Glycoside Hydrolase Family 5 / Subf 52

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (10); Uniprot accession (6);
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 cellodextrinase A (CedA;Fisuc_1584;FSU_2070) (Cel5C) 3.2.1.74 Fibrobacter succinogenes subsp. succinogenes S85 AAA50210.1
ACX75179.1
ADL26975.1
C9RRJ3
Q59441
  52
 cellodextrinase (UmCel5M) 3.2.1.74 uncultured bacterium ABE60715.1 Q1PDD7   52
 4348JG28_001 3.2.1.- uncultured bacterium ABW39345.1 A9LDT9   52
 4348JG48_005 3.2.1.- uncultured bacterium ABW39351.1 A9LDU5   52
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 SARM_0083 / 0_01399 / MH-11 (fragment; probable frameshift) 3.2.1.- uncultured organism ADX05757.1     52
 SARM_0085 / 0_04975 / TW-16 3.2.1.- uncultured organism ADX05752.1     52
 SARM_0066 / 2698429_129360 / TW-22 3.2.1.- uncultured organism ADX05737.1     52
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