Glycoside Hydrolase Family 5 / Subf 4

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (598); Uniprot accession (185); PDB accession (34); 3D entries (16); cryst (0)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 Clocel_3111   Clostridium cellulovorans 743B ADL52801.1 D9STR7   4
 Clocel_3242   Clostridium cellulovorans 743B ADL52928.1 P28623   4
 Clocel_3359 (EngE)   Clostridium cellulovorans 743B ADL53038.1 D9SV64   4
 endo-β-1,4-glucanase / xylanase D (EngD) 3.2.1.4
3.2.1.73
3.2.1.8
Clostridium cellulovorans ATCC 35269 AAA23233.1 P28623 3ICG[A,B,C,D]
3NDY[A,B,C,D]
3NDZ[A,B,C,D]
4
 endo-β-1,4-glucanase E (EngE) 3.2.1.4 Clostridium cellulovorans ATCC 35269 AAD39739.1 Q9XD99   4
 Clocl_0350   [Clostridium] clariflavum DSM 19732 AEV67086.1     4
 Clole_2863   Clostridium lentocellum DSM 5427 ADZ84561.1     4
 Clole_1765   Clostridium lentocellum DSM 5427 ADZ83488.1     4
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Clostridium longisporum AAC37035.1 P54937   4
 Cspa_c15090 (Engd2)   Clostridium saccharoperbutylacetonicum N1-4(HMT) AGF55279.1     4
 CLSAP_14720 (EngD)   Clostridium saccharoperbutylacetonicum N1-504 AQR94165.1     4
 Clo1100_1989   Clostridium sp. BNL1100 AEY66181.1     4
 Clo1100_2996   Clostridium sp. BNL1100 AEY67147.1     4
 CYFUS_004726   Cystobacter fuscus DSM 52655 ATB39282.1     4
 Desde_0328   Desulfitobacterium dehalogenans ATCC 51507 AFL98798.1     4
 DICTH_1476   Dictyoglomus thermophilum H-6-12 ACI18413.1 B5YFI6   4
 Dtur_1586   Dictyoglomus turgidum DSM 6724 ACK42859.1 B8E2L5   4
 I597_0070 (EngD)   Dokdonia donghaensis DSW-1 ANH59008.1     4
 MED134_00965   Dokdonia sp. MED134 EAQ39146.1     4
 Echvi_1163   Echinicola vietnamensis DSM 17526 AGA77434.1     4
 endoglucanase (EcCel5A) (Cel5A) 3.2.1.4 Eubacterium cellulosolvens 5 BAE46390.1 Q3LHN3   4
 endoglucanase (EcCel5A) (Cel5A) 3.2.1.4 Eubacterium cellulosolvens 5 BAE46390.1 Q3LHN3   4
 EUS_08060   [Eubacterium] siraeum 70/3 CBK96050.1 D4JSI1   4
 EUS_07020 (fragment)   [Eubacterium] siraeum 70/3 CBK95965.1 D4JS96   4
 EUS_07800   [Eubacterium] siraeum 70/3 CBK96026.1 D4JSF7   4
 EUS_16610   [Eubacterium] siraeum 70/3 CBK96759.1 D4JUJ0   4
 EUS_17890   [Eubacterium] siraeum 70/3 CBK96866.1 D4JUU7   4
 EUS_28120   [Eubacterium] siraeum 70/3 CBK97722.1 D4JXA3   4
 ES1_21880   [Eubacterium] siraeum V10Sc8a CBL35038.1 D4MMQ5   4
 ES1_13800   [Eubacterium] siraeum V10Sc8a CBL34359.1 D4MKS6   4
 ES1_22160   [Eubacterium] siraeum V10Sc8a CBL35063.1 D4MMT0   4
 ES1_22300   [Eubacterium] siraeum V10Sc8a CBL35076.1 D4MMU3   4
 ES1_24330   [Eubacterium] siraeum V10Sc8a CBL35246.1 D4MNB3   4
 ES1_25010 (probable fragment)   [Eubacterium] siraeum V10Sc8a CBL35306.1 D4MNH3   4
 Fisuc_0786 / FSU_1228 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ACX74396.1
ADL25822.1
C9RNF0   4
 Fisuc_3081 / FSU_0347 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ACX76661.1
ADL25927.1
C9RQB4   4
 endo-β-1,4-glucanase G (CelG;Fisuc_0897;FSU_1346) 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 AAB38548.1
ACX74504.1
ADL25356.1
Q47916   4
 OP10G_3034   Fimbriimonas ginsengisoli Gsoil 348 AIE86402.1     4
 OP10G_0309   Fimbriimonas ginsengisoli Gsoil 348 AIE83677.1     4
 Fjoh_0774   Flavobacterium johnsoniae UW101 ABQ03808.1 A5FLW7   4
 FORMA_02100   Formosa sp. Hel3_A1_48 AOR25405.1     4
 GE40 (fragment)   Geobacillus thermodenitrificans T81 ATG84593.1     4
 YC6258_01260   Gynuella sunshinyii YC6258 AJQ93308.1     4
 SD1D_0137   Herbinix luporum SD1D CUH91691.1     4
 I598_1837 (EngD)   Isoptericola dokdonensis DS-3 ANC31385.1     4
 endo-β-1,4-glucanase (CpCel5C;Cphy_2058) (Cel5C) 3.2.1.4 Lachnoclostridium phytofermentans ISDg ABX42426.1 A9KIH4   4
 Cphy_3202 (Cel5B)   Lachnoclostridium phytofermentans ISDg ABX43556.1 A9KRR2   4
 Lbys_2950   Leadbetterella byssophila DSM 17132 ADQ18612.1 E4RT74   4
 BBK82_30445   Lentzea guizhouensis DHS C013 ANZ39721.1     4
 BBK82_39200   Lentzea guizhouensis DHS C013 ANZ41121.1     4
 BBK82_39605   Lentzea guizhouensis DHS C013 ANZ41179.1     4
 LG3211_1842 (CelA)   Lysobacter gummosus 3.2.11 ALN90813.1     4
 Mahau_1114   Mahella australiensis 50-1 BON AEE96311.1     4
 YQ22_01505   Maribacter sp. 1_2014MBL_MicDiv APA63131.1     4
 MPTP_0437   Melissococcus plutonius ATCC 35311 BAK20916.1     4
 MPD5_1472   Melissococcus plutonius DAT561 BAL62675.1     4
 MEPL_c003880 (CelB)   Melissococcus plutonius S1 AIM25574.1     4
 Micau_0727   Micromonospora aurantiaca ATCC 27029 ADL44291.1 D9T9S5   4
 GA0070611_2248   Micromonospora auratinigra DSM 44815 SBT43216.1     4
 GA0070614_3821   Micromonospora coxensis DSM 45161 SCG64564.1     4
 GA0070610_1990   Micromonospora echinofusca DSM 43913 SCG15747.1     4
 GA0070618_5666   Micromonospora echinospora DSM 43816 SCF35569.1     4
 GA0070621_2658   Micromonospora narathiwatensis DSM 45248 SBT46588.1     4
 GA0070623_1261   Micromonospora rifamycinica DSM 44983 SCG45534.1     4
 GA0070623_3936   Micromonospora rifamycinica DSM 44983 SCG74880.1     4
 ML5_0971   Micromonospora sp. L5 ADU06511.1 D3CGB3   4
 MgSA37_02219 (EngD)   Mucilaginibacter gotjawali SA3-7 BAU54048.1     4
 MgSA37_02218 (Cela_2)   Mucilaginibacter gotjawali SA3-7 BAU54047.1     4
 MgSA37_02220 (Cela_3)   Mucilaginibacter gotjawali SA3-7 BAU54049.1     4
 MgSA37_02211 (Cela_1)   Mucilaginibacter gotjawali SA3-7 BAU54040.1     4
 SAMN05216490_2359   Mucilaginibacter mallensis MP1X4 SDT04183.1     4
 SAMN05216490_0706   Mucilaginibacter mallensis MP1X4 SDS19204.1     4
 SAMN05216490_3503   Mucilaginibacter mallensis MP1X4 SDT44428.1     4
 SAMN05216490_3497   Mucilaginibacter mallensis MP1X4 SDT44259.1     4
 SAMN05216490_2365   Mucilaginibacter mallensis MP1X4 SDT04517.1     4
 Niako_2370   Niastella koreensis GR20-10 AEV98714.1     4
 Niako_2373   Niastella koreensis GR20-10 AEV98717.1     4
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Paenibacillus barcinonensis BP-23 CAA73113.1 O08342   4
 PBOR_29450   Paenibacillus borealis DSM 13188 AIQ60609.1     4
 AR543_12135   Paenibacillus bovis BD3526 ANF96686.1     4
 LPB68_20605   Paenibacillus crassostreae LPB0068 AOZ94365.1     4
 B9T62_17370   Paenibacillus donghaensis KCTC 13049 ASA22401.1     4
 B9T62_37575   Paenibacillus donghaensis KCTC 13049 ASA26634.1     4
 B9T62_36890   Paenibacillus donghaensis KCTC 13049 ASA25821.1     4
 A3958_15225   Paenibacillus glucanolyticus 5162 ANA81244.1     4
 B4V02_25495   Paenibacillus kribbensis AM49 ASR49789.1     4
 endo-β-1,4-glucanase B (CelB;EG-B) 3.2.1.4 Paenibacillus lautus PL236 AAA22408.1
CAA01934.1
P23550   4
 PM3016_3665   Paenibacillus mucilaginosus 3016 AFC30484.1     4
 PM3016_1781   Paenibacillus mucilaginosus 3016 AFC28691.1     4
 PM3016_3663   Paenibacillus mucilaginosus 3016 AFC30482.1     4
 PM3016_6225   Paenibacillus mucilaginosus 3016 AFC32864.1     4
 B2K_19065   Paenibacillus mucilaginosus K02 AFH62790.1
AFK65347.1
    4
 B2K_09070   Paenibacillus mucilaginosus K02 AFH60868.1
AFK65326.1
    4
 B2K_19055   Paenibacillus mucilaginosus K02 AFH62788.1     4
 KNP414_01469   Paenibacillus mucilaginosus KNP414 AEI40033.1     4
 KNP414_04220   Paenibacillus mucilaginosus KNP414 AEI42752.1     4
 KNP414_04222   Paenibacillus mucilaginosus KNP414 AEI42754.1     4
 PODO_03840   Paenibacillus odorifer DSM 15391 AIQ72470.1     4
 Sequence 7 from patent US 6630340 (fragment)   Paenibacillus pabuli AAR65339.1     4
 Sequence 11 from patent US 6630340 (fragment)   Paenibacillus pabuli AAR65342.1     4
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