Glycoside Hydrolase Family 5 / Subf 50

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (22); Uniprot accession (1);
All (22) Eukaryota (22)
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 CGB_L3610C   Cryptococcus gattii WM276 ADV25348.1     50
 CNAG_05652   Cryptococcus neoformans var. grubii H99 AFR99083.1     50
 CNH02900   Cryptococcus neoformans var. neoformans JEC21 AAW45154.1 Q5KD09   50
 LRAMOSA10401   Lichtheimia ramosa CDS09041.1     50
 MGL_0748   Malassezia globosa CBS 7966 EDP44941.1     50
 MSYG_3070   Malassezia sympodialis ATCC 42132 SHO78723.1     50
 MSYG_2412   Malassezia sympodialis ATCC 42132 SHO78070.1     50
 MSYG_4240   Malassezia sympodialis ATCC 42132 SHO79887.1     50
 MSYG_3905   Malassezia sympodialis ATCC 42132 SHO79555.1     50
 BN887_01986   Melanopsichium pennsylvanicum 4 CDI51074.1     50
 BN887_05784 (fragment)   Melanopsichium pennsylvanicum 4 CDI52106.1     50
 PIIN_03381   Serendipita indica DSM 11827 CCA69481.1     50
 PIIN_10526 (fragment)   Serendipita indica DSM 11827 CCA76533.1     50
 sr11470   Sporisorium reilianum SRZ2 CBQ67520.1     50
 sr10239   Sporisorium reilianum SRZ2 CBQ70574.1     50
 SPSC_03466   Sporisorium scitamineum SscI8 CDR87670.1     50
 SPSC_02360   Sporisorium scitamineum SscI8 CDU23731.1     50
 UBRO_01770   Ustilago bromivora UB2112 SAM77391.1     50
 UBRO_00201   Ustilago bromivora UB2112 SAM72210.1     50
 UM00128.1 (Umay-Bgl506)   Ustilago maydis 521 EAK81513.1     50
 Glycoside hydrolase, superfamily   Xanthophyllomyces dendrorhous CDZ96181.1     50
 glycoside hydrolase   Xanthophyllomyces dendrorhous CDZ98740.1     50
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