.1 D5BJU6  
 ZPR_4337   Zunongwangia profunda SM-A87 ADF54639.1 D5BB99   13

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