Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13367); Uniprot accession (1922); PDB accession (214); 3D entries (76); cryst (0)
All (11985) Archaea (92) Bacteria (9640) Eukaryota (2127) Viruses (6) unclassified (120) Structure (76) Characterized (549)
| 1 | ... | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | ... | 97 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 SBI_00359 (fragment)   Streptomyces bingchenggensis BCW-1 ADI03480.1 D7BYF2   4
 SBI_02918   Streptomyces bingchenggensis BCW-1 ADI06039.1 D7C4I8   19
 SCAT_p0083   Streptomyces cattleya NRRL 8057 = DSM 46488 CCB71109.1     40
 SCAT_p1024   Streptomyces cattleya NRRL 8057 = DSM 46488 CCB72048.1     18
 SCATT_p07120   Streptomyces cattleya NRRL 8057 = DSM 46488 AEW98905.1     18
 SCATT_p16620   Streptomyces cattleya NRRL 8057 = DSM 46488 AEW99855.1     40
 CVT27_23580   Streptomyces cavourensis 1AS2a ATY98106.1    
 CVT27_28035   Streptomyces cavourensis 1AS2a ATY98913.1     2
 BB341_00650   Streptomyces clavuligerus F613-1 ANW21741.1     2
 SCO0457 or SCF51A.35   Streptomyces coelicolor A3(2) CAB56687.1
NP_624777.1
Q9RL30   19
 SCO0949 or SCM11.04c   Streptomyces coelicolor A3(2) CAB61915.1
NP_625246.1
Q9RIV7   18
 SCO6234 (ManA2;SC2H4.16)   Streptomyces coelicolor A3(2) CAA20610.1
NP_630335.1
O86599   8
 SCO0554 (ManA;SCF11.34c)   Streptomyces coelicolor A3(2) CAD55266.1
CAB57406.1
CAB59611.1
NP_733506.1
Q8CK53   8
 SCO7637 or SC10F4.10c   Streptomyces coelicolor A3(2) CAC16970.1
NP_631677.1
Q9F3Q0   2
 B446_31815   Streptomyces collinus Tu 365 AGS73167.1     18
 B446_00590   Streptomyces collinus Tu 365 AGS66958.1    
 B446_30100 (probable fragment)   Streptomyces collinus Tu 365 AGS72824.1     40
 B446_32895   Streptomyces collinus Tu 365 AGS73383.1     43
 B446_34700   Streptomyces collinus Tu 365 AGS73736.1    
 TU94_26220   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP04440.1     2
 TU94_04450   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP00836.1     8
 BN159_0466 (Celb1)   Streptomyces davaonensis JCM 4913 CCK24845.1     4
 BN159_1009   Streptomyces davaonensis JCM 4913 CCK25388.1     43
 BN159_1272   Streptomyces davaonensis JCM 4913 CCK25651.1     2
 BN159_1456   Streptomyces davaonensis JCM 4913 CCK25835.1     18
 BN159_2662   Streptomyces davaonensis JCM 4913 CCK27041.1     51
 BN159_5046   Streptomyces davaonensis JCM 4913 CCK29425.1     8
 KY5_5124   Streptomyces formicae KY5 ATL30142.1     28
 KY5_7386   Streptomyces formicae KY5 ATL32404.1     18
 β-1,4-mannase   Streptomyces fradiae k11 ADK91084.1     8
 SFUL_5095   Streptomyces fulvissimus DSM 40593 AGK79989.1    
 SFUL_6132   Streptomyces fulvissimus DSM 40593 AGK81015.1     2
 B1H19_05605   Streptomyces gilvosporeus F607 ARF53723.1    
 B1H19_36315   Streptomyces gilvosporeus F607 ARF58923.1     18
 SGLAU_02095   Streptomyces glaucescens GLA.O AIR96447.1    
 SGLAU_25530   Streptomyces glaucescens GLA.O AIS01044.1     8
 SGLAU_28405   Streptomyces glaucescens GLA.O AIS01618.1     8
 SGLAU_30920 (CelA)   Streptomyces glaucescens GLA.O AIS02118.1     2
 WQO_33325   Streptomyces globisporus C-1027 ALU97802.1     19
 WQO_24910   Streptomyces globisporus C-1027 ALU96278.1     51
 WQO_28580   Streptomyces globisporus C-1027 ALU96942.1     2
 WQO_24285   Streptomyces globisporus C-1027 ALU96161.1    
 DIJ69_09380   Streptomyces globisporus TFH56 AWL86138.1    
 DIJ69_04765   Streptomyces globisporus TFH56 AWL85329.1     2
 DIJ69_08750   Streptomyces globisporus TFH56 AWL86031.1     51
 DIJ69_00295   Streptomyces globisporus TFH56 AWL84539.1     19
 AVL59_16115   Streptomyces griseochromogenes ATCC 14511 ANP56544.1     18
 AVL59_19435   Streptomyces griseochromogenes ATCC 14511 ANP51490.1     51
 AVL59_17735   Streptomyces griseochromogenes ATCC 14511 ANP51215.1     43
 chitosanase II (ChoII) 3.2.1.132 Streptomyces griseus HUT 6037 BAC65342.1 Q83VL5   2
 SGR_1341 (ChoII)   Streptomyces griseus subsp. griseus NBRC 13350 BAG18170.1 B1VVI6   2
 SGR_2234   Streptomyces griseus subsp. griseus NBRC 13350 BAG19063.1 B1W138  
 SHJG_0530   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY85807.1     18
 SHJG_7499 (partial)   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY92766.1     40
 SHJG_7711   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY92978.1    
 SHJG_8384   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY93649.1     51
 SHJGH_8145   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF67807.1     51
 SHJGH_7473   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF67135.1    
 SHJGH_0363   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF60029.1     18
 SHJGH_7259   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF66921.1     40
 SHL15_8397   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO99347.1     18
 SHL15_6376   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO97412.1     40
 SHL15_7292   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO98301.1     51
 SHL15_6577   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO97609.1    
 SHXM_01100   Streptomyces hygroscopicus XM201 AQW47637.1     8
 SHXM_09064   Streptomyces hygroscopicus XM201 AQW55601.1     43
 SHXM_05206   Streptomyces hygroscopicus XM201 AQW51743.1     1
 SHXM_02183   Streptomyces hygroscopicus XM201 AQW48720.1     51
 SHXM_04453   Streptomyces hygroscopicus XM201 AQW50990.1     40
 SHXM_02185   Streptomyces hygroscopicus XM201 AQW48722.1     19
 ABB07_02795   Streptomyces incarnatus NRRL 8089 AKJ08988.1     43
 ABB07_03975   Streptomyces incarnatus NRRL 8089 AKJ09211.1     18
 SIRAN5394   Streptomyces iranensis CDR08747.1     1
 SIRAN1856   Streptomyces iranensis CDR04864.1     19
 SIRAN836   Streptomyces iranensis CDR02600.1     43
 SIRAN1854   Streptomyces iranensis CDR04855.1     51
 SIRAN6226   Streptomyces iranensis CDR09620.1     40
 SIRAN8881   Streptomyces iranensis CDR16057.1     8
 SLA_5106   Streptomyces laurentii ATCC 31255 BAU85988.1    
 SLA_6677   Streptomyces laurentii ATCC 31255 BAU87543.1     51
 SLA_0107   Streptomyces laurentii ATCC 31255 BAU81062.1     40
 SLAV_33160   Streptomyces lavendulae subsp. lavendulae CCM 3239 ATZ28404.1     51
 SLAV_36905   Streptomyces lavendulae subsp. lavendulae CCM 3239 ATZ29146.1    
 SLAV_02485   Streptomyces lavendulae subsp. lavendulae CCM 3239 ATZ22421.1     51
 SLAV_11005   Streptomyces lavendulae subsp. lavendulae CCM 3239 ATZ24069.1     18
 Sle_14000   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR60862.1     8
 Sle_15630   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR61025.1     2
 Sle_59560   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR65412.1     8
 Sle_18090   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR61271.1     40
 SLINC_1228   Streptomyces lincolnensis NRRL 2936 ANS63452.1     8
 SLINC_0697   Streptomyces lincolnensis NRRL 2936 ANS62921.1     4
 SLINC_7771   Streptomyces lincolnensis NRRL 2936 ANS69995.1     43
 SLINC_8289 (fragment)   Streptomyces lincolnensis NRRL 2936 ANS70513.1     4
 SLINC_6472   Streptomyces lincolnensis NRRL 2936 ANS68696.1     18
 SLINC_3798   Streptomyces lincolnensis NRRL 2936 ANS66022.1     1
 SLINC_8278   Streptomyces lincolnensis NRRL 2936 ANS70502.1     4
 β-mannanase (ManA;SlMan) 3.2.1.78 Streptomyces lividans 1326 AAA26710.2 P51529   8
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Streptomyces lividans 1326   P27035   2
 SLIV_33190   Streptomyces lividans TK24 AIJ17522.1     18
 SLIV_35170   Streptomyces lividans TK24 AIJ17911.1     8
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