Glycoside Hydrolase Family 5 / Subf 4

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (596); Uniprot accession (185); PDB accession (34); 3D entries (16); cryst (0)
unclassified
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 endoglucanase (LC2)   uncultured microorganism ADB80100.1 D3JVT1   4
 endoglucanase / xylanase (CelA;RuCelA)   uncultured microorganism ADK55024.1 E2DQY5   4
 BT-05   uncultured microorganism ADR64667.1 E5F2L2   4
 BT-06   uncultured microorganism ADR64668.1 E5F2L3   4
 cellulase (BT-01) (partial) 3.2.1.4 uncultured microorganism ADR64663.1 E5F2K8   4
 BT-02 (fragment)   uncultured microorganism ADR64664.1 E5F2K9   4
 BT-04   uncultured microorganism ADR64666.1 E5F2L1   4
 cellulase (Umcel5B29;UmCel5B_29)   uncultured microorganism AEK98797.1     4
 cellulase (Cel5-A24) (fragment)   uncultured microorganism AEV46036.1     4
 cellulase (Cel5-A7) (fragment)   uncultured microorganism AEV46031.1     4
 cellulase (cel5-A9) (fragment)   uncultured microorganism AEV46032.1     4
 cellulase (Cel5-A12) (fragment)   uncultured microorganism AEV46033.1     4
 cellulase (Cel5-A15) (fragment)   uncultured microorganism AEV46034.1     4
 cellulase (Cel5-A22) (fragment)   uncultured microorganism AEV46035.1     4
 cellulase (Cel5-A26) (fragment)   uncultured microorganism AEV46037.1     4
 cellulase (Cel5-A27) (fragment)   uncultured microorganism AEV46038.1     4
 cellulase (Cel5-A28) (fragment)   uncultured microorganism AEV46039.1     4
 cellulase (Cel5-A32) (fragment)   uncultured microorganism AEV46040.1     4
 cellulase (Cel5_A24)   uncultured microorganism AEX97595.1     4
 cellulase (Cel5_A27)   uncultured microorganism AEX97596.1     4
 cellulase (Cel14b22)   uncultured microorganism AFQ39736.1     4
 endo-β-1,4-glucanase (CelZ)   uncultured microorganism AHB33631.1     4
 cellulase (Cel28A)   uncultured microorganism AHW46443.1     4
 β-glucanase (RuCelA;C29-2) 3.2.1.- uncultured microorganism ACA61132.1 B1PLH5   4
 β-glucanase (C35-2) 3.2.1.- uncultured microorganism ACA61135.1 B1PLH8   4
 β-glucanase (C67-1) 3.2.1.- uncultured microorganism ACA61137.1 B1PLI0   4
 β-glucanase (C5614-1) 3.2.1.- uncultured microorganism ACA61140.1 B1PLI3   4
 cellulase (DC2-3)   uncultured microorganism ACA61144.1 B1PLI7   4
 β-glucanase (DC2-4) 3.2.1.- uncultured microorganism ACA61145.1 B1PLI8   4
 β-glucanase (DC3-1) 3.2.1.4 uncultured microorganism ACA61149.1 B1PLJ2   4
 β-glucanase (DC23-3) 3.2.1.- uncultured microorganism ACA61160.1 B1PLK3   4
 endoglucanase   uncultured organism ANS70888.1     4
 cellulase CM3   uncultured organism ARI46375.1     4
 β-glucanase 3.2.1.- uncultured organism ADD61809.1 D9ZEQ5   4
 β-glucanase 3.2.1.4 uncultured organism ADD61911.1 D9ZF07   4
 ORF   uncultured organism ADD61973.1 D9ZF69   4
 SARM_0071 / 181694_69520 / TX-1 3.2.1.4 uncultured organism ADX05742.1     4
 SARM_0050 / 1194088_27810 / TW-48   uncultured organism ADX05721.1     4
 SARM_0034 / 694713_55880 / TW-39 3.2.1.4 uncultured organism ADX05705.1     4
 SARM_0032 / 558318_19410 / MH-20 3.2.1.4 uncultured organism ADX05703.1     4
 SARM_0027 / 458803_07710 / TW-20   uncultured organism ADX05698.1     4
 SARM_0017 / 3953955_161040 / TW-49 3.2.1.4 uncultured organism ADX05688.1     4
 SARM_0084 / 0_04358 / TW-56 (fragment; probable frameshift) 3.2.1.4 uncultured organism ADX05760.1     4
 SARM_0063 / 2527869_58630 / TW-33 3.2.1.4 uncultured organism ADX05734.1   4YHG[A,B] 4
 SARM_0058 / 2395619_81340 / TW-44 3.2.1.4 uncultured organism ADX05729.1     4
 ORF (fragment)   uncultured prokaryote CRY96300.1     4
 β-glucanase (RR.01;RR.01-2) 3.2.1.- unidentified microorganism CAJ19135.1 Q2YI68   4
 glucanase (RR.02-2;BglC) 3.2.1.- unidentified microorganism CAJ19139.1 Q2YI64   4
 β-glucanase (RR.06;RR.06-1;BglC) 3.2.1.- unidentified microorganism CAJ19140.1 Q2YI63   4
 glucanase (RR.10;RR.10-1) 3.2.1.- unidentified microorganism CAJ19146.1 Q2YI57   4
 glucanase (RR.14;RR.14-2) (Cel5A) 3.2.1.4 unidentified microorganism CAJ19151.1 Q2YI52   4
 endo-β-1,4-glucanase (UmCel28;CC1) 3.2.1.4 unidentified microorganism ABX76045.1 A9UGW1   4
 endoglucanase (UmCelE2;EC2) 3.2.1.4 unidentified microorganism ABX76046.1 A9UGW2   4
 endoglucanase (UmCelS15;SC1) (fragment) 3.2.1.4 unidentified microorganism ABX76048.1 A9UGW4   4
 endoglucanase (UmCelC23;CC2) 3.2.1.4 unidentified microorganism ABX76050.1 A9UGW6   4
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