Glycoside Hydrolase Family 5 / Subf 51

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (60); Uniprot accession (5);
All (60) Bacteria (59) Eukaryota (1)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SAMN04489716_1987   Actinoplanes derwentensis DSM 43941 SDS92153.1     51
 Amir_4225   Actinosynnema mirum DSM 43827 ACU38080.1 C6WHG1   51
 CNX65_21150   Actinosynnema pretiosum X47 ATE55482.1     51
 ATC03_16080   Agromyces aureus AR33 ANJ28000.1     51
 SAMN04489726_7161   Allokutzneria albata DSM 44149 SDN55869.1     51
 AJAP_23210   Amycolatopsis japonica MG417-CF17 AIG77495.1     51
 SAMN04489733_2631   Amycolatopsis keratiniphila FH 1893 SDU27618.1     51
 AORI_3215   Amycolatopsis orientalis HCCB10007 AGM05800.1     51
 Caci_0861   Catenulispora acidiphila DSM 44928 ACU69794.1 C7Q2F2   51
 CYFUS_000205   Cystobacter fuscus DSM 52655 ATB34798.1     51
 ORF   Kibdelosporangium sp. MJ126-NF4 CTQ91713.1     51
 glycoside hydrolase   Kitasatospora aburaviensis ATCC 31860 SCN11942.1     51
 B6264_29585   Kitasatospora aureofaciens DM-1 ARF82471.1     51
 BBK82_01160   Lentzea guizhouensis DHS C013 ANZ34894.1     51
 A0128_10240   Leptospira alstonii GWTS #1 AOP34192.1     51
 MEBOL_004061   Melittangium boletus DSM 14713 ATB30600.1     51
 SAMN04489834_0712   Microterricola viridarii DSM 21772 SDS02127.1     51
 AWU67_16445   Microterricola viridarii ERGS5:02 AMB60182.1     51
 STAUR_3107   Stigmatella aurantiaca DW4/3-1 ADO70899.1 Q08WV3   51
 Orf1   Stigmatella aurantiaca SG A15 CAD19084.1 Q8RJY7   51
 DC74_730   Streptomyces albulus NK660 AIA01252.1     51
 SAZ_04175   Streptomyces albulus ZPM AKA01749.1     51
 BV401_37205   Streptomyces autolyticus CGMCC0516 AQA16748.1     51
 BN159_2662   Streptomyces davawensis JCM 4913 CCK27041.1     51
 WQO_24910   Streptomyces globisporus C-1027 ALU96278.1     51
 AVL59_19435   Streptomyces griseochromogenes ATCC 14511 ANP51490.1     51
 SHJG_8384   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY93649.1     51
 SHJGH_8145   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF67807.1     51
 SHL15_7292   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO98301.1     51
 SHXM_02183   Streptomyces hygroscopicus XM201 AQW48720.1     51
 SIRAN1854   Streptomyces iranensis CDR04855.1     51
 SLA_6677   Streptomyces laurentii ATCC 31255 BAU87543.1     51
 SNOD_10585   Streptomyces nodosus ATCC 14899 AJE40444.1     51
 SNOUR_37440   Streptomyces noursei ATCC 11455 ANZ20716.1     51
 LK06_026100   Streptomyces pluripotens MUSC 135 ARP74454.1     51
 LK07_27255   Streptomyces pluripotens MUSC 137 ASN28729.1     51
 SPRI_1196   Streptomyces pristinaespiralis HCCB 10218 ALC19502.1     51
 BFF78_02860   Streptomyces puniciscabiei TW1S1 AOR30148.1     51
 M271_08970   Streptomyces rapamycinicus NRRL 5491 AGP53412.1     51
 TUE45_pSRTUE45c_0357   Streptomyces reticuli CUW32989.1     51
 SCAB_1101   Streptomyces scabiei 87.22 CBG67339.1 C9ZCV5   51
 CGL27_39820   Streptomyces sp. 11-1-2 ASQ98354.1     51
 SAMN06272775_0341   Streptomyces sp. 2323.1 SOE09250.1     51
 SAMN05444521_0518   Streptomyces sp. 3124.6 SHH43567.1     51
 ASR50_33700   Streptomyces sp. 4F ALV54726.1     51
 GZL_08340   Streptomyces sp. 769 AJC60868.1     51
 B1K54_04390   Streptomyces sp. fd1-xmd AQT71041.1     51
 M444_05780   Streptomyces sp. Mg1 AKL64978.1     51
 QR97_33925   Streptomyces sp. PBH53 AKN74059.1     51
 A6E92_08370   Streptomyces sp. S8 ARI52190.1     51
 B6R96_32350   Streptomyces sp. Sge12 ARE78068.1     51
 SAMN05216371_0646   Streptomyces sp. TLI_053 SDS80184.1     51
 BSL84_03095   Streptomyces sp. TN58 APU38900.1     51
 TK78_09270   Streptomyces sp. Tue 6075 Tue6075 APS19128.1     51
 BN2537_16313   Streptomyces venezuelae ATCC 15439 CUM43674.1     51
 BN2537_1569   Streptomyces venezuelae ATCC 15439 CUM36302.1     51
 AQF52_7445   Streptomyces venezuelae ATCC 15439 ALO13031.1     51
 AQF52_0493   Streptomyces venezuelae ATCC 15439 ALO06091.1     51
 Strvi_3249   Streptomyces violaceusniger Tu 4113 AEM82937.1     51
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