Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11450); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10074) Archaea (67) Bacteria (7903) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 ASAC_0734   Acidilobus saccharovorans 345-15 ADL19140.1 D9Q1F2   19
 SE86_04550 (fragment)   Acidilobus sp. 7A AMD30698.1     19
 SE86_03690 (fragment)   Acidilobus sp. 7A AMD30586.1     19
 SE86_03695 (fragment)   Acidilobus sp. 7A AMD30587.1     19
 QT06_C0001G0664   archaeon GW2011_AR15 AJF61504.1     13
 Cmaq_0936   Caldivirga maquilingensis IC-167 ABW01768.1 A8MDB2   19
 NMY3_02071   Candidatus Nitrocosmicus oleophilus MY3 ALI36272.1    
 CSP5_0161   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM33477.1     19
 cellulase (EBI-244) 3.2.1.4 Desulfurococcaceae archaeon EBI-244 AEB53062.1    
 HTIA_1529   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33656.1    
 HTIA_2116   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ34230.1    
 HTIA_2117   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ34231.1    
 HTIA_2121   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ34235.1    
 HTIA_2123   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ34237.1    
 HTIA_0485   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ32630.1    
 Huta_2398   Halorhabdus utahensis DSM 12940 ACV12564.1 C7NMC5  
 Huta_2396   Halorhabdus utahensis DSM 12940 ACV12562.1 C7NMC3   7
 Huta_2388   Halorhabdus utahensis DSM 12940 ACV12554.1 C7NVN1  
 Huta_2395   Halorhabdus utahensis DSM 12940 ACV12561.1 C7NMC2  
 Huta_2393   Halorhabdus utahensis DSM 12940 ACV12559.1 C7NVN6  
 Huta_0302   Halorhabdus utahensis DSM 12940 ACV10489.1 C7NQN0  
 Huta_2394   Halorhabdus utahensis DSM 12940 ACV12560.1 C7NMC1  
 cellulase / cellobiohydrolase (Hu-CBH1;Huta_2387) 3.2.1.- Halorhabdus utahensis DSM 12940 ACV12553.1    
 HALLA_01325   Halostagnicola larsenii XH-48 AHG01968.1    
 Htur_4673   Haloterrigena turkmenica DSM 5511 ADB63456.1 D2S259   7
 Htur_4674   Haloterrigena turkmenica DSM 5511 ADB63457.1 D2S260  
 Htur_2510   Haloterrigena turkmenica DSM 5511 ADB61387.1 D2RVV8  
 Igag_0312   Ignisphaera aggregans DSM 17230 ADM27158.1 E0SQT4   19
 Igag_0570   Ignisphaera aggregans DSM 17230 ADM27405.1 E0SSD3   1
 Igag_0224   Ignisphaera aggregans DSM 17230 ADM27073.1 E0SQC3   1
 PTO1452   Picrophilus torridus DSM 9790 AAT44037.1 Q6KZ15   19
 endo-β-1,4-glucanase (EglB;TCel4;PAB0632) 3.2.1.4 Pyrococcus abyssi GE5 CAB49854.1
AEG76944.1
NP_126623.1
Q9V052   1
 endo-β-1,4-glucanase (EGPh;EglB;TCel3;PH1171) 3.2.1.4 Pyrococcus horikoshii OT3 AAQ31833.1
AAQ31832.1
BAA30271.1
NP_143072.1
O58925 2ZUM[A]
2ZUN[A,B,C]
3AXX[A,B,C]
3QHM[A,B,C]
3QHN[A,B,C]
3QHO[A,B,C]
3VVG[A,B,C]
3W6L[A,B,C]
3W6M[A,B,C]
4DM1[A,B,C]
4DM2[A,B,C]
1
 Py04_1787   Pyrococcus sp. ST04 AFK23355.1     1
 L593_05380   Salinarchaeum sp. Harcht-Bsk1 AGN01025.1     7
 L593_12875   Salinarchaeum sp. Harcht-Bsk1 AGN02514.1    
 L593_12880   Salinarchaeum sp. Harcht-Bsk1 AGN02515.1    
 L593_12885   Salinarchaeum sp. Harcht-Bsk1 AGN02516.1    
 Shell_0798   Staphylothermus hellenicus DSM 12710 ADI31911.1 D7D815   1
 SiH_2292   Sulfolobus islandicus HVE10/4 ADX83632.1     19
 LD85_2652   Sulfolobus islandicus L.D.8.5 ADB88268.1 D2PGC8   19
 LS215_2522   Sulfolobus islandicus L.S.2.15 ACP36477.1 C3ML75   19
 SiL_2199   Sulfolobus islandicus LAL14/1 AGJ63637.1     19
 M1425_2350   Sulfolobus islandicus M.14.25 ACP39078.1 C3MSD5   19
 M1627_2428   Sulfolobus islandicus M.16.27 ACP56280.1 C3N1Q3   19
 M164_2357   Sulfolobus islandicus M.16.4 ACR42955.1 C4KL74   19
 SiRe_2238   Sulfolobus islandicus REY15A ADX86291.1     19
 YG5714_2494   Sulfolobus islandicus Y.G.57.14 ACP46730.1 C3NAD7   19
 YN1551_0410   Sulfolobus islandicus Y.N.15.51 ACP47578.1 C3NL64   19
 Ssol98_010100014313   Sulfolobus solfataricus 98/2 AET42931.1     19
 SULC_0786   Sulfolobus solfataricus 98/2 SULC AKA75856.1     19
 SSOP1_3102   Sulfolobus solfataricus P1 SAI86656.1     19
 SSO3007   Sulfolobus solfataricus P2 CAC24030.1
AAK43109.1
NP_344319.1
Q97UK4   19
 SULA_0786   Sulfolobus solfataricus SULA AKA78548.1     19
 SULB_0788   Sulfolobus solfataricus SULB AKA73158.1     19
 BFU36_07080   Sulfolobus sp. A20 AOL16496.1     19
 A3L01_06720   Thermococcus barossii SHCK-94 ASJ05073.1    
 CHITON_2145   Thermococcus chitonophagus DSM 10152 CUX78924.1     1
 A3L04_02950   Thermococcus chitonophagus GC74 ASJ17552.1     1
 TES1_1923   Thermococcus paralvinellae ES1 AHF81298.1    
 ADU37_CDS22600   Thermococcus sp. 2319x1 ALV63957.1     1
 CDI07_06685   Thermococcus sp. 5-4 ASA77995.1    
 Tpen_1672   Thermofilum pendens Hrk 5 ABL79067.1 A1S0T7   19
 TVG0696003   Thermoplasma volcanium GSS1 BAB59829.1
NP_111209.1
Q97AX2   19
 TUZN_0393   Thermoproteus uzoniensis 768-20 AEA11889.1     19
 Sequence 2 from patent US 6329187 (fragment)   unidentified archaeon AEPII1a AAQ77850.1     1
 Vdis_1602   Vulcanisaeta distributa DSM 14429 ADN50980.1 E1QTR3   19
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