Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | ... | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 Sequence 314 from patent US 7241613   unidentified ABU33875.1     9
 Sequence 380 from patent US 7241613   unidentified ABU33941.1     9
 β-glucanase (RR.01;RR.01-2) 3.2.1.- unidentified microorganism CAJ19135.1 Q2YI68   4
 glucanase (RR.02-2;BglC) 3.2.1.- unidentified microorganism CAJ19139.1 Q2YI64   4
 β-glucanase (RR.06;RR.06-1;BglC) 3.2.1.- unidentified microorganism CAJ19140.1 Q2YI63   4
 glucanase (RR.10;RR.10-1) 3.2.1.- unidentified microorganism CAJ19146.1 Q2YI57   4
 endoglucanase (RR.13;RR.13-2) 3.2.1.- unidentified microorganism CAJ19149.1 Q2YI54   2
 glucanase (RR.14;RR.14-2) (Cel5A) 3.2.1.4 unidentified microorganism CAJ19151.1 Q2YI52   4
 endo-β-1,4-glucanase (UmCel28;CC1) 3.2.1.4 unidentified microorganism ABX76045.1 A9UGW1   4
 endoglucanase (UmCelE2;EC2) 3.2.1.4 unidentified microorganism ABX76046.1 A9UGW2   4
 endoglucanase (UmCelS15;SC1) (fragment) 3.2.1.4 unidentified microorganism ABX76048.1 A9UGW4   4
 endoglucanase (UmCelC23;CC2) 3.2.1.4 unidentified microorganism ABX76050.1 A9UGW6   4
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 PEp14_00015 (CeL)   Erwinia phage PEp14 AEY69604.1     1
 glycoside hydrolase   Erwinia phage vB_EamP-S6 AEJ81614.1     1
 SopranoGao_18   Klebsiella phage SopranoGao ASV45041.1     1
 POR1_70   Pseudomonas phage POR1 ALH46275.1    
 SKUL_18   Pseudomonas phage Skulduggery ARV77117.1     1
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