Glycoside Hydrolase Family 5 / Subf 4

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (596); Uniprot accession (185); PDB accession (34); 3D entries (16); cryst (0)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SGGB_0358 (CeL)   Streptococcus gallolyticus subsp. gallolyticus ATCC 43143 BAK27255.1     4
 SGGBAA2069_c03180 (CelB)   Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069 CBZ47490.1     4
 BTR42_01930   Streptococcus gallolyticus subsp. gallolyticus DSM 16831 AQP41385.1     4
 GALLO_0330   Streptococcus gallolyticus UCN34 CBI12822.1 D3HH73   4
 SBI_09923   Streptomyces bingchenggensis BCW-1 ADI13041.1 D7CDJ9   4
 SBI_09963   Streptomyces bingchenggensis BCW-1 ADI13081.1 D7CF65   4
 SBI_00359 (fragment)   Streptomyces bingchenggensis BCW-1 ADI03480.1 D7BYF2   4
 BN159_0466 (Celb1)   Streptomyces davawensis JCM 4913 CCK24845.1     4
 SLINC_0697   Streptomyces lincolnensis NRRL 2936 ANS62921.1     4
 SLINC_8289 (fragment)   Streptomyces lincolnensis NRRL 2936 ANS70513.1     4
 SLINC_8278   Streptomyces lincolnensis NRRL 2936 ANS70502.1     4
 SCAB_86471   Streptomyces scabiei 87.22 CBG75588.1 C9Z367   4
 SAMN05444521_0298   Streptomyces sp. 3124.6 SHH37621.1     4
 AS200_05365   Streptomyces sp. CdTB01 ALV31540.1     4
 AA958_27115   Streptomyces sp. CNQ-509 AKH87057.1     4
 A4E84_04105   Streptomyces sp. S10(2016) AMW15165.1     4
 CAG99_11965   Streptomyces sp. SCSIO 03032 ARQ69488.1     4
 SVTN_01005   Streptomyces vietnamensis GIM4.0001 AJF63299.1     4
 SXIM_49970   Streptomyces xiamenensis 318 AKG46381.1     4
 TERTU_3361   Teredinibacter turnerae T7901 ACR12247.1 C5BQM3   4
 endoglucanase A (fragment)   uncultured bacterium ALX72722.1     4
 endoglucanase E (fragment)   uncultured bacterium ALX72725.1     4
 cellulase (glycosyl hydrolase family 5) (fragment)   uncultured bacterium AMP56163.1     4
 glycoside hydrolase   uncultured bacterium AMO13178.1     4
 glycoside hydrolase   uncultured bacterium AMO13175.1     4
 glycoside hydrolase   uncultured bacterium AMO13172.1     4
 glycoside hydrolase   uncultured bacterium AMO13177.1     4
 glycoside hydrolase   uncultured bacterium AMO13173.1     4
 glycoside hydrolase   uncultured bacterium AMO13176.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23783.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23780.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23776.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23785.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23786.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23778.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23788.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23791.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23781.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23777.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23782.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23787.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23779.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23784.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23790.1     4
 glycosyl hydrolase family 5 protein, partial (fragment)   uncultured bacterium ANN23789.1     4
 endoglucanase, glycoside hydrolase family GH5   uncultured bacterium AOE06904.1     4
 cellulase, glycoside hydrolase family GH5-4   uncultured bacterium AOE06289.1     4
 endoglucanase (GH5)   uncultured bacterium AOE12941.1     4
 glycosyl hydrolase family 5   uncultured bacterium AKI88012.1     4
 xyloglucan-specific endo-β-1,4-glucanase (XEG5A) (Xeg5A) 3.2.1.151 uncultured bacterium ACZ54907.1 D2K7Z0 4W84[A,B]
4W85[A,B]
4W86[A,B]
4W87[A,B]
4W88[A,B]
4W89[A,B]
4
 bifunctional mannanase-xyloglucanase (MNXEG) 3.2.1.73
3.2.1.78
uncultured bacterium ADA62505.1 D2KKK4   4
 exo-xyloglucanase (XEG5B) (Xeg5B) 3.2.1.- uncultured bacterium ADB44000.1 D2XML9 4W8A[A]
4W8B[A]
4
 cellulase (CL1;C0001)   uncultured bacterium ADD82896.1 D4PAK6   4
 Cel   uncultured bacterium CAD61243.1 Q6A3Q6   4
 CMC3B6-ORF25 (En2)   uncultured bacterium AEV59723.1     4
 EXO02C10-ORF13 (En5) 3.2.1.- uncultured bacterium AEV59735.1
AGO64722.1
AGO64723.1
AGO64724.1
AGO64725.1
AGO64726.1
AGO64727.1
AGO64728.1
AGO64729.1
AGO64730.1
AGO64731.1
AGO64732.1
    4
 endo-β-1,4-glucanase (En3;CMC6A4-ORF12) 3.2.1.4 uncultured bacterium AEV59725.1     4
 cellulase (Exo2b;EXO02C10-ORF14) 3.2.1.4 uncultured bacterium AEV59736.1     4
 cellulase (YBcontig404-00027-37) 3.2.1.4 uncultured bacterium ADU86901.1     4
 cellulase (YBcontig310-00038-19) 3.2.1.4 uncultured bacterium ADU86902.1     4
 YBcontig210-00018-3   uncultured bacterium ADU86903.1     4
 YBcontig212-01208-46   uncultured bacterium ADU86905.1     4
 YBcontig310-00030-17   uncultured bacterium ADU86907.1     4
 YBcontig310-00038-18   uncultured bacterium ADU86908.1     4
 YBcontig310-00424-17   uncultured bacterium ADU86909.1     4
 YBcontig311-00171-5   uncultured bacterium ADU86910.1     4
 YBcontig217-00001-5 (partial)   uncultured bacterium ADU86906.1     4
 endo-β-1,4-glucanase (CRS100) (Cel5A)   uncultured bacterium AFJ44731.1     4
 endo-β-1,4-glucanase (CRS400) (partial) (Cel5D)   uncultured bacterium AFJ44729.1     4
 endo-β-1,4-glucanase (CRS300) (partial) (Cel5C)   uncultured bacterium AFJ44730.1     4
 cellulase-xylanase A (Cel5A)   uncultured bacterium AFO64636.1     4
 cellulase-xylanase B (Cel5B)   uncultured bacterium AFO64637.1     4
 endoglycosidase (GH6248) (Cel5A) 3.2.1.4
3.2.1.73
3.2.1.78
3.2.1.8
uncultured bacterium ABB46200.1 Q283N5   4
 ORF (fragment)   uncultured bacterium AGO64706.1     4
 ORF (fragment)   uncultured bacterium AGO64707.1     4
 ORF (fragment)   uncultured bacterium AGO64708.1     4
 ORF (fragment)   uncultured bacterium AGO64709.1
AGO64710.1
    4
 ORF (fragment)   uncultured bacterium AGO64711.1     4
 ORF (fragment)   uncultured bacterium AGO64712.1     4
 ORF (fragment)   uncultured bacterium AGO64713.1     4
 ORF (fragment)   uncultured bacterium AGO64714.1     4
 ORF (fragment)   uncultured bacterium AGO64715.1     4
 ORF (fragment)   uncultured bacterium AGO64716.1
AGO64717.1
AGO64718.1
    4
 ORF (fragment)   uncultured bacterium AGO64719.1     4
 ORF (fragment)   uncultured bacterium AGO64720.1     4
 ORF (fragment)   uncultured bacterium AGO64721.1     4
 ORF (fragment)   uncultured bacterium AGO64733.1     4
 ORF (fragment)   uncultured bacterium AGW24153.1
ANN23772.1
ANN23773.1
ANN23774.1
ANN23775.1
    4
 ORF (fragment)   uncultured bacterium AGW24154.1     4
 ORF (fragment)   uncultured bacterium AGW24155.1     4
 ORF (fragment)   uncultured bacterium AGW24156.1     4
 4348GL13_002 / 4348GL9_002   uncultured bacterium ABW39333.1
ABW39340.1
A9LDS7   4
 4348GL14_002   uncultured bacterium ABW39334.1 A9LDS8   4
 4348GL2_002   uncultured bacterium ABW39335.1 A9LDS9   4
 4348GL5_001   uncultured bacterium ABW39338.1 A9LDT2   4
 4348GL6_003   uncultured bacterium ABW39339.1 A9LDT3   4
 4348JG23_005 (fragment)   uncultured bacterium ABW39343.1 A9LDT7   4
 4348JG24_006   uncultured bacterium ABW39344.1 A9LDT8   4
 4348JG36_001   uncultured bacterium ABW39347.1 A9LDU1   4
 4348JG38_003   uncultured bacterium ABW39348.1 A9LDU2   4
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