Glycoside Hydrolase Family 5 / Subf 45

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (20); Uniprot accession (3);
All (20) Bacteria (20)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 dqs_2441   Azoarcus olearius DQS4 ANQ85471.1     45
 azo2311   Azoarcus sp. BH72 CAL94928.1 A1K7X3   45
 AzCIB_4213   Azoarcus sp. CIB AKU14106.1     45
 AZKH_4274 (Spr1)   Azoarcus sp. KH32C BAL26553.1     45
 ACG10_17745   Azotobacter chroococcum B3 ASL27949.1     45
 Achr_34060   Azotobacter chroococcum NCIMB 8003 AJE22811.1     45
 AvCA_07130   Azotobacter vinelandii CA AGK15534.1     45
 AvCA6_07130   Azotobacter vinelandii CA6 AGK19467.1     45
 Avin_07130   Azotobacter vinelandii DJ ATCC BAA-1303 ACO76963.1 C1DLL5   45
 Despr_2680   Desulfobulbus propionicus DSM 2032 ADW18816.1     45
 JT25_011745   Methylomonas denitrificans FJG1 AMK77149.1     45
 Metme_4332   Methylomonas methanica MC09 AEG02681.1     45
 CEK71_07825   Methylovulum psychrotolerans HV10_M2 ASF45997.1     45
 SAMN05216221_3467   Pseudomonas oryzae KCTC 32247 SDT09889.1     45
 SAMN05216296_1878   Pseudomonas pohangensis DSM 17875 SDU11870.1     45
 THL1_2874   Pseudomonas sp. TCU-HL1 AOE85422.1     45
 AC731_012240   Thauera humireducens SgZ-1 AMO37644.1     45
 CCZ27_10140   Thauera sp. K11 ATE60263.1     45
 Tmz1t_0862   Thauera sp. MZ1T ACK53629.1 C4ZLL7   45
 glucan 1,3-β-glucosidase (Ey-baC)   uncultured bacterium ALO61088.1     45
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