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Glycoside Hydrolase Family 5 / Subf 4

Activities in Sub FamilyGlucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-);
Oligoxyloglucan reducing-end-specific cellobiohydrolase (EC 3.2.1.150);
Xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151);
Endo-β-1,4-glucanase (EC 3.2.1.4);
Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (427); Uniprot accession (139); PDB accession (56); 3D entries (28); cryst (0)
Summary
Download GH5_4 (1913) Taxonomic display Structure (28) Characterized (126)
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Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3DSubf
 glucomannanase (AceceDRAFT_0142) 3.2.1.- pubmed
 Acetivibrio cellulolyticus WP_010248927.1 A0A5S8WF61 6MQ4[A] 4
 endo-β-1,4-glucanase E (CelE;EgE) (Cel5C) 3.2.1.4
3.2.1.8
3.2.1.-		 pubmed
pubmed
pubmed
 Acetivibrio thermocellus AAA23224.1 P10477 4IM4[A,B,C,D,E,F] 4
 endoglucanase (BlCel5B; BLi01882; BL01230) (Cel5B) 3.2.1.4 pubmed
 Bacillus licheniformis DSM 13 = ATCC 14580 AAU40777.1
AAU23417.1		 Q65JI7 4YZP[A]
4YZT[A] 		4
 cellulase (CelB) 3.2.1.4 pubmed
 Bacillus sp. BG-CS10 ADD62401.1 D4P8C6 5E09[A]
5E0C[A]
5XRC[A,B,C] 		4
 endo-xyloglucanase (BcGH5; BACCELL_02631) 3.2.1.151 pubmed
 Bacteroides cellulosilyticus DSM 14838 EEF89776.1 E2NEB7   4
 endo-xyloglucanase (BfGH5; HMPREF9446_01793) 3.2.1.151 pubmed
 Bacteroides fluxus YIT 12057 EGF57191.1 F3PST1   4
 endo-xyloglucanase (CelA; BoGH5A; BoGH5; BACOVA_02653; Bovatus_03072) 3.2.1.151 pubmed
 Bacteroides ovatus ATCC 8483 ALJ47680.1 A7LXT7 3ZMR[A,B] 4
 endo-xyloglucanase (BuGH5; BuGH5A; BACUNI_00321) 3.2.1.151 pubmed
 Bacteroides uniformis ATCC 8492 EDO56034.1 A7UYE9   4
 endo-xyloglucanase (BuGH5B; BACUNI_03803) 3.2.1.151 pubmed
 Bacteroides uniformis ATCC 8492 EDO52192.1     4
 endo-cellulase (AC2aCel5A) (Cel5A) 3.2.1.4 pubmed
 Bacteroidetes bacterium AC2a AIJ19564.1 A0A076MPD7 4YHE[A,B] 4
 endo-β-1,4-glucanase 1 (End1;EglI;EGI) 3.2.1.4 pubmed
 Butyrivibrio fibrisolvens H17C CAA35574.1 P20847   4
 β-1,3-1,4-glucanase / lichenase (F32EG5) 3.2.1.6 pubmed
 Caldicellulosiruptor sp. F32 AGM71677.1 R9RX81 4X0V[A,B,C,D,E,F,G,H]
5H4R[A] 		4
 endoglucanase / xylanase (CGSCsYakCAS_09989) (Cel5A) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 Cellulosilyticum ruminicola CGMCC 1.5065 ACZ98591.1 D2KFI9   4
 endo-xyloglucanase (CjGH5E; CJA_3337) (Cel5E) 3.2.1.151 pubmed
 Cellvibrio japonicus Ueda107 ACE83841.1 B3PF23   4
 endo-xyloglucanase (CjGH5D; CJA_3010) (Cel5D) 3.2.1.151 pubmed
 Cellvibrio japonicus Ueda107 ACE84905.1 B3PD52 5OYC[A,B]
5OYD[A,B]
5OYE[A,B]
6HA9[A,B]
6HAA[A,B]
8OZ1[A] 		4
 endo-xyloglucanase (CjGH5F; CJA_2959) (Cel5F) 3.2.1.151 pubmed
 Cellvibrio japonicus Ueda107 ACE86198.1 B3PCP9   4
 endo-/exo-type cellulase (CelEdx16) 3.2.1.4 pubmed
 Clostridiaceae bacterium AN-C16-KBRB ADK66823.1 E0A3Q5   4
 glucomannanase (CAC0826) 3.2.1.151
3.2.1.-		 pubmed
pubmed
 Clostridium acetobutylicum ATCC 824 AAK78802.1
NP_347462.1		 Q97KU0 6PZ7[A] 4
 endo-β-1,4-glucanase / xylanase B (EngB;Clocel_1150) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 Clostridium cellulovorans 743B AAA23231.1
ADL50906.1		 C5RHC3
P28621		   4
 endo-β-1,4-glucanase / xylanase D (EngD) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 Clostridium cellulovorans ATCC 35269 AAA23233.1 P28623 3ICG[A,B,C,D]
3NDY[A,B,C,D]
3NDZ[A,B,C,D] 		4
 endo-β-1,4-glucanase E / dual cellulase-mannanase (EngE) 3.2.1.4
3.2.1.-		 pubmed
pubmed
 Clostridium cellulovorans ATCC 35269 AAD39739.1 D9SV64
Q9XD99		 6UI3[A] 4
 endo-β-1,4-glucanase (CelA) 3.2.1.4 pubmed
 Clostridium longisporum AAC37035.1 P54937 6Q1I[A,B] 4
 endo-xyloglucanase (DgGH5; HMPREF9455_00295) 3.2.1.151 pubmed
 Dysgonomonas gadei ATCC BAA-286 EGJ99262.1 F5IT78   4
 endoglucanase (EcCel5A) (Cel5A) 3.2.1.4 pubmed
pubmed
 Eubacterium cellulosolvens 5 BAE46390.1 Q3LHN3   4
 endoglucanase (EcCel5A) (Cel5A) 3.2.1.4 pubmed
pubmed
 Eubacterium cellulosolvens 5 BAE46390.1 Q3LHN3   4
 Fisuc_3081 / FSU_0347 3.2.1.4 pubmed
 Fibrobacter succinogenes subsp. succinogenes S85 ACX76661.1
ADL25927.1		 C9RQB4   4
 endo-β-1,4-glucanase G (CelG;Fisuc_0897;FSU_1346) 3.2.1.4 pubmed
 Fibrobacter succinogenes subsp. succinogenes S85 AAB38548.1
ACX74504.1
ADL25356.1		 C9RNQ8
Q47916		   4
 endoglucanase (GE40) (fragment) 3.2.1.4 pubmed
 Geobacillus thermodenitrificans T81 ATG84593.1 A0A291I5R3   4
 β-glucanase (CelB; BhCel5B; BH0603) (Cel5B) 3.2.1.4 pubmed
 Halalkalibacterium halodurans C-125 BAB04322.1
NP_241469.1		 Q9KF82 4V2X[A] 4
 endo-β-1,4-glucanase (CpCel5C;Cphy_2058) (Cel5C) 3.2.1.4 doi
 Lachnoclostridium phytofermentans ISDg ABX42426.1 A9KIH4   4
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 pubmed
 Paenibacillus barcinonensis BP-23 CAA73113.1 O08342   4
 endo-β-1,4-glucanase B (CelB;EG-B) 3.2.1.4 pubmed
 Paenibacillus lautus PL236 AAA22408.1
CAA01934.1		 P23550   4
 xyloglucanase (XG5; PpXG5) 3.2.1.151 pubmed
 Paenibacillus pabuli AAR65335.1 H9KVH3 2JEP[A,B]
2JEQ[A] 		4
 cellulase 5B (Cel5B) 3.2.1.4 pubmed
 Paenibacillus polymyxa GS01 ABV08876.1 A9Q742   4
 xyloglucanase (XEG5) (Xeg5) 3.2.1.151 pubmed
 Paenibacillus sp. KM21 BAE44526.1 Q3MUH8   4
 endo-β-1,4-glucanase (Cel5A) 3.2.1.4 pubmed
 Paenibacillus xylanilyticus KJ-03 AFC68970.1 H9A9K4   4
 endo-xyloglucanase (Bacsa_0886) 3.2.1.151 pubmed
 Phocaeicola salanitronis DSM 18170 ADY35478.1 F0R2T3 6WQY[A] 4
 endo-β-1,4-glucanase A (CelA; Cca; RceCel5A; Ccel_1099) (Cel5A) 3.2.1.4 pubmed
 Ruminiclostridium cellulolyticum H10 AAA23221.1
AAA51444.1
ACL75458.1		 P17901 1EDG[A] 4
 endo-1,4-glucanase I (EGI) 3.2.1.4 pubmed
 Ruminococcus albus F-40 AAA26469.1 P16216   4
 endo-1,4-glucanase V (EgV) 3.2.1.4
3.2.1.73
3.2.1.8		 pubmed
pubmed
pubmed
pubmed
 Ruminococcus albus F-40 BAA92146.1 Q9LCC5   4
 β-1,4-endoglucanase VII (EgVII) (Cel5D) 3.2.1.4 pubmed
 Ruminococcus albus F-40 BAA92430.1 Q9LCC4   4
 endo-β-1,4-glucanase A (CelA;EgA) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 Ruminococcus albus SY3 AAA26467.1
CAA38692.1		 P23660
Q59733		   4
 endo-β-1,4-glucanase B (CelB;EgB) 3.2.1.4 pubmed
 Ruminococcus albus SY3 CAA38693.1 P23661   4
 glucomannanase (RUM_05520) 3.2.1.- pubmed
 Ruminococcus champanellensis 18P13 = JCM 17042 CBL16772.1 D4LAX7 6WQP[A,B]
6WQV[A,B,C,D] 		4
 endo-β-1,4-glucanase (GH5A;RUM_02800) (Cel5A) 3.2.1.4 pubmed
 Ruminococcus champanellensis 18P13 = JCM 17042 CBL16523.1 D4LA78   4
 glucomannanase (RfGH5-1/2) 3.2.1.- pubmed
pubmed
 Ruminococcus flavefaciens WP_009984467.1 A0A8I3B056 6XSU[A,B] 4
 endo-β-1,4-glucanase A (EndA) 3.2.1.4 pubmed
 Ruminococcus flavefaciens 17 CAB05881.1
AAB19708.1		 O05143
Q53302		   4
 endo-β-1,4-glucanase 5D (Sde_2636) (Cel5D) 3.2.1.4 pubmed
 Saccharophagus degradans 2-40 ABD81896.1 Q21HD3   4
 cellulase (EngV) (fragment) 3.2.1.4 doi
 Salinivibrio sp. NTU-05 ACJ71329.1 B8XGR7   4
 mixed-linkage β-glucanase/xyloglucanase (Orf4; CMCase; PbrCel5A; PBR_0368) (Cel5A) 3.2.1.151
3.2.1.73		 pubmed
pubmed
 Segatella bryantii B14 AAC97596.1
AAA22909.1		 D8DY19
O06842
Q44878		 3L55[A,B]
3VDH[A,B]
5D9M[A,B]
5D9N[A,B]
5D9O[A,B]
5D9P[A,B]
6D2W[A,B] 		4
 endoxylanase (GH5H) 3.2.1.8 pubmed
 uncultured bacterium AMO13178.1 A0A140HJ13   4
 endocellulase (GH5E) 3.2.1.4 pubmed
 uncultured bacterium AMO13175.1 A0A127JB79   4
 endocellulase (GH5G) 3.2.1.4 pubmed
 uncultured bacterium AMO13177.1 A0A140HJ12   4
 endocellulase (GH5C) 3.2.1.4 pubmed
 uncultured bacterium AMO13173.1 A0A140HJ08   4
 endocellulase / endoxylanase (GH5F) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 uncultured bacterium AMO13176.1 A0A140HJ11   4
 xyloglucan-specific endo-β-1,4-glucanase (XEG5A) (Xeg5A) 3.2.1.151 pubmed
 uncultured bacterium ACZ54907.1 D2K7Z0 4W84[A,B]
4W85[A,B]
4W86[A,B]
4W87[A,B]
4W88[A,B]
4W89[A,B] 		4
 bifunctional mannanase-xyloglucanase (MNXEG) 3.2.1.73 pubmed
 uncultured bacterium ADA62505.1 D2KKK4   4
 exo-xyloglucanase (XEG5B) (Xeg5B) 3.2.1.150 pubmed
 uncultured bacterium ADB44000.1 D2XML9 4W8A[A]
4W8B[A] 		4
 cellulase (CL1;C0001) 3.2.1.4 pubmed
 uncultured bacterium ADD82896.1 D4PAK6   4
 endo-β-1,3(4)-glucanase (EXO02C10-ORF13;En5) 3.2.1.6 pubmed
 uncultured bacterium AEV59735.1
AGO64722.1
AGO64723.1
AGO64724.1
AGO64725.1
AGO64726.1
AGO64727.1
AGO64728.1
AGO64729.1
AGO64730.1
AGO64731.1
AGO64732.1		 G9BYB6
S4VGU8
S4VGV3
S4VJK3
S4VJK8
S4VMG2
S4VMG6		   4
 endo-β-1,4-glucanase (En3;CMC6A4-ORF12) 3.2.1.4 pubmed
 uncultured bacterium AEV59725.1 G9BYA6   4
 cellulase (Exo2b;EXO02C10-ORF14) 3.2.1.4 pubmed
 uncultured bacterium AEV59736.1 G9BYB7   4
 cellulase (YBcontig404-00027-37) 3.2.1.4 pubmed
 uncultured bacterium ADU86901.1 H2BCH0   4
 cellulase (YBcontig310-00038-19) 3.2.1.4 pubmed
 uncultured bacterium ADU86902.1 H2BCH1   4
 endo-β-1,4-glucanase (YBcontig310-00424-17) 3.2.1.4 pubmed
 uncultured bacterium ADU86909.1 H2BCH8 6XSO[A,B] 4
 cellulase-xylanase A (Cel5A) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 uncultured bacterium AFO64636.1 I7D7K5   4
 cellulase-xylanase B (Cel5B) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 uncultured bacterium AFO64637.1 I7CY19   4
 endoglycosidase (GH6248) (Cel5A) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 uncultured bacterium ABB46200.1 Q283N5   4
 endoglucanase 3.2.1.4 pubmed
 uncultured bacterium Contig33 AHF24998.1 W0FJI5   4
 endoglucanase 3.2.1.4 pubmed
 uncultured bacterium Contig783 AHF24720.1 W0FP00   4
 endoglucanase (partial) 3.2.1.4 pubmed
 uncultured bacterium Contigcl_8 AHF25528.1 W0FKV0   4
 r_06-02 3.2.1.4 pubmed
 uncultured bacterium r_06 AFN57700.1 I6YKE5   4
 endoglucanase (GH5_h) 3.2.1.4
3.2.1.78		 pubmed
pubmed
 uncultured Bacteroidetes bacterium AIT97141.1 A0A097KUR6   4
 endoglucanase (GH5_g) 3.2.1.73 pubmed
 uncultured Bacteroidetes bacterium AIT97140.1 A0A097KUQ0   4
 endoglucanase (Cel1; GC_Cel1) 3.2.1.151
3.2.1.4		 pubmed
pubmed
 uncultured Dictyoglomus sp. QRN45942.1 A0A891XJN2   4
 xylanase / endoglucanase (PRU_2231) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 Prevotella ruminicola 23 AAC36862.1
ADE83418.1		 D5EV54
Q45397		   4
 endoglucanase (CelA;BrEND) 3.2.1.4 pubmed
 Xylanibacter ruminicola AR20 1814455A     4
 endo-β-1,3-1,4-glucanase (EngA; ZgEngA; zobellia_208) 3.2.1.6 pubmed
 Zobellia galactanivorans DsijT CAZ94281.1 G0L8Z3 6GL0[A,B,C]
6GL2[A] 		4
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3DSubf
 xyloglucan-specific endo-β-1,4-glucanase (Xeg5A; AO090003001590) (Xeg5A) 3.2.1.151 pubmed
 Aspergillus oryzae RIB40 EIT83526.1
BAE58401.1
BAE58402.1		 I8IVP5
Q2UJ63
Q2UJ64		   4
 endoglucanase (Epi2) 3.2.1.4 doi
 Epidinium caudatum BAC57893.1 Q86S92   4
 endo-β-1,4-glucanase (Epi3) (probable fragment) 3.2.1.4 doi
 Epidinium caudatum BAA76394.1 Q9XXV3   4
 CMCase (Cmc-06) (Cel5A) 3.2.1.4 pubmed
 Epidinium ecaudatum CAH69214.1
CAL91975.1		 Q5F324   4
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 pubmed
 Neocallimastix frontalis AAC63094.1 Q01409   4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 pubmed
 Neocallimastix patriciarum AAE59927.1
CAA83238.1		 Q12647   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.8		 pubmed
pubmed
pubmed
pubmed
pubmed
pubmed
 Neocallimastix patriciarum W5 AAC06321.1
AEX92707.1		 O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.8		 pubmed
pubmed
pubmed
pubmed
pubmed
pubmed
 Neocallimastix patriciarum W5 AAC06321.1 H2BPT1
O59943		   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.8		 pubmed
pubmed
pubmed
pubmed
pubmed
pubmed
 Neocallimastix patriciarum W5 AAC06321.1 H2BPT1
O59943		   4
 endo-β-1,4-glucanase (CelB2) (fragment) 3.2.1.4 pubmed
 Orpinomyces joyonii SG4 AAB69348.1 O13334   4
 endo-β-1,4-glucanase (CelB29) 3.2.1.4 pubmed
 Orpinomyces joyonii SG4 AAB69347.1 O13333   4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 pubmed
 Orpinomyces sp. PC-2 AAD04193.1
AAE59925.1		 P78719   4
 endo-β-1,4-glucanase E (CelE) 3.2.1.4 pubmed
 Orpinomyces sp. PC-2 AAC05164.1 Q9HFE0   4
 endoglucanase 5C (PdCel5C) (Cel5C) 3.2.1.4 pubmed
 Penicillium decumbens 114-2 AFG25592.1 H9TUB0   4
 endoglucanase A (CelA;EglA) (partial) 3.2.1.4 doi
 Piromyces rhizinflatus 2301 AAF00074.2 Q9URH5 3AYR[A]
3AYS[A] 		4
 endoglucanase (Egl-1) (Cel5B) 3.2.1.4 pubmed
 Piromyces rhizinflatus 2301 AAD43818.1 Q9Y870   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4
3.2.1.73		 pubmed
pubmed
 Piromyces sp. equi CAB92326.1 Q9P867   4
 endo-xyloglucanase (Type 1-7.1;partial) 3.2.1.151 pubmed
 uncultured bovine rumen ciliate AEQ16450.1 G5DDB8 6XRK[A,B] 4
unclassified
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3DSubf
 endoglucanase / xylanase (CelA;RuCelA) 3.2.1.73 pubmed
 uncultured microorganism ADK55024.1 E2DQY5   4
 cellulase (BT-01) (partial) 3.2.1.4 pubmed
 uncultured microorganism ADR64663.1 E5F2K8   4
 cellulase (Umcel5B29;UmCel5B_29) 3.2.1.4 pubmed
 uncultured microorganism AEK98797.1 G0Z5J9   4
 cellulase (Cel14b22) 3.2.1.4 pubmed
 uncultured microorganism AFQ39736.1 M4HLK8   4
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