Glycoside Hydrolase Family 5 / Subf 9

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (591); Uniprot accession (79); PDB accession (13); 3D entries (2); cryst (0)
Eukaryota
Protein Name EC# OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 exo-β-1,3-glucanase (Xog;Xog1;Exg;Ca49c10.05) 3.2.1.58 Candida albicans CAA39908.1
AAV05307.1
CAA21969.1
P29717
1CZ1[A] 1.85
1EQC[A] <carb_like_CTS>
1.85
1EQP[A] 1.90
2PB1[A] α-D-Glcp2F-(1-4)-GLU
β-D-Glcp2F-(1-1)-<non_carb>
1.90
2PBO[A] 1.85
2PC8[A] β-D-Glcp
1.80
2PF0[A] 1.90
3N9K[A] β-D-Glcp-(1-3)-β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.70
3O6A[A] 2.00
4M80[A] 1.86
4M81[A] α-D-Glcp1F
β-D-Glcp-(1-1)-<non_carb>
1.86
4M82[A] β-D-Glcp
β-D-Glcp-(1-6)-β-D-Glcp-(1-1)-<non_carb>
1.59
9
 exo-β-1,3-glucanase 1 / flavonoid β-glucosidase (Exg1;Bgl1;Scw6;YLR300W) 3.2.1.21
3.2.1.58
Saccharomyces cerevisiae S288c AAA34599.1
AAB67345.1
AAT93088.1
NP_013403.1
P23776
1H4P[A,B] 1.75
9
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