Glycoside Hydrolase Family 5 / Subf 4

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (596); Uniprot accession (185); PDB accession (34); 3D entries (16); cryst (0)
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 EGX48303.1   Arthrobotrys oligospora ATCC 24927 EGX48303.1     4
 AN8068.2   Aspergillus nidulans FGSC A4 EAA59690.1 C8V683
Q5AUG2
  4
 AO090003001341 + AO090003001342 (fragments)   Aspergillus oryzae RIB40 BAE58401.1
BAE58402.1
    4
 glycoside hydrolase family 5 protein (Bofut4_p114590.1)   Botrytis cinerea T4 CCD46753.1     4
 endoglucanase (Epi2)   Epidinium caudatum BAC57893.1 Q86S92   4
 endo-β-1,4-glucanase (Epi3) (probable fragment) 3.2.1.4 Epidinium caudatum BAA76394.1 Q9XXV3   4
 Cmc-01A (partial) (fragment)   Epidinium ecaudatum CAL91973.1 B7FBJ8   4
 Cmc-02 (partial)   Epidinium ecaudatum CAL91969.1 B7FBJ4   4
 cellulase (Cmc-13) (fragment)   Epidinium ecaudatum CAL91971.1 B7FBJ6   4
 Cmc-01B (fragment)   Epidinium ecaudatum CAL91974.1 B7FBJ9   4
 CMCase (Cmc-06) (Cel5A) 3.2.1.4 Epidinium ecaudatum CAH69214.1
CAL91975.1
Q5F324   4
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX94583.1 E4ZSZ5   4
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Neocallimastix frontalis AAC63094.1 Q01409   4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Neocallimastix patriciarum AAE59927.1
CAA83238.1
Q12647   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1
AEX92707.1
O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 cellulase (fragment)   Neocallimastix sp. GMLF1 ADQ12983.1 E5FVN2   4
 endo-β-1,4-glucanase (CelB2) (fragment) 3.2.1.4 Orpinomyces joyonii SG4 AAB69348.1 O13334   4
 endo-β-1,4-glucanase (CelB29) 3.2.1.4 Orpinomyces joyonii SG4 AAB69347.1 O13333   4
 EG5, partial   Orpinomyces sp. C1A ANS13827.1     4
 CelE (fragment)   Orpinomyces sp. FCT 2 ACY25184.1 D0V738   4
 endoglucanase (CelB)   Orpinomyces sp. LT-3 AEO51792.1     4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Orpinomyces sp. PC-2 AAD04193.1
AAE59925.1
P78719   4
 endo-β-1,4-glucanase E (CelE) 3.2.1.4 Orpinomyces sp. PC-2 AAC05164.1 Q9HFE0   4
 Gp43 (fragment)   Paracoccidioides brasiliensis PB4 AAT46288.1 Q6GWX9   4
 endoglucanase 5C (PdCel5C) (Cel5C) 3.2.1.4 Penicillium decumbens 114-2 AFG25592.1     4
 endo-β-1,4-glucanase 4   Penicillium oxalicum GZ-2 AIO06743.1     4
 Pc21g14410   Penicillium rubens Wisconsin 54-1255 CAP96338.1 B6HI44   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4 Piromyces equi CAB92326.1 Q9P867   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4 Piromyces equi CAB92326.1 Q9P867   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4 Piromyces equi CAB92326.1 Q9P867   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4 Piromyces equi CAB92326.1 Q9P867   4
 endoglucanase A (CelA;EglA) (partial) 3.2.1.4 Piromyces rhizinflatus 2301 AAF00074.2   3AYR[A]
3AYS[A]
4
 endoglucanase (Egl-1) (Cel5B) 3.2.1.4 Piromyces rhizinflatus 2301 AAD43818.1 Q9Y870   4
 Cmc-02 (partial)   Polyplastron multivesiculatum CAL91970.1 B7FBJ5   4
 cellulase (Cmc-13) (fragment)   Polyplastron multivesiculatum CAL91972.1 B7FBJ7   4
 CelA (partial)   Polyplastron multivesiculatum BAC57896.2
BAC57896.1
Q86S89   4
 CelA (partial)   Polyplastron multivesiculatum BAC57896.2
BAC57896.1
Q86S89   4
 sscle_07g056950   Sclerotinia sclerotiorum 1980 UF-70 APA10925.1     4
 Type 1-7.1 (partial)   uncultured bovine rumen ciliate AEQ16450.1     4
 CMC5 (fragment)   uncultured equine caecal ciliate CDG46722.1     4
 CMC6 (fragment)   uncultured equine caecal ciliate CDG46723.1     4
 CMC9 (fragment)   uncultured equine caecal ciliate CDG46724.1     4
 CMC9 (fragment)   uncultured equine caecal ciliate CDG46724.1     4
 endo-β-1,4-D-glucanase, partial (fragment)   uncultured Neocallimastigomycetes ANI24562.1
ANI24564.1
    4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24575.1
ANI24572.1
    4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24568.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24567.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24574.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24577.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24576.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24563.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24573.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24570.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24566.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24571.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24560.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24569.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24565.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24561.1     4
 NT0287A89   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57333.1 A4UWS3   4
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