Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (36); Uniprot accession (2);

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
HVS_16090 (Mana3)		Acetivibrio saccincola GGR1	AUG59057.1			55
AD2_01411		Acetivibrio thermocellus AD2	ALX08404.1			55
β-mannanase (CtMan5A;Cthe_0821) (Man5A)	3.2.1.78	Acetivibrio thermocellus ATCC 27405	ABN52056.1	A3DDM7		55
Clo1313_1398		Acetivibrio thermocellus DSM 1313	ADU74461.1			55
LQRI_1412		Acetivibrio thermocellus DSM 2360 LQRI	ANV76153.1			55
N1236_07485		Acetivibrio thermocellus M3	UWV48345.1			55
CDL62_01880		Alkalitalea saponilacus DSM 24412	ASB47989.1			55
ANA_C11786		Anabaena sp. 90	AFW94547.1			55
acsn021_18570		Anaerocolumna cellulosilytica SN021	BCJ94288.1			55
R2R35_04170		Anaerocolumna sp. AGMB13020	WOO37700.1			55
D1816_19595		Aquimarina sp. AD10	AXT62472.1			55
D1818_21425		Aquimarina sp. BL5	AXT53263.1			55
Clole_1968		Cellulosilyticum lentocellum DSM 5427	ADZ83685.1			55
EKH84_11980		Cellulosilyticum sp. WCF-2	QEH69067.1			55
MKQ68_15065		Chitinophaga horti R8	UYQ91413.1			55
D4L85_32750		Chryseolinea soli KIS68-18	AYB35062.1			55
endoglucanase (Eng5D)		Clostridium cellulovorans	BAV13034.1			55
endoglucanase G (EngG;Clocel_2600)	3.2.1.4	Clostridium cellulovorans 743B	ADL52309.1	D9SQV3		55
Clo1100_0407		Clostridium sp. BNL1100	AEY64693.1			55
HGD76_00620		Dolichospermum flos-aquae CCAP 1403/13F	QJB42966.1			55
HEQ26_03225		Dolichospermum sp. DL01	QSV61913.1			55
HEQ29_22935		Dolichospermum sp. LBC05a	QSV60817.1			55
BMF77_04383		Dolichospermum sp. UHCC 0315A	QEI43761.1			55
HEP80_23140		Dolichospermum sp. UKL201	QSV56277.1			55
Fisuc_2933 / FSU_0196		Fibrobacter succinogenes subsp. succinogenes S85	ACX76513.1 ADL26912.1			55
D770_09880		Flammeovirgaceae bacterium 311	AHM60233.1			55
NHM04_09985		Gilvimarinus sp. DA14	UTF58809.1			55
Ccel_0379 (P76)		Ruminiclostridium cellulolyticum H10	ACL74764.1			55
EHE19_014405		Ruminiclostridium herbifermentans MA18	QNU66064.1			55
P0092_02170		Ruminiclostridium papyrosolvens DSM 2782	WES34810.1			55
KV697_00165		Sphingomonas sanguinis NP2-R2	QXT35874.1			55
CWM47_11860		Spirosoma pollinicola HA7	AUD02460.1			55
CWM47_04130		Spirosoma pollinicola HA7	AUD01083.1			55
HH216_01635		Spirosoma rhododendri CJU-R4	QJD77265.1			55
HNV11_08650		Spirosoma taeanense TS118	QJW89446.1			55
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