Glycoside Hydrolase Family 5 / Subf 55

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13); Uniprot accession (3);
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 ANA_C11786   Anabaena sp. 90 AFW94547.1     55
 Ccel_0379 (P76)   [Clostridium] cellulolyticum H10 ACL74764.1 B8I5U7   55
 endoglucanase (Eng5D)   Clostridium cellulovorans BAV13034.1     55
 endoglucanase G (EngG;Clocel_2600) 3.2.1.- Clostridium cellulovorans 743B ADL52309.1 D9SQV3   55
 Clole_1968   Clostridium lentocellum DSM 5427 ADZ83685.1     55
 Clo1100_0407   Clostridium sp. BNL1100 AEY64693.1     55
 HVS_16090 (Mana3)   Herbivorax saccincola GGR1 AUG59057.1     55
 AD2_01411   Ruminiclostridium thermocellum AD2 ALX08404.1     55
 β-mannanase (CtMan5A;Cthe_0821) (Man5A) 3.2.1.78 Ruminiclostridium thermocellum ATCC 27405 ABN52056.1 A3DDM7   55
 Clo1313_1398   Ruminiclostridium thermocellum DSM 1313 ADU74461.1     55
 LQRI_1412   Ruminiclostridium thermocellum DSM 2360 LQRI ANV76153.1     55
 CWM47_11860   Spirosoma sp. HA7 AUD02460.1     55
 CWM47_04130   Spirosoma sp. HA7 AUD01083.1     55
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