Glycoside Hydrolase Family 5 / Subf 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (3516); Uniprot accession (276); PDB accession (20); 3D entries (9); cryst (0)
All (3119) Bacteria (2943) Eukaryota (174) unclassified (2) Structure (9) Characterized (60)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 FFUJ_11390   Fusarium fujikuroi IMI 58289 CCT75371.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Fusarium graminearum 0656-004 2 A WA/MF06-059 CDL74336.1     5
 unnamed protein product   Fusarium graminearum PH-1 CEF73786.1     5
 endo-β-1,4-glucanase (FgCel5A;FGSG_03795;FG03795) (Cel5A)   Fusarium graminearum PH-1 CEF78665.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Fusarium solani 0610-001 2 A WA/MF06-071 CDL74337.1     5
 β-1,4-endoglucanase (GlCel5A;GL28282) (Cel5A) 3.2.1.4 Ganoderma lucidum     5D8W[A,B]
5D8Z[A,B]
5
 endo-β-1,4-glucanase (Cel5G) (Cel5G)   Gloeophyllum trabeum AEJ35166.1     5
 endo-β-1,4-glucanase (GtCel5A) (Cel5A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 ADH51728.1 D7REW1
P84194
  5
 ORF (fragment)   Gloeoporus dichrous 133/Gd CDL74355.1     5
 glycoside hydrolase family 5 endoglucanase, partial (Glu-1) (fragment)   Grifola frondosa 136 CDL74353.1
CDL74354.1
    5
 ORF (fragment)   Heterobasidion annosum FB-HA-37 CDL74347.1     5
 predicted protein   Hordeum vulgare subsp. vulgare BAK01092.1     5
 endo-β-1,4-glucanase 3 (CMC3;Egl2) 3.2.1.4 Humicola grisea var. thermoidea IFO9854 BAA12676.1     5
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Hypholoma sp. 150 150/K 107 CDL74350.1     5
 endoglucanase II (EgII)   Hypocrea orientalis EU7-22 AFD50195.1     5
 ORF   Hypocrella siamensis MTCC 10142 ANH56493.1     5
 cellulase   Inonotus hispidus Haeb08 AIY53679.1     5
 endoglucanase (EG)   Inonotus obliquus JL01 AMK37824.1     5
 endoglucanase (Cen1;En-1) 3.2.1.4 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX91913.1 E5R4E5   5
 endocellulase (Cel5A)   Leucoagaricus gongylophorus Ae322 CDJ79817.1     5
 endocellulase (Cel5B)   Leucoagaricus gongylophorus Ae322 CDJ79818.1     5
 EgL (fragment)   Limacella glischra AEQ58911.1     5
 EgL (fragment)   Limacella illinita AEQ58912.1     5
 endo-β-1,4-glucanase 1 (Egl1) 3.2.1.4 Macrophomina phaseolina AAB51451.1 Q12638   5
 endo-β-1,4-glucanase 2 (Egl2) 3.2.1.4 Macrophomina phaseolina AAB03889.1 Q12637   5
 MG00319.4   Magnaporthe oryzae 70-15 XP_368925.1 G4NCZ5   5
 MG10083.4   Magnaporthe oryzae 70-15 XP_365863.1 G4N908   5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Marasmius oreades FB-MO-71 CDL74348.1     5
 ORF (fragment)   Microdochium bolleyi 0629-022 2 WA/MF06-285 CDL74339.1     5
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1
Q7SDR1   5
 endo-β-1,4-glucanase (EGb1;EGb2) (Cel5C) 3.2.1.4 Penicillium brasilianum IBT 20888 ACB06750.1 B8Q961   5
 endo-β-1,4-glucanase (Egl1)   Penicillium crustosum 601 AHA15977.1     5
 endoglucanase II / 5A (Eg2;Egl2) (Cel5A) 3.2.1.4 Penicillium decumbens 114-2 / JU-A10 ABY28340.1 A9Z054   5
 endoglucanase/cellulase 1   Penicillium digitatum Pd01 AFV30215.1     5
 endoglucanase 1 (Egl1;Pe-Egl1) (partial) 3.2.1.4 Penicillium echinulatum 9A01S2 ACR82487.1 C5J4L7   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 Penicillium janthinellum Biourge IMET 43733 (C41) CAA61740.1 Q12665   5
 endo-β-1,4-glucanase 5   Penicillium oxalicum GZ-2 AIO06744.1     5
 Pc18g06080   Penicillium rubens Wisconsin 54-1255 CAP94832.1 B6HCI5   5
 Pc20g01940   Penicillium rubens Wisconsin 54-1255 CAP85523.1 B6HE68   5
 Pc22g19230   Penicillium rubens Wisconsin 54-1255 CAP99211.1 B6HVQ6   5
 glycoside hydrolase family 5 endoglucanase, partial (Glu-1) (fragment)   Penicillium sp. 0728-003 B PDA/MF07-022 CDL74340.1     5
 glycoside hydrolase family 5 endoglucanase, partial (Glu-2) (fragment)   Penicillium sp. 0728-003 B PDA/MF07-022 CDL74341.1     5
 endoglucanase (Cel5A) 3.2.1.4 Pestalotiopsis sp. AN 7 BAI66446.1 D2KTU9   5
 endoglucanase (Cel5A) (Cel5A)   Phanerochaete chrysosporium AAU12275.2
AAU12275.1
Q66NB7   5
 endo-β-1,4-glucanase (EgG5) 3.2.1.4 Phialophora sp. G5 / CGMCC 3328 ADZ44606.1     5
 ORF (fragment)   Phoma sp. 0729-001 C PDA/MF07-028 CDL74342.1     5
 EgL (fragment)   Pluteus cervinus AEQ58913.1     5
 EgL (fragment)   Pluteus petasatus AEQ58915.1     5
 Pa_1_5990   Podospora anserina S mat+ CAP60294.1
CDP22932.1
B2AB32   5
 unnamed protein product   Podospora anserina S mat+ CAP61800.1
CDP28876.1
B2AED4   5
 unnamed protein product   Podospora anserina S mat+ CAP73319.1
CDP25722.1
B2B694   5
 endoglucanase III (Cel4;EGIII)   Polyporus arcularius 69B-8 BAF75943.1 A7M6Q1   5
 endo-β-1,4-glucanase (PpCel5A) (Cel5A) 3.2.1.4 Postia placenta Mad-698-R ADH51729.1 D7REW2   5
 endo-β-1,4-glucanase (PpCel5B) (Cel5B) 3.2.1.4 Postia placenta Mad-698-R XP_002475436.1
ADH51730.1
D7REW3   5
 broad specificity endo-β-glucanase (Egl5A;TeEgl5A) 3.2.1.4 Rasamsonia emersonii CBS 394.64 AHV83755.1
CAJ75961.1
    5
 endo-β-1,4-glucanase (Eg1) 3.2.1.4 Rasamsonia emersonii IMI 392299 AAL33639.2
AAL33630.1
AAL33639.1
Q8WZD7   5
 ORF (fragment)   Rhizoctonia solani 0628-006 1 A WA/MF06-181 CDL74343.1     5
 endoglucanase VII (EgVII)   Rhizopus stolonifer var. reflexus TP-02 AII80538.1     5
 endo-β-1,4-glucanase I (Eg1) 3.2.1.4 Robillarda sp. Y-20 BAA90480.1
JX0131
P23044
Q9P981
  5
 endo-β-1,4-glucanase 1 / carboxymethylcellulase 1 (Cmc1) 3.2.1.4 Saitozyma flava MUT-6 AAC60541.1
BAA03070.1
Q04469   5
 endo-1-4-β-cellulase   Saitozyma flava OO2 APB92618.1     5
 endo-β-1,4-glucanase I (EG1;EGI;EGII;SCHCODRAFT_40122) 3.2.1.4 Schizophyllum commune H4-8 EFI96731.1 P81190   5
 sscle_03g023660   Sclerotinia sclerotiorum 1980 UF-70 APA07596.1     5
 sscle_03g026960   Sclerotinia sclerotiorum 1980 UF-70 APA07926.1     5
 sscle_14g099920   Sclerotinia sclerotiorum 1980 UF-70 APA15222.1     5
 PIIN_01190   Serendipita indica DSM 11827 CCA67360.1     5
 PIIN_01192   Serendipita indica DSM 11827 CCA67361.1     5
 PIIN_08751 (fragment)   Serendipita indica DSM 11827 CCA74782.1     5
 PIIN_10600 (fragment)   Serendipita indica DSM 11827 CCA76609.1     5
 PIIN_10779 (fragment)   Serendipita indica DSM 11827 CCA76793.1     5
 cellulase   Stegonsporium opalus ARO48344.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Stereum rugosum 0629-045 2 D PDA/MF06-294 CDL74344.1     5
 endoglucanase (EG)   Taiwanofungus camphoratus B479 AIO10991.1     5
 endo-β-1,4-glucanase 5A (TCE0_013f01292) (Cel5A) 3.2.1.4 Talaromyces cellulolyticus Y-94 GAM33994.1     5
 endo-β-1,4-glucanase 5 (Eng5) 3.2.1.4 Talaromyces pinophilus KMJ601 ACN43345.1 C0L2S4   5
 endoglucanase 2 (EG2;EGIIa) (partial) (Cel5A) 3.2.1.4 Talaromyces verruculosus B221-151     5L9C[A,B,C,D]
5I6S[A]
5
 endo-β-1,4-glucanase (Eg1;Eng1;TaCel5A) (Cel5A) 3.2.1.4 Thermoascus aurantiacus IFO 9748 AAL88714.2
AAL16412.1
ACE10214.1
CAT02251.1
CAZ67882.1
Q8TG26
Q96UI5
1GZJ[A,B]
1H1N[A,B]
5
 endoglucanase   Thermoascus aurantiacus RCKK AFY52522.1     5
 endo-β-1,4-glucanase (Eg1)   Thermoascus aurantiacus var. levisporus AAX51678.1 Q2VRK9   5
 MYCTH_52068   Thermothelomyces thermophila ATCC 42464 AEO58455.1     5
 endo-β-1,4-glucanase (EG II;StCel5A;MYCTH_86753) (Cel5A) 3.2.1.4 Thermothelomyces thermophila ATCC 42464 AEO53769.1
AEM23898.1
    5
 THITE_2107758   Thielavia terrestris NRRL 8126 AEO62940.1     5
 THITE_118353   Thielavia terrestris NRRL 8126 AEO67179.1     5
 THITE_124883   Thielavia terrestris NRRL 8126 AEO68519.1     5
 THITE_123205   Thielavia terrestris NRRL 8126 AEO69910.1     5
 THITE_72629   Thielavia terrestris NRRL 8126 AEO70679.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Trametes cinnabarina 285/PB CDL74356.1     5
 endoglucanase (Eg-1) 3.2.1.4 Trametes hirsuta BAD01163.1
BAD01164.1
Q75UV6   5
 endoglucanase (TvEG) 3.2.1.4 Trametes versicolor       5
 endo-β-1,4-glucanase (Glu1)   Trichoderma asperellum PQ34 AHW57398.1     5
 endo-β-1,4-glucanase (Glu2)   Trichoderma asperellum PQ34 AHW57399.1     5
 endoglucanase II (EgII)   Trichoderma atroviride AJP16798.1     5
 endo-β-1,4-glucanase II (EG2;EGII;Egl2;EG-II;TrEGII;TrCel5A) (formerly EGIII) (Cel5A) 3.2.1.4 Trichoderma reesei AAA34213.1
AAQ24883.1
AAR60515.1
ABA64553.1
ABE22094.1
P07982 3QR3[A,B] 5
 Cel5b (Cel5B)   Trichoderma reesei QM6A AAP57754.1
ABH83954.1
ABH83956.1
Q7Z9M6   5
 endo-β-1,4-glucanase (C4endoII) 3.2.1.4 Trichoderma sp. C-4 AAR29981.1 Q6S4S0   5
 endoglucanase III (EgIII;EG III)   Trichoderma sp. SSL ACH92572.1 B5TYI3   5
 endoglucanase   Trichoderma viride ABQ95572.1 A5Z0S4   5
 endoglucanase III (EG3;EGIII) 3.2.1.4 Trichoderma viride AS 3.3711 AAQ21383.1 Q7Z7X2   5
 endoglucanase VIII (EgvIII) 3.2.1.4 Trichoderma viride AS 3.3711 ACD36972.1 B4YEW2   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 Trichoderma viride MC300-1 BAA36216.1 O93833   5
 endoglucanase (EG)   Trichoderma viride wdf1 ADJ10627.1 D9I7P5   5
 ORF (fragment)   Ulocladium sp. 0729-007 1 C PDA/MF07-034 CDL74345.1     5
 ORF (fragment)   uncultured fungus CCC18707.1     5
 ORF (fragment)   uncultured fungus CCC18708.1     5
 ORF (fragment)   uncultured fungus CCC18709.1     5
 ORF (fragment)   uncultured fungus CCC18710.1     5
 ORF (fragment)   uncultured fungus CCC18711.1     5
 ORF (fragment)   uncultured fungus CCC18712.1     5
 ORF (fragment)   uncultured fungus CCC18713.1     5
 ORF (fragment)   uncultured fungus CCC18714.1     5
 ORF (fragment)   uncultured fungus CCC18716.1     5
 ORF (fragment)   uncultured fungus CCC18718.1     5
 EgL (fragment)   Volvariella bombycina AEQ58920.1     5
 endoglucanase I (EG1;EGI) 3.2.1.4 Volvariella volvacea V14 AAG59832.1
AEQ58914.1
Q9C3Z8   5
 endoglucanase I (EgI;NCel5A) (Cel5A) 3.2.1.4 Volvariella volvacea WX32 ACE06751.1     5
unclassified
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 ORF (fragment)   uncultured organism AGU11433.1     5
 ORF, partial   uncultured organism AGU11481.1     5
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