Glycoside Hydrolase Family 5 / Subf 4

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (601); Uniprot accession (185); PDB accession (34); 3D entries (16); cryst (0)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 Sequence 7 from patent US 6630340 (fragment)   Paenibacillus pabuli AAR65339.1     4
 Sequence 11 from patent US 6630340 (fragment)   Paenibacillus pabuli AAR65342.1     4
 xyloglucanase (XG5;PpXG5) 3.2.1.151 Paenibacillus pabuli AAR65335.1 H9KVH3 2JEP[A,B]
2JEQ[A]
4
 Sequence 8 from patent US 6630340 (fragment)   Paenibacillus pabuli AAR65340.1     4
 Sequence 5 from patent US 6630340 (fragment)   Paenibacillus pabuli AAR65337.1     4
 Sequence 6 from patent US 6630340 (fragment)   Paenibacillus pabuli AAR65338.1     4
 Sequence 9 from patent US 6630340 (fragment)   Paenibacillus pabuli AAR65341.1     4
 ABE82_25675   Paenibacillus peoriae HS311 ALA44669.1     4
 VK72_26355   Paenibacillus polymyxa ATCC 15970 APQ61948.1     4
 LK13_12800   Paenibacillus polymyxa CF05 AIY09407.1     4
 X809_27405   Paenibacillus polymyxa CR1 AHC22551.1
AIW42401.1
    4
 PPE_04909   Paenibacillus polymyxa E681 ADM72668.1 E0RA79   4
 cellulase 5B (Cel5B) 3.2.1.4 Paenibacillus polymyxa GS01 ABV08876.1 A9Q742   4
 AOU00_12510   Paenibacillus polymyxa J AOK90579.1     4
 PPM_5029 (CelC)   Paenibacillus polymyxa M1 CCI71836.1     4
 RE92_11905   Paenibacillus polymyxa Sb3-1 AJE51689.1     4
 PPSC2_c5412   Paenibacillus polymyxa SC2 ADO59348.1 E3EC08   4
 PPSQR21_051310   Paenibacillus polymyxa SQR-21 SQR21 AHM68714.1     4
 PPYC1_00265   Paenibacillus polymyxa YC0136 APB68897.1     4
 PPYC2_00275   Paenibacillus polymyxa YC0573 APB73548.1     4
 Sequence 4 from patent US 6630340 3.2.1.151 Paenibacillus sp. AAR65336.1     4
 BBD42_16440   Paenibacillus sp. BIHB4019 ANY70776.1     4
 H70737_04035   Paenibacillus sp. FSL H7-0737 AIQ22098.1     4
 P40081_30990   Paenibacillus sp. FSL P4-0081 AIQ32060.1     4
 R50345_03735   Paenibacillus sp. FSL R5-0345 AIQ33839.1     4
 R70723_26640   Paenibacillus sp. FSL R7-0273 AIQ49083.1     4
 R70723_20100   Paenibacillus sp. FSL R7-0273 AIQ47948.1     4
 R70331_19215   Paenibacillus sp. FSL R7-0331 AIQ53446.1     4
 R70331_25320   Paenibacillus sp. FSL R7-0331 AIQ54513.1     4
 ASL14_12175   Paenibacillus sp. IHB B 3084 ALP36808.1     4
 endoglucanase (EG5C)   Paenibacillus sp. IHB B 3084 AHA61672.1     4
 xyloglucanase (XEG5) (Xeg5) 3.2.1.151 Paenibacillus sp. KM21 BAE44526.1 Q3MUH8   4
 endoglucanase (EgL)   Paenibacillus sp. KSM-N546 BAJ22272.1 E1CAH3   4
 cellulase (CelP)   Paenibacillus sp. M33 ALF95239.1
ALF95239.2
    4
 GYMC10_1332   Paenibacillus sp. Y412MC10 ACX63618.1 D3EJE6   4
 HPL003_07225   Paenibacillus terrae HPL-003 AET58208.1     4
 endoglucanase   Paenibacillus terrae HPL-003 AHZ10945.1     4
 BS614_17320   Paenibacillus xylanexedens PAMC 22703 APO45603.1     4
 BS614_16030   Paenibacillus xylanexedens PAMC 22703 APO45372.1     4
 BS614_22430   Paenibacillus xylanexedens PAMC 22703 APO46518.1     4
 endo-β-1,4-glucanase (Cel5A) 3.2.1.4 Paenibacillus xylanilyticus KJ-03 AFC68970.1     4
 CPT03_02415   Pedobacter ginsengisoli T01R-27 ATP55398.1     4
 BFS30_09240   Pedobacter steynii DX4 AOM80706.1     4
 ING2E5A_1211   Petrimonas mucosa DSM 28695 SCM57160.1     4
 CIK06_21725   Plantactinospora sp. KBS50 ASW56215.1     4
 BTO07_06605   Polaribacter sp. SA4-12 ARV14840.1     4
 mixed-linkage β-glucanase/xyloglucanase (Orf4;CMCase;PBR_0368) (Cel5A) 3.2.1.151
3.2.1.73
Prevotella bryantii B14 AAC97596.1
AAA22909.1
O06842
Q44878
3L55[A,B]
3VDH[A,B]
5D9M[A,B]
5D9N[A,B]
5D9O[A,B]
5D9P[A,B]
4
 Prede_2171   Prevotella dentalis DSM 3688 AGB29444.1     4
 ADJ77_01650   Prevotella fusca JCM 17724 AKU68585.1     4
 HMPREF0659_A6565   Prevotella melaninogenica ATCC 25845 ADK97059.1 D9RV86   4
 CEP85_10005   Prevotella melaninogenica FDAARGOS_306 ASE18437.1     4
 PRU_2516   Prevotella ruminicola 23 ADE83642.1 D5EWN8   4
 xylanase / endoglucanase (PRU_2231) 3.2.1.4
3.2.1.8
Prevotella ruminicola 23 AAC36862.1
ADE83418.1
D5EV54
Q45397
  4
 endoglucanase (CelA;BrEND) 3.2.1.4 Prevotella ruminicola AR20 1814455A     4
 ORF   Prevotella sp. Sc00026 AHG56239.1     4
 ORF   Prevotella sp. Sc00026 AGH13958.1     4
 ORF   Prevotella sp. Sc00028 AGH14017.1     4
 ORF   Prevotella sp. Sc00033 AGH14046.1     4
 ORF   Prevotella sp. Sc00044 AGH14098.1     4
 ORF   Prevotella sp. Sc00066 AGH14127.1     4
 PSM36_3305   Proteiniphilum saccharofermentans SCD22090.1     4
 PSM36_3305   Proteiniphilum saccharofermentans SCD22090.1     4
 RO1_39790   Roseburia intestinalis XB6B4 CBL14187.1 D4L3J7   4
 endo-β-1,4-glucanase E (CelE;EgE) (Cel5C) 3.1.1.72
3.2.1.4
Ruminiclostridium thermocellum AAA23224.1 P10477 4IM4[A,B,C,D,E,F] 4
 AD2_01437   Ruminiclostridium thermocellum AD2 ALX08430.1     4
 acetylxylan esterase / 6-O-glycoside deacetylase (CelE;CtCE2;Cthe_0797) (Cel5C) 3.1.1.72
3.1.1.-
Ruminiclostridium thermocellum ATCC 27405 ABN52032.1 A3DDK3   4
 Clo1313_1425   Ruminiclostridium thermocellum DSM 1313 ADU74487.1     4
 LQRI_1438   Ruminiclostridium thermocellum DSM 2360 LQRI ANV76179.1     4
 Rumal_2636   Ruminococcus albus 7 = DSM 20455 ADU23111.1 E0L7H1   4
 Rumal_0022   Ruminococcus albus 7 = DSM 20455 ADU20585.1 E0L8B2   4
 Rumal_0564   Ruminococcus albus 7 = DSM 20455 ADU21113.1 E0L593   4
 Rumal_0896   Ruminococcus albus 7 = DSM 20455 ADU21423.1 E0L6F8   4
 Rumal_1082 (Cel5D) 3.2.1.4 Ruminococcus albus 7 = DSM 20455 ADU21608.1 E0L8I8   4
 endo-1,4-glucanase I (EGI) 3.2.1.4 Ruminococcus albus F-40 AAA26469.1 P16216   4
 endo-1,4-glucanase V (EgV) 3.2.1.4 Ruminococcus albus F-40 BAA92146.1 Q9LCC5   4
 β-1,4-endoglucanase VII (EgVII) (Cel5D) 3.2.1.4 Ruminococcus albus F-40 BAA92430.1 Q9LCC4   4
 endo-β-1,4-glucanase A (CelA;EgA) 3.2.1.4 Ruminococcus albus SY3 AAA26467.1
CAA38692.1
P23660
Q59733
  4
 endo-β-1,4-glucanase B (CelB;EgB) 3.2.1.4 Ruminococcus albus SY3 CAA38693.1 P23661   4
 RBI_I01803   Ruminococcus bicirculans 80/3 CCO05502.1     4
 RBI_I01493   Ruminococcus bicirculans 80/3 CCO05195.1     4
 RBI_I00082   Ruminococcus bicirculans 80/3 CCO03822.1     4
 RBI_I01961   Ruminococcus bicirculans 80/3 CCO05659.1     4
 RBI_II00321 (CelB)   Ruminococcus bicirculans 80/3 CCO06082.1     4
 RUMCAL_02387   Ruminococcus callidus ATCC 27760 ERJ92483.1     4
 RUM_03950   Ruminococcus champanellensis 18P13 = JCM 17042 CBL16630.1 D4LAI5   4
 RUM_05520   Ruminococcus champanellensis 18P13 = JCM 17042 CBL16772.1 D4LAX7   4
 RUM_13140   Ruminococcus champanellensis 18P13 = JCM 17042 CBL17440.1 D4LCU5   4
 endo-β-1,4-glucanase (GH5A;RUM_02800) (Cel5A) 3.2.1.4 Ruminococcus champanellensis 18P13 = JCM 17042 CBL16523.1 D4LA78   4
 RUM_12300   Ruminococcus champanellensis 18P13 = JCM 17042 CBL17363.1 D4LCL8   4
 endoglucanase   Ruminococcus flavefaciens WP_009986298.1     4
 RfGH5-1/2   Ruminococcus flavefaciens WP_009984467.1     4
 RF007C_13650   Ruminococcus flavefaciens 007c EWM52390.1     4
 RF007C_04235   Ruminococcus flavefaciens 007c EWM54675.1     4
 endo-β-1,4-glucanase A (EndA) 3.2.1.4 Ruminococcus flavefaciens 17 CAB05881.1
AAB19708.1
O05143
Q53302
  4
 RfCel5A (CBM-Rf1)   Ruminococcus flavefaciens FD-1 WP_009983134.1     4
 BN566_01553   Ruminococcus sp. CAG:254 CCZ83818.1     4
 BN611_00060   Ruminococcus sp. CAG:330 CDE11886.1     4
 BN645_01588   Ruminococcus sp. CAG:403 CDE32105.1     4
 BN739_01413 (fragment)   Ruminococcus sp. CAG:624 CDF01666.1     4
 endoglucanase 5C (Sde_0325) (Cel5C)   Saccharophagus degradans 2-40 ABD79589.1 Q21NZ0   4
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